传染性软疣的超微结构

我们对2例传染性软沈用电子显微镜作了超微结构观察.病例1:7岁女孩,发病已8个月,四肢有数十个米粒到绿豆大的半球状坚实丘疹,脐凹明显,有的基底部有红晕,挤压时排出凝乳样小体.     

Imiquimod therapy for molluscum contagiosum

BACKGROUND: Molluscum contagiosum virus (MCV) is a large double-stranded DNA virus that is a member of the family Poxviridae, and which has a worldwide distribution. As with other poxviruses, MCV does not appear to develop latency but evades the immune system through the production of viral specific proteins. Objective: To evaluate the therapeutic efficacy of imiquimod 5% cream for MCV. METHODS: Thirteen children >5 and <10 years old, 19 immune-competent adults and four adults with advanced, but stable HIV-1 disease with >10 MCV lesions were treated with topical 5% imiquimod cream three times weekly for up to 16 weeks. RESULTS: Fourteen of 19 immune-competent adults, four of four adults with HIV-1 disease, and six of 13 children had resolution of their MCV lesions in <16 weeks of imiquimod therapy. Children tended to have more pruritus and inflammatory reactions with imiquimod, although most treated lesions appeared to respond. The development of new MCV lesions resulted in a lower overall resolution of the lesions in children. Imiquimod appeared to be the most efficacious in patients with HIV-1 disease and in the genital area in immune-competent adults. CONCLUSION: Although topical imiquimod appears to have some efficacy in the therapy of MCV, in children the pruritus correlated relatively well with the development of new lesions. In adults, areas that would be expected to have better penetration appeared to respond more consistently. Although the HIV-1-positive patients had the largest clinical lesions at the onset of therapy, as a group they had the best overall response to therapy.     

Treatment modalities for molluscum contagiosum

ABSTRACT: Molluscum contagiosum (MC) is caused by a poxvirus which produces cutaneous lesions which appear as small, firm, umbilicated papules. In general, there are three clinical presentations of MC: the childhood variety due to casual contact; the sexually transmitted variety in adults; and the aggressive form seen in patients infected with the human immunodeficiency virus (HIV). Removal of MC lesions is usually straightforward in the first two presentations and can include mechanical removal with a blade or curette, cryosurgery, podophyllin or podophyllotoxin, cantharidin, various acids or retinoids. In the HIV seropositive patient such treatments are usually inadequate due to the very large number of lesions and the rapid recurrence after mechanical removal. Combination therapy has been more successful in such cases especially if treatment includes such experimental antiviral/immunomodulatory agents as imiquimod or cidofovir.