甲壳素及其衍生物的质量分析研究进展

评述了甲壳素及其衍生物的质量分析研究进展。从外观性状、比旋度、黏度、溶解度、热稳定性等介绍了性状;从光谱法、色谱法和物理化学反应等介绍了鉴别;从含氮量、相对分子质量及其分布、酸碱度、干燥失重、炽灼残渣、重金属、蛋白质、离解常数、纯度等介绍了检查;从脱乙酰度、取代度、氨基葡萄糖、甲壳素及其衍生物含量等讨论了含量测定,并对其质量标准前景作了展望。     

中药了哥王研究进展

目的对中药了哥王的化学成分和药理作用等方面研究做一系统概述。方法通过系统查阅国内外发表的30余篇文献,对其化学成分和药理作用等方面研究进行了总结归纳。结果了哥王主要含有香豆素类、黄酮类、木脂素类等多种化学成分。具有抗菌、抗病毒、抗炎、抗癌等药理作用。临床用于上呼吸道感染、肝炎、乳腺炎等病症的治疗。结论本文旨在为中药了哥王的进一步开发利用提供一定参考。     

胃食管反流性疾病的药物治疗

本文综述了近年来出现的治疗胃食管反流性疾病的药物，如西沙必利、红霉素、思密达等的作用机理、用法用途、疗效观察及副反应等，并与临床上的习惯用药如多潘立酮、雷尼替丁、法莫替丁等做了比较，认为新药的确有疗效可靠、作用强大、副作用少或价廉等优点，体现了药物发展的特色。     

手参属藏药材研究进展及质量标记物预测分析

我国兰科手参属藏药材包括手参、西南手参、粗脉(短距)手参、角距手参和峨眉手参,均可作为藏药材手掌参入药,具有补益气血、补肾益精等功效。近年来发现手参、西南手参等具有防治阿尔茨海默病、抗肿瘤、降糖等活性而引起了广泛关注。本文作者对手参属藏药材的传统应用、化学成分、药理活性等进行了综述,并在此基础上对手参属质量标记物进行了预测分析,以期为手参属藏药材进一步的开发利用、质量标准研究等提供参考。     

微生物相关的免疫抑制剂

主要介绍了几种微生物产生的免疫抑制剂。从发现时间、结构、作用机制等方面将各种免疫抑制剂作了比较，对其适应症、副作用等进行了阐述。大环内酯类、杂环类、直链类、芳香族类免疫抑制剂各有其特点，在治疗器官移植、自身免疫系统疾病等方面发挥着不同的作用。     

山药的研究进展

本文综述了山药的化学成分,从调节脾胃、抗衰老、降糖脂、抗肿瘤等多方面介绍了山药的药理作用,同时综述了山药在日常生活中对于传染病、小孩腹泻、肥胖等的应用情况以及山药的不良反应.     

栀子的化学成分与药理作用

综述了近年来对栀子中的栀子色素、萜类、精油等化学成分的研究进展，并对其抗炎、保肝、抗肿瘤、抗氧化等药理活性作了简要分析。     

微囊化基因工程细胞研究进展

文章综述了微囊技术的发展、一般概念、制备过程、方法和原理等内容，并对近年微囊化基因工程细胞的研究进展、优点等做了相关回顾。     

灵芝的化学成分和药理作用

灵芝含有多糖、三萜类、核苷、甾醇、生物碱、氨基酸、微量元素等多种化学成分,具有抗肿瘤、保肝、调节免疫、抗衰老等生物活性。综述了近年来对灵芝的化学成分、药理作用等的研究进展。     

姜黄素的提取及其含量测定研究进展

姜黄素是国内外食品行业允许使用的重要天然色素之一,其提取方法除醇提法与碱水提取法之外,渗漉、超声、酶等方法也应用于提取中,提高了收率,降低了成本.精制方面也出现了活性炭柱层析法、大孔树脂法等,简化了工艺流程,提高了姜黄素质量.姜黄素的测定方法主要有高效液相色谱法、薄层扫描法、分光光度法、库仑滴定法等.     

Harvey A. K. Whitney Lecture. To a new beginning from converging paths

The implementation of the pharmaceutical care concept is discussed. Current activities of professional pharmacy organizations are laying the groundwork for the new emphasis on patient outcomes, which is seen in the mission statements of the American Pharmaceutical Association (APhA) and the Joint Commission of Pharmacy Practitioners (JCPP). APhA is revalidating its standards of practice; the American Association of Colleges of Pharmacy (AACP) has formed a Commission to Implement Change in Pharmaceutical Education; the American Council on Pharmaceutical Education (ACPE) is revising its standards to be consistent with entry-level practitioners' ability to provide pharmaceutical care and seeking ways in which pharmacists currently practicing in all sites can upgrade their skills. These groups are called on to implement pharmaceutical care: To make known the "value-added services" encompassed in pharmaceutical care, JCPP should market to the public its concept of pharmacists' mission. APhA should analyze pharmaceutical services currently provided and promote postgraduate training programs in pharmaceutical care. ACPE must focus on ways pharmacists can achieve the competencies required for pharmaceutical care, and AACP must ensure that academic programs are consistent with the needed competencies. ASHP should hold a national conference on implementation of pharmaceutical care, create a commission for this purpose, direct more effort at pharmacists practicing in nonhospital settings, and accelerate its clinical skills development program. Employers should put less emphasis on "clinical" designations and Pharm.D. degrees and more on the ability to provide pharmaceutical care. Implementation of pharmaceutical care is imperative.     

Pharmaceutical information activities

This paper reviewed the progress of the pharmaceutical information activities after the war during fifty years. Activities of the pharmaceutical information organizations, progress of pharmaceutical information tools and techniques, the pharmaceutical information education in universities are described.     

我国医药企业营销模式的战略选择

目的 探讨新医改背景下中国医药企业营销模式的战略选择.方法 解读新医改方案,对两家医药企业(扬子江药业和恒瑞医药)典型的营销模式进行比较分析.结果与结论 医药企业营销模式应顺应医药市场两级分化的趋势,借助商业渠道提升营销活力,通过专业培训提高人员素质.此外,开展营销推广时学术活动应与公益活动有机结合.     

美国UIC医院药学教育和服务实践

目的 介绍美国医院药学的教育和实践,为我国医院药学的发展提供借鉴。方法 结合查阅文献,阐述笔者实地考察美国伊利诺伊大学芝加哥分校（UIC）医院药学教学和服务实践。结果 Pharm.D教育在美国日趋成熟并彰显作用;UIC药学部由住院中心药房、门诊药房、卫星药房、药品分装室、临床药学等部门组成,高度的信息化和自动化很好保障了日常药品调剂的安全性和工作效率;临床药学服务覆盖器官移植、肿瘤药学、儿科药学、抗凝门诊、戒烟门诊、抗菌药物管理、慢病管理及远程医疗等众多领域;绩效考核制度充分体现科学性和人性化。结论 UIC医院药学管理高度信息化和智能化,临床药学服务系统而精细,充分体现药师在药物治疗中的作用和地位,值得国内借鉴和学习。     

我国化学制药企业的内向国际化经营

目的:探讨我国化学制药企业的内向国际化经营及其对开展外向国际化经营的影响。方法:运用国际化经营的理论,结合我国化学制药企业内向国际化经营的实际情况,进行实证分析。结果与结论:我国化学制药企业通过有效的内向国际化经营在技术、资金、实力等方面得到了增强,从长远看有利于外向国际化经营的实现。     

浅析一例肝硬化患者的药学监护信息

通过我院临床药师在参与消化内科临床医疗活动中,对一例肝硬化患者开展药学监护活动的实践经验,并结合药学服务理论知识,分析、总结肝硬化患者在药学监护中应关注的药学信息要点,为药师参与临床合理用药及开展药学监护工作提供参考和积累经验。     

The challenges of defining pharmaceutical care on an international level

The objective of this article is to gain insight into the place of pharmaceutical care in health care and into the different interpretations of the term “pharmaceutical care” around the world. Based upon a literature review, communication with peers and results from an international questionnaire, the different influences on and interpretation of the terminology are outlined, and the place of pharmaceutical care within the health system is defined. The Dutch situation with regard to pharmacy and pharmaceutical care is used as an example of the national development of a definition. Different linguistic and cultural influences on the construction of the definition are discussed. There are different definitions of pharmaceutical care, although several countries use the 1990 definition of Hepler and Strand as a working definition. The term is often used without an explanation of its content. Influences of health systems, cultures and languages across different countries on the interpretation of the term are often overlooked. We conclude that, even after 20 years of evolution of the definition of pharmaceutical care in different cultures, for an observer it is not absolutely clear what pharmaceutical care is, and where exactly it fits into health care in different countries. The definition of social and culturally bound activities such as pharmaceutical care need rephrasing, depending on factors in the country of practice and health care system developments over time. Additionally there are conceptual language differences.     

Millennium Pharmaceuticals

Millennium Pharmaceuticals is a public company, founded in 1993 and based in Cambridge, Massachusetts, that has pioneered the exploitation of genomic methods in the identification of novel therapeutic targets. By exploiting its technologies it was able to generate substantial revenues through strategic partnerships with companies such as Bayer, Aventis and Abbott. These revenues augmented the cash raised from its flotation and have enabled Millennium to revise its corporate strategic, by acquiring the product-driven pharmaceutical biotechnology companies Leukosite and COR Therapeutics, and evolve towards its aim of becoming an integrated pharmaceutical company. This analysis of its patenting activity since its inception indicates that genomic-related patent applications still currently account for most of its patenting activities.     

虎杖及其化学成分的质量控制

虎杖为中国传统中草药,已在多种中药制剂中应用,临床用途广泛,含有多种活性药理成分。根据有关文献,对虎杖及其质量控制状况作一综述,为其进一步研究及开发利用提供依据。     

Managing the interface with marketing to improve delivery of pharmacovigilance within the pharmaceutical industry.

The pharmaceutical industry is under pressure to improve the scientific quality of its decisions concerning the benefit and risks of its products while ensuring compliance with acceptable standards of marketing. All those in a pharmaceutical company who currently work within pharmacovigilance should be encouraged to lead from the front to examine ongoing marketing activities to see how they can be adapted more towards pharmacovigilance and risk management. The current irony is that the personnel who have the greatest influence on benefit-risk decisions of a product are not necessarily those who acknowledge that they are performing pharmacovigilance. Indeed, for all concerned, whether their orientation is scientific and commercial, effective communication with prescribers and consumers usually underpins product success. Also, a substantial 'marketing' budget is culturally acceptable for the pharmaceutical industry so it is logical to assume that resource for postmarketing activity is often made available. Given these realities, I suggest we should strive for an integrated marketing and risk-management plan based on the best available evidence and that being fully aware and in control of the safety issues for your products is the best way to commercialise them successfully. This approach can still be consistent with other corporate responsibilities such as trying to reduce the financial burden of product development. If this article stimulates further debate about how the pharmaceutical industry can more effectively organise resources and operations to support pharmacovigilance, risk management, and marketing, then it will have achieved its purpose.