动力髋螺钉治疗股骨粗隆间骨折体会

目的：应用动力髋螺钉（DHS）内固定治疗股骨粗隆间骨折的体会。方法：对DHS内固定治疗45例股骨粗隆间骨折的分类、手术方法、术后处理及疗效进行评价。结果：所有病例术后完全随访,骨折愈合,无髋内翻、下肢外旋及短缩畸形,患髋关节功能优良率92%,疗效肯定。结论：DHS内固定是治疗股骨粗隆间骨折的理想方法。     

DHS内固定治疗股骨粗隆间骨折46例临床分析

目的观察动力加压髋螺钉（DHS）内固定在股骨粗隆间骨折治疗中的应用及疗效。方法对2002年7月至2006年1月用DHS内固定治疗的46例股骨粗隆间骨折的类型、手术方法、术后处理及疗效进行总结和随访。结果46例病例全部得到随访，平均随访12个月，均骨性愈合，无钉板断裂，无加压螺钉穿透股骨头，出现髋内翻畸形1例，患髋关节评价优良率95．7％。结论DHS内固定治疗股骨粗隆间骨折固定可靠，并发症少，能早期下床活动，是股骨粗隆间骨折治疗的理想方法。     

DHS内固定治疗老年股骨粗隆间骨折92例临床分析

目的 探讨老年股骨粗隆间骨折DH8内固定方式体会及其疗效.方法 DHS内固定方式手术治疗股骨粗隆间骨折92例,并进行临床分析.结果 动力髋螺钉(DHS)效果优良.结论 DHS是治疗股骨粗隆间骨折最常用的内固定装置之一,具有动静力加压及张力带作用.     

动力髋螺钉治疗股骨粗隆间骨折

目的：分析应用动力髋螺钉(Dynamic Hip Screw DHS)内固定治疗股骨粗隆间骨折的疗效；方法：对我院从1998年以来用DHS内固定治疗46例股骨粗隆间骨折的分析和术前、中、后的处理及疗效进行评价，平均随访1年半；结果：本组全部随访，疗效满意；结论：作者认为DHS内固定是目前治疗股骨粗隆间骨折的理想方法。     

动力髋螺钉内固定治疗股骨粗隆间骨折

目的 探讨DHS治疗股骨粗隆间骨折的疗效.方法 对我院1998年12月～2004年12月收治的股骨粗隆间骨折46例,均为新鲜骨折,使用DHS内固定,进行手术方法、术后结果分析.结果 所有患者均获得随访,骨折均愈合,髋关节功能优良率93%.结论 DHS内固定治疗股骨粗隆间骨折,固定牢固,可以早期行关节功能锻炼,减少并发症,降低病残率,疗效满意.     

35例动力髋螺钉治疗股骨粗隆间骨折的疗效评价

目的 分析应用动力髋螺钉（DHS）内固定治疗股骨粗隆间骨折的疗效。方法 对我院从1996年4月至2001年8月用DHS内固定治疗35例股骨粗隆间骨折的分类。手术方法，术后处理及疗效进行评价，平均随访1年3个月。结果 所有病例术后完全随访，骨折愈合，无髋内翻，下肢外旋及短缩畸形，患髋关节功能优良率达89.6%,疗效肯定。结论 DHS内固定是治疗股骨粗隆间骨折的理想方法。     

应用DHS治疗股骨粗隆间骨折23例

目的:观察动力加压髋螺钉(DHS)内固定在股骨粗隆间骨折治疗中的应用及疗效。方法:对2006年10月—2008年11月用DHS治疗的23例股骨粗隆间骨折的类型、手术方法、术后处理及疗效进行随访。结果:按照Evans标准分类:Ⅱ型6例,Ⅲ型14例,Ⅳ型3例,23例全部例得到随访,均骨性愈合,无钉板断裂,无加压螺钉穿透股骨头,无感染,疗效评分优良率95.7%。结论:DHS内固定治疗股骨粗隆间骨折固定可靠,并发症少,能早期下床活动,是股骨粗隆间骨折治疗的理想方法。     

股骨粗隆间骨折DHS内固定治疗36例临床分析

目的观察AO动力髋螺钉(DHS)内固定治疗股骨粗隆间骨折的疗效。方法对2008年10月—2010年10月间36例股骨粗隆间骨折患者用DHS内固定治疗,对其骨折的分类、手术方法及疗效进行分析。结果所有病例术后随访骨折均愈合,髋关节功能优良率达88.9%。结论 DHS内固定是治疗股骨粗隆间骨折一种理想而有效的方法。     

DHS内固定治疗股骨粗隆间骨折

目的观察动力髋螺钉（DHS）在股骨粗隆间骨折中的应用及疗效。方法用手术的方法,采用DHS内固定治疗42例股骨粗隆间骨折。结果经过8个月～2年的随访,骨折全部愈合。1例髋内翻。结论DHS在治疗股骨粗隆间骨折中具有固定牢靠、并发症少、能早期起床活动等优点。在良好的手术环境和技术条件下,DHS是股骨粗隆间骨折首选的内固定材料。     

闭合复位DHS内固定治疗股骨粗隆间骨折51例

目的 探讨闭合复位DHS内固定治疗股骨粗隆间骨折的临床疗效.方法 回顾分析51例年龄53～84岁股骨粗隆间骨折患者,采用闭合复位DHS手术治疗的临床资料.结果 51例患者,随访4～12个月,平均6个月,DHS内固定牢固,功能恢复好.结论 股骨粗隆间骨折采用DHS内固定对无手术禁忌证的患者行积极的内固定治疗,结合术后功能锻炼,疗效良好.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.