共查询到20条相似文献,搜索用时 15 毫秒
1.
Apostolova N Garcia-Bou R Hernandez-Mijares A Herance R Rocha M Victor VM 《Pharmaceutical research》2011,28(11):2910-2919
Purpose
Mitochondrial dysfunction plays a key role in sepsis. 相似文献2.
Ingeborg M. van Geijlswijk Kristiaan B. van der Heijden A. C. G. Egberts Hubert P. L. M. Korzilius Marcel G. Smits 《Psychopharmacology》2010,212(3):379-391
Rationale
Pharmacokinetics of melatonin in children might differ from that in adults. 相似文献3.
Ramaekers JG Conen S de Kam PJ Braat S Peeters P Theunissen EL Ivgy-May N 《Psychopharmacology》2011,215(2):321-332
Introduction
Esmirtazapine is evaluated as a novel drug for treatment of insomnia. 相似文献4.
Purpose
To develop and evaluate liposomal formulations prepared with an isolated mitochondrial fraction as a mitochondria-specific delivery vehicle 相似文献5.
Samuel R. Chamberlain Jon E. Grant Anna Costa Ulrich Müller Barbara J. Sahakian 《Psychopharmacology》2010,212(4):597-601
Rationale
Individuals with trichotillomania often report significant difficulty resisting the urges and drive to pull hair. 相似文献6.
Monica L. Andersen Eileen Kessler Kevin S. Murnane Jessica C. McClung Sergio Tufik Leonard L. Howell 《Psychopharmacology》2010,210(3):439-448
Rationale
Modafinil is currently used as a treatment for daytime sleepiness. 相似文献7.
Theunissen EL Kauert GF Toennes SW Moeller MR Sambeth A Blanchard MM Ramaekers JG 《Psychopharmacology》2012,220(2):341-350
Rationale
Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis. 相似文献8.
Virgilijus Beiša Augustas Beiša Simonas Ūselis Kęstutis Strupas 《Central European Journal of Medicine》2012,7(3):371-375
Introduction
Differential diagnosis and treatment of recurrent hyperparathyroidism are complicated. 相似文献9.
Lorenza De Carolis Maria Antonietta Stasi Ottaviano Serlupi-Crescenzi Franco Borsini Paolo Nencini 《Psychopharmacology》2010,212(1):105-115
Rationale
The biological underpinnings of schizophrenic polydipsia are poorly understood. 相似文献10.
Rationale
Rats raised in isolation self-administer more amphetamine than rats raised in enrichment. 相似文献11.
Kenji Sugibayashi Hiroaki Todo Takeshi Oshizaka Yoko Owada 《Pharmaceutical research》2010,27(1):134-142
Purpose
To calculate the skin concentration of active ingredients in cosmetics and topical pharmaceuticals using silicone membrane permeation. 相似文献12.
Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population
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Li Hui Xiao Li Yin Jie Chen Hong Liang Zhu Guang Ya Zhang Xiao Qiong Wang Jia Hong Liu Cheng Zhu Dong Wu Xu Xin Yu Guang Zhong Yin 《Human psychopharmacology》2018,33(2)
Background
Elevated phospholipase A2 (PLA2) activity is reported to be involved in the development of schizophrenia. Further study revealed an association between PLA2 groups XIIA (PLA2G12A) polymorphism and patients with schizophrenia in a northeast Chinese Han population.Objective
This study will further examine whether PLA2G12A rs3087494 polymorphism is associated with patients with schizophrenia in a southern Chinese Han population.Methods
This polymorphism was genotyped in 438 patients with schizophrenia (diagnosed according to Diagnostic and Statistical Manual of Mental Disorders‐IV) and 876 healthy controls using a case–control design. Demographic and clinical data were collected in all subjects.Results
The allele and genotype frequencies of PLA2G12A rs3087494 polymorphism significantly differed between groups (both, p < .001). These differences still were significant by adjusting for sex and age. However, there was no difference in age at onset among 3 genotype groups in patients with schizophrenia by adjusting for the variables (F = 0.22, p = .80). Stepwise multivariate regression analysis showed that this polymorphism was not associated with age at onset in patients with schizophrenia (β = .008, t = .07, p = .94).Conclusions
Our results indicated that even though PLA2G12A rs3087494 polymorphism did not influence age at onset in patients with schizophrenia, it may play an important role in the susceptibility to schizophrenia in a southern Chinese Han population. 相似文献13.
Garcia-Carmona JA Almela P Baroja-Mazo A Milanes MV Laorden ML 《Psychopharmacology》2012,220(2):379-393
Rationale
Evidence suggests that corticotropin-releasing factor (CRF) system is an important mediator in the negative symptoms of opioid withdrawal. 相似文献14.
Michael Derks Markus Abt Anne Mwangi Georgina Meneses-Lorente 《European journal of clinical pharmacology》2010,66(8):775-783
Purpose
Evaluate dalcetrapib’s potential to prolong QT intervals in healthy subjects. 相似文献15.
Purpose
To characterise phase separations in aged hot-melt-extruded solid dispersions at a micron to submicron scale. 相似文献16.
Zoltan Kozinszky Iván Devosa János Sikovanyecz Dávid Szabó Zoltán Pál Katalin Barabás Attila Pál 《Central European Journal of Medicine》2011,6(6):701-709
Background
Contraceptive and sociodemographic risks of repeat induced abortion have not yet been interpreted in Central Eastern Europe. 相似文献17.
Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive,methamphetamine‐using men who have sex with men
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Adam W. Carrico Violeta J. Rodriguez Deborah L. Jones Mahendra Kumar 《Human psychopharmacology》2018,33(1)
Objective
This study examined if methamphetamine use alone (METH + HIV?) and methamphetamine use in combination with HIV (METH + HIV+) were associated with hypothalamic‐pituitary‐adrenal (HPA) axis dysregulation as well as insulin resistance relative to a nonmethamphetamine‐using, HIV‐negative comparison group (METH‐HIV?).Methods
Using an intact groups design, serum levels of HPA axis hormones in 46 METH + HIV? and 127 METH + HIV+ men who have sex with men (MSM) were compared to 136 METH‐HIV? men.Results
There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = ?0.19, p < .05). Compared to METH‐HIV? men, METH + HIV+ MSM displayed 10% higher log10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine‐using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH‐HIV? men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors.Conclusions
Further research is needed to characterize the bio‐behavioral pathways that explain dysregulated HPA axis functioning in HIV‐positive, methamphetamine‐using MSM. 相似文献18.
Thomas M. Polasek Sebastian Polak Matthew P. Doogue Amin Rostami-Hodjegan John O. Miners 《European journal of clinical pharmacology》2009,65(12):1203-1210
Objective
To assess the inter-individual variability in phenytoin (PHT) clearance predicted from in vitro kinetic data. 相似文献19.
Purpose
In this study, we evaluated the effect of hydrogel structural properties on proliferation and biosynthesis activity of encapsulated chondrocytes. 相似文献20.