血清同型半胱氨酸水平在阻塞性睡眠呼吸暂停低通气综合征和冠心病患者中的变化及其作用

目的:观察血清同型半胱氨酸(Hcy)水平在阻塞性睡眠呼吸暂停低通气综合征(OSHAS)及冠心病(CHD)患者中的变化和作用。方法:收集临床确诊CHD、OSAHS、CHD+OSAHS患者各30例,分别为CHD组、OSAHS组和CHD+OSAHS组。平行检测各组血清Hcy水平及睡眠呼吸监测指标:呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(SaO2)及平均SaO2,比较各组Hcy水平的差异以及Hcy水平与睡眠呼吸监测指标的相关性。并与30例体检健康者(健康对照组)对比分析。结果:(1)血清Hcy水平:三病例组明显高于健康对照组(P0.01),CHD+OSAHS组明显高于CHD组和OSAHS组(P0.01),CHD组与OSAHS组比较,差异无统计学意义(P0.05)。(2)病例组血清Hcy水平与AHI呈正相关(r=0.64,P0.01),与夜间平均SaO2和夜间最低SaO2均呈负相关(r分别为-0.64、-0.65,P0.01)。结论:血清Hcy水平升高与OSAHS患者SaO2减低有关,可能有利于CHD的发生与发展。     

阻塞性睡眠呼吸暂停低通气综合征患者间接胆红素和尿酸水平的变化

目的:检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者体内间接胆红素(I-BIL)与尿酸(UA)水平,探讨其对OSAHS患者易患心血管疾病的作用机制。方法:对OSAHS病人和健康对照组进行多导睡眠监测。次晨采空腹静脉血4ml,检测血清I-BIL和UA。结果:I-BIL水平正常对照组14.53±3.64μmol/L,轻度、中度、重度OSAHS组患者均低于正常对照组(P<0.05~0.01);UA水平正常对照组252.05±75.64μmol/L,轻度、中度、重度OSAHS组患者均高于正常对照组(P<0.05~0.01)。相关分析显示I-BIL与呼吸暂停低通气指数(AHI)呈负相关(r=-0.32,P<0.01),最低血氧饱和度(SaO2)与AHI呈负相关(r=-0.56,P<0.01),UA与AHI呈正相关(r=0.27,P<0.05)。结论:OSAHS患者体内I-BIL水平降低,UA水平升高可能是OSAHS患者易患高血压、冠心病等心血管疾病的机制之一。     

精神分裂症共病代谢综合征患者血清同型半胱氨酸的对照研究

目的对精神分裂症共病代谢综合征(MS)患者血清同型半胱氨酸(Hcy)水平进行对照研究。方法 33例首次确诊为MS的精神分裂症患者作为观察组,33例不伴有MS的精神分裂症患者作为对照组,分别测定其空腹血清Hcy水平;同时测定腰围、体质量指数(BMI)、空腹血糖(FBG)、血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血压[收缩压(SBP)/舒张压(DBP)]等MS相关指标。结果①观察组血清Hcy水平显著高于对照组,两组比较差异有统计学意义(t=-2.775,P0.01);②观察组高Hcy血症的发生率显著高于对照组,两组比较差异有统计学意义(χ2=6.061,P0.05);③观察组的血清Hcy水平与HDL-C、LDL-C具有相关性(r=-0.346,0.373;P0.05),而与腰围、BMI、FBG、TC、TG、SBP、DBP均无显著的相关;对照组的血清Hcy水平与腰围、BMI、FBG、TC、TG、HDL-C、LDL-C、SBP、DBP均无显著的相关性。结论与不伴发MS的精神分裂症患者相比,伴发MS的精神分裂症患者血清Hcy水平显著增高;伴发MS的精神分裂症患者的血清Hcy水平与HDL-C、LDL-C有关。     

血清Hcy表达评估桥本氏甲状腺炎合并冠心病患者突发心绞痛的临床意义

目的 探讨血清Hcy表达评估桥本氏甲状腺炎合并冠心病患者突发心绞痛的临床意义.方法 选取本院于2015年1月至2016年10月收治老年桥本氏甲状腺炎合并冠心病患者80例作为研究对象,根据是否突发心绞痛分为心绞痛组38例和非心绞痛组42例.测定和对比两组患者血清同型半胱氨酸(Hcy)、甲状旁腺激素(PTH)、促甲状腺激素 (TSH)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)表达.冠状动脉造影测定和比较两组不同冠状动脉狭窄分级人数和冠状动脉狭窄率.相关性分析Hcy表达与各检测指标关系.结果 心绞痛组患者Hcy、TC、LDL-C和TG表达显著高于非心绞痛组患者(P<0.05),而PTH、TSH和HDL-C表达显著低于非心绞痛组患者(P<0.05),心绞痛组冠状动脉狭窄C级患者人数显著高于非心绞痛组(χ2=3.872,P=0.037),冠状动脉狭窄率显著高于非心绞痛组(P<0.05),Hcy与TC、TG、LDL-C和冠状动脉狭窄率表达呈正相关(P<0.05),与HDL-C、PTH和TSH呈负相关(P<0.05).以甲状腺炎合并冠心病患者是否突发心绞痛为因变量,将年龄、Hcy、TC、TG、HDL-C、LDL-C、PTH、TSH、CAS为自变量,引入多因素Logistic回归模型,结果显示,Hcy、TC、TG、HDL-C、LDL-C、TSH、CAS均是突发心绞痛的危险因素(P<0.05),选择多因素Logistic回归模型分析中OR值>1的因素做ROC曲线分析,ROC曲线面积(AUC)表现为Hcy>TC>TG>LDL-C>CAS>HDL-C>TSH,Hcy诊断的敏感性低于CAS、TG、TC、HDL-C,而特异性则最高,临界值在25.57.结论 高表达Hcy是HT合并冠心病患者突发心绞痛的高风险因素,应对此类患者及时采取相应治疗手段.     

重叠综合征患者血清肾上腺素及去甲肾上腺素表达水平的研究

目的 探讨血清肾上腺素(E)和去甲肾上腺素(NE)在重叠综合征(OS)中的表达及与患者缺氧程度的相关性.推测E及NE对重叠综合征的发生发展的作用.方法 选取慢性阻塞性肺疾病患者(单纯COPD组)、阻塞性睡眠呼吸暂停低通气综合征患者(单纯OSAHS组)、重叠综合征患者(OS组)及对照组各30例,四组患者均行肺功能检查及多导睡眠监测,记录睡眠呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度(LSaO2)、平均血氧饱和度(MSaO2)、最长呼吸暂停时间(LAT).并采用酶联免疫法分别检测四组患者的E及NE的表达水平,对各项指标进行统计学处理.结果 (1)多导睡眠检测指标:OS组患者AHI、LAT均高于单纯OSAHS组、单纯COPD组、对照组(P＜0.05),而LSaO2、MSaO2均低于单纯OSAHS组、单纯COPD组、对照组(P＜0.05).(2)E及NE的表达水平:OS组患者的E及NE表达水平均高于单纯OSAHS组、单纯COPD组、对照组(P＜0.01).(3)各组E及NE与睡眠监测指标的相关性:OS组及OSAHS组患者血清E及NE与AHl、LAT呈正相关(P＜0.01),与LSaO2及MSaO2呈负相关(P＜0.05).COPD组患者血清E及NE与AHI、LAT无相关性(P＞0.05),与LSaO2及MSaO2呈负相关(P＜0.05).结论 OS患者较单纯COPD和OSAHS患者更易引起交感神经活性增强,E及NE表达水平的失调与病变严重程度密切相关.缺氧可能通过影响E及NE的水平促进重叠综合征病情的发生及发展.     

病毒性肝炎患者血液流变学指标和血脂水平的检测分析

目的:探讨病毒性肝炎患者血液流变学及部分血脂指标的异常变化。方法:189例病毒性肝炎患者分为急性肝炎组、轻度慢性肝炎组、中度慢性肝炎组、重度慢性肝炎组、肝硬化组、重症肝炎组。采用血液流变技术测定全血粘度(ηb)、血浆粘度(ηp)、红细胞压积(Hct)、血沉(ESR)、血沉方程K值(Kesr)、红细胞聚集指数(RE)、红细胞电泳指数(EE);采用罗氏MODULAR全自动生化分析仪测定甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C),并与55例健康人群对照分析。结果:各肝病组ηb、ηp、RE、EE均高于对照组(P<0.01,肝硬化组和重症肝炎组ηp除外),Hct、Kesr低于对照组(P<0.01),ESR和Kesr在肝硬化组和重症肝炎组有显著性差异(P<0.05)。肝硬化组、重症肝炎组TG、TC、HDL-C、LDL-C水平与对照组比较均显著下降(P<0.01),ηb、ESR、Kesr、RE、TC、LDL-C与急性肝炎组和不同程度慢性肝炎组间比较均有显著性差异(p<0.05);重症肝炎组TC与肝硬化组比较有显著性差异(P<0.01);急性肝炎组与不同程度慢性肝炎组比较,Hct、RE、EE、TG、HDL-C、LDL-C具有显著性差异(P<0.01);重度慢性肝炎组ηb、RE、EE、TC、HDL-C、LDL-C与轻、中度慢性肝炎组间均有显著性差异(P<0.01)。结论:病毒性肝炎患者存在不同程度的血流变指标和血脂异常变化,分析其变化规律对临床诊断及治疗有重要意义。     

中老年急性脑出血和脑梗死患者血脂水平分析

目的:分析中老年急性脑出血(CH)与脑梗死(CI)患者血脂水平的变化。方法:检测50例CH和65例CI及50例健康人群的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白(a)〔Lp(a)〕的血浆含量,并进行比较分析。结果:CH组的TC高于对照组(P<0.01),HDL-C显著低于对照组(P<0.01),TC、LDL-C、ApoB显著低于CI组;中老年CH患者随年龄变化血脂代谢的变化不一致。豆纹动脉(LSA)出血组的HDL-C显著低于对照组,TC、LDL-C、ApoB显著高于非豆纹动脉出血(NLSA)组,与CI组无差别,NLSA出血组的TC显著低于对照组和CI组。结论:血脂代谢紊乱容易导致脑LSA粥样硬化,是中老年人CH的危险因素及常见出血部位。     

浙江汉族长寿人群血脂水平及ApoB基因Xba I-RFLP和3'-VNTR多态性的相关性研究

 目的：研究浙江汉族长寿人群的血脂水平及载脂蛋白B（ApoB）基因Xba I-限制性片段长度多态性(RFLP)和3’-可变数目串联重复序列(VNTR)多态性对血脂四项和载脂蛋白水平是否有影响,了解长寿发生的机制。方法：采用体格检查与实验室研究分别对长寿老人组、长寿子女组、正常对照组和非长寿子女组进行血样采集、ApoB基因Xba I-RFLP和3'-VNTR分型。结果：血清甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）及ApoB 与长寿呈负相关（P<0.05）, 高密度脂蛋白胆固醇（HDL-C）与长寿呈正相关（P<0.01）。拥有X⁺X^-基因型的人,除TG外,TC、LDL-C及ApoB均高于拥有X^-X^-基因型的人（P<0.01）,其HDL-C低于拥有X^-X^-基因型的人（P<0.01）;拥有大等位基因的人,其TC、TG、LDL-C及ApoB均高于拥有小等位基因的人（P<0.01）,而HDL-C含量较低（P<0.01）。结论：高TG、LDL-C、ApoB和低HDL-C不利于长寿,拥有X^-X^-基因型和3'-VNTR分型小等位基因的人血脂水平较健康,也利于长寿。     

变应性鼻炎患者血清IL-17、IL-4、IFN-γ与血脂相关指标的表达及关系研究

目的 观察白介素-17(IL-17)、白介素-4(IL-4)、干扰素-γ(IFN-γ)与血脂在变应性鼻炎(AR)患者血清中的表达,并探讨血脂与上述指标及AR疾病之间的可能关系。方法 选取2021年4月至2022年6月在首都医科大学附属北京同仁医院诊治的160例AR患者(其中60例合并支气管哮喘)作为病例组。选取同期进行健康体检的100例健康志愿者作为健康对照组。比较AR患者及健康对照组血清中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及IL-17、IL-4、IFN-γ、总IgE(TIgE)水平的差异,并分析上述指标间可能的相关性。结果 AR患者IL-17、IL-4、TIgE及TC、TG、LDL-C水平显著高于健康对照组,IFN-γ及HDL-C水平低于健康对照组(P<0.05),合并支气管哮喘患者的IL-17、TIgE、TC、LDL-C较单纯AR组高,IL-4、IFN-γ较单纯AR组低(P<0.05);AR患者中女性的TC、LDL-C的水平低于男性(P<0.05);血清TC、LDL-C的表达与IL-17、IL-4...     

高血压合并OSAHS患者治疗前后血清Hcy、CRP、氧饱和度及血压变化及其临床意义

目的分析高血压合并阻塞性呼吸暂停低通气综合征(OSAHS)患者治疗前后血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)、氧饱和度及血压的变化及意义。方法选择医院收治的100例高血压患者,按是否合并OSAHS分为高血压组[n=46,呼吸暂停低通气指数(AHI)<5次/h]与合并组(n=54,AHI≥5次/h),均于治疗前后检测血清Hcy、CRP、血氧饱和度(SaO_2)水平,并检测动态血压变化,分析上述指标与高血压合并OSAHS病情变化的关系。结果合并组Hcy、CRP、AHI高于高血压组,最低SaO_2低于高血压组,其治疗后Hcy、CRP、AHI低于治疗前,SaO_2高于治疗前(P<0.05);合并组随OSAHS病情程度的提升,Hcy、CRP、AHI逐渐升高,最低SaO_2降低(P<0.05),各组治疗后Hcy、CRP、AHI水平均低于治疗前,最低SaO_2高于治疗前(P <0.05);高血压+轻度、中度、重度OSAHS组整体血压昼夜节律变化幅度高于高血压组(P<0. 05),治疗后,除高血压+轻度OSAHS组mSBP、mDBP外,各组血压较治疗前降低(P <0.05);高血压合并OSAHS患者Hcy、CRP与AHI、nSBP均呈正相关,与最低SaO_2呈负相关(P <0.05)。结论高血压合并OSAHS患者随OSAHS程度的上升,Hcy、CRP、AHI水平上升,最低SaO_2降低,且其Hcy、CRP的变化可影响患者通气功能及血压变化节律。     

Lipid, glucose and homocysteine metabolism in women treated with a GnRH agonist with or without raloxifene

BACKGROUND: Although GnRH analogues are widely used to treat a variety of sex hormone-related diseases, little is known about their effect on metabolism. Therefore, we have evaluated the effect of a GnRH analogue, administered with or without raloxifene, on serum levels of lipoproteins, glucose, insulin and homocysteine (Hcy). METHODS: One hundred premenopausal women with symptomatic uterine leiomyomas were initially enrolled and randomized to receive 3.75 mg/28 days leuprolide acetate depot associated with 60 mg/day raloxifene hydrochloride (group A) or 1 placebo tablet/day (group B) for six cycles of 28 days. At entry and at cycle 6, subjects underwent anthropometric measurements, including body mass index and waist-to-hip ratio measurements, and blood chemistry assays for serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, Hcy, vitamin B(12) and folate concentrations. Insulin resistance was evaluated with the homeostasis model assessment (HOMA) score. RESULTS: Baseline parameters were similar in the two groups. At cycle 6, TC, HDL-C, LDL-C and TG levels were significantly increased (P < 0.05) in group B. In group A, LDL-C levels were unchanged, and TC, HDL-C and TG levels were increased (P < 0.05). Serum TC and LDL-C levels differed (P < 0.05) between the groups. Glucose levels were unchanged between and within groups, whereas insulin levels and HOMA scores increased (P < 0.05) versus baseline in group B. Post-treatment Hcy levels were higher (P < 0.05) versus baseline in group B; they were unchanged in group A. Serum vitamin B(12) and folate concentrations were unchanged in both groups. CONCLUSIONS: GnRH analogues alter serum lipoprotein and Hcy levels and increase insulin resistance. These acute metabolic changes may be prevented or reduced by raloxifene.     

What is a good marker for serum cholesterol to identify high-risk patients at general health checks?

Conventional measurement of lipid concentrations includes total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TG). Several guidelines for cardiovascular diseases recommend using LDL-C as the primary target of therapy in conjunction with assessing risk factors for cardiovascular diseases (CVD); however, emerging findings have revealed that lowering LDL-C to the goal with statins is not enough to prevent primary and secondary CVD. Thus, we need new parameters to better integrate residual risks into CVD risk stratification. Recently, non-HDL-C, apolipoprotein B (apoB), and LDL-C/HDL-C have been suggested. Non-HDL-C, indicating the cholesterol contents of all atherogenic lipoproteins and retaining continuity with the concept of cholesterol, is quickly computed by subtracting HDL-C from TC, needs no additional costs, and includes atherogenic TG-rich lipoproteins, called remnant lipoproteins. In addition, non-HDL-C has been shown to be an excellent predictor of CVD, free from dietary variations. ApoB, the number of atherogenic lipoproteins, is also a valuable parameter with slightly better performance than non-HDL-C in epidemiological studies, but it costs more and takes longer than conventional lipid examinations. Several lipid parameters, such as TC/HDL-C, non-HDL-C/HDL-C, LDL-C/HDL-C, are also available in clinical practice and epidemiological study; however, we should note that LDL-C/HDL-C is not reliable in cases of high TG. Thus, in general health checks, we should first pay attention to the absolute values of LDL-C, HDL-C, and TG for the diagnosis and subsequently use non-HDL-C, apoB, and other parameters, considering the pathophysiological condition, convenience, and costs.     

66例脑梗死患者血浆血脂分析和Hcy测定的临床应用

目的：探讨脑梗死患者血脂和同型半胱氨酸（Hcy）分析的临床意义。方法：生化法和化学发光免疫分析了66例脑梗死和58例正常对照组血浆中总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）和同型半胱氨酸（Hcy）水平。结果：66例脑梗死患者较之58例正常对照组血浆TC、TG、LDL—C和Hcy显著增高（P均〈0．05和〈0．01）,而HDL—C显著降低（P〈0．05）。结论：血浆TC、TG、LDL—C、HDL—C和Hcy与脑梗死密切相关,并具有诊断和治疗随访的临床价值。     

2型糖尿病视网膜病变患者超敏C反应蛋白、血脂指标变化及相关危险因素分析

目的:观察2型糖尿病视网膜病变(DR)患者超敏C反应蛋白(hs-CRP)、血脂代谢相关指标变化,并分析其危险因素。方法:回顾性分析2018-02—2019-08本院收治的161例2型糖尿病(T2DM)患者,将其分成A组(Ⅰ型,未发生视网膜病变,62例);B组[Ⅱ、Ⅲ型,非增殖性的糖尿病性视网膜病变(NPDR),43例];C组[Ⅳ、Ⅴ型,增殖性的糖尿病性视网膜病变(PDR),56例],以同期体检健康者52例作为对照组。比较各组hs-CRP、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及TG/HDL-C、TC/HDL-C、LDL-C/HDL-C比值水平变化差异,采用Spearman分析hs-CRP与各检测指标的相关性,Logistic回归分析DR可能的危险因素。结果:除LDL-C,hs-CRP、血脂代谢(TG、TC、HDL-C)及比值(TG/HDL-C、TC/HDL-C、LDL-C/HDL-C)在各组间比较,差异有统计意义(均P<0.05)。DR患者血液hs-CRP与TG(r=0.505)、TC(r=0.236)、LDL-C(r=0.313)、TG/HDL-C(r=0.50)、TC/HDL-C(r=0.385)、LDL-C/HDL-C(r=0.405)水平均呈正相关(均P<0.05),Logistic回归模型分析发现除了TC外其余各项指标均为T2DM患者发生DR的可能危险因素。结论:DR患者hs-CRP和血脂代谢指标对评估DR患者风险具有预测价值。     

血脂异常与老年冠心病患者冠脉病变程度的相关性研究

目的 探讨血脂异常与老年冠心病患者冠脉病变程度的相关性。方法 选取2015年5月~2017年1月本院心内科住院的明确诊断为冠状动脉粥样硬化性心脏病（CHD）的150例老年患者设为CHD组。选取同期收治的150例非CHD患者为对照组。比较两组血清中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平,并计算N-HDL-C、LDL-C/N-HDL-C、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值。比较不同冠脉病变支数、不同病情严重程度的CHD患者的血脂及其比值。对血脂与冠脉病变支数、病情严重程度积分进行相关性分析。结果 CHD组患者LDL-C、TG、TC、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值均高于对照组,HDL-C水平低于对照组,差异均有统计学意义（P＜0.05）;不同冠脉病变支数各亚组间的TC、TG、N-HDL-C水平、TC/HDL-C比值差异存在统计学意义（P＜0.05）;TC、TG、N-HDL-C水平、TC/HDL-C比值均与冠脉病变支数均呈正相关（P＜0.05）;不同病情严重程度亚组间的LDL-C、TC、TG、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值差异存在统计学意义（P＜0.05）;CHD患者LDL-C、TC、TG、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值与冠状动脉病变积分均呈正相关（P＜0.05）。结论 可以通过对血脂指标的监测,并计算N-HDL-C、TC/HDL-C、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值,来评估CHD病情的临床进展。     

乳腺癌骨转移患者血脂和血浆CA15-3联检对早期诊断的临床价值

目的:为了探讨乳腺癌骨转移患者血脂和血浆CA15-3联检对早期诊断的临床意义。方法:42例乳腺癌骨转移组、38例乳腺癌无骨转移组患者生化法和电化学发光免疫分析测定了血脂(TC、TG、HDL-C和LDL-C)水平和血浆CA15-3水平,并与42例乳腺良性病变组进行了对比性研究。结果:38例乳腺癌无骨转移组患者血清TC水平较之42例乳腺良性病变组患者明显降低(P<0.05),而血清TG、HDL-C和LDL-C水平无明显差异(P>0.05)。42例乳腺癌骨转移组患者较之乳腺良性病变组和乳腺癌无骨转移组患者血清TC和HDL-C水平明显降低(P均<0.01和<0.05),而血清TG和LDL-C水平明显增高(P均<0.05)。在血浆CA15-3测定中,38例乳腺癌无骨转移组患者较之42例乳腺良性病变组患者明显增高(P<0.05),42例乳腺癌骨转移组患者较之42例乳腺良性病变组患者非常明显增高(P<0.01),从而显示,血浆CA15-3水平随乳腺癌患者的严重程度而增加。结论:乳腺癌骨转移早期诊断的重要标志是血脂TC和HDL-C水平的明显降低以及血浆CA15-3水平的明显增高。     

Effects of strength training and nutritional counseling on metabolic health indicators in aging women.

PURPOSE: Effects of strength training (ST) and nutritional counseling (NC) on metabolic health indicators were examined in 50 aging women. METHODS: Subjects performed ST for 21 weeks. NC was given to obtain sufficient energy and protein intake, and recommended intake of fat and fiber. RESULTS: NC increased intake of protein and polyunsaturated fat by 4.5% and 10.7% and decreased intake of saturated fat by 18.3%. Serum concentrations of total cholesterol (TC), LDL-cholesterol (LDL-C), total and HDL-cholesterol (HDL-C) ratio and triacylglycerols (TAG) decreased, and serum HDL-C increased in all subjects after ST. Respectively, systolic and diastolic blood pressure and serum insulin concentration decreased in all subjects. NC contributed to the decreases in levels of serum LDL-C after the first half of ST and serum TC and HDL-C ratio during both ST periods. Changes in serum TAG concentrations correlated positively with intake of carbohydrates, and negatively with monounsaturated fat in all subjects. Respectively, changes in serum TC levels were related to protein intake, and changes in serum HDL-C to intake of fat, and inversely to carbohydrate and protein in all subjects. Relationships between serum TC and HDL-C levels and protein intake were only observable in the ST+NC group. CONCLUSIONS: The long-term ST had favorable effects on serum lipids, lipoproteins, insulin concentration, and blood pressure. However, NC further contributed to positive changes in serum lipids and lipoproteins.     

Lipid, lipoproteins and atherogenesis profiles in sickle cell disease among Central African patients

Lipid and lipopproteins disorders are well established in sera from sickle cell disease (SCD) patients out of Central Africa. The present case-control study was conducted to compare serum levels of total cholesterol (TC), HDL-C, triglycerides (TG), LDL-C and TC/HDL-C ratio (atherogenic index) from SCD homozygotes (SS) in steady state, SCD heterozygotes (AS) and controls (AA) in Brazzaville, Congo. Significant reductions of TC and LDL-C vs. increase in TG were reported in SS. However, significant decrease in HDL-C and increase in atherogenic index were observed in AS. We recommend prevention of oxidative stress, dyslipidemia and atherosclerosis in SCD using hygiene-diet measures. Only longitudinal studies in large populations will provide pathophysiological basis of lipid and lipoproteins disorders in SCD.