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11例肝豆状核变性的磁共振影像学观察 总被引:2,自引:0,他引:2
11例肝豆状核变性的磁共振影像学观察刘吉良,李义召,张凤芝,张守瑞自1990年以来,我们观察了11例肝豆状核变性(HLD)患者的磁共振(MRI)影像学改变,目的是研究HLD的MRI表现与临床症状、病程进展、治疗效果之间的相互关系。并对HLD脑病灶的M... 相似文献
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多发性硬化三例标本MRI长T2信号与病理对照研究 总被引:7,自引:0,他引:7
采用磁共振成像(MRI)与病理对照方法探讨多发性硬化(MS)MRI异常长T2信号与病理改变的关系。对3例经10%福尔马林固定的全脑标本(其中1例含脊髓)行自旋回波(SE)序列扫描,对照MRI图像所示的长T2信号行标本大体及镜下观察。3例MS均显示有长T2信号,其病理基础除MS斑块外还可见坏死软化灶及空洞形成。斑块状长T2信号具有特征性的MRI表现:直角脱髓鞘征,见于病程长者(例1)。坏死软化灶及空洞形成引起的非斑块状长T2信号形态分布不一,以病程短、起病急者为著(例2、3),后者脊髓受累程度亦严重。MRI是诊断MS最有价值的影像学检查方法。MS长T2信号的病理基础除典型硬化斑外还有坏死软化灶及空洞形成。当临床拟诊为MS,而MRI仅显示非斑块状长T2信号时,应警惕为急性发病的MS。 相似文献
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肝豆状核变性离体培养细胞内金属硫蛋白代射的研究 总被引:4,自引:0,他引:4
测定了一般培养条件下以及经各种浓度铜孵育后肝豆状核变性(HLD)患者,杂合子的离体培养皮肤成纤维细胞内金属硫蛋白(MT)含量的变化。发现,一般培养条件下,三组间MT含量无显著性差异,但经高浓度铜孵育后,患者MT的含量明显比另二组高。讨论了MT异常在HLD发病机理中的重要作用。 相似文献
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铜孵育对肝豆状核变性培养细胞内铜在不同分子量蛋白上分布… 总被引:1,自引:0,他引:1
研究不同浓度铜孵育后,肝豆状核变性(HLD)患者和杂合子离体培养皮肤成纤维细胞内铜在不同分子量蛋白上分布的变化规律,提出了在HLD患者细胞内,可能存在铜进入细胞后从大分子蛋白向金属硫蛋白(MT)转移的过程,并对MT异常在HLD发病机理中的作用进行了讨论。 相似文献
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急性脊髓炎的MRI与临床 总被引:3,自引:0,他引:3
目的探讨急性脊髓炎的脊髓MRI表现特点,以及MRI是否有助于本病的诊断。方法对21例急性脊髓炎患者进行了脊髓MRI矢状面和横轴面扫描。结果本病以上胸段及下颈段受累多见,部分病例可无异常,大部分病例病变区范围大,MRI显示的病变上界高于临床感觉障碍平面的上界,脊髓呈均匀一致肿胀,T2加权像呈斑片状或条索状高信号,增强扫描可无强化或轻度斑点状强化。结论认为MRI对本病的诊断与鉴别诊断有其特殊的价值,是其它检查不能替代的。 相似文献
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亚急性联合变性的磁共振表现 总被引:17,自引:1,他引:16
目的评价磁共振成像(MRI)对亚急性联合变性(SCD)的诊断价值。方法对临床和实验室检查确诊的7例SCD患者进行MRI检查。结果有3例异常,均位于胸段脊髓,2例T2加权为片状或条状高信号区,1例胸髓变细。结论MRI对SCD有一定的诊断价值。 相似文献
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磁共振成像对肾上腺脑白质营养不良的诊断价值 总被引:2,自引:0,他引:2
报告4例肾上腺脑白质营养不良(ALD)患者的磁共振成像(MRI)表现。MRI表现为双侧对称的白质异常信号,主要位于枕、顶、颞叶,视放射和胼胝体压部,T1加权为低信号,T2加权为高信号,有增强效应。多维成像和高对比强度使MRI比CT有更强的敏感性,能明确病变的部位及其严重程度,故MRI是诊断ALD的有效手段。 相似文献
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多发性硬化的MRI增强的临床意义研究 总被引:4,自引:1,他引:3
目的探讨在MRI增强中多发性硬化(MS)病灶强化的机制与临床的关系。方法对23例MS患者均作MRI平扫与增强扫描,其中9例作MRI平扫与增强复查,使用德国西门子公司P80.2T永磁型MR成像仪,采用SE序列。造影剂使用GD-DTPA,剂量为0.1ml/kg。结果MRI平扫,MS病灶呈长T1长T2的斑片状异常信号,静脉注入GD-DTPA后产生的强化。用以分析MS的MRI强化特征与临床分型的关系。结论不同临床类型的MS患者,在MRI平扫及增强上均有不同的表现,这可能与MS斑的形成有不同的病理机制有关 相似文献
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32例肝豆状核变性患者的脑电图研究 总被引:1,自引:0,他引:1
对32例肝豆状核变性(HLD)患者的脑电图(EEG)、颅脑CT、颅脑磁共振(MRI)和血清铜、铜蓝蛋白、铜氧化酶、尿铜及肝功能进行了比较研究。结果表明,EEG的异常率略高于CT、MRI、血清铜、铜蓝蛋白、铜氧化酶的异常率,但无显著性差异;EEG的异常率显著低于尿酮的异常率和显著高于SGPT的异常率,其间有显著性差异。这提示,HLD患者的EEG异常不但直接反映大脑功能状况,而且还可间接地反映患者体内 相似文献
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The comparative effectiveness of the inhibitory influence of tetanic stimulation of hypothalamus, amygdala and limbic cortex on EMG-response of m. digastricus evoked by electrical stimulation of tooth pulp nociceptive afferents was studied in cats anesthetized with a mixture of chloralose and nembutal. It was found that inhibition of the EMG-component of the jaw-opening reflex is most pronounced in case of stimulation of medial and lateral region of the hypothalamus, the inhibitory effect of central and medial nuclei of the amygdala is less pronounced and the effect of the limbic cortex is the weakest. It was shown that the mechanism of the antinociceptive effect of tetanic stimulation of the hypothalamus is not related to the concomitant increase of the blood pressure. After stabilization of the blood pressure the suppressive effect of the hypothalamus remains without changes, that points out to a direct, primary, not baro-afferent mechanism of the inhibition of the activity of nociceptive neurons of the trigeminal sensory nuclei. Noradrenaline, injected intravenously, induced a large increase of the blood pressure accompanied by a pronounced inhibition of the pain reflex. Angiotensin causes the same degree of blood pressure elevation without changes in the amplitude of the EMG-response of the pain reflex. Hypothalamic and noradrenergic mechanisms for control of pain sensitivity are discussed. 相似文献
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药物治疗与合并认知行为治疗对强迫症疗效的比较 总被引:2,自引:0,他引:2
目的探讨认知行为心理治疗(CBT)在强迫症(OCD)患者各亚型治疗中的有效性和规律性。方法本研究为临床对照研究。符合入组标准的强迫症患者按患者自愿原则分为两组,治疗观察3、6、12个月。疗效评定分别运用Yale-Brown强迫量表,自拟的自评好转程度量表和临床疗效评定。结果认知行为心理治疗合并药物治疗组31例,临床有效率70.9%,其中治愈率1.8%。单纯药物治疗组24例,临床有效率33.3%。Yale-Brown强迫量表和自评量表得分在6个月和12个月两组有显著差异(P<0.05)。其中强迫症亚型(怕脏型、反复检查型和反复担心型)的疗效比较,怕脏型在治疗3个月末两组间自评量表评分有显著性差异(P<0.05);反复担心型在治疗6个月末两组间Yale-Brown强迫量表总分有显著性差异(P<0.05);反复检查型两组间无统计学差异。结论认知行为心理治疗合并药物治疗强迫症的疗效明显优于单纯药物治疗。强迫症的亚型在治疗中的有效性次序为:反复担心型>怕脏型>反复检查型。 相似文献
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R. Eccles D. I. Wallis 《Journal of neural transmission (Vienna, Austria : 1996)》1976,39(1-2):113-130
Summary Vasomotor responses from the nasal mucosa and tongue, and contractions of the nictitating membrane, were recorded on stimulation of the cervical sympathetic or internal carotid nerves.Preganglionic sympathetic nerve fibres which elicited a membrane response possessed a lower threshold than those which evoked nasal vasoconstriction, while the latter displayed a lower threshold than fibres which evoked tongue vasoconstriction. The sympathetic vasodilator fibres to the tongue, whose activity was revealed after-receptor blockade, had a similar threshold to the vasoconstrictor fibres.Membrane contraction, nasal vasoconstriction and occasionally tongue vasoconstriction could be evoked by stimulating the internal carotid nerve. The postganglionic fibres innervating the nasal mucosa had a similar threshold to those of the nictitating membrane, which may indicate that there are small myelinated fibres innervating the mucosa.The preganglionic compound nerve action potential had four major components, S1–S4. S1, S2 and usually S3 fibres were associated with membrane contraction; S2, S3 and sometimes S1 fibres were associated with nasal vasoconstriction; and S3, usually S2 and occasionally S1 fibres were associated with vasoconstriction in the tongue. It is concluded that each of these three groups of nerve fibres, but not S4 fibres, may include fibres associated functionally with the three effectors.There was a considerable difference between the relative amplitude of the responses of the three effectors elicited by stimulation of the cervical sympathetic nerve at frequencies between 0.2 and 2 Hz. Vasoconstrictor responses were relatively larger than membrane contractions suggesting differences in the mechanisms of neurotransmission at the neuroeffector junctions. 相似文献
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Nodal FR Doubell TP Jiang ZD Thompson ID King AJ 《The Journal of comparative neurology》2005,485(3):202-217
Neurons in the deeper layers of the superior colliculus (SC) have spatially tuned receptive fields that are arranged to form a map of auditory space. The spatial tuning of these neurons emerges gradually in an experience-dependent manner after the onset of hearing, but the relative contributions of peripheral and central factors in this process of maturation are unknown. We have studied the postnatal development of the projection to the ferret SC from the nucleus of the brachium of the inferior colliculus (nBIC), its main source of auditory input, to determine whether the emergence of auditory map topography can be attributed to anatomical rewiring of this projection. The pattern of retrograde labeling produced by injections of fluorescent microspheres in the SC on postnatal day (P) 0 and just after the age of hearing onset (P29), showed that the nBIC-SC projection is topographically organized in the rostrocaudal axis, along which sound azimuth is represented, from birth. Injections of biotinylated dextran amine-fluorescein into the nBIC at different ages (P30, 60, and 90) labeled axons with numerous terminals and en passant boutons throughout the deeper layers of the SC. This labeling covered the entire mediolateral extent of the SC, but, in keeping with the pattern of retrograde labeling following microsphere injections in the SC, was more restricted rostrocaudally. No systematic changes were observed with age. The stability of the nBIC-SC projection over this period suggests that developmental changes in auditory spatial tuning involve other processes, rather than a gross refinement of the projection from the nBIC. 相似文献
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Summary The distribution of aminergic and non-aminergic nerve fibres to the different constituents of the wall of the digestive tract in various regions is described. Aminergic fibres synapse with all nervous perikarya. Densely interlacing networks of nerve fibres are found in both layers of the tunica muscularis and in the lamina muscularis mucosae. A finely meshed plexus is observed in relation to the wall of the blood vessels in the wall of the gut. There are many fibres connecting the muscular and the vascular plexus. No nerve fibres have been observed in direct relation to the epithelium.The functional implications of these findings are discussed. 相似文献