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1.
目的了解福建省孕妇人群血清维生素D(VD)营养状况及VD水平影响因素,为孕期VD补充提供依据。方法采用多阶段按人口比例整群随机抽样法,抽取9个设区市的10个县(区),每个监测点(区/县)调查孕妇至少30人。采用统一问卷进行调查,液相色谱串联质谱法测定孕妇体内血清中VD水平。非条件Logistic回归分析建立模型,进行单因素和多因素分析,计算OR值及95%可信区间,筛选出与VD缺乏相关的危险因素。结果 304例孕妇中VD充足8例(2.6%),不足130例(42.8%),缺乏166例(54.6%),单因素非条件Logistic回归分析显示,孕前体质量偏重或偏轻,来自城市,无中等体力活动是孕妇血清VD缺乏的影响因素,多因素非条件Logistic回归分析显示,孕前体质量偏重(OR=2.385,95%:1.171~4.858)、来自城市(OR=1.714,95%:1.061~2.768)是孕妇VD缺乏的独立影响因素。结论福建省大部分孕妇(97.4%)存在VD不足或缺乏状态,而孕前体质量偏重、来自城市是孕妇体内VD缺乏的重要影响因素,应倡导育龄妇女孕前维持正常的体质量、适当增加户外活动以获得良好的妊娠结局。[营养学报,2019,41(6):544-549] 相似文献
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目的 探讨妊娠期维生素D(Vit D)水平及对母婴结局的影响。方法 选取2016—2021年在温州市中心医院就诊的妊娠期女性20 282例,采用质谱法测定受试者血清25-羟维生素D含量,分析Vit D缺乏的影响因素及其与母婴不良结局的关系。结果 妊娠期Vit D水平为22.00(16.10~29.40) ng/ml, Vit D缺乏(<20 ng/ml)检出率为41.93%,Vit D不足(20 ng/ml≤Vit D<30 ng/ml)检出率34.75%。Vit D缺乏风险随检测孕周和年龄增大而下降;孕次>2次、产次>1次及检测时期BMI值过高是Vit D缺乏的危险因素(OR>1,P<0.05)。相对于春季和冬季,夏季与秋季是Vit D缺乏的保护因素(OR<1,P<0.05)。Vit D缺乏可显著增加子痫前期的发病风险(OR=2.29,95%CI:1.23~4.25,P<0.05)。结论 妊娠期Vit D缺乏或不足现象较为严重,Vit D水平受年龄、孕/产次、季节等多种因素影响,Vit D缺乏是子痫前期的危险因素,需加强妊娠期Vi... 相似文献
3.
调查分析2013-2018年舟山海岛地区0~12岁儿童25-羟维生素D[25-(OH)D]水平,为儿童健康管理工作提供科学依据.方法 收集2013年1月至2018年12月在舟山市妇幼保健院参加体检的5 424名0~12岁儿童为研究对象,采用电化学发光法检测其25-(OH)D含量.结果 5 424名儿童25-(OH)D检测结果中位数为29.9 μg/L,维生素D充足率仅为49.4%.儿童25-(OH)D水平和维生素D充足率随着年龄增长而显著下降(Z/x2值分别为2 043.65,1 535.52,P值均<0.01).结论 舟山海岛地区儿童维生素D营养充足率较低,7岁后学龄儿童缺乏更加严重,需加强宣教干预,建议增加户外运动,定期检测25-(OH)D水平,必要时合理补充维生素D制剂. 相似文献
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目的 调查西安市城区孕妇与新生儿维生素D营养状况,并进行相关因素分析,以了解孕妇与新生儿维生素D缺乏的流行现况及相关因素.方法 随机抽取冬春季和夏秋季两个时间段共182对在西安市第四医院产科分娩的孕妇及其新生儿为研究对象,采用问卷设计调查孕妇孕期维生素D的摄入情况.分娩当天抽取孕妇静脉血,分娩后采集新生儿脐血,检测血中25羟基维生素D、碱性磷酸酶、钙、磷的含量,对新生儿进行全面查体并记录.结果 新生儿脐血25羟基维生素D水平为(36.76±16.92)nmol/L,孕妇血清25羟基维生素D水平为(38.54±17.18)nmol/L,两者呈显著正相关(r=0.794,P<0.001);夏秋季组新生儿脐血25羟基维生素D[(39.23±17.11)]nmol/L明显高于冬春季组[(34.01±16.38)nmol/L],两组比较差异有统计学意义(t=2.08,P<0.05);如以血清25羟基维生素D<50nmol/L判断为维生素D缺乏时,分别有88.46%的孕妇及91.20%的新生儿为维生素D缺乏者.结论 西安城区孕妇及新生儿维生素D缺乏发病率较高;孕母维生素D营养状况决定脐血维生素D水平;孕期应补充足量维生素D以改善孕妇及新生儿维生素D营养状况. 相似文献
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目的 分析早中期妊娠孕妇血清中维生素D及微量元素水平。 方法 回顾性分析2016年2月—2017年11月于某妇幼保健所进行产前检查的421例孕妇临床资料,孕早期组271例,孕中期组150例。抽取两组孕妇空腹肘静脉血,采用酶联免疫吸附法检测血清25-羟基维生素D水平,采用全自动生化分析仪检测血清微量元素含量。比较两组孕妇维生素D及微量元素水平、维生素D摄入状况。 结果 孕早期女性维生素D(27.57±6.23)nmol/L及钙水平为(1.62±0.18)nmol/L,均低于孕中期(28.25±6.07)nmol/L、(1.63±0.16)nmol/L,血清镁水平为(1.49±0.25)nmol/L、铁水平为(7.87±0.37)nmol/L,均高于孕中期(1.39±0.27)nmol/L、(7.79±0.41)nmol/L,差异有统计学意义(P<0.05);孕早期维生素D缺乏率为24.72%,高于孕中期15.33%,孕中期维生素D摄入不足率为70.00%,高于孕早期59.04%,差异有统计学意义(P<0.05)。 结论 与孕中期孕妇相比,孕早期孕妇维生素D缺乏现象较为严重,而微量元素水平基本一致。 相似文献
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目的 对上海地区体检人群血清维生素D水平及相关因素进行分析。 方法 采用随机数据表法选择2017年在上海市某医院进行体检成年居民为调查对象,进行问卷调查和维生素D检测,调查内容包括调查对象人口学特征和维生素D相关影响因素,并对血清中25-羟基维生素D[25(OH)D]水平进行检测。采用描述流行病学方法对结果进行分析。 结果 共对1 000名上海地区体检人群进行调查,男性572人,女性428人,平均年龄(54.77 ± 15.30)岁,学生244人,在职513人,退休243人,分别占24.4%、51.3%、24.3%。高中及以上学历689人,占68.9%。月均收入以≥3 000元为主,有674人,占67.4%。上海地区体检人群血清25(OH)D平均为(27.44 ± 9.63)μg/L,范围值为12~56 μg/L,维生素D缺乏率、不足率、充足率分别为16.8%、32.2%、51.0%。性别、晒太阳时间和户外活动时间不同其血清中25(OH)D水平不同,差异有统计学意义( P<0.05或 P<0.01)。 结论 近一半上海地区体检人群维生素D不足或缺乏,性别、户外活动时间等因素影响人群的25(OH)D水平,建议增加人群的日晒时间及户外活动时间。 相似文献
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目的 了解南京地区妊娠中晚期孕妇维生素D水平,并分析其与年龄、孕周、孕前体质量指数(BMI)以及季节变化之间的关系,为临床开展维生素D检测及补充提供依据。方法 收集2015年1至12月在南京医科大学附属妇产医院建卡并定期产检的880名妊娠21~36周孕妇为研究对象,酶联免疫吸附法(ELISA)测定血清25羟-维生素D[25-(OH)D]浓度。结果 孕妇血清维生素D水平为(42.03±19.22)nmol/L,维生素D充足者仅42例(4.77%)。季节变化对维生素D水平有影响(P=0.016 4),夏季 [(44.61±23.57)nmol/L]和秋季[(43.43±19.31)nmol/L]高于春季[(39.68±16.91)nmol/L]和冬季[(39.65±13.36)nmol/L](均P<0.05)。不同孕周间血清维生素D水平差异无统计学意义(P=0.929 4)。不同年龄组间孕妇血清维生素D水平差异有统计学意义(P=0.038 3)。维生素D和孕前BMI间无相关性。结论 维生素D作为孕妇以及胎儿生长发育的必要营养素,营养状况不容乐观,建议积极开展维生素D检测。 相似文献
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近年来孕妇维生素D缺乏逐渐引起重视,孕妇维生素D缺乏除影响孕妇本身外,还可能对胎儿长期产生影响。本文就孕妇维生素D缺乏的原因和孕期维生素D缺乏对胎儿及生后不同阶段产生的影响进行综述,从而提高对孕妇补充维生素D的认识,以便更好地预防相关疾病的发生。 相似文献
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目的 通过对泰州地区部分儿童血清25羟维生素D检测,了解健康儿童25羟维生素D水平,为佝偻病防治提供依据。方法 选取2013年10月-2014年9月儿保门诊儿童共476 例。取清晨空腹血,采用串联质谱法检测其血清25羟维生素D水平。结果 泰州市儿童各年龄组血清25羟维生素D水平均呈偏态分布,以中位数表示,分别为婴儿组、幼儿组、学龄前期组、学龄组。经秩和检验,不同年龄组维生素D水平差异有统计学意义( P<0.05)。各年龄组维生素D水平男女性别差异无统计学意义( P>0.05)。476例儿童中, 维生素D严重缺乏(≤5 ng/ml)占3.15%(15/476); 缺乏(≤15 ng/ml) 占38.45%(183/476);不足或以下(15~20 ng/ml)占17.86% (85/476);充足(>20 ng/ml)占40.55%(193/467) ;过量(>100 ng/ml)为0。维生素D不足(≤20 ng/ml) 的儿童占59.45% (283/476),其中婴儿组为9.3% (8/476);幼儿组为36.21%(42/467);学龄前组为70.13%(54/567 );学龄期组为90.86%(179/476),以学龄期儿童为主,各组间差异有统计学意义( P<0.05)。不同季节血清维生素D值差异有统计学意义( P<0.05)。结论 泰州市儿童维生素D水平随年龄增长而下降,学龄儿童维生素D缺乏尤为严重,3岁以上儿童需注意补充维生素D,尤其是冬季。 相似文献
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维生素D(Vit D)是一种类固醇衍生物,对人体具有重要作用,Vit D缺乏可导致多种疾病。近年来发现孕期Vit D缺乏现象严重。本文主要从孕期Vit D缺乏对新生儿不良出生结局的影响进行综述,以期提高对孕期Vit D补充的认识,减少新生儿不良出生结局的发生。 相似文献
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Vitamin D status is essential for preventing bone disease. Young Korean women have the highest vitamin D deficiency prevalence compared with other demographic groups. This study aimed to establish the optimal vitamin D intake level for maintaining an adequate serum 25-hydroxyvitamin D (25[OH]D) level by season in young Korean women (mean age: 23.1 years). Each participant (wintertime, n = 101; summertime, n = 117) completed a lifestyle survey, dietary record, bone mineral density, and biochemical tests. Seasonal factors impacting 25(OH)D were identified, vitamin D intake for sufficient 25(OH)D levels was calculated, and the relationship between 25(OH)D and intact parathyroid hormone (iPTH) was analyzed. During summertime, 25(OH)D levels were higher than in wintertime (17.9 vs. 15.0 ng/mL). A 1 µg/1000 kcal increase in vitamin D intake increased 25(OH)D levels by 0.170 ng/mL in wintertime and 0.149 ng/mL in summertime. iPTH levels reached a theoretical plateau corresponding to an 18.4 ng/mL 25(OH)D level. The vitamin D intake threshold for maintaining 25(OH)D levels at ≥20 and ≥18.4 ng/mL was ≥10.97 μg/day. For a sufficient level of 25(OH)D in young Korean women, increasing summertime UV irradiation time and increasing vitamin D supplements and vitamin D-containing foods throughout the year is beneficial. 相似文献
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目的探讨孕晚期孕妇血脂水平与新生儿体重相关性。方法随机抽取2010年7月-2011年1月湖北省妇幼保健院孕晚期孕妇为研究对象,在研究对象知情同意后纳入本研究。根据新生儿体重分为三组不同体重组,检测孕妇血脂水平,分析孕妇血脂与新生儿体重的相关性。结果三组新生儿出生体重分别为(2 658±123)g(、3 386±203)g和(4 335±317)g,三组新生儿体重间差异有统计学意义(P〈0.05)。三组新生儿孕母在TC、TG、HDL-C和LDL-C差异有统计学意义(P〈0.05),而在ApoA和ApoB方面差异无统计学意义(P〉0.05)。相关性分析表明,新生儿体重与孕晚期孕妇血清TC和TG正相关(P〈0.05),与HDL-C和LDL-C负相关(P〈0.05),与ApoA和ApoB无关(P〉0.05)。结论孕妇孕晚期血脂水平可显著影响新生儿出生体重。 相似文献
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目的了解孕妇妊娠各期血清微量元素Zn、Fe、Cu、Ca、Mg的含量.方法采用日本岛津AA-6800型原子吸收仪测定北京地区妇女早孕108例、中孕107例、晚孕108例母体血清中5种微量元素含量,选择62例正常育龄未妊娠妇女血清微量元素含量做对照组进行分析研究.结果血清Zn、Fe、Mg孕期各组均低于非孕期对照组,并随孕周增加而逐渐降低.Cu含量孕期各组均高于未孕组,并随孕周增加而逐渐升高.Ca含量孕期各组与非孕组比较,差异无显著性.可能与孕期孕妇通过药物或饮食调节进行补钙有关.结论孕期动态监测孕妇血清微量元素,以指导不同孕期微量元素补充,对预防不良妊娠结局有重要的临床价值. 相似文献
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目的 了解上海市嘉定区妇女孕前、孕中期和孕晚期体内维生素D(Vitamin D, VD)水平的现状, 探讨孕中期和孕晚期VD水平的影响因素。 方法 选取2016年9月至2018年12月在上海市嘉定区妇幼保健院参加孕前检查并随访到分娩的94名妇女为研究对象, 采用化学发光法检测孕前、中期和晚期血清中的VD水平, 共检测282份血清。 结果 94名妇女的孕前、孕中期和晚期的VD缺乏率分别为:40.4%、57.4%和48.9%。混合线性模型结果显示, 近1年内有过染发/烫发的妇女孕期血清VD水平较低(P < 0.05), 孕期经常喝牛奶和吃深海鱼的妇女在孕期VD水平较高(P < 0.05)。 结论 上海嘉定区妇女孕前和孕期VD缺乏普遍, 应该重视在孕前和孕期VD的补充。 相似文献
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Objective: Fractures of bones, especially forearm fractures, are very common in children and their number is increasing. This study was designed to determine the impact of vitamin D serum levels and vitamin D receptor (VDR) polymorphisms on the occurrence of low-energy fractures in children. Methods: The study group consisted of 100 children with clinically relevant bone fractures and a control group consisted of 127 children without fractures. Total vitamin D [25(OH)D3 plus 25(OH)D2] serum concentrations were evaluated in every patient. Genotypes for 4 restriction fragment length polymorphisms of the vitamin D receptor gene (FokI, ApaI, TaqI, and BsmI) were determined by standard polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) techniques. Results: Differences in concentrations of vitamin D were observed between the group with bone fractures (median = 12 ng/ml) and the control group (median = 16 ng/ml; p = 0.000044). Higher levels of vitamin D reduced the risk of fracture by 1.06 times (p = 0.0005). No impact of particular VDR polymorphism on the occurrence of low-energy fractures in children was detected. However, there were significant differences in the prevalence of FokI polymorphism genotypes between the fracture and control groups (p = 0.05). Furthermore, the recessive “aa” genotype of ApaI polymorphism and the dominant “TT” genotype of TaqI polymorphism were associated with higher levels of vitamin D (p = 0.005 and p = 0.036, respectively). Conclusions: Vitamin D deficiency is an independent risk factor for fractures in children. ApaI polymorphism recessive “aa” and TaqI polymorphism dominant “TT” genotypes are associated with higher levels of vitamin D in serum. 相似文献
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Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth. 相似文献
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BACKGROUND/OBJECTIVESRecently, the recommended nutrient intakes (RNI) for vitamin D for Malaysian aged 1–70 yrs has been revised from 5 µg/day to 15 µg/day. This study is aimed to assess the adequacy of vitamin D intake based on revised RNI and to recommend several dietary strategies to increase total vitamin D intake. SUBJECTS/METHODSVitamin D intake from both food and supplement of 217 pregnant women was assessed using a validated food frequency questionnaire. Hypothetical effect of expanded supplementation and food fortifications strategies were modelled using the consumption data. RESULTSThe results revealed that more than half (67.7%) of pregnant women had inadequate vitamin D intake (RNI < 15 µg/day). The modelling results demonstrated the potential of universal provision of 10 µg/day of multivitamins supplements in increasing vitamin D intake. Moreover, mandatory fortification of both milk and malted drink at single level of 5 µg/serving would lead to increase in vitamin D intake of Malaysians, particularly pregnant women. CONCLUSIONSThe outcome of this study can be used as a reference for public health professionals to re-evaluate the existing Malaysian food fortification policies and supplementation recommendation for vitamin D for pregnant women. 相似文献
18.
Background: vitamin D (VD) may be a protective factor for retinoblastoma, though no temporal association has been reported during pregnancy or the child’s first year of life. Serum VD concentrations are determined by both distal (DF) and proximal factors (PF). Objective: To identify if DF and PF can predict VD insufficiency (VDI) and VD deficiency (VDD) in women of childbearing age; and to test whether maternal exposure to DF and PF during pregnancy and a child’s exposure during the first 11.9 months postpartum are associated with sporadic retinoblastoma (SRb) in children. Methods: This is a secondary analysis of data from the Epidemiology of SRb in Mexico (EpiRbMx) study and the National Health and Nutrition Survey 2018–2019 (ENSANUT 2018–2019, for its acronym in Spanish). The association of DF and PF with VDD or VDI was estimated using ENSANUT 2018–2019, and the association of DF and PF with SRb using EpiRbMx. All were estimated using logistic regression, with comparable samples selected from ENSANUT 2018–2019 and EpiRbMx. Results: Altitude, latitude and obesity predicted VDI and VDD in ENSANUT women. In EpiRbMx, residence in a rural location during pregnancy increased the risk of SRb. For children, rural residence and latitude increased the risk of SRb, while the number of days exposed to the spring–summer season during months 6 to 11.9 of life was protective. Conclusions: risk of VDI and VDD in women (ENSANUT 2018–2019) increased with altitude, urban dwelling, overweight and obesity. The child and mother’s place of residence, including altitude, latitude and rural classification were important predictors of SRb in EpiRbMx. 相似文献
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孕期大量钙从母体转移给胎儿,以满足胎儿骨骼发育的需求,孕妇除改变自身的代谢外,需要适当增加钙和维生素D摄入量.目前孕妇维生素D需要量和补充量的问题尚未最后明确和定论.本文主要综述相关的研究进展,以供营养工作者在制定孕妇维生素D需要量和补充量时参考. 相似文献
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