自血光量子疗法对家兔脊髓损伤后超氧化物歧化酶的影响

目的：探讨自血光量子疗法治疗脊髓损伤的作用机制。方法４２只家兔随机分成对照组、损伤组和治疗组,用化学比色法分别测定各组血液和脊髓组织中超氧化物歧化酶（ＳＯＤ）活力。结果伤后不同时点血液和脊髓组织中ＳＯＤ活力与对照组比较均明显下降（Ｐ〈０．０１）;治疗组在采用自血光量子疗法治疗后,与相应时点损伤组比较均明显升高（Ｐ〈０．０１）。结论自血光量子疗法可以提高血液和脊髓组织中ＳＯＤ活性。     

自血光量子疗法治疗不同时间脊髓损伤的实验研究

４０只家兔造成不完全性脊髓损伤，通过运动功能、脊髓诱发电位、光镜和电镜的对比，研究自血光量子疗法（ＡＬＱ）治疗不同时间脊髓损伤的效果。发现：ＡＬＱ６ｄ治疗组疗效最好；ＡＬＱ立即治疗组次之；对照组最差。说明ＡＬＱ有“双相”作用。一方面ＡＬＱ可以使血液稀释、血栓形成减少、组织灌注压提高和血流速度加快，伤后立即治疗则加重脊髓局部出血；另一方面又可以通过改善血液循环，促进出血、水肿吸收、消退，保护尚未受损的脊髓组织避免或减轻继发性损伤，促进功能恢复。实验结果提示：不完全性脊髓损伤应该根据损伤程度，伤后２～６ｄ开始ＡＬＱ治疗为宜。     

自血光量子疗法和腹蛇抗栓酶治疗截瘫59例报告

自血光量子疗法和腹蛇抗栓酶治疗截瘫５９例报告吴家云，李芳玲，朱淑华，韩永生，董萍，汪义萍脊髓损伤常常导致患者永久性残废，一直是国内外研究的重点课题。近两年，我院采用自血光量子疗法（Ａｕｔｏｈｅｍｏ－ｔｈｅｒａｐｙｏｆＬｉｇｈｔＱｕａｎｔａ，简称ＡＬＱ...     

外伤性截瘫兔自血光量子治疗减轻戊巴比妥钠对中枢神经系统的抑制

目的和方法：应用自血光量子疗法治疗兔脊髓损伤。结果：治疗组按戊巴比妥钠３０ｍｇ／ｋｇ静注后清醒时间明显缩短（Ｐ＜０．０１）；动脉血气分析ＰａＯ２、ＳａＯ２和ＣａＯ２均非常显著性升高（Ｐ＜０．０１）。血液流变学检测全血粘度降低，红细胞电泳速度加快，红细胞聚集指数下降。结论：这些均有利于改善脑组织微循环，促进氧供和代谢，减轻了戊巴比妥钠对中枢神经系统的抑制。     

自血光量子疗法治疗不同程度的脊髓损伤

６０只家兔造成轻瘫、重瘫和全瘫三种实验模型。用自血光量子疗法治疗，通过运动功能，脊，髓诱发电位、光间和电镜的对比研究及统计学处理，发现自血光量子疗法能改善脊髓血液循环，保护神经元和传导束的细胞、亚细胞结构、促进运动功能和感觉功能的恢复。     

自血光量子疗法治疗截瘫的护理体会

自血光量子疗法治疗截瘫的护理体会张宗兰江文琴自血光量子疗法简称（ＡＬＱ），是一种把患者自血在体外置于特制的石英瓶内，经过紫外线照射、充氧和磁极化后再回输到体内的新方法。此疗法不仅可以提高血氧饱和度，降低血液粘稠度〔１，２〕，减轻脂质过氧化〔３〕，而且...     

自血光量子疗法治疗实验性脊髓损伤的脊髓诱发电位评价

本实验对６Ｏ只家兔造成轻瘫，重瘫，全瘫三种实验模型，就不同程度损伤及自血先量子治疗后的脊髓诱发电位进行检测，借此对自血先量子疗法之疗效作一评价。结果表明：轻瘫、重瘫治疗组脊时诱发电位恢复率高于各自对照组，且轻瘫组疗效高于重瘫组。提示自血光量于疗法有利于脊髓功能的恢复。     

自血光量子疗法治疗外伤性截瘫32例

自血光量子疗法治疗外伤性截瘫３２例安徽省临泉县人民医院（２３６４００）陆颖辉，庞贺兰，符国龙自血光量子疗法（ａｕｔｏｈｅｍｏ－ｔｈｅｒａｐｙｏｆｌｉｇｈｔｑｕａｎｔａ，简称ＡＬＱ），是一种把患者血液在体外经过紫外线照射和充氧后再回输到体内的治疗方法。...     

三七总皂甙对脊髓损伤早期保护作用的实验研究

采用７２只成年健康杂种猫，随机分为正常、对照和治疗３组，Ａｌｌｅｎ法４００ｇｃｆ制作猫急性脊髓损伤模型，观察了三七总皂甙对脊髓损伤后早期６ｈ的治疗保护作用。结果表明，治疗组与对照组比较，脊髓损伤区血流量明显增加，脂质过氧化产物丙二醛含量、水含量及离子含量的异常改变得到改善，节段性脊髓诱发电位回复较好，光、电镜检查发现治疗组脊髓损伤后伤区组织损害程度明显减轻，提示三七总皂甙对脊髓损伤早期的继发性损害具有一定的保护作用。     

光量子自血疗法治疗晚期胃癌的护理

光量子自血疗法治疗晚期胃癌的护理山东省临沂地区肿瘤医院周建丰山东省沂水中心医院陈希云光量子自血疗法是治疗疾病的一项新技术，在临床上已被广泛应用。近年来由于血卟啉及补骨脂素等光效应物质的应用，此疗法用于恶性肿瘤的治疗，取得了较好的效果。我院应用此疗法治...     

兔颈髓牵张性损伤早期脊髓血流变化的特点及意义

目的 观察兔颈髓不同程度牵张性损伤早期脊髓血流的动态变化，探讨其特点和意义。方法 构建颈髓牵张性损伤模型，应用激光多普勒血流仪按不同时相点检测颈5、6段脊髓血流变化，同时取相同节段颈髓行组织病理检查。结果 对照组A脊髓血流量平均基线值和B组、C组、D组牵张前无统计学差异。随着牵张距离的不断增加，颈髓血流量呈进行性下降。当颈髓牵张损伤程度超过脊髓微血管自我调节能力时，则脊髓血流不能恢复。各组颈髓组织病理学检查结果与相应的颈髓血流量变化趋势一致。结论 脊髓血流量的降低是颈髓牵张性损伤继发神经功能障碍的基础，与颈髓的牵张程度呈正相关。     

Role of endogenous norepinephrine and effects of alpha- and beta-blockers in experimental spinal cord compression injury

The changes in spinal cord micro-circulation were investigated after administering alpha- and beta-blockers to rabbits with acute spinal cord injury. Immediately after the 8th thoracic spinal cord was injured by applying pressure with a weight (50 g) for 1 minute, an alpha or beta-blocker was injected into the subarachnoid space of the injured region of the spinal cord. Spinal cord edema, blood flow, vascular permeability, and the mean arterial pressure were compared between the groups treated with each agent and the control group. One hour after the injury, the water content of the spinal cord was significantly lower in the phenoxybenzamine-treated group than in the control group. After 6 hours, however, no significant difference was observed between these two groups. The spinal cord blood flow was higher in the phenoxybenzamine-treated group than in the control group until 6 hours after the injury. These results suggest involvement of norepinephrine in the formation of edema at the early stage of spinal cord injury.     

椎板外冲击对脊髓血流影响的实验研究

目的应用一种闭合性脊髓损伤模型,通过不同强度冲击力作用于椎板,研究这种间接性冲击伤对脊髓的影响,并探讨血管机制在脊髓损伤中的作用。方法选用雄性SD大鼠120只,随机分为四组,每组30只,A组为假手术对照组,B、C、D、三组分别给予10、15、20N的椎板外冲击负荷,在相应的时间点进行心率、血压及脊髓血流测量观察。结果各组在各个时段的血压和心率无明显变化。C、D组血流表现为规律性的变化。结论椎板外冲击负荷能改变脊髓微循环血流,从而对脊髓产生影响;其对脊髓灰质微循环血流的改变更明显。     

脊髓急性牵拉损伤动物模型机理研究

目的对犬脊髓(神经根)急性牵拉损伤的病理机制进行初步探讨。方法12只健康成年杂种犬，随机分为对照组和不同程度牵拉损伤组。前后路联合手术离断脊柱后施加纵向牵拉损伤，对牵拉应变率、体感诱发电位(SEP)、神经源性脊髓运动诱发电位(NMEP)、硬膜下压力(SP)、硬膜血流量(EBF)等进行持续观察。伤后取脊髓及神经根标本进行HE、髓鞘神经中丝(NF)及胶原纤维酸性蛋白(GFAP)抗体免疫组织化学染色及电镜超微结构观察。结果牵拉损伤涉及牵拉节段和其上下脊髓及神经根的损伤。牵拉后出现硬膜下压力的显著增高和硬膜血流的显著降低。SEP异常的出现较NMEP更早。结论牵拉后脊髓内压力的增加导致脊髓血流减少。以及直接的机械性牵拉损伤可能是脊髓牵拉损伤的重要机制。     

The Effects of Hypertonic Saline on Spinal Cord Blood Flow Following Compression Injury

Summary  7.5% hypertonic saline was administered following spinal cord injury to test its effect on spinal cord blood flow. Four different groups of rats underwent 10 minutes of spinal cord compression (45g) at the C3 to C5 levels. A fifth group was not injured, but received hypertonic saline (5 ml/kg) at 5, 15 and 60 minutes following injury. Somatosensory evoked potentials and spinal cord blood flow were measured prior to and for 4 hours following the injury. The administration of hypertonic saline caused a significant increase in flow when administered 5 minutes following injury. Topical nitroprusside administration did not cause any increase in spinal cord blood flow during this time period. Hypertonic saline administration at the later time periods did not increase spinal cord blood flow. The group of animals which were not injured, but received hypertonic saline also showed no significant change in flow. The somatosensory evoked response of the treated animals was maintained for 4 hours after the injury where as the untreated animals began to lose their evoked responses 3 hours after injury.     

一氧化氮合成酶抑制剂对大鼠损伤脊髓血流及功能的影响

通过Nystrom脊髓后路压迫模型（35．0g／10min）造成脊髓中度损伤，应用激光多普勒血流仪观测了大鼠伤前30min，蛛网膜下腔注射生理盐水及亚硝基左旋精氨酸甲酯（L－NAME）0．15mg、1．5mg三组动物伤后局部脊髓血流的动态变化，并评定了伤后4周神经功能恢复情况。结果发现，L－NAME0.15mg短时间内抑制了脊髓血流，而L－NAME1．5mg较长时间抑制了脊髓血流。4周后L－NAME0．15mg组脊髓功能优于盐水组，而L－NAME1．5mg组脊髓功能较盐水组差。结果提示，适量的L－NAME由于短时间限制了一氧化氮（NO）的释放，有利于神经功能恢复；大剂量的L－NAME由于持续抑制了NO释放而致脊髓损伤加重。     

神经节苷脂有髓损伤的保护作用观察

目的：观察神经节苷脂对损伤脊髓神经组织的保护作用,并初步探讨其作用机制。方法：重度脊髓损伤大鼠随机分为对照组及神经节苷脂治疗组（n=15)。在蛛网膜下腔注射生理盐水20μl或神经节苷脂30μg。观察体重变化局部血流量、凋亡细胞原位标记、神经功能评价和定量组织学分析。结果：局部血流量2组无明显差异,治疗组存活8率、体重、神经功能评分和残余神经组织面积明显高于对照组,而TUNEL阳性细胞数量明显低于对照组。结论：神经节苷脂对损伤脊髓组织有明显保护作用,可能是通过对神经细胞凋亡的阻断来发挥作用的。     

Effet de l''administration continue de nimodipine à la phase aiguë d''un traumatisme médullaire chez le babouin

This study was carried out to assess the putative improvement of spinal cord blood flow obtained with a calcium channel blocker after acute spinal cord injury in ten baboons. The injury was generated by compressing the cord at L1 level for 5 seconds with a balloon catheter inflated to 2 bars with Ringer's solution. Subsequently, five monkeys received a saline infusion, and five others a nimodipine infusion (0.04 mg.kg-1 x h-1), for seven days. Spinal cord blood flow (SCBF) was measured using a scanographic technique with stable xenon. Somatosensory evoked potentials (SEP), magnetic resonance imaging (MRI) and a histological study of the spine were carried out a different times of the study. SCBF and SEP were recorded before injury. Thereafter SCBF was measured every thirty minutes during the four hours following the injury, as well as on day 7. SEP and MRI were recorded on days 1 and 7. The histological study was carried out on the eighth day. Three spinal cord and vertebral segments were collected, fixed, sliced and stained. SCBF before injury was not significantly different in either group (39.8 +/- 15.9 ml x 100 g-1 x min-1 for the treatment group 40.9 +/- 16.3 ml x 100 g-1 x min-1 for the control group). During the injury, there were major variations between animals. The results were expressed as percentages of each animal's control SCBF (before injury). Immediately after injury, SCBF increased in both groups. However, in the control group, SCBF decreased more than in the treatment group on the seventh day after injury (80 to 90% vs 25 to 50%, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)