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氧化应激与多种口腔疾病的发生、发展有着密切联系,但具体的作用通路和分子机制尚不明确;口腔非贵金属合金材料中部分金属离子的析出,通过不同的机制,引起邻近的组织和细胞的氧化应激,这是口腔氧化应激的主要诱因之一;另一方面,抗氧化剂在口腔领域的应用为口腔疾病的预防、治疗提供了新的思路。本文就氧化应激与口腔疾病相关的研究现状、其产生机制及抗氧化剂的应用做一综述,以期从氧化应激角度,为探索口腔疾病的干预、治疗措施、研究相应的靶点药物提供理论参考,以及为探讨口腔合金材料中的金属离子是否通过氧化应激的机制直接或间接诱导口腔疾病提供研究思路。 相似文献
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随着老年人口不断增加的趋势,到口腔门诊就诊的人数也随之增加。影响老年人口腔就诊的因素较多,老年患者寻求治疗最常见的原因是牙疼、牙龈肿胀、咀嚼困难等,另外,老年人通过各种媒体了解了口腔卫生与全身健康的关系,促使他们更注重口腔疾病的治疗。美观等社交因素也是老年人寻求口腔治疗的原因。1.全身状况的评价老年人常伴有多系统性疾病,在口腔疾病就诊时首先要了解这些系统性疾病的情况,是否影响牙 相似文献
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口腔健康相关生活质量(OHRQOL)是反映口腔疾病及其防治对患者的身体功能、心理功能和社会功能等影响的综合评估。OHRQOL的洲评为口腔健康状况的评估提供了全面的信息,为口腔疾病防治效果的评价及不同治疗方法的比较提供了较客观的依据。 相似文献
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目的探讨先心病儿童父母的心理压力与口腔特定疾病之间的相关性。方法根据"第三次全国口腔健康流行病学调查方案"和心理问卷调查,随机抽取北京安贞医院小儿心脏科病房的住院儿童父母80人,对结果进行统计学分析。结果①先心病儿童父母口腔高发疾病主要为:牙周病、复发性口腔溃疡、磨牙症,发病率均大于第三次全国口腔健康流行病调查结果;②30岁以上的先心病儿童父母心理压力处于四级和五级水平的比例高于一级和二级水平,其差异有统计学意义(P〈0.05)。③经统计学分析,牙周病与心理压力之间具有一定的相关性(P〈0.05)。结论先心病儿童父母应注重口腔疾病和心理压力的防治。 相似文献
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目的通过流行病学调查方法了解风湿免疫患者口腔健康状况,为风湿免疫患者口腔疾病的预防与治疗提供依据。方法对中国医科大学附属盛京医院风湿免疫科病房309例患者进行口腔专科检查,填写调查问卷,检查结果采用SPSS软件进行统计学分析。结果风湿免疫疾病患者口腔健康者不足4%,牙周炎患病率为91.9%,患龋率为67.2%。口腔卫生与性别、年龄、学历、口腔护理情况及吸烟显著相关;牙周病的发生与年龄、口腔护理、吸烟相关;患龋率高低与性别、年龄、吸烟相关。风湿免疫疾病中,牙周炎发病率最高的是骨关节炎、皮肌炎及类风湿性关节炎;舍格伦综合征患者患龋率最高。结论口腔健康水平可能与风湿免疫疾病相关,应从多角度分析风湿免疫疾病患者口腔健康不良原因,采取积极预防措施。 相似文献
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Abstract Having addressed the problem of standard methods and comparability of epidemiological data and recognizing the problems which remain, at an intercountry level, even when data have been carefully selected, the Oral Health unit of WHO has been able to develop a global picture of dental caries prevalence and is constructing similar maps for periodontal diseases. Inevitably, the precision and representativeness of such data vary from country to country, but they are nevertheless invaluable for their intended purpose of providing a good approximation of disease prevalence and trends. It is clear that populations in highly developed countries almost always have high or very high prevalence of dental caries. It is even more striking that developing countries have or have had low to extremely low prevalence of the disease, but are suffering rapid and unmanageable increases in prevalence. At the same time, high to very high prevalence of periodontal diseases persists in all populations, though the problem seems to be greatest in developing countries. It is extremely disappointing and indeed tragic that this state of affairs can exist in 1976 when, for decades, we have had effective preventive measures available and have new methods appearing almost daily. The WHO oral health programme has given prevention its top priority position and its approach is based on the premise that we can and must implement the preventive methodology we have, to halt increases in dental caries prevalence, to reduce its prevalence and to control periodontal diseases. 相似文献
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Korbinian Benz Philipp Hahn Marcel Hanisch Katrin Lücke Thomas Lücke Jochen Jackowski 《The British journal of oral & maxillofacial surgery》2019,57(9):831-838
Fabry disease and Pompe disease are rare lysosomal storage disorders that belong to a heterogeneous group of more than 200 distinct inborn metabolic diseases. Mutations followed by loss of function of enzymes or transporters that are localised in the acidic environment of the lysosome may result in degradation of many substrates, such as glycosaminoglycans, glycosphingolipids, glycogen, cholesterol, oligosaccharides, glycoproteins, and peptides, or the excretion of the products degraded by the lysosome. Our aim was to identify the oral signs and symptoms of Fabry disease and Pompe disease from a systematic review made using MEDLINE/PubMed, and a hand search for relevant articles, following the PRISMA guidelines. Both diseases show various craniofacial and oral changes, including supernumerary teeth, dental agenesis, angiokeratoma, and telangiectases in Fabry disease; and macroglossia, teeth fusion, and taurodontism in Pompe disease. Common clinical signs of Fabry disease include hyposalivation, hypohidrosis, and xerophthalmia, and a generally reduced physical resilience was apparent in patients with Pompe disease. Oral and craniofacial changes in patients with both diseases extend over their entire lifetime and can be detected even in an infant. Lysosomal storage diseases should be taken into consideration in the differential diagnosis of relevant diverse symptoms, because treatment, when available, is most effective when started early. The main therapeutic concepts are enzymatic replacement for Pompe disease, whereas patients with Fabry disease require additional oral chaperone treatment or enzyme replacement. 相似文献
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Oral Diseases (2010) 16 , 217–218 The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry, oral and maxillofacial medicine, oral and maxillofacial pathology, oral and maxillofacial radiology and oral and maxillofacial surgery) and particularly by hospital‐centred practitioners. This series has selected some of the more recognized relevant eponymous conditions and presents them alphabetically. The information is based largely on data available from MEDLINE and a number of internet websites as noted below: the authors would welcome any corrections. This document summarizes data about Hodgkin disease. 相似文献
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The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry, oral and maxillofacial medicine, oral and maxillofacial pathology, oral and maxillofacial radiology and oral and maxillofacial surgery) and particularly by hospital-centred practitioners. This series has selected some of the more recognised relevant eponymous conditions and presents them alphabetically. The information is based largely on data available from MEDLINE and a number of internet websites as noted below: the authors would welcome any corrections. This document summarises data about Christmas disease. 相似文献
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Bengtsson Viveca Wallin Persson G. Rutger Berglund Johan Renvert Stefan 《Clinical oral investigations》2019,23(3):1171-1179
Clinical Oral Investigations - To assess if carotid calcifications detected in panoramic radiographs are associated with future events of stroke, and/or ischemic heart diseases over... 相似文献
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The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry, oral and maxillofacial medicine, oral and maxillofacial pathology, oral and maxillofacial radiology and oral and maxillofacial surgery) and particularly by hospital-centred practitioners. This series has selected some of the more recognised relevant eponymous conditions and presents them alphabetically. The information is based largely on data available from MEDLINE and a number of internet websites as noted below: the authors would welcome any corrections. This document summarises data about Paget disease of bone. 相似文献
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动脉硬化和心肌梗死等心血管疾病的发生,源于一套复杂的遗传和环境因素。口腔感染是动脉粥样硬化、心脏病和脑卒中等心脑血管疾病以及妊娠并发症(自发性早产)和糖尿病发病率和死亡率升高的潜在危险因素。临床研究显示,牙周炎患者有高标志的全身性炎症反应物,如C-反应蛋白、白细胞介素-6、结合珠蛋白和纤维蛋白原,这些标志物在急性心肌梗死的牙周炎患者中要较单纯急性心肌梗死的患者高很多。下面就口腔感染引发心血管疾病的机制作一综述。 相似文献
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The lifespan of the US population is increasing, with the elderly desiring successful aging. This goal is jeopardized as multiple systemic conditions and their treatments become more prevalent with age, causing impaired systemic and oral health and influencing an older person's quality of life. To obtain successful aging, a compression of morbidity must be obtained through prevention and management of disease. This paper describes the most common systemic diseases causing morbidity and mortality in persons aged 65+ years: diseases of the heart, malignant neoplasms, cerebrovascular diseases, chronic obstructive pulmonary disease, pneumonia, influenza, diabetes mellitus, trauma, Alzheimer's disease, renal diseases, septicemia, and liver diseases. Disease prevalence and the impact of medications and other therapeutic measures used to treat these conditions are discussed. Oral sequelae are reviewed with guidelines for early detection of these deleterious consequences, considerations for oral treatment, and patient management. An understanding of the impact of systemic diseases and treatment on oral health is imperative for dental practitioners to appropriately treat and manage older patients with these conditions. With a focus on early detection and prevention, oral health care providers can improve the quality of life of this population and aid in the attainment of successful aging. 相似文献