Ectodermal dysplasia: Retrospective study of fifteen cases

The aim of this article is to review possible cranio-maxillofacial deformative consequences associated with hypohidrotic ectodermal dysplasia and embryonic malformations, which include dental ageneses, and describe the oral habilitation. Hypohidrotic ectodermal dysplasia patients had a clinical examination and underwent radiographic and Steiner's analyses and a respiratory capability test before assessment and treatment. Fifteen patients (eight males and seven females, aged 5-45 years) had tooth ageneses (from hypodontia to anodontia) associated with cutaneous dyshydrosis and hair and nail dystrophy. Most patients had sparse or absent hair, a short face with an unusual facial concavity, a maxillary retrusion and a relative mandibular protrusion. Dentists must conduct a comprehensive and multidisciplinary approach to these patients in order to improve their dental, masticatory, growth and orthognathic conditions.     

Management pathway for congenital heart disease at Kenyatta National Hospital, Nairobi

BACKGROUND: Congenital heart disease (CHD) is a significant cause of death amongst infants. The timing of treatment in relation to the natural history of the disease correlates with the treatment outcome. OBJECTIVES: To determine the age at first suspicion of CHD, the age at confirmation of the diagnosis of CHD and the percentage follow-up at the first post diagnosis out patient clinic and to determine the influence of patient's sex, parental income and parental education have on the MP. DESIGN: A five year retrospective study. SETTING: Kenyatta National Hospital between January 1st 2000 and December 31st 2004. SUBJECTS: Two hundred and fourteen patients were studied. RESULTS: The overall mean age at referral to a paediatric cardiologist was 16.9 +/- 24.4 months [n = 102]. The mean age at which CHD was confirmed by echocardiography was 18.6 +/- 25.6 months [n = 202]. The mean age at which CHD was first suspected in patients from the province with the highest parental income was 9.5 +/- 5.1 months [n = 6]. The mean age at which CHD was first suspected in patients from a province with a significantly lower parent income was 19.1 +/- 23.2 months [n = 22], (p = 0. 046). The mean age at which CHD was confirmed in referred male patients was 16.0 +/- 17.6 months [n=48] and the mean age at which CHD was confirmed in referred female patients was 18.8 +/- 21.7 months [n = 52] (p = 0.25). CONCLUSION: The mean age at referral to a paediatric cardiologist was 16.9 months. This suggests that a significant number of patients may miss the opportunity to have optimal surgical intervention. Parental income appears to influence the MP, however, the level of parental education and patient sex did not.     

Unilateral or bilateral vagotomy performed on prepubertal rats at puberty onset of female rat deregulates ovarian function

BACKGROUND: Injecting a neurotoxin virus into ovary of adult rats has provided morphologic evidence of a multisynaptic neural pathway between ovary and central nervous system (CNS). Vagus nerve is one of the pathways used by CNS to send and receive information to and from the ovary. METHODS: The present study analyzed whether or not vagal innervation of ovaries in prepubertal rats modulated, in a stimulatory fashion, functions of the ovary and whether the modulating function of these nerves was asymmetric. RESULTS: Animals vagotomized at 24 and 28 days of age showed delay in age of onset of puberty. Unilateral or bilateral vagotomy performed at 24 days of age did not modify ovulation rates or number of ova shed. In turn, bilateral vagotomy performed at 28 days of age resulted in a significant increase in number of ova shed by ovulating animals. Unilateral and bilateral vagotomy performed on day 24 or 28 resulted in a decrease in estradiol serum levels. Unilateral vagotomy performed on 24-day-old rats did not modify progesterone levels, while bilateral vagotomy on the same age group resulted in a significant increase of progesterone levels. In turn, unilateral and bilateral vagotomy performed on rats aged 28 days resulted in lower progesterone levels. CONCLUSIONS: Present results confirmed results of previous studies, indicating that interrupting ovarian innervation had an effect on regulation of ovarian functions by CNS and that these effects varied according to age at which denervation was performed.     

正常(牙合)人13～18岁下颌骨宽度生长发育的纵向研究

目的:分析正常人下颌骨各部位宽度的生长发育特点,探讨其发育规律.方法:对2 6名正常青少年每年同期摄取头颅定位后前位片,连续6年,并进行X线头影测量分析.结果:(1)相对于18岁,13岁时下颌骨各部位宽度的发育量均完成93%以上;除外髁突内侧点、髁突颈点间距,女性发育完成量大于男性.(2)男女性下颌基骨宽度在15～16岁均有一生长高峰;女性13～17岁下颌角点间距增加,17岁后稳定,角前切迹点间距生长量不多;男性下颌基骨宽度的发育可持续到青春迸发期后.(3)髁状突间宽度,女性生长至17岁即稳定,男性仍有生长,集中表现在髁状突外上方间宽度.喙突间距女性16岁后稳定;男性晚于女性 1年进入稳定期.结论:上述结果可为正畸临床制定矫治计划提供参考.     

某铜矿矽肺患者生存时间分析

目的:应用生存分析方法研究矽肺死亡病例的生存时间和相关影响因素。方法:收集某铜矿企业48例矽肺病死亡患者的病历资料和职业病报告,建立数据库,计算接尘年龄、接尘工龄、发病年龄、生存时间等,采用Kaplan-Meier法描述不同组别矽肺死亡病例的生存率,运用COX比例风险模型分析矽肺死亡病例生存时间影响因素。结果:48例肺病死亡患者平均接尘年龄为(24.4±6.0)岁,平均接尘工龄(22.5±8.7)年,平均发病年龄(62.6±11.1)岁;生存时间中位数(P25,P75)为14.0(7,22)年;死亡时最高矽肺分期、是否合并肺结核、是否合并肺癌、是否有吸烟史之间生存率的比较,差异没有显著意义(P>0.05);COX回归结果表明接尘年龄、发病年龄是影响生存时间的重要因素。结论:生存分析方法能有效地处理矽肺死亡病例生存资料;尘肺患者的生存时间受多种因素的影响,接尘工龄、接尘年龄、发病年龄等指标是综合分析尘肺发展规律,评价防治效果的重要参数。     

上海市1个月至5岁儿童睡眠时间的流行病学调查

目的 了解上海市1个月－5岁儿童的睡眠时间及其相关影响因素。方法 1999年和2000年8－9月间在上海5个行政区随机抽3266名儿童,由专人负责对其家长进行儿童家庭社会环境与睡眠健康问卷调查,调查的应答率为97.83%。结果 上海地区小于48个月的儿童睡眠时间明显低于国外报道的同年龄段儿童睡眠基本需求量。影响儿童睡眠时间的主要因素有抚养人的睡觉时间少、孩子属困难型气质、与父母同睡等。结论 目前上海地区小年龄组儿童睡眠时间偏少,其主要影响因素以社会家庭环境因素为主,尤其是父母对孩子睡眠行为的不正确应答。     

Henoch-Schonlein purpura in children. Influence of age on the incidence of nephritis and arthritis

OBJECTIVE: To assess the epidemiological, clinical, and laboratory findings in children affected with Henoch-Schonlein purpura HSP, and to analyze the influence of age on the incidence of nephritis and arthritis. METHODS: This is a retrospective study of the case records of all patients admitted to Prince Rahmah Hospital, Irbid, Jordan with HSP from September 1997 to December 2006, and to King Abdullah University Hospital, Irbid, Jordan from August 2005 to December 2006. RESULTS: The clinical manifestations included purpura in 100% of the 68 patients, arthritis in 75%, and nephritis in 29%. The incidence of nephritis varied according to the age of patients. It occurred in 19% of children less than 5 years of age, and in 67% of children 10 years of age and above. Henoch-Schonlein purpura nephritis was mild in all age groups. The incidence of arthritis also varied according to the age of patients. Arthritis occurred in 56% of children less than 5 years of age, and in 89% of children 10 years of age and above. CONCLUSION: The incidence of nephritis and arthritis in children affected with HSP is age related. Older children have a higher incidence of nephritis and arthritis, while younger children have a lower incidence of nephritis and arthritis. Renal involvement was mild during the acute phase of the disease in all age groups.     

儿童青少年双生子胰岛素敏感性的遗传度估计及影响因素分析

目的:分析影响儿童青少年的胰岛素敏感性的遗传和环境因素,并探讨其中体质指数(body mass index, BMI)、年龄和性别的作用.方法:选择5～18岁同性别双生子296对,平均年龄(12.4±3.5)岁,其中同卵双生子(MZ)223对,异卵双生子(DZ)73对.在DNA卵性鉴定基础上,应用Mx软件模型拟合分别计算BMI调整前后稳态模型胰岛素抵抗指数(homeostasis model assessment insulin resistance index, HOMA IR)和β细胞功能指数(HOMA β-cell function index,HBCI)的遗传度,并检验年龄和性别对于模型的作用.结果:HOMA IR与年龄、性别和BMI相关,HBCI与年龄相关,遗传分析HOMA IR、HBCI的模型为ACE,BMI调整前后HOMA IR男女生遗传度不同,HBCI无明显变化.调整后HOMA IR、HBCI遗传度分别为0.25、0.24.结论:儿童青少年人群中HOMA IR、HBCI受遗传和环境因素共同作用,环境因素的影响似乎更大;BMI是影响机体胰岛素敏感性的重要因素;年龄和性别对遗传度的影响可能不大.     

天津9～14岁女童颈椎骨骨龄测量法的建立与分析

目的:初步建立天津9～14岁女童颈椎骨龄的量化计算方法,为正畸临床诊断和制定治疗计划提供依据。方法:通过对天津地区135名9～14岁女童的X线头颅侧位定位片的第三(C3)、第四(C4)颈椎椎体进行测量分析,观察颈椎体随年龄变化的形态变化规律。结果:C3、C4椎体形态随年龄增长呈规律性变化,根据测量椎体深度和高度比值,建立了天津女童的颈椎骨龄多元回归方程。结论:在常规头颅侧位片上,应用该方法能够迅速得出颈椎骨龄参考值,为临床提供参考。     

已婚育龄妇女生殖道感染者循证护理干预效果评价

目的了解已婚育龄妇女对生殖道感染有关知识的认知情况,探索循证护理干预对生殖道感染患者的影响。方法对198名社区已婚育龄妇女应用循征护理干预,解决已婚育龄夫妇生殖道感染患者常见的生殖健康问题。结果已婚育龄妇女对生殖保健方面的知识及预防措施知晓率较低;采用循征护理干预前后妇女目标疾病的患病率明显下降。结论循征护理干预是解决已婚育龄妇女生殖道感染患者常见生殖健康问题的有效方法。加强育龄妇女生殖保健服务,通过各种渠道及各种形式开展有关生殖道感染的危害性和防治知识教育,是提高自我保健意识和生殖健康水平的有效措施。     

Cardiovascular age of aviation personnel： based on the principal component analysis of heart rate and blood pressure variability

Heartratevariability (HRV)analysisisofpotentialuseinaerospacemedicineforitsabilitytoassesscardiovas cularautonomicregulationnoninvasivelyandquantitative ly[1- 3] ,whichisessentialforsafetyinflightoperations .ButitisdifficulttoapplyconventionalHRVanalysisdi rectlytoclinicalaerospacemedicineowingtomanyindicesinvolvedinHRVandthecomplexcorrelationamongthoseindices .Colosimoetal[4 ] reportedthatacardiacagecouldbeestimatedbythestatisticalanalysisoftheHRVdataob tainedunderrestingandhead uptilting…     

子宫肌瘤全子宫切除术后性心理障碍研究

目的 :对子宫肌瘤患者手术后性心理障碍及相关因素进行探讨。方法 :对 12 8例子宫肌瘤患者收集病史资料 ,同时采用自制问卷对患者进行调查。结果 :6 1 7%的患者术后对性生活有明显的焦虑和抑郁心理 ,其中术时年龄 <5 0岁患者性心理异常发生率较高 ;阴道干燥、阴道变短、女性角色淡化、焦虑、疼痛等症在术后半年内发生率最高 ;术后性生活的恢复时间与年龄相关 ,年龄越轻 ,性生活恢复越快。性生活的恢复与心理治疗有密切的关系。结论 :进行心理治疗 ,促进性功能恢复是治疗子宫肌瘤术后病人的重要组成部分。     

青少年寻常痤疮发病规律的流行病学研究

目的:探讨青少年寻常痤疮发病规律及其与机体病理变化的关系.方法:应用流行病学调查方法研究840名青少年学生的寻常痤疮发病率、发病年龄、性别特点及面部皮损特征.结果:1.青春期寻常痤疮患病率为86.9%,男性患病率高于女性(P＜0.01);2.发病年龄在12～17岁之间,男性发病年龄大于女性(P＜0.05);3.青春期患者痤疮是以正常肤色的白头粉刺为主,数量在30个以内,皮损单一;4.面部皮损分区以左右分布为主(P＜0.01).结论:青春期是寻常痤疮的高发期,其患病率、皮损程度、分布与年龄、性别具有密切关系.     

严重创伤患者早期外周血淋巴细胞变化与预后之间的关系

目的: 探讨严重创伤早期外周血淋巴细胞变化趋势与预后间的关系。方法: 选取2017年6月至2020年6月北京大学人民医院创伤救治中心收治的严重多发伤患者作为研究对象进行回顾性研究, 观察入院后连续5 d血常规中淋巴细胞变化趋势并进行分组, 第1组: 淋巴细胞减少后在5 d内恢复正常; 第2组: 淋巴细胞减少后未恢复正常; 第3组: 淋巴细胞一直处于正常水平, 并记录各组患者在住院28 d后的转归情况。对收集的临床资料进行统计学分析, 了解创伤早期淋巴细胞变化趋势与预后间的关系。同时, 为排除年龄的影响, 依据年龄是否≥65岁进行分层, 并根据住院时间是否≥28 d分为住院时间延长组和住院时间非延长组, 在不同年龄组中分别探讨淋巴细胞变化与住院时间的关系。结果: 共纳入患者83例, 其中男性66例, 女性17例, 主要受伤机制为车祸伤和高处坠落伤, 创伤严重程度评分(injury severe score, ISS)为(30±11)分。根据连续5 d淋巴细胞变化趋势分组, 第1组32例, 第2组33例, 第3组18例。第2组33例患者中, 在住院28 d内死亡5例, 死亡率为15.2%(5/33), 未出院9例, 均高于其他两组(P < 0.05)。进一步按年龄进行分层后, 发现在高年龄患者中淋巴细胞处于低水平是住院时间≥28 d的危险因素, 但在低年龄患者中, 发现中性粒细胞持续偏高与预后不良相关。结论: 严重创伤后外周血淋巴细胞一直处于低水平与预后不佳密切相关, 尤其在高年龄患者中明显, 淋巴细胞可作为一项可靠指标用于预后评估。     

年龄、性别及某些内分泌疾病对血清骨钙素水平的影响

目的 :研究性别、年龄及常见内分泌疾病对血清骨钙素 (BGP)水平的影响。方法 :数据来源于本中心实验室资料。糖尿病的诊断标准按 1985年WHO标准进行。甲亢以血清TT3、TT4水平作为诊断标准。结果 :(1)BGP水平有明显的性别差异 ,女性BGP高于男性 ;(2 )年龄对BGP水平有显著影响 ,BGP水平在 40岁以前达到高峰 ,随年龄增长有下降的趋势 ,70岁以后BGP水平大幅度降低 ;(3)甲亢患者BGP水平明显升高 ,但 2型糖尿病患者无明显变化。结论 :性别、年龄对BGP有明显影响 ,甲亢患者BGP水平明显升高 ,但 2型糖尿病患者无明显变化。     

重度二尖瓣狭窄患者经皮球囊二尖瓣成形术后妊娠的随访

目的:观察经皮球囊二尖瓣成形术(percutaneous balloon mitral valvuloplasty,PBMV)在育龄期风湿性心脏病?二尖瓣狭窄患者中的安全性?可行性及术后妊娠对心功能?手术效果的影响?方法:回顾性分析本院自2000年1月~2011年12月9例行PBMV的育龄期风湿性心脏病?重度二尖瓣狭窄女性患者,观察术前?术后及孕期血流动力学变化,出院后随访2.5~7.0年?结果:手术前后左心房压力?二尖瓣跨瓣压差及二尖瓣瓣口平均面积差异均有统计学意义?9例患者无1例手术操作相关并发症?术后所有患者均正常妊娠,孕期随访患者心功能?二尖瓣瓣口面积无明显变化?孕前及产后二尖瓣跨瓣压差?瓣口平均面积无显著差异?所有患者均自然分娩,胎儿Apgar评分9~10分?结论:PBMV术在重度二尖瓣狭窄的育龄期青年女性中具有良好的耐受性?安全性及可行性?     

中国人群玫瑰痤疮发病与饮酒、吸烟的关系

目的：探讨玫瑰痤疮的发病与饮酒、吸烟、性别及年龄的关系,为玫瑰痤疮的诊治及机制探讨提供一定 依据。方法：收集在中南大学湘雅医院皮肤科就诊并诊断为玫瑰痤疮的患者1 180 例,同时收集非玫瑰痤疮患者 1 008例作为对照,对两组玫瑰痤疮发病因素进行logistic回归分析,并进一步比较两组不同年龄组之间的差异。结果： 两组性别间比较差异无统计学意义(P>0.05)。logistic 回归分析显示饮酒对玫瑰痤疮的发病无影响(P>0.05);抽烟、性 别、年龄对玫瑰痤疮发病有影响(P<0.05)。25~34 岁年龄段的玫瑰痤疮患者占比最高。结论：玫瑰痤疮的发病与饮酒 无关;而吸烟、性别和年龄对其发病率有影响,其中抽烟、女性为危险因素,玫瑰痤疮最多发年龄在25~34岁。     

Development of fibrocartilage layers in Achilles tendon enthesis in rabbits

Objective: The details regarding the development of fibrocartilage layers in Achilles tendon (AT) enthesis are unknown. Therefore, we evaluated the development of fibrocartilage layers in AT enthesis using a rabbit model.Materials and Methods: Forty-eight male Japanese white rabbits were used in this study. Six of them were euthanized at different stages (day 1, and 1, 2, 4, 6, 8, 12, and 24 weeks of age). The proliferation, apoptosis, Sox9-positivity rates, and chondrocyte number were evaluated. Additionally, safranin O-stained glycosaminoglycan (GAG) areas, width of AT enthesis, and calcaneus length were assessed. All parameters were compared to those at 24 weeks of age.Results: The level of chondrocyte apoptosis was high from 1 to 8 weeks of age, and high expression level of Sox9 was maintained from day 1 to 6 weeks of age, which decreased gradually. Safranin O-stained GAG areas increased up to 12 weeks, calcaneus length increased up to 6 weeks, and the width of AT enthesis increased up to 1 week of age.Conclusion: The changes in chondrocyte and extracellular matrix were completed by 8 and 12 weeks of age, respectively. The development of fibrocartilage layers in AT enthesis was completed by 12 weeks of age. Our results contribute to the administration of appropriate treatments based on age and aid in the development of novel methods for regenerating AT enthesis.     

二孩政策下父母亲生育年龄对于儿童发育短期和长期影响因素分析

目的:探讨全面二孩政策下父母人口学特征对于新生儿以及儿童长期身体发育的影响,为提高优生优育质量提供参考依据。方法:于2014年12月—2020年12月采用分层随机抽样方法调查天津市210个新生儿家庭的人口学资料和儿童身体指标,研究人口学特征和儿童发育情况,采取单因素χ2检验和成对t检验方法分析儿童发育的影响因素。结果:在调查的218个家庭中,高龄产妇（>35岁）所占比例大于低龄产妇（47.7% vs.14.1%）,二胎比例也大于一胎比例（82.0% vs.18.0%）。新生儿的身体指标（出生体重、出生28 d增重和出生身长）与产妇的文化程度、分娩医院、胎次以及分娩方式没有明显的相关性（均P>0. 05）,但与父母年龄存在相关性。不同母亲年龄组间出生体重（χ2 =58.91,P<0.01）、出生28 d增重（χ2 =67.34,P<0.01）、出生身长（χ2 =61.32,P<0.01）有差异,不同父亲年龄组间出生体重（χ2 =68.34,P<0.01）、出生28 d增重（χ2 =72.11,P<0.01）、出生身长（χ2 =75.41,P<0.01）有差异。本项目后期追踪调查了210个家庭的儿童生长状况,结果表明父母年龄对于儿童的体重、身长、牙齿和头围发育均具有长期影响（均P<0.01）。结论:在全面二孩政策下,高龄父母显著增多。父母年龄对于新生儿的身体发育存在影响,并且对于儿童的体重、身长、牙齿和头围发育等存在长期作用。     

健康人生物学衰老标志物的个体化评价及衰老程度判定

目的 (1)应用已建立的生物学年龄积分公式对健康人群进行生物学年龄的个体化评价及衰老程度判定.(2)观察不同衰老程度生物学标志物的差异,为临床进行衰老干预提供靶点.方法 2003年对沈阳、北京、大连地区2876名30～98岁受试者进行筛选,最终入选健康人852名,按年龄分为4组:青年组(＜45岁),中年组(45～59岁),年轻老人组(60～74岁),老年组(≥75岁).利用已构建的生物学年龄积分公式进行个体化生物学年龄积分计算,以生物学年龄积分为因变量,时序年龄为自变量作线性回归将852人分为延缓衰老,正常衰老和提前衰老.按衰老程度和时序年龄分组对构建生物学年龄积分的7个生物学标志物[颈动脉舒张期最大前向血流速度(EDV)、脉压(PP)、颈动脉内膜中层厚度(IMT)、二尖瓣环侧壁充盈早期峰流速度(MVEL)、二尖瓣E/A比值(E/A)、胱蛋白酶抑制剂(CYSC)、纤维蛋白原(FIB)]进行双因素方差分析.同时观察,在不同年龄组不同衰老程度间的差异.结果 (1)按衰老程度分组后,相同年龄组内的时序年龄比较差异无统计学意义,但生物学年龄积分比较差异有统计学意义(青年组:F=91.8,P＜0.01;中年组:F=134.5,P＜0.01;年轻老人组:F=199.5,P＜0.01;老年组:F=82.0,P＜0.01).(2)7项生物学标志物在衰老程度分组和时序年龄分组的双因素方差分析中,不同年龄组间及不同衰老程度间差异均有统计学意义.(3)PP在提前衰老均较正常衰老和延缓衰老有显著增加[青年组:(49.0±6.9)、(37.6±6.4)、(30.8±7.6)mm Hg,F=93.2,P＜0.01;中年组:(52.9±7.3)、(44.3±5.9)、(32.7±8.4)mm Hg,F=125.7,P＜0.01;年轻老人组:(61.9±7.6)、(51.6±6.6)、(37.1±8.7)mm Hg,F=196.5,P＜0.01;老年组(72.2±13.7)、(61.1±6.8)、(43.8±10.8)mm Hg,F=60.2,P＜0.01].EDV在提前衰老均较正常衰老和延缓衰老显著降低.IMT、MVEL、E/A、CYSC及FIB在不同年龄组内的衰老程度间比较差异有统计学意义.结论 (1)生物学年龄积分在衰老评价中具有重要作用,为临床进行衰老干预提供了目标人群.(2)IMT、EDV、E/A、MVEL、PP、FIB、CYSC 7项生物学标志物可用于构建衰老生物学年龄积分公式,为衰老干预提供靶点.

Abstract：

Objective To estimate the degree of biological aging for healthy people by the biological age score equation and observe the differences of various aging biomarkers so as to provide targets for clinical anti-aging intervention.Methods A total of 2876 subjects aged 30 - 98 years old were recruited from 3Chinese cities in 2003.After screening,852 healthy subjects were finally selected and assigned into 4 groups according to ages:young group (＜45 yr),middle-aged group (45 -59 yr),young-elder group (60 -74yr) and elder group (≥75 yr).They received a total of 108 physical,morphological,physiologic and biochemical examinations.The biological age score equation was employed to compute the individual biological age scores for all subjects.Then the biological age score was taken as a dependent variable and the chronological age as an independent variable for linear regression.Based on the confidence interval with ± 1standard deviation of regression line,they were divided into 3 groups (delayed aging,normal aging and early aging).According to the chronological ages and degrees of aging,two-way analysis of variance was conducted for the following 7 biomarkers:end diastolic velocity (EDV),intima-media thickness (IMT),ratio of peak velocity of early filling to atrial filling (E/A),mitral valve annulus lateral wall of peak velocity of early filling (MVEL),arterial pulse pressure (PP),fibrinogen (FIB) and cystatin C (CYSC).At the same time,the differences of 7 biomarkers were observed in different aging groups in 4 age groups.Results (1) A comparison of biological age score:there were no significant differences in chronological age among 3biological aging groups in same chronological age groups.However,there were some significant differences in biological age score (young group:F = 91.8,P ＜ 0.01;middle-aged group:F = 134.5,P ＜ 0.01;young-elder group:F = 199.5,P ＜ 0.01;elder group:F = 82.1,P ＜ 0.01).(2) Two-way analysis of variance (aging groups and chronological age groups for biomarkers):there were significant differences of 7biomarkers in different chronological age groups and different aging groups.(3) A comparison of biomarkers among aging groups:there were significant differences in PP among 3 aging groups in 4 age groups.PP increased significantly in early aging group to normal aging group and delayed aging group (young group:49.0±6.9,37.6 ±6.4,30.8±7.6 mm Hg,F=93.2,P＜0.01;middle-aged group:52.9±7.3,44.3 ±5.9,32.7±8.4 mm Hg,F=125.7,P＜0.01;young-elder group:61.9±7.6,51.6±6.6,37.1 ±8.7mm Hg,F=196.5,P＜0.01;elder group:72.2 ±13.7,61.1 ±6.8,43.8 ± 10.8 mm Hg,F =60.2,P ＜0.01).There were significant differences in EDV among 3 aging groups in 4 age groups.EDV increased significantly in early aging group to normal aging group and delayed aging group.There were significant changes in IMT,MVEL,E/A,CYSC and FIB among aging groups in different age groups.Conclusion (1) Biological age score plays an essential role in the evaluation of aging.Based on individual evaluation of biological age score,the degrees of aging can be categorized by grouping so that a clinician may provide clinical anti-aging interventions within the target groups.(2) The above 7 biomarkers are competent for the evaluation of aging.They can not only be used to construct biological age score equation,but also provide clinical targeted interventions for aging.