PHASE II CLINICAL TRIAL OF LASTET CAPSULE IN COMBINATION CHEMOTHERAPY OF MALIGNANT TUMORSIN CHINA

ＰＨＡＳＥＩＩＣＬＩＮＩＣＡＬＴＲＩＡＬＯＦＬＡＳＴＥＴＣＡＰＳＵＬＥＩＮＣＯＭＢＩＮＡＴＩＯＮＣＨＥＭＯＴＨＥＲＡＰＹＯＦＭＡＬＩＧＮＡＮＴＴＵＭＯＲＳＩＮＣＨＩＮＡＺｈａｎｇｔｉａｎｚｅ；张天泽；ＹｉｎＪｉｌｉａｎｇ；印季良；ＨｅＹｏｕｊｉａｎ；...     

THE TECHNIQUE OF THE NORMOTHERMIC AND HYPOTHERMIC TOTAL HEPATIC VASCULAR EXCLUSION FOR RESECTION OF THE LIVER TUMORS

ＴＨＥＴＥＣＨＮＩＱＵＥＯＦＴＨＥＮＯＲＭＯＴＨＥＲＭＩＣＡＮＤＨＹＰＯＴＨＥＲＭＩＣＴＯＴＡＬＨＥＰＡＴＩＣＶＡＳＣＵＬＡＲＥＸＣＬＵＳＩＯＮＦＯＲＲＥＳＥＣＴＩＯＮＯＦＴＨＥＬＩＶＥＲＴＵＭＯＲＳＨｕａｎｇＪｉｅｆｕ黄洁夫ＬｉＧｕｉｓｈｅｎｇ李桂...     

CLINICAL EVALUATION OF CERVICAL ESOPHAGEAL RECONSTRUCTION AFTER RESECTION OF THORACIC ESOPHAGEAL CARCINOMA

ＣＬＩＮＩＣＡＬＥＶＡＬＵＡＴＩＯＮＯＦＣＥＲＶＩＣＡＬＥＳＯＰＨＡＧＥＡＬＲＥＣＯＮＳＴＲＵＣＴＩＯＮＡＦＴＥＲＲＥＳＥＣＴＩＯＮＯＦＴＨＯＲＡＣＩＣＥＳＯＰＨＡＧＥＡＬＣＡＲＣＩＮＯＭＡＸｕＪｉｎｌｉａｎｇ许金良；ＳｈａｏＬｉｎｇｆａｎｇ邵令方；...     

THE THERAPEUTIC EFFECT OF INTRATUMORAL INJECTION OF GM-CSF GENE-MODIFIED ALLOGENIC MACROPHAGES ON TUMOR-BEARING MICE

ＴＨＥＴＨＥＲＡＰＥＵＴＩＣＥＦＦＥＣＴＯＦＩＮＴＲＡＴＵＭＯＲＡＬＩＮＪＥＣＴＩＯＮＯＦＧＭＣＳＦＧＥＮＥＭＯＤＩＦＩＥＤＡＬＬＯＧＥＮＩＣＭＡＣＲＯＰＨＡＧＥＳＯＮＴＵＭＯＲＢＥＡＲＩＮＧＭＩＣＥＹｕＹｉｚｈｉ于益芝ＣａｏＸｕｅｔａｏ?..     

THE HISTOPATHOLOGICAL TYPING OF 48 CASES OF ESOPHAGEAL ADENOCARCINOMA AND ITS TISSUE ORIGIN

ＴＨＥＨＩＳＴＯＰＡＴＨＯＬＯＧＩＣＡＬＴＹＰＩＮＧＯＦ４８ＣＡＳＥＳＯＦＥＳＯＰＨＡＧＥＡＬＡＤＥＮＯＣＡＲＣＩＮＯＭＡＡＮＤＩＴＳＴＩＳＳＵＥＯＲＩＧＩＮＨｕａｎｇＺｈｉｚｈｉ黄致治；ＸｉｅＦａｎｇ谢芳；ＴａｎＬｉｊｕｎ谭立军；ＦｕＹｕａｎｇｅｎ...     

THE EFFECT OF RETINOIC ACID ON CELL MEMBRANE AND METASTATIC ABILITY OF MOUSE FORESTOMACH CARCINOMA C

ＴＨＥＥＦＦＥＣＴＯＦＲＥＴＩＮＯＩＣＡＣＩＤＯＮＣＥＬＬＭＥＭＢＲＡＮＥＡＮＤＭＥＴＡＳＴＡＴＩＣＡＢＩＬＩＴＹＯＦＭＯＵＳＥＦＯＲＥＳＴＯＭＡＣＨＣＡＲＣＩＮＯＭＡＣＥＬＬＹｕＸｉａｏｄａｎ于晓；ＺｈａｏＸｕｅｍｅｉ赵雪梅；ＧａｏＪｉｎ高进（Ｉｎ...     

STUDIES ON THE GAP JUNCTIONAL INTERCELLULARCOMMUNICATION OF HUMAN NASOPHARYNGEALCARCINOMA CELLS AND THE EFFECT OF RII

ＳＴＵＤＩＥＳＯＮＴＨＥＧＡＰＪＵＮＣＴＩＯＮＡＬＩＮＴＥＲＣＥＬＬＵＬＡＲＣＯＭＭＵＮＩＣＡＴＩＯＮＯＦＨＵＭＡＮＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡ　ＣＥＬＬＳＡＮＤＴＨＥＥＦＦＥＣＴＯＦＲＩＩＨａｎＬｉｑｕｎ韩立群；ＧａｏＪｉｎ高进；...     

A PRELIMINARY STUDY OF THE ANTI-CANCER EFFECT OF TANSHINONE ON HEPATIC CANCER AND ITS MECHANISM OF ACTION IN MICE

ＡＰＲＥＬＩＭＩＮＡＲＹＳＴＵＤＹＯＦＴＨＥＡＮＴＩＣＡＮＣＥＲＥＦＦＥＣＴＯＦＴＡＮＳＨＩＮＯＮＥＯＮＨＥＰＡＴＩＣＣＡＮＣＥＲＡＮＤＩＴＳＭＥＣＨＡＮＩＳＭＯＦＡＣＴＩＯＮＩＮＭＩＣＥＷａｎｇＸｉｕｊｉｅ王修杰ＹｕａｎＳｈｕｌａｎ袁淑兰Ｗａｎｇ...     

THE ANTICANCER EFFECT AND ANTI－DNA TOPOISOMERASE II EFFECT OF EXTRACTS OF CAMELLIA PTILOPHYLLA CHANG AND CAMELLIA SINENSIS

ＴＨＥＡＮＴＩＣＡＮＣＥＲＥＦＦＥＣＴＡＮＤＡＮＴＩ－ＤＮＡＴＯＰＯＩＳＯＭＥＲＡＳＥＩＩＥＦＦＥＣＴＯＦＥＸＴＲＡＣＴＳＯＦＣＡＭＥＬＬＩＡＰＴＩＬＯＰＨＹＬＬＡＣＨＡＮＧＡＮＤＣＡＭＥＬＬＩＡＳＩＮＥＮＳＩＳＸｉｅＢｉｎｓｆｅｎ；谢冰芬；ＬｉｕＺ...     

CLINICOPATHOLOGICAL AND SURGICAL STUDY OF VERRUCOUS CARCINOMA OF PENIS

ＣＬＩＮＩＣＯＰＡＴＨＯＬＯＧＩＣＡＬＡＮＤＳＵＲＧＩＣＡＬＳＴＵＤＹＯＦＶＥＲＲＵＣＯＵＳＣＡＲＣＩＮＯＭＡＯＦＰＥＮＩＳＷａｎｇＸｕｚｈｏｕ；ＺｈａｎｇＺｉｘｕａｎ；ＧａｏＺｈｏｎｇｙｕ；ＬｉａｎｓＳｉｔａｉ；ＴｉａｎＪｉｘｉ王绪洲，张紫萱，高促...     

Surgical management of localized soft tissue tumors

Soft tissue tumors are rare and can arise from a variety of soft tissues and viscera in a variety of body sites. Their management requires a thorough understanding of the biology of the different histologies and molecular subtypes as well as the constraints of specific anatomic sites. The surgical approach has undergone significant changes thanks to a better understanding of the natural history of the different histologic subtypes, the importance of site, and the different sensitivity to available drugs. The soft tissue tumor family includes 3 major, distinct categories: desmoid‐type fibromatosis, soft tissue sarcoma, and gastrointestinal stromal tumor. In general, limb‐sparing and function‐sparing approaches should be used when feasible for tumors located in the extremities and girdles. Resections of adherent structures/viscera, which may be close but not invaded, may be needed in tumors arising in the retroperitoneum/abdomen to minimize microscopic intralesional margins, maximize local tumor control, and possibly improve survival. Margins of resection and the use of adjuvant/neadjuvant radiation therapy and/or chemotherapy are contingent on an accurate histologic diagnosis. Treatment planning should include multidisciplinary consultation to determine optimal therapy, taking into consideration tumor histology, site and extent of the disease, its natural history and sensitivity to available treatments, surgical challenges, and—of course—quality of life. Cancer 2014;120:2638–2648. © 2014 American Cancer Society.     

原发性骨平滑肌肉瘤诊断与治疗的研究进展

平滑肌肉瘤是一种通常发生于女性生殖道和胃肠道的恶性肿瘤,极少数发生于腹膜后腔和腹腔.平滑肌肉瘤也发生于软组织,占所有恶性软组织肿瘤的5%﹪～10%﹪[1],占新确诊的骨与软组织肉瘤的14%﹪[2],相比之下,原发性骨平滑肌肉瘤罕见.     

Lucy Wortham James lecture. Regional perfusion. Current sophistication, what next?

A review of the development of regional chemotherapy by perfusion is presented. Techniques have been developed for most regions of the body. Early response rates ranged from 48% for glioblastoma and 55% with carcinoma to 67% with soft tissue sarcoma and 84% with melanoma. By 1984, 1325 patients had been perfused 1509 times. The best responses have occurred with melanoma and soft tissue sarcoma of the limbs. Thus, at 10 years, the cumulative overall survival for Stage I melanoma of the limbs, combining regional perfusion and conservative excisional surgery, was 77%. The best results occurred in female patients with upper-limb disease (83%), and the poorest results were in male patients with lower-limb disease (53%). The overall 10-year survival for regional melanoma was 41%, ranging from 23% for in-transit metastases to 51% for patients with positive regional nodes treated by perfusion and regional lymph node dissection. The 10-year survival for perfusion and limb-sparing excision for soft tissue sarcoma was 65%. Advantages and complications are presented and discussed. Questions and plans for the future are reviewed.     

Soft tissue sarcoma: the predominant primary malignancy in the retroperitoneum

Purpose. In the clinical work-up of a retroperitoneal mass, the diagnosis of soft tissue sarcoma is often not considered. Incidence rates of various malignant and benign retroperitoneal tumours were studied to determine the incidence of soft tissue sarcoma in comparison with other neoplasms in the retroperitoneal space.Method. Nation-wide data on retroperitoneal tumours, collected prospectively over a 5-year period (1 January 1989- 1 January 1994), were supplied by the Netherlands Cancer Registry and The Dutch Network and National Database for Pathology.Results. Seven hundred and six patients with a primary retroperitoneal neoplasm were identified; 566 patients had a malignant tumour (80%). A soft tissue sarcoma (STS) was the most frequently diagnosed malignant tumour (n = 192), The agestandardised incidence of retroperitoneal STS was 2.5 per million person-years. The male/female ratio for STS was 0.73. In females, STS comprised 41%of all malignant retroperitoneal tumours, carcinoma of unknown primary tumour site (CUP) comprised 31%, and malignant lymphomas (ML) comprised 22%, whereas in males these values were 28% (STS), 30% (CUP), and 32% (ML), respectively.Discussion. Soft tissue sarcomas, albeit rare, are relatively common primary tumours in the retroperitoneum, especially in women.     

Prognostic factors predicting survival in the treatment of retroperitoneal sarcoma.

METHODS: Retroperitoneal soft tissue sarcomas are rare tumours. The management of these tumours has been difficult because of low resectability and a high recurrence rate. A retrospective review of a prospectively compiled database of 32 consecutive patients with retroperitoneal sarcomas treated at Oulu University Hospital between 1977 and 1996 was performed. RESULTS: The resectability rate of primary tumours was 75%, and 44% of the patients underwent radical resection. The recurrence rate after radical resection was 57% and the resectability rate for recurrent tumours after radical primary operation, 50%. The actuarial overall 5-year survival rate was 31%, 10-year survival rate 19% and median survival 36 months. In univariate analysis the principal factors associated with prognosis were radical resection, recurrent disease, pre-operative loss of weight and histological tumour grade. Complete excision of the primary tumour was the only significant predictor of survival in multivariate analysis. CONCLUSIONS: Complete resection of retroperitoneal sarcoma continues to be the most important prognostic factor. The inefficiency of adjuvant therapy, the high recurrence rate and the very low chance of curing the patient after recurrence make the prognosis of these patients poor.     

85例软组织肉瘤回顾分析及软组织肉瘤诊治进展

目的通过近5年85例软组织肉瘤回顾分析以探索本地区软组织肉瘤的临床特点及诊治进展。方法采用经病理证实的软组织肉瘤的调查统计，对此临床资料进行回顾性发析。结果好发年龄段为30～70岁，占78-8％（67／85）；发病部位依次为下肢、躯干、腹腔、后腹膜、上肢及头颈，前3位占65．8％（56／85）；前6位病理类型为纤维肉瘤、平滑肌肉瘤、恶性纤维组织细胞瘤、皮肤隆突性纤维肉瘤、横纹肌及滑膜肉瘤，占69．4％（59／85）。常见转移部位为肺、肝、淋巴结和多发转移，远处转移占58-8％，大多属Ⅲ及Ⅳ期期局部复发近30％；预后与肿瘤大小、部位、深度、分期、分级、复发几率及转移灶数目有关。结论本组软组织肉瘤病种复杂，分布广泛，异质性明显；病期晚，肿块大且转移多见。诊断采用CT、MRI为主的影像学、病理形态学及免疫组织化学（IHC），必要时加电镜检查；治疗以手术为主，手术加放疗为基础模式，据分期、分级和生物学特性加高活性联合方案等综合治疗，软组织肉瘤靶向治疗为目前研究热点。     

Disease incidence and results of extremity lesion treatment: mersey region soft tissue sarcomas (1975-1985)

Purpose. The incidence and treatment results of extremity soft tissue sarcoma (STS) in the Mersey Region, in the absence of a Multi-Disciplinary Unit, for the period 1975-1985, have been analysed.Subjects and methods. Data from cases presenting with STS within the Mersey region, from 1 January 1975 until 31 December 1985, were reviewed. Only patients with sarcoma of head and neck, thoracic wall, abdominal wall, retroperitoneum, limb girdle or extremity were included. Extremity lesions were staged according to the MTS system. Pathological data also were assigned a grade according to tumour differentiation, mitosis count and tumour necrosis. Data from patients with a minimum follow-up of 5 years were collated, and patterns of treatment failure were investigated. Finally, time to first occurrence was analysed.Results and Discussion. The incidence of STS in this study was identical to that reported by the US Department of Health in 1976. Five year survival rate for Stage I tumours was only 51.7% which compares very unfavourably with contemporary series from Multi-Disciplinary Units. Five year survival rate following wide local excision +/- adjuvant therapy is 52.4%, while that following amputation +/- adjuvant therapy is 45.5%. While not attaining the results reported by other centres, limb-sparing surgery does not appear to appreciably prejudice long-term survival.Conclusions. STS are rare in the UK, leading to poor classification and suboptimal treatment of lesions. It is important to establish multidisciplinary teams of surgeons, radiologists, radiotherapists and oncologists to plan and organise multimodality therapy for STS.     

Prognostic significance of histologic parameters of soft tissue sarcomas.

BACKGROUND AND METHODS. A univariate and multivariate analysis for the correlation between histomorphologic factors and prognosis was made using data from 1116 patients with soft tissue sarcoma, including 1005 cases available with complete histologic and follow-up data. RESULTS. The overall 5-year survival rate was 43.6%. The univariate analysis using Kaplan-Meier survival curves showed that tumor differentiation, cellularity, nuclear atypia, cellular pleomorphism, mitotic activity, amount of fibrous stroma, extent of myxoid areas, extent of tumor necrosis, and histologic grading (determined by the estimated range of malignancy for each type of sarcoma using a reported guideline) were all significant prognostic factors in the overall soft tissue sarcoma group. By a multivariate analysis using a procedure based on the Weibull model to failure data, the histologic grading and extent of tumor necrosis were proved to be prognostically significant in the overall sarcoma group. However, after additional analysis on each histologic type of sarcoma, it was determined that both tumor necrosis and histologic grading were applicable in only two types: malignant fibrous histiocytoma and leiomyosarcoma. Liposarcoma, synovial sarcoma, and malignant schwannoma each also showed some determinable factor of prognostic significance. CONCLUSIONS. It was concluded that there seemed to be no single universal prognostic parameter that could be applied to each soft tissue sarcoma type. These results suggest that the predictive significance of the various histologic parameters should be based on each specific type of sarcoma.     

Sarcomas in north west England: III. Survival.

Survival data on a population-based series of bone, soft tissue and visceral sarcomas diagnosed in the North West of England between 1982-84 and subjected to histopathological peer review are presented. Five-year crude survival for all cases was 34%. Survival in males and females did not differ significantly (P = 0.6, 5-year survival 32% vs 36%) but was markedly worse for patients diagnosed over the median age of 60 years, even when allowance was made for underlying mortality (P = 0.03, 34% vs 44%). Five-year survival rates for the major site groups were: bone 44%; soft tissues of head, neck and trunk 36%; soft tissues of extremities 35%; female genital tract 35%; retroperitoneum 15%; gastro-intestinal tract 13%. Analysis by the major histological types revealed the following survival rates: leiomyosarcoma--female genital tract 25%, gastro-intestinal tract 14%, non-visceral soft tissue 21%; malignant fibrous histiocytoma of soft tissue 29%; liposarcoma 52%; osteosarcoma of bone 46%; and chondrosarcoma of bone 50%.     

Soft tissue sarcomas in Osaka, Japan (1962-1985): review of 290 cases

Two hundred and ninety patients with soft tissue sarcomas (STS) in Osaka, Japan, were reviewed. The patients' ages ranged from one month to 84 years (mean 51 years) with a male to female ratio of 1.23:1. The tumors were located in the extremities (120 cases), the trunk (76 cases), the abdominal cavity (40 cases), and the head and neck (43 cases). Histologically the tumors were classified as malignant fibrous histiocytoma (101 cases, 34.8%), liposarcoma (28 cases, 9.7%), synovial sarcoma (24 cases, 8.3%), rhabdomyosarcoma (23 cases, 7.9%), neurogenic sarcoma (20 cases, 6.9%), fibrosarcoma (16 cases, 5.5%), leiomyosarcoma (16 cases, 5.5%) and others. From the present study, it appears that there are no significant differences between STS in Japan and Western countries with regard to the distributions of histological type and primary site.