Clinical Study on Effect of Fuzheng Kangbai Granule on Long-Term Survival of Patients with Acute Leukemia

Atthepresenttime,chemotherapyisthechieftreatmentofacuteleukemia(AL).Butwhilechemotherapyeliminatespathogens,italsodamagetheorganismitself.Andtherefore,whenALhasgottencompleteremissionbychemotherapyandenteredintominimalresidualleukemia(MRL)state,thepatientswould,inevitably,sufferfromDeficiency,showingthecharacteristicsof"bodyimpairmentafterEvilpathogenremoved"and"bothDeficiencyofQiandYinSyndrome"(l).Theauthorsexpectedtorebuildandrestoretheimmunefunction,andtopreventtherecurrenceandprolongt…     

Protective Effect of Herba Dracocephali on Lipoperoxidation Damage in Patients with Coronary Heart Disease

ＰｒｏｔｅｃｔｉｖｅＥｆｆｅｃｔｏｆＨｅｒｂａＤｒａｃｏｃｅｐｈａｌｉｏｎＬｉｐｏｐｅｒｏｘｉｄａｔｉｏｎＤａｒｎａｇｅｉｎＰａｌｉｅｎｔｓｗｉｔｈＣｏｒｏｎａｒｙＨｅａｒｔＤｉｓｅａｓｅＹａｎｇＳｈｕｉ－ｘｉａｎｇ（杨水祥）；ＬｉＴｉａｎ－ｄｅ（李...     

Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on microenvironment of ova in patients with endometriosis

Objective:To observe the effect of Quyu Jiedu Granules(祛瘀解毒颗料,QJG) on the micro-environment of ova in patients with endometriosis(EM).Methods:Twenty EM patients who received in vitro fertilization and embryo transfer(IVF-ET) were randomized equally into a treated group and a control group. Further,20 patients who received IVF-ET due to oviduct factors were enrolled into a non-endometriosis group. The dosage of gonadotrophic hormone used,the number of ova attained,fertilization rate and clinical pregnancy...     

Clinical Observation on Artificial Shexiang Baoxin Pill in Treating 112 Patients of Coronary Heart Disease with Angina Pectoris

Clinical Observation on Artificial Shexiang Baoxin Pill in Treating 112 Patients of Coronary Heart Disease with Angina Pectoris@王受益@戴瑞鸿@金椿     

Study on Syndrome Element Characteristics and Its Correlation with Coronary Angiography in 324 Patients with Coronary Heart Disease

Objective： Recently, a new traditional Chinese medicine differentiation theory ＂Syndrome Element（SE）＂ has been raised. In this study, the main syndrome element types and their correlations with the results of coronary angiography （CAG） in patients with coronary heart disease （CHD） were investigated. Methods： Epidemiology cross-sectional study method was employed and 324 patients with CHD were enrolled, and their syndrome element types as well as the CAG results were analyzed. The correlations among syndrome element types, Gensini score, and the number of abnormal branches were also analyzed based on the distribution characteristics of syndrome element and coronary angiography results in the 324 cases. Results：According to their occurrence frequency in 324 CHD patients, the top eight major heart syndrome elements were Xin （心） blood stasis （85.8%）, Xin qi deficiency （79.6%）, Xin heat blockage （41.1%）, Xin phlegm with turbid fluid （38.0%）, Xin qi stagnation （24.7%）, Xin yang deficiency （18.9%）, Xin yin deficiency （17.5%） and Xin cold coagulation （4.4%）, respectively, which suggested that Xin blood stasis and Xin qi deficiency were the two most common syndrome elements. Also, as coronary artery Gensini score increased, the changing trend of the syndrome element was ＂Xin yang deficiency with blood stasis＂ to ＂Xin phlegm obstruction with heat blockage＂ to ＂Xin yin deficiency with blood stasis＂ to ＂Xin qi deficiency with blood stasis＂ to ＂Xin cold coagulation with phlegm and turbid fluid, ＂Xin cold coagulation with blood stasis＂ to ＂Xin deficiency of qi, yin and yang＂. As the number of abnormal branches increased, the syndrome element changing trend was simultaneous occurrence of cold and heat syndrome＂ to ＂Xin qi and yang deficiency with blood stasis＂ to ＂Xin retention of phlegm with turbid fluid＂ to ＂Xin cold coagulation in the heart meridian＂, ＂Xin deficiency of both qi and yin＂. The result of this study shows that     

Does Percutaneous Coronary Intervention on Off Days have an Effect on Long-term Prognosis in Patients with Coronary Artery Disease in China?

As generally known, many hospitals provide routine care on weekdays but only emergency or urgent care on holidays and weekends. Hospital staffing is numerically reduced on holidays and weekends, as well as the available expertise on duty. The onset of acute myocardial infarction (AMI) on off days was reported to be associated with higher short-term mortality[1,2]. A similar phenomenon was also observed in patients with emergent diseases who were admitted on weekends and in the nighttime, as well as those who received elective procedures on weekends[3-5].     

Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with Primary Hypertension and Coronary Artery Disease

Objective:To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque (GAAP) in patients with primary hypertension and coronary heart disease (PHT-CHD).Methods:Seventynine patients with PHT-CHD were randomly divided into the treated group (39 patients) treated with garlicin and fosinopril and the control group (40 patients) treated with fosinopril alone. The change of CAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 (ICAM-1) and high sensitive C-reactive protein (hs-CRP) were measured by ELISA, with the observation proceeding for 52 weeks totally. Results:By the end of the experiment, the number of complex plaques, Crouse integrals, intima-media thickness, serum ICAM-1 and hs-CRP were significantly lower in the treated group than those in the control group with significant difference (P<0.05). Conclusion:Garlicin could stabilize CMP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.     

Clinical Observation on Effect of Shenqi Fuzheng(参芪扶正)Injection Combined with Chemotherapy in Treating Post-operational Patients with Colorectal Carcinoma

Chemotherapy(CT)is the most impor-tant therapeutic means in treating post-oper-ational patients with colorectal carcinoma(CA),but its efficacy is often affected bythe toxic side-effects of CT agents.TCMcould reinforce body resistance and tonifythe qi,alleviate the toxic side-effects of CT,thus strengthening the efficacy of organismagainst tumor.Shenqi Fuzheng(参芪扶正,     

Effects of Shenmai Injection on Blood SOD Activity and MDA Level in Senile Patients with Coronary Heart Disease

In order to approach the effects of Shenmai Injection on SOD activity and MDA level in the senilepatients with coronary heart disease,48 cases,who had stenosis of over 70% in more than one branchesof the coronary arteries,were assigned randomly into a treatment group (given Shenmai Injection plusthe routine treatment) and a control group (given the routine treatment only).The superoxide dismutase(SOD) activity and malondialdehyde (MDA) level were determined before treatment and at the end of a3-week treatment.The results showed that in the treatment group,the SOD activity was significantlyincreased (P<0.05) and the MDA level markedly decreased (P<0.01) in the treatment group.It can beconcluded that Shenmai Injection may enhance the antioxidant ability of the senile patients withcoronary heart disease.     

Effect of Salvia Miltiorrhizae Composita on Erythrocyte Membrane Phospholipid in Patients with Coronary heart Disease

Ｅｆｆｅｃｔ　ｏｆ　Ｓａｌｖｉａ　Ｍｉｌｔｉｏｒｒｈｉｚａｅ　Ｃｏｍｐｏｓｉｔａ　ｏｎ　Ｅｒｙｔｈｒｏｃｙｔｅ　Ｍｅｍｂｒａｎｅ　Ｐｈｏｓｐｈｏｌｉｐｉｄ　ｉｎ　Ｐａｔｉｅｎｔｓ　ｗｉｔｈ　Ｃｏｒｏｎａｒｙ　Ｈｅａｒｔ　ＤｉｓｅａｓｅＷＥＩＸｉａｏ－...     

Clinical Study on Chronopharmacokinetics of Digoxin in Patients with Congestive Heart Failure

Digoxinisamediumspeeddigitalis,oneofmostcommonlyusedoraldrugsinclinicalpracticeforthetreatmentofcongestiveheartfailure(CHF).Thetherapeuticdosageisveryclosetothetoxicdosage,sotherangeofthetherapeuticdosageiswithinanarrowlimit.Althoughtheserumdigoxinconcentrationtestshavebeenconductedforpatientsonthedigitalisduringrecentlyyears,thedeathrateofdigoxinintoxicationwasashighas4.6%["Zj.Inordertofindaguidanceforrationaluseofdigoxinandprovideareferencefortheclinicaltreatment,weconductedself~controlled…     

Clinical Observation on Effect of Yangxue Qingnao Granule(养血清脑颗粒剂)in Treating Patients with Cerebral Arteriosclerosis

Objective:To observe the efficacy of Yangxue Qingnao granule (YXQNG,养血清脑颗粒剂) in treating cerebral arteriosclerosis and to explore its mechanisms. Methods: One hundred and sixty-seven patients with arteriosclerosis were randomly divided into the treated group treated with conventional medical treatment plus YXQNG and the control group treated with conventional medical treatment alone, to observe the changes before and after treatment in scores of chief symptoms, mean velocity of cerebral blood flow (VM), plasma nitric oxide (NO), calcitonin gene related peptide (CGRP) and endothelin (ET) levels. Results: (1)After treatment in the treated group, the scores of chief symptoms such as vertigo, headache and tinnitus were significantly lower than those in the control group (P<0. 05 or P<0. 01) ; (2) NO and CGRP level in the treated group after treatment obviously elevated, and ET and VM markedly reduced ( P < 0. 01), while no evident change of these parameters was found in the control group (P<0. 01). C     

A Clinical Investigation on Tong Xin Luo Capsule in Treatment of Coronary Heart Disease with Silent Myocardial Ischemia

36 cases of coronary heart disease with silent myocardial ischemia(SMI)were treated sequentially withTong Xin Luo(TXL)capsule and isosorbide dinitrate in random order.The results showed that bothdrugs were effective in decreasing episodes of SMI and shortening the duration of asymptomaticmyocardial ischemia.TXL,however,was found with a better action and was superior to isosorbidedinitrate.It was also found that TXL could improve diastolic function of the left ventricle as well.     

Clinical Observation in 40 Cases of Postmenopausal Coronary Heart Disease Treated with Yanghuo Sanzi Tang

Modem researches have shown that the incidence ofcoronary heart disease (CHD) among the womenbefore menopause is only 30% of that in men.However,the incidence and mortality of CHDamong the women after menopause jumps by 400%over those before menopause,higher than that inmen.With the age increasing every 10 years,the     

Effect of Xinmaitong Capsule on Total Insche mia Burden in Coronary Heart Disease Patients with Myocardial Ische mia and Analysis of Its The rapeutical Mechanis m

Effect of Xinmaitong Capsule on Total Insche mia Burden in Coronary Heart Disease Patients with Myocardial Ische mia and Analysis of Its The rapeutical Mechanis m@丘瑞香@邝翠仪@刘红健@冯君@贺敬波@蓝军     

ORIGINAL ARTICLES——Clinical Study on Effect of Garlicin in Stabilizing the Carotid Artery Atherosclerotic Plaque in Patients with Primary Hypertension and Coronary Artery Disease

Objective： To investigate the effect of garlicin in treating carotid artery atherosclerotic plaque （OAAP） in patients with primary hypertension and coronary heart disease （PHT-OHD）. Methods： Seventynine patients with PHT-OHD were randomly divided into the treated group （39 patients） treated with garlicin and fosinopril and the control group （40 patients） treated with fosinopril alone. The change of OAAP was evaluated by high frequency ultrasonic examination every six months, and the changes of intercellular adhesion molecule-1 （IOAM-1） and high sensitive O-reactive protein （hs-ORP） were measured by ELISA, with the observation proceeding for 52 weeks totally. Results： By the end of the experiment, the number of complex plaques, Orouse integrals, intima-media thickness, serum IOAM-1 and hs-ORP were significantly lower in the treated group than those in the control group with significant difference （P〈0.05）. Conclusion： Garlicin could stabilize CAAP to a certain extent and shows a definite vascular protective effect in patients with PHT-CHD.     

Comparative Study of the Effect of Shugan Shuru Granule(疏肝舒乳颗粒)on Pathology and p53 Gene Expression in Patients with Hyperplastic Disease of Breast

Objective: To study the effect of Shugan Shuru Granule (疏肝舒乳颗粒, SSG) on the p53 gene expression in patients with hyperplastic disease of breast (HDB) to indirectly explore the mechanism of SSG's effect on HDB on the molecular pathological level. Methods: Sixty-six patients with HDB were allocated in the treated group and the control group, with the former treated with SSG and the latter not. All patients underwent breast operation and their diseased mammary tissues were cut out, sectioned, and observed under microscopy with HE staining and immunohistochemical staining, with ABC method adopted to estimate the degree of hyperplasia and p53 gene expression. The severity of HDB was classified into normal, mild, moderate and severe grades (marked as 0 to Ⅲ ), according to the degree of hyperplasia in the mammary gland.Results: Hyperplasia in the control group mostly belonged to grade Ⅰ - Ⅲ before treatment, showing overgrowth of gland and proliferation of glandular epithelial cells, which were high columnar shaped, more stratified, with papillary or substantive dysplasia. While in the treated group, most belonged to grade 0- Ⅰ after SSG treatment, with proliferated gland and dysplasia recovered to normal or disappeared. The positive rate of p53 gene expression in the treated group was 9.09%, and in the control group 39.39%, comparison between the two groups showing significant difference ( P＜0.01), the intensity in the former was significantly weaker than that in the latter. Conclusion: SSG could not only inhibit the proliferation of mammary duct epithelia and Iobuli, but also inhibit the over-expression of P53. Therefore, it could be regarded as an effective remedy for treatment of HDB and prevention of mammary cancer genesis.     

Effect of Tianhuang Granule(田黄冲剂) on Intracranial Pressure and Serum Matrix Metalloproteinase-9 in Patients with Acute Cerebral Hemorrhage

<正>Objective:To study the effect and mechanism of Tianhuang Granule(田黄冲剂,THG)on hydrocephalus in the patients with acute cerebral hemorrhage(ACH)through intracranial pressure(ICP) monitoring,serum matrix metalloproteinase-9(MMP-9)level observation,and National Institutes of Health Stroke Scale(NIHSS)scoring(for nerve function deficit).Methods:Sixty patients with ACH were equally randomized into two groups by lottery,the control group and the THG group;all were treated with conventional therapy, but to the patients in the THG group,THG was given orally in addition for 28 days.Changes of ICP,MMP-9 expression,and NIHSS scores,as well as the degree of cerebral hematoma and hydrocephalus(by cranial CT scanning)in the patients,were estimated and compared.Results:(1)ICP was lowered more significantly in the THG group,showing a significant difference between groups on day 7(P0.05).(2)MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group.(3)The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3(P0.05),but in the control group,the day of significant reduction was delayed to day 14,and the degrees on day 7 and day 14 in the two groups were significantly different(P0.05 and P0.01).(4)NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28(P0.05 and P0.01).Conclusion:THG can effectively lower ICP,down-regulate MMP-9 expression,promote the absorption of cerebral hematoma and hydrocephalus,and improve the nerve function,showing a clinical effectiveness than conventional therapy.     

The Effect of Acupuncture on Serum IgE Level in Patients with Chronic Urticaria

The pathogenesis for chronic urticaria is not clear yet, and there has been no assured effective therapies for it. In the present study on the therapeutic effects of acupuncture for chronic urticaria and its mechanisms in immunity, the author put the stre…