共查询到20条相似文献,搜索用时 31 毫秒
1.
N. F. Avrova V. P. Ivanova V. A. Tyurin I. A. Gamalei I. V. Klyubin I. A. Shchepetkin E. V. Borunov Yu. Yu. Tyurina 《Bulletin of experimental biology and medicine》1994,117(1):45-47
It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced
generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10−11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10−8 M PMA in mouse macrophages in comparison with the effect of PMA alone.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 44–46, January, 1994
Presented by A. N. Klimov, Member of the Russian Academy of Medical Sciences 相似文献
2.
G. V. Poryadin A. N. Samsonov A. I. Makarkov 《Bulletin of experimental biology and medicine》1995,120(4):994-998
Both ADP and adenosine were found to potentiate the anaphylactic contracture of isolated guinea pig ileum (smooth-muscle preparations).
When ADP or adenosine was added after the induced anaphylactic reaction, a biphasic change in ileal tonus — relaxation followed
by contraction — was noted. The contractile response was abolished by Dimedrol, but not by Troventol. ADP suppressed (or,
in some ileal smooth-muscle preparations, reversed) the relaxation response to epinephrine and ocriprenaline and potentiated
the naphazoline-induced smooth-muscle contraction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
10, pp. 361–365, October, 1995
Presented by Yu. A. Vladimirov, Member of the Russian Academy of Medical Sciences 相似文献
3.
I. G. Rebrov G. N. Kryzhanovskii N. P. Belykh T. F. Shukalova R. N. Glebov 《Bulletin of experimental biology and medicine》1994,118(2):852-855
A study is performed of the effect of the convulsants picrotoxin and bicuculline, blockers of GABA-dependent Cl−-conductivity, on the rate of desensitization of muscimol-induced36Cl− entry into synaptoneurosomes isolated from rat cortex. Both picrotoxin and bicuculline, despite the difference in the mechanisms
of inhibition of the GABA receptor/Cl− ionophore complex, markedly reduce the rate of desensitization. However, the initial moment of the action of both convulsants
is characterized by inhibition of Cl− transport alone, without a drop of the rate of desensitization.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
8, pp. 160–163, August, 1994 相似文献
4.
E. I. Solntseva Yu. V. Bukanova R. U. Ostrovskaya T. A. Gudasheva T. A. Voronina V. G. Skrebitskii 《Bulletin of experimental biology and medicine》1996,121(2):138-142
The effect of two nootropics, piracetam and N-phenylacetyl-L-prolyglycine ethyl ester (GVS-111), is studied by measuring high-threshold
K+ and Ca2+ currents in isolated snail neurons using a two-microelectrode patch-clamp technique. Piracetam and GVS-111 are shown to reduce
the amplitude of both the K+ and the Ca2+ (to a lesser extent) current. The threshold concentrations for GVS-111 and piracetam are 10−9-10−8 M and 1–5×10−4 M, respectively. It is assumed that the antiamnestic effect of the nootropics is partially mediated by a blockade of ion
channels of the neuronal membrane.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 151–155, February, 1996
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
5.
A. N. Orekhov V. V. Tertov V. L. Nazarova 《Bulletin of experimental biology and medicine》1995,120(2):759-762
Atherogenic low-density proteins (LDL) found in human blood — desialylated, electronegative, and small dense LDL — share many
chemical and physical characteristics and appear to represent the same subfraction of multiply modified lipoproteins.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
8, pp. 118–121, August, 1995
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
6.
Met-enkephalin in a concentration range of 10−15 to 10−9 M exhibited an immunomodulating effect upon concanavalin A-induced proliferation of mouse lymphocytesin vitro. The effect of met-enkephalin was shown to depend on the stage of lymphocyte activation, the time of opioid administration,
and the dose of mitogen. Met-enkephalin produced the maximal effect when given in the phases of increase or decrease of the
proliferative response. Met-enkephalin augmented the proliferative response to the suboptimal dose of concanavalin A and,
on the contrary, inhibited the response to the optimal dose of mitogen. Administration of met-enkephalin at different times
could both inhibit and stimulate proliferation depending on the stage of lymphocyte activation. An inhibitory effect was induced
by δ-class opioid ligand, while κ-ligand was responsible for stimulation. Naloxone abolished the stimulating effect of opioids.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 398–401, April, 1995
Presented by R. V. Petrov, Member of the Russian Academy of Medical Sciences 相似文献
7.
K. B. Belozerov A. M. Volobuev N. V. Gulyaeva 《Bulletin of experimental biology and medicine》1995,119(4):432-434
A new method for analyzing noninvasively procured biological materials — expired air condensates — using infrared spectroscopy
is described. The proposed method, which involves smoothing out of the condensate spectra and subtraction of the interpolated
water spectrum, may be employed in basic research and in developing diagnostic procedures based on quantitative estimation
of the organic condensate component.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 446–448, April, 1995
Presented by A. D. Ado, Member of the Russian Academy of Medical Sciences 相似文献
8.
G. A. Belokrylov O. Ya. Popova O. N. Derevnina I. V. Molchanova 《Bulletin of experimental biology and medicine》1994,117(5):497-499
It is shown that the effect of amino-acid preparations (levamine-70–70, cerebrolysin, and aviamine) is dose-dependent. Thus,
levamine-70 and cerebrolysin at 65 mg/kg do not affect the immune response but stimulate phagocytosis. Aviamine at 65 mg/kg
inhibits the immune response but stimulates phagocytosis and in a dose of 6.5×10−2 mg/kg boosts both processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 500–501, May, 1994
Presented by A. D. Ado, Member of the Russian Academy of Medical Sciences 相似文献
9.
V. V. Semchenko S. S. Stepanov E. D. Sergeeva 《Bulletin of experimental biology and medicine》1995,119(4):429-431
Paramembranous specialized formations of the synaptic cytoskeleton — dense projections and postsynaptic condensation of axospinous
synapses of the molecular layer of white rat sensorimotor and cerebellar cortex — in health and acute total ischemia are studied
by selective contrast staining with phosphotungstic acid. A direct relationship is revealed between the pattern and degree
of deformation of the contact plane, on the one hand, and the postsynaptic condensation and ratio of the volumes of pre- and
postsynaptic accumulations of paramembranous filaments, on the other.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 443–445, April, 1995
Presented by L. V. Poluektov, Member of the Russian Academy of Medical Sciences 相似文献
10.
Synthesis and properties of the immunotoxin CD5-ricin 总被引:1,自引:0,他引:1
G. V. Vikha L. D. Uzhinova A. Zh. Kashaeva V. V. Goshev A. V. Krylov A. Yu. Baryshnikov R. G. Vasilov 《Bulletin of experimental biology and medicine》1995,119(1):70-73
Synthesis and properties of an immunotoxin produced by conjugating ricin with a novel monoclonal antibody (IgG3 of the ICO-104
class) are described. Cytolytic activity of the synthesized immunotoxin, determined by two independent methods and expressed
in LD50, is 0.3–0.6×10−7 M. Its specificity for target cells containing the CD5 antigen is shown.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
1, pp. 76–79, January, 1995
(Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences) 相似文献
11.
V. M. Smirnov 《Bulletin of experimental biology and medicine》1997,124(1):635-638
The mechanism by which heart rate is increased upon stimulation of vagal centers is studied using frog heart preparations
perfused with Ringer—Locke solution containing atropine and/or benzohexonium. Atropine stimulates vagus-induced heart-rate
acceleration in dilutions of 10−6 and 10−5 g/ml. In a dilution of 10−4 g/ml both atropine and benzohexonium abolish vagal tachycardia. Rausedyl (3–4 injections, 5 mg/kg, at 18–20-h interval) prevents
tachycardia. Stimulation of both halves of the medulla oblongata increases heart rate to a greater extent than stimulation
of one half.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 16–20, July, 1997 相似文献
12.
Yu. B. Deshevoi B. B. Moroz K. V. Sudakov E. A. Yumatov R. M. Salieva 《Bulletin of experimental biology and medicine》1995,119(4):336-339
Examination of processes occurring in the hematopoietic system of rats subjected to emotional stress shortly after 30-day
exposure to low-dose γ-radiation revealed the inhibitory influence of radiation exposure on the development of adaptive reactions
by this system in the stressed animals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 349—353, April, 1995 相似文献
13.
V. A. Myshkin Z. G. Khaibullina S. A. Bashkatov V. P. Krivonogov D. A. Enikeev 《Bulletin of experimental biology and medicine》1995,120(2):785-788
Three pyrimidine derivatives — methyluracil, hydroxymethacil (a new compound), and its lithium salt — were tested in model
systems of differing complexity for antioxidant properties in comparison with the well-known antioxidant ionol. Tests for
antiradical activity and for effects on spontaneous and Fe2+-ascorbate- or NADPH-dependent lipid peroxidation revealed high antioxidant activity (comparable to that of ionol) of the
hydroxymethacil lithium salt.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
8, pp. 142–144, August, 1995
Presented by G.N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
14.
I. A. Sokolova A. A. Shakhnazarov S. N. Sergeev D. V. Davydov V. S. Baranov 《Bulletin of experimental biology and medicine》1995,119(6):564-567
Two once-weekly intravenous injections of the polyethylene oxide Polyox WSR-301 (yielding a blood concentration of the order
of 5×10−6 g/ml) led to a 38% decrease in the area occupied by sudanophilic lesions in the aortic arch of rats fed an atherogenic diet
for two weeks. Perfusion under constant pressure of the formalin-fixed vascular system in the posterior part of the body with
physiological saline and then with polyethylene oxide (10−5 g/ml) was without effect in normal rats and in those with mild lipoidosis, but reduced hydrodynamic vascular resistance by
9–14.5% in rats with pronounced lipoidosis. Intravenous injection of polyethylene oxide into anesthetized rats with pronounced
lipoidosis in doses that were subthreshold for normal rats (blood concentrations of the polymer were of the order of 10−7 g/ml) caused a 20% decrease in the total peripheral resistance to blood flow, with a 17–20% rise of the blood flow rate in
the carotid artery.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 587–589, June, 1995
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
15.
T. V. Grekhova R. R. Gainetdinov T. D. Sotnikova L. M. Krasnykh V. S. Kudrin S. A. Sergeeva I. S. Morozov 《Bulletin of experimental biology and medicine》1995,119(3):294-296
It is demonstrated that bromantane induces a pronounced and prolonged (8 h) increase in the release of dopanime. Tetrodotoxin
(10−6 M) perfused via a microdialysis probe partially inhibits the bromantane-induced release of dopamine. The extracellular content
of the dopamine metabolites 3,4-dioxyphenylacetic and homovanillic acids is slightly decreased. The possible mechanisms of
action of bromantane on the dopamin- and serotoninergic systems of the brain are discussed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
. 3, pp. 302–304, March, 1995
Presented by M. D. Mashkovskii, Member of the Russian Academy of Medical Sciences 相似文献
16.
On the basis of the initial parameters of behavior in the “open field,” “forced swimming,” and “emotional resonance” tests,
the main behavioral parameters — the number of squares crossed, the number of standing postures, and the time of passive swimming
— are shown to be predictable for stress in rats with different types of behavior.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 89–92, January, 1994
Presented by P. V. Simonov, Member of the Russian Academy of Medical Sciences 相似文献
17.
S. B. Cheknev D. V. Kuyavskaya I. A. Tarkhanova E. E. Babaeva L. M. Bartova A. Ya. Kul'berg 《Bulletin of experimental biology and medicine》1994,118(1):737-742
The cytotoxic activity of natural killer cells and the intensity of conjugate formation are studiedin vitro in the natural cytotoxicity reaction against3H-uridine-labeled human erythromyeloleukotic cells K-562 in the presence of fibronectin, γ-globulin, and fibronectin/γ-globulin
combination. It is demonstrated that fibronectin does not change natural cytotoxicity, γ-globulin increases the activity of
human natural killer cells, and the fibronectin — γ-globulin combination increases both the intensity of conjugate formation
and the cytotoxic activity of natural killer cells.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 54–59, July, 1994 相似文献
18.
O. A. Golovleva E. A. Korepanov V. S. Efimov Yu. A. Vladimirov 《Bulletin of experimental biology and medicine》1994,118(1):725-727
Ionophore activity of ionenes, like that of polymyxins, is shown to be potentiated by long-chain antiions. Rapid stoichiometric
anion equilibration in isoosmotic buffered sugar medium revealed that the amplitude of Cl−/OH− exchange in erythrocytes induced by an ionene-detergent complex gradually drops with the decrease of both the charge density
and the number of monomeric moieties in the polymeric chain. This is also paralleled by passive K+ leakage from the cells.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 44–46, July, 1994 相似文献
19.
I. V. Kubasov I. I. Krivoi E. V. Lopatina 《Bulletin of experimental biology and medicine》1994,118(5):1153-1155
Nerve stimulation is performed in rat phrenicodiaphragmal preparations with armine-inhibited acetylcholinesterase. Acetylcholine
(1×10−7 M) is added to the saline for 15 min, and as it is washed off (during 1–2 h), the amplitude of isometric contractions and
of the total action potential increases in the continuously stimulated muscle. Contractions in response to direct muscle stimulation
remain unchanged. The membrane resting potential of muscle fibers exposed to acetylcholine shifts by 2–3 mV toward hyperpolarization
and remains at this level for 2 h after the removal of acetylcholine from the saline.
Presented by S. N. Golikov, Member of the Russian Academy of Medical Sciences
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
11, pp. 457–459, November, 1994 相似文献
20.
N. I. Lisyanyi I. A. Gnedkova I. A. Brodskaya 《Bulletin of experimental biology and medicine》1994,117(2):155-157
Common immunoregulatory carbohydrate receptors on the membranes of neurons and sysngeneic peripheral lymphocytes of mice are
detected by using lectins. Brain neuron membranes possess no receptors characteristic of immature lymphocytes. The common
immunoregulatory receptors on brain neurons and mononuclear cells of peripheral immune organs are shown to represent one the
mechanisms of integration of the nervous and immune systems.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
2, pp. 155–157, February, 1994
Presented by A. P. Romodanov, Member of the Russian Academy of Medical Sciences 相似文献