Squamous cell carcinoma arising in the lining of an epidermoid cyst within the sublingual gland--a case report

We present the case of squamous cell carcinoma that arose in the lining of an epidermoid cyst that developed within the sublingual gland in a 64-year-old woman. Malignant transformation in epidermoid cysts is rare, particularly in the floor of the mouth. We know of no cases reported of an epidermoid cyst arising within the sublingual gland.     

Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst – a clinicopathologic analysis of 116 reported cases

J Oral Pathol Med (2011) 40 : 733–738 Purpose: To review the literature on primary intraosseous squamous cell carcinoma (PIOSCC) associated with odontogenic cyst. Methods: All well‐documented cases of PIOSCC published between 1938 and 2010 were collected. Only cases of PIOSCC arising from the lining of an odontogenic cyst, including the keratocystic odontogenic tumor, were selected. Age, sex, signs and symptoms, affected jaw, cyst type, treatment, histopathology, and outcome were recorded. Results: The mean age was 60.2 years (range 1.3–90). There were 80 (69%) men and 36 (31%) women. Mass and pain were the most common presenting symptoms. The mandible was affected in 92 (79%) patients and the maxilla in 24 (21%). It was a residual/radicular cyst in 70 (60%) patients and a dentigerous cyst or a keratocystic odontogenic tumor in the remaining 40%. The histopathology was well‐differentiated SCC in 53 (46%) patients and moderately differentiated SCC in 47 (40%) patients. Fifty‐three (46%) patients were treated with surgery alone and 44 (38%) with surgery and radiotherapy. Fifty‐eight (62%) patients survived 2 years and 36 (38%) survived 5 years. Conclusion: PIOSCC has a predilection for men (M/F ratio of 2.22:1), affects mainly adults in their 6–8th decades, occurs most frequently (79%) in the mandible, and is associated mainly with a residual/radicular cyst. Histologically, the well‐to‐moderately differentiated SCC was the most common. Surgery alone or combined therapy of surgery and radiation was the most common approach. The prognosis is 62% surviving 2 years and 38% 5 years.     

Odontogenic ghost cell carcinoma: a case report with immunohistochemical and ultrastructural characterization

Folpe AL, Tsue T, Rogerson L, Weymuller E, Oda D, True LD: Odontogenic ghost cell carcinoma: a case report with immunohistochemical and ultrastructural characterization. J Oral Pathol Med 1998; 27: 185-9. C Munksgaard, 1998. The odontogenic ghost cell tumor (OGCT) is the rare, neoplastic variant of the calcifying odontogenic cyst (COC). To date, there have been only four reports of malignant OGCTs, in five patients. We report an additional case of a malignant odontogenic ghost cell tumor that involved the right maxilla of a 20-year-old man. Our report includes its immunocytochemical and ultrastructural characterization.     

龈乳头鳞状细胞乳头状瘤1例

鳞状细胞乳头状瘤是一种由黏膜复层鳞状上皮发生而来的良性肿瘤,常见于颊、腭、唇和舌部。本文报告1例发生于牙龈乳头的鳞状细胞乳头状瘤,并结合文献对其病因、临床特点以及治疗方法等进行讨论。     

Squamous cell carcinoma arising in mucosal plasmacytosis

The authors present an unusual case of invasive squamous cell carcinoma (SCC) developing in a pre-existing plasmacytosis of the lip. The roles of chronic inflammation, immunosuppression, and smoking in the pathogenesis of this tumour are briefly discussed. The authors highlight a significant side effect of the use of immunosuppressive drugs in benign conditions.     

Massive residual dental cyst: Case report

A case report is presented of a massive residual dental cyst that involved over half an edentulous mandible. Presentation, diagnosis and management of the massive cyst is discussed.     

Massive residual dental cyst: Case report

A case report is presented of a massive residual dental cyst that involved over half an edentulous mandible. Presentation, diagnosis and management of the massive cyst is discussed.     

口腔基底样鳞状细胞癌1例报告及文献复习

基底样鳞状细胞癌(basaloid squamous cell carcinoma,BSCC)是鳞状细胞癌中一种罕见的、具有侵袭性的变异类型,好发于上消化-呼吸道。BSCC在病理学上与传统鳞状细胞癌及鳞状细胞异常增生相似,但更具侵袭性,预后也较差。本文报告1例少见的发生于右上牙龈的基底样鳞状细胞癌,并结合文献,对其临床表现、组织病理学特点、治疗及预后等进行讨论。     

左侧面部巨大基底细胞样鳞状细胞癌1例报告

基底细胞样鳞状细胞癌是鳞状细胞癌中的一种特殊亚型,临床较为少见,发生于口腔颌面部皮肤者更少。本文报告1例57岁男性患者,因左侧面部溃烂就诊,临床检查发现左侧面部较大面积皮肤破溃,活检病理报告为基底细胞样鳞状细胞癌。全麻下扩大切除肿瘤后,以前臂游离皮瓣修复缺损,术后配合放疗,目前已随访12个月,未见复发。本文结合相关文献,对基底细胞样鳞状细胞癌的临床特点及危险因素、组织来源、诊断及鉴别诊断、治疗及预后进行分析。     

Squamous cell carcinoma arising in residual odontogenic cyst. Report of a case and review of literature

Odontogenic cysts are common pathologic lesions found in the oral and perioral structures. A case of squamous cell carcinoma arising within the lining of a large odontogenic cyst is described. Clinical and pathologic aspects of the previously reported cases are presented.     

Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity

Dyskeratosis congenita is a rare genetic disorder that results from progressive failure of the bone marrow. It presents with a classic triad of reticular pigmentations of the skin, dystrophic nails, and oral leukoplakia; patients rarely develop cancers. We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue.     

Spindle cell carcinoma of the gingiva: report of an autopsy case

An autopsied case of an 80-year-old man with spindle cell carcinoma of the gingiva is reported. The tumor was polypoid and mostly composed of a sarcomatous proliferation of spindle cells with a small focus of squamous cell carcinoma at the stalk portion. The carcinoma metastasized to a cervical lymph node, lungs and pleura with extension to the diaphragm. In the metastatic lymph node, the squamous cell component was more prominent than the spindle cell one, while only anaplastic pleomorphic carcinoma cells were found in the lungs. The spindle or anaplastic cells were immunohistochemically positive for vimentin and carci-noembryonic antigen (CEA) but not for other epithelial antigens. We have concluded that the sarcomatoid component arose from the oral squamous cell carcinoma by a metaplastic process. This is the first case report of an oral spindle cell carcinoma examined by autopsy.     

Oral squamous cell carcinoma arising in a patient with Werner syndrome

Werner syndrome (WS) is an autosomal recessive disorder characterized by physical signs and symptoms, including premature aging and scleroderma-like skin changes. The gene responsible for WS is the WRN gene. A significant proportion of WS-related malignant tumours are non-epithelial types, and the incidence of oral squamous cell carcinoma (SCC) is rare. A case of oral SCC of the lower alveolus and gingiva arising in a 63-year-old woman with WS is reported here. Biopsy confirmed moderately differentiated SCC. Surgical resection was performed and there was no recurrence or metastasis at the 3-year follow-up. Mutation analysis using next-generation sequencing, detected no mutations in the genes encoding the molecules strongly involved in the development of oral SCC, such as TP53 or PIK3CA. No obvious mutations were detected. Based on the results of the study, the results of mutation analysis suggest that this case might be genetically different from the common mechanisms of SCC in the oral cavity.     

Squamous cell carcinoma arising in an odontogenic cyst

Squamous cell carcinoma arising is an odontogenic cyst is rare, Eversole finding 36 cases in his review of the literature in 1975. Since then, a further 10 have been recorded in the English literature. We now report another case and describe its management. The need to histologically examine all odontogenic cysts is stressed.     

原发性颌骨内鳞状细胞癌1例报告及文献复习

原发性颌骨内癌是一种罕见的来源于牙源性上皮剩余的恶性肿瘤。本文报告1例发生于右侧下颌骨内的鳞状细胞癌病例。该患者表现为右侧下颌骨拔牙创口迁延不愈且伴肉芽组织形成,局部疼痛,但不影响进食及言语功能。采用手术切除、左侧血管化游离腓骨肌皮瓣修复,术后病理检查证实为鳞状细胞癌。