三维超声心动图估测功能性单心室心功能及同步性

目的应用三维超声心动图评估功能性单心室患儿的整体心功能及同步性,探讨三维超声心动图在功能性单心室患儿的应用。方法研究对象分两组,病例组为36例功能性单心室患儿,对照组为36例正常儿童,应用Q-lab软件分析并计算单心室主心腔及正常儿童左心室的舒张末期容积(EDV)、收缩末期容积(ESV)、射血分数(EF)、16节段达到收缩末最小容积时间的标准差和最大差值(Tmsv16-SD、Tmsv16-Dif)、被标准化为心动周期的百分比(Tmsv16-SD%、Tmsv16-Dif%)、12节段达到收缩末最小容积时间的标准差和最大差值(Tmsv 12-SD、Tmsv 12-Dif)、被标准化为心动周期的百分比(Tmsv 12-SD%、Tmsv 12-Dif%)。结果病例组的EDV(48.64±33.62)ml明显大于对照组的EDV(35.82±16.71)ml,P<0.05。病例组的ESV(25.12±19.81)ml明显大于对照组的ESV(11.42±5.94)ml,P<0.05。功能性单心室患儿的EF(49.80±8.83%)明显小于正常儿童的EF(68.26±5.50%),P<0.05。功能性单心室患儿的Tmsv16-SD、Tmsv16-Dif、Tmsv16-SD%、Tmsv16-Dif%、Tmsv 12-SD、Tmsv 12-Dif、Tmsv 12-SD%及Tmsv 12-Dif%与正常儿童相比,有明显增大,P<0.05。结论功能性单心室患者存在收缩功能不全及不同步,实时三维超声心动图可评估功能性单心室患者整体心功能及同步性。     

实时三维超声心动图评价不同QRS间期心衰患者左室收缩同步性的研究

目的探讨实时三维超声心动图在评价不同QRS波时限的心力衰竭患者左室收缩功能及其同步性上的可行性和临床价值。方法27例正常对照组（A组）及35例病例组（B组）均进行二维和三维超声心动图检查;依据QRS宽度将B组分为B1组、B2组。获取各组的左室射血分数（LVEF）、左室舒张末期容积（LVEDV）、左室收缩末期容积（LVESV）;应用Qlab软件描绘左室容量一时间曲线,计算左室16节段、12节段收缩期容积达峰时间的标准差（Tmsv—SD）、最大差异（Tmsv—Dif）及其标准化值（Tmsv—SD％、Tmsv—Di物）;常规体表心电图记录QRS时限。结果①Bl、B2两组LVEF、LVEDV、LVESV及收缩同步性参数与A组比较,差异均有统计学意义（P〈0．05）。②A组左室收缩均呈同步性,B1组中33％的患者收缩不同步,B2组中78％的患者收缩不同步。结论①无论心力衰竭患者的QRS波时限增宽与否,均有一定比例患者存在心脏运动不同步现象。②RT-3DE能够准确评价不同宽度QRS时限心衰患者的心肌收缩同步性。     

实时三维超声心动图评价左室收缩功能及同步性与心电活动的关系

目的应用实时三维超声心动图评价不同患者左室收缩功能及收缩同步性的价值,探讨不同步性与心电活动的关系。资料与方法应用GEViVid7.0采集40例心衰患者(A组)、40例心衰高危因素患者(B组)和30例健康志愿者(C组)的左室全容积图像。采用左室16节段时间-容积曲线分析后,计算左室16节段、12节段达到最小收缩容积的时间(Tmsv)的标准差(SD)和最大差值(Dif):即Tmsvl6-SD、Tmsvl6-Dif、Tmsv12-SD、Tmsv12-Dif;获取左室舒张末容积(LVEDV)、收缩末容积(LVESV)、左室射血分数(LVEF)。常规体表心电图获取P-R间期、QRS波宽度。结果①A、B两组LVEDV、LVESV、LVEF及收缩不同步性指标与C组各组间比较,差异均有显著性意义(P<0.05);②A组LVEF与收缩不同步性指标有良好的负相关性,以Tmsvl6-SD%相关性最高,(r=-0.721,P<0.001);Tmsvl6-SD%与QRS宽度呈弱相关(r=0.314,P=0.049),并且有27.5%的患者QRS<120ms,但存在左室机械不同步;③B组Tmsvl6-SD%与LVEF、QRS宽度之间无相关性。结论实时三维超声心动图能真实反映左室收缩功能及收缩同步性,能客观揭示机械不同步性与心电活动的关系,为慢性心力衰竭的防治提供简便、有效、可靠的依据。     

实时三维超声心动图评价尿毒症性心肌病左心室收缩功能及同步性

目的:探讨实时三维超声心动图(RT-3DE)评价尿毒症性心肌病(UM)患者左心室收缩功能及其同步性的应用价值。方法:①对30例尿毒症性心肌病患者和20例正常对照组采用RT-3DE采集其左心室容积和射血分数,同时应用二维超声心动图Si mpson法、M型Teichholz法进行检测,将三种方法所测的数据与磁共振显像技术所测的数据进行比较;②RT-3DE检查获取左心室全容积图像,应用QLAB4.2软件分析左心室17节段达到收缩期最小容积点时间(Tmsv)的标准差(Tmsv16-SD、Tmsv12-SD和Tmsv6-SD)及最大时间差(Tmsv16-Dif、Tmsv12-Dif和Tmsv6-Dif),对标准差及最大时间差行心率校正。结果:①UM组Teichholz法、Si mpson法所测LVEDV和LVESV均高于或低于RT-3DE测值,其差异均有统计学意义(P0.05);②正常组与UM患者16节段、12节段(中间段和基底段)和6节段(基底段)Tmsv的标准差和最大时间差值均有显著性差异,UM组均大于正常组(P0.05或P0.01)。结论:①在UM患者中,RT-3DE法的左室容积及射血分数数据准确性高;②RT-3DE为临床评价UM患者左心室收缩同步化及收缩功能提供了更加快速、简便、准确及无创性的新方法。     

实时三维经胸超声心动图评价右室不同部位起搏对左室收缩同步性和收缩功能的影响

目的 应用实时三维经胸超声心动图(RT-3D-TTE)评价右室流出道( RVOT)间隔部与右室心尖部(RVA)起搏对左室收缩同步性和收缩功能的影响.资料与方法 65例缓慢心律失常患者采用掷硬币随机法分为RVOT间隔起搏组35例,RVA起搏组30例.于起搏器植入术前当天、术后1个月、3个月、6个月及12个月分别行RT-3D-TTE检查并采集三维全容积图像,用Qlab软件测量左室16节段的最小容积点距离心电图QRS起始点平均时间的标准差(Tmsv 16-SD)和最大时间差(Tmsv 16-Dif).测量左室舒张末期内径( LVEDD)和左室射血分数(LVEF).结果 RVOT组和RVA组术前当天Tmsv 16-SD、Tmsv 16-Dif、LVEDD和LVEF差异无统计学意义(P＞0.05),但两组内术后1个月、3个月、6个月、12个月Tmsv16-SD、Tmsv 16-Dif均较术前增大(P＜ 0.05); RVOT组术后LVEDD和LVEF与术前比较差异无统计学意义(P＞0.05); RVA组术后6个月、12个月LVEDD较术前增大,LVEF减小(P＜0.05).两组间术后1个月、3个月Tmsv 16-SD、Tmsv 16-Dif、LVEDD和LVEF差异均无统计学意义(P＞0.05);RVOT组术后6个月、12个月Tmsv 16-SD、Tmsv 16-Dif、LVEDD较RVA组小;LVEF较RVA组大,差异有统计学意义(P＜0.05).结论 RVOT和RVA起搏均可引起心脏收缩不同步,对左室整体收缩功能有一定影响.RVOT间隔部起搏较RVA起搏对左室同步性的影响小,是较好的右室起搏部位.     

MSCT与超声心动图评价成人左心室整体收缩功能的对比研究

目的 与超声心动图对比,探讨MSCT评估左室整体收缩功能与超声心动图的相关性,评价MSCT测量左室整体收缩功能的可行性及准确性.方法 回顾性分析MSCT冠状动脉CTA检查的50例患者的资料,以10％ R-R间期间隔重建图像,测定出左心室舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、左室射血分数(EF),同时进行超声心动图检查,与超声心动图所测得的相应指标进行相关性分析.结果 10％R-R间期间隔测定的心功能指标与超声心动图检查的各项指标的相关性很高,r在(0.70～0.96)之间,EDV、ESV、SV值:MSCT＞超声心动图,EF值:MSCT≤超声心动图.结论 MSCT冠状动脉造影检查所获得的整体心功能指标数据较准确、可靠,具有较高的临床应用价值,临床可应用10％R-R间期间隔重建图像测定心功能,相对简便快捷.     

应用三维超声斑点追踪技术评估左室型单心室收缩功能的研究

目的应用三维超声斑点追踪技术(three-dimensional speckle tracking echocardiography,3DSTE)研究左室型单心室患儿在腔-肺动脉吻合(Glenn)术前及术后心室收缩功能变化。方法左室型单心室患儿17例于Glenn术前及术后分别进行三维超声检查和心脏磁共振检查,并取年龄、性别匹配的正常儿童进行对照。结果与正常儿童对比,左室型单心室患儿术前射血分数(55. 567±3. 577)%vs (63. 628±3. 739)%、扭转角度(5. 776±2. 819)°vs (11. 801±1. 769)°、扭力(1. 653±0. 860)°/cm vs (3. 123±0. 490)°/cm)、心尖旋转角度(2. 135±2. 303)°vs (5. 415±1. 562)°、心底旋转角度(-3. 672±1. 751)°vs (-6. 490±1. 090)°明显减低(P 0. 01),术后射血分数、扭转角度、扭力、心底旋转角度较术前增大(P 0. 05)。心底旋转角度与EF3DSTE相关性最好(r=0. 827)。结论左室型单心室患儿心室收缩功能和扭转运动减弱,术后有所改善;三维超声斑点追踪技术可以比较准确地估测左室型单心室的心功能,心底旋转角度是评估心室收缩功能的良好指标。     

时间-空间相关成像技术评估中孕期胎儿心功能的初步研究

目的 评估时间-空间相关成像( STIC)技术在中孕期胎儿心功能检查中的应用.资料与方法 110例孕20～27+6周胎儿常规超声筛查心脏无异常,用STIC技术扫描获得胎儿心脏整个心动周期的容积数据,存盘后采用体器官计算机辅助分析软件(VOCAL)进行脱机分析,手动描画出心室舒张末期容积(EDV)、收缩末期容积(ESV).计算心室的每搏量(SV)、心排血量(CO)、射血分数(EF),评价SV、CO、EF与孕龄的相关性.结果 110例胎儿中,94例(85.5％)获得满意的心脏容积数据.左、右心室SV从孕20周的(0.33±0.06) ml和(0.40±0.07) ml增加至孕27+6周的(1.13±0.11) ml和(1.29±0.11) ml,左、右心室CO从孕20周的( 49.66±8.10) ml/min和(59.96±9.43) ml/min增加至孕27+6周的(163.51±17.68) ml/min和(187.57±15.98) ml/min;左、右心室SV和CO随孕龄增加而增加,与孕龄呈正相关(左心室SV及CO r=0.93,P＜0.05.右心室:SV r =0.95,P＜0.05; CO r=0.94,P＜0.05).左、右心室EF分别为(49.48±4.12)％和(51.07±4.00)％,与孕龄无明显相关性(r=0.02、0.04,P＞ 0.05).结论 STIC技术能较为准确客观地测量胎儿心室容积,评价胎儿心功能,有望成为胎儿心功能检查的一种新方法.     

320排CT与二维超声心动图评价冠心病左心功能的初步比较研究

目的探讨320排CT和二维超声心动图对冠心病心功能评价的相关性及320排CT在冠心病左心室功能评价中的价值。资料与方法搜集2009年9月至12月间行320排CT冠状动脉造影检查和二维超声心动图的冠心病患者45例,其中男29例,女16例,平均年龄(64±9)岁。利用冠状动脉CT血管造影(CTA)的原始数据进行多期相重建,在专用心功能分析软件(Vitrea FX)中进行左心功能分析,利用Simpson法计算出左心功能指标:舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)和射血分数(EF)。结果 320排CT与二维超声心动图两种方法的冠心病心功能指标差异无统计学意义(P>0.05),两种方法的冠心病心功能指标:EDV、ESV、SV和EF相关性高,相关系数分别为0.867、0.791、0.723和0.674。结论 320排CT在冠心病左心功能定量评价方面结果准确、可靠,与二维超声心动图测得的心功能指标差异无统计学意义,两种方法各指标间相关性高。320排CT心功能分析与冠状动脉造影检查协议相同,收缩末期和舒张末期图像可以通过回顾性心电门控冠状动脉CTA数据获得,心功能分析包含于冠状动脉检查中,患者无需...     

冠状动脉SYNTAX评分与左心功能指数间相关性研究

目的 分析冠心病患者冠状动脉病变复杂程度与左心功能指数间的相关性.方法 69例冠心病患者根据冠状动脉CT血管成像(CTA) SYNTAX评分分为低危组(27例)、中危组(23例)、高危组(19例).使用SPSS16软件,采用ANOVA分析比较3组左心功能的差异,采用Spearman秩相关分析SYNTAX评分与左心功能指标间的相关性.结果 低、中、高危3组患者间左心室舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、射血分数(EF)、心肌质量(MM)差异有统计学意义(F值分别为7.254、9.181、13.004、7.544、5.276,P均<0.05).冠状动脉SYNTAX评分与左心室EF呈显著负相关(r=-0.702,P<0.05),与MM呈显著正相关(r=0.638,P<0.05).结论 冠状动脉SYNTAX评分与左心室EF呈显著负相关,与左心室MM呈显著正相关.     

128层CT冠状动脉成像对左心室功能的评价

目的:应用冠状动脉成像原始数据,了解左心室形态变化,评价整体左心室功能。方法:收集90例患者冠状动脉成像原始数据,行MPR,观察左心室形态和各心肌节段的变化,并应用心功能分析软件自动计算出左心室收缩末期容积(ESV)、舒张末期容积(EDV)和射血分数(EF)。根据冠状动脉、左心室形态及整体左心室功能,将所有患者分为对照组、冠心病组、左心室肥厚组及心功能衰竭组,结合各组左心室形态变化,将左心室ESV、EDV和EF进行统计学比较和分析。结果:对照组患者冠状动脉和左心室形态正常;冠心病组左心室壁局限性增厚7例和变薄13例;左心室肥厚组左心室缩小、心室壁增厚;心功能衰竭组心室扩大、室壁普遍变薄。对照组、冠心病组、左心室肥厚组、心功能衰竭组平均EDV和ESV分别为(133.58±14.91)mL、(51.33±11.06)mL;(130.68±11.53)mL、(56.16±8.24)mL;(97.59±8.18)mL、(29.53±4.78)mL;(229.40±50.64)mL、(171.27±60.64)mL。冠心病组与对照组平均EDV和ESV比较,差异无统计学意义,左心室肥厚组及心功能衰竭组与对照组比较,差异均有统计学意义(P0.001)。对照组、冠心病组、左心室肥厚组、心功能衰竭组EF分别为(61.25±5.83)%、(56.37±6.79)%、(68.94±5.36)%和(26.33±8.30)%,差异均有统计学意义。结论:应用冠状动脉成像原始数据,结合冠状动脉及左心室形态改变,无创评价左心室整体功能,实用而可行,可为临床提供更多有价值的信息。     

双源CT在主动脉瓣置换术前左心功能评价中的应用

目的:以磁共振成像(MRI)为金标准,用双源CT(DSCT)定量评价左心功能,探讨DSCT在主动脉瓣置换术前左心功能评价中的应用价值.方法:选取临床诊断主动脉瓣病变欲行主动脉瓣置换术的患者21例,全部病例均行DSCT和MRI心功能分析检查.由有经验的2位放射科医生独立进行,结果以均数士标准差表示.两种仪器间测量值应用配对样本t检验及相关分析检验,同一仪器测量值的差异相互关系用组内相关系数描述,P ＜0.05为有统计学意义.结果:DSCT和MRI两种方法测量的心功能指标差异无统计学意义,舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、左室射血分数(EF)相关性高,r值(EDV)=0.93,r值(ESV)=0.94,r值(SV)=0.89,r值(EF)=0.85.EDV均值:DSCT＞ MRI;ESV均值:DSCT＞ MRI;SV均值:DSCT＞ MRI; EF均值:DSCT＞ MRI.同一仪器三次测量值的差异相互关系(ICC值):MRI测量的EDV、ESV、SV、EF值的ICC值在0.8～1之间;DSCT测量的EDV、ESV、SV、EF值的ICC值在0.6～0.75之间.结论:DSCT在左心室收缩功能定量评价方面准确、可靠,重复性好,并可在不增加放射剂量的前提下,一次DSCT冠状动脉造影检查同时评估冠状动脉狭窄情况和左心室收缩功能,能够为临床主动脉瓣置换术前评估及制订手术方案提供更多重要的参考信息.     

Factors influencing the variations of ejection fraction during exercise in chronic aortic regurgitation

The influence of left ventricular volume variations and regurgitant fraction variations upon left ventricular ejection fraction during exercise was examined using equilibrium radionuclide angiography in patients suffering from aortic regurgitation. Ejection fraction (EF), regurgitant fraction (RF), end diastolic volume (EDV) and end systolic volume (ESV) variations from rest to peak exercise were determined in 44 patients suffering from chronic aortic regurgitation (AR) and in 8 healthy volunteers (C). In C, EF increased (+0.10 +/- 0.03, P less than 0.01) and ESV decreased significantly (-23% +/- 12%, P less than 0.01), RF and EDV did not vary significantly. In AR patients, EF, EDV and ESV did not vary significantly because of important scattering of individual values. Changes in EF and ESV were inversely correlated (r = -0.79, P less than 0.01) and RF decreased significantly (-0.12 +/- 0.10, P less than 0.01). Volumes and EF changes during exercise occurred in three different ways. In a 1st subgroup of 7 patients, EF increased (+0.09 +/- 0.03, P less than 0.05) in conjunction with a reduction of ESV (-24% +/- 12%, P less than 0.05) without a significant change in EDV. In a 2nd group of 22 patients, EF decreased (-0.04 +/- 0.07, P less than 0.01) in association with an increase in ESV (+17% +/- 16%, P less than 0.01) and no change in EDV. In a 2nd group of 22 patients, EF decreased (-0.04 +/- 0.07, P less than 0.01) in association with an increase in ESV (+17% +/- 16%, P less than 0.01) and no change in EDV. In a 3rd subgroup of 15 patients, EF decreased (-0.02 +/- 0.06, P less than 0.01) despite a reduction in ESV (-7% +/- 6%, P less than 0.01) because of a dramatic EDV decrease (-10% +/- 6%, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)     

Factors influencing the variations of ejection fraction during exercise in chronic aortic regurgitation

The influence of left ventricular volume variations and regurgitant fraction variations upon left ventricular ejection fraction, during exercise was examined using equilibrium radionuclide angiography in patients suffering from aortic regurgitation. Ejection fraction (EF), regurgitant fraction (RF), end diastolic volume (EDV) and end systolic volume (ESV) variations from rest to peak exercise were determined in 44 patients suffering from chronic aortic regurgitation (AR) and in 8 healthy volunteers (C). In C, EF increased (+0.10±0.03, P<0.01) and ESV decreased significantly (-23%±12%, P<0.01) RF and EDV did not vary significantly. In AR patients, EF, EDV and ESV did not vary significantly because of important scattering of individual values. Changes in EF and ESV were inversely correlated (r=-0.79, P<0.01) and RF decreased significantly (-0.12±0.10, P<0.01). Volumes and EF changes during exercise occurred in three different ways. In a 1st subgroup of 7 patients, EF increased (+0.09±0.03, P<0.05) in conjunction with a reduction of ESV (-24%±12%, P<0.05) without a significant change in EDV. In a 2nd group of 22 patients. EF decreased (-0.04±0.07, P<0.01) in association with an increase in ESV (+17%±16%, P<0.01) and no change in EDV. In a 3rd subgroup of 15 patients, EF decreased (-0.02±0.06, P<0.01) despite a reduction in ESV (-7%±6%, P<0.01) because of a dramatic EDV decrease (-10%±6%, P<0.05). In this subgroup, changes in EF were inversely correlated with changes in ESV (r=-0.55, P<0.01) and positively related to EDV variations (r=0.42, P=0.02). EDV related to EDV variations (r=0.42, P=0.02). EDV changes were weakly, but significantly, correlated to RF decrease (r=0.39, P<0.05). We conclude that changes in left ventricular ejection fraction during exercise in patients with chronic aortic regurgitation are significantly related in some patients to changes in ventricular loading conditions as well as contractile state. Therefore, a correct interpretation of EF changes during exercise requires the simultaneous determination of changes in LV volumes.Abbreviations EDV end diastolic volume - EF ejection fraction - ESV end systolic volume - LV left ventricle - RV right ventricle     

彩色多普勒评价射心通胶囊对急性心肌梗死患者左室重构的影响

目的:探讨运用彩色多普勒超声评价射心通胶囊对急性心肌梗死患者左室重构的影响。方法:58例急性心肌梗死患者分为射心通组和培哚普利组,各29例,除常规西医治疗外,射心通组以射心通胶囊治疗3月,培哚普利组以培哚普利治疗3月。治疗前后均运用彩色多普勒测量左室舒张末期内径(LVIDd)、收缩末期内径(LVIDs)、左室舒张末期容积(EDV)、收缩末期容积(ESV)和左室射血分数(EF)并进行比较。结果:两组患者LVIDd、LVIDs、EDV、ESV和EF用药前后均有明显改变(P<0.05),组间疗效比较无统计学差异(P>0.05)。结论:彩色多普勒对射心通胶囊抑制急性心肌梗死后左室重构有较好的评价作用。     

Assessment of left ventricular parameters using 16-MDCT and new software for endocardial and epicardial border delineation

OBJECTIVE: The purpose of our study was to quantify left ventricular function and mass derived from retrospectively ECG-gated 16-MDCT coronary angiography data sets using a new analysis software based on automatic contour detection in comparison to corresponding standard of reference measurements acquired with MRI. SUBJECTS AND METHODS: Multiplanar reformations in the short-axis orientation were calculated from axial contrast-enhanced CT images in 18 patients (men, 15; women, three; age range, 38-70 years; mean, 57.4 +/- 10.2 [SD] years) who were referred for CT coronary angiography. End-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and left ventricular mass (LVM) were analyzed with a recently developed imaging software using an automated contour detection algorithm of left ventricular endo- and epicardial contours and by manual tracing. The data were compared with similar measurements on MRI as the standard of reference. RESULTS: EDV, ESV, EF, and LVM derived from an automated contour detection algorithm were not statistically significantly different from manual tracing (CT(auto) vs CT(manual): EDV = 137.1 +/- 45.7 mL vs 134.2 +/- 39.9 mL, ESV = 58.8 +/- 34.2 mL vs 58.1 +/-30.1 mL, EF = 59.2% +/- 13.7% vs 58.1% +/- 12.0%, LVM = 130.9 +/- 29.1 g vs 133.7 +/- 33.2 g; p > 0.05). However, EDV (118.7 +/- 43.6 mL), ESV (50.1 +/- 33.5 mL), and LVM (142.8 +/-38.4 g) as calculated on MR data sets were statistically significantly different from those calculated on CT (p < 0.05), whereas MRI-based EF (59.9% +/- 14.4%) did not differ statistically significantly from those based on both CT algorithms (p > 0.05). CONCLUSION: Automatic and manual analysis of data acquired during CT coronary angiography using a 16-MDCT scanner allows a reliable assessment of left ventricular ejection fraction and a rough estimation of left ventricular volumes and mass.     

双源CT与超声心动图定量评价冠心病左心功能的比较研究

目的:以超声心动图为对照标准,探讨双源CT定量评价左心功能的可行性和准确性及其优势。方法:选取2011年1月～6月冠心病患者58例,其中合并II型糖尿病患者29例。全部病例于3天内行心脏双源CT及超声心动图检查。比较双源CT与超声心动图所测得的左心功能各参数。结果:双源CT和超声心动图所测左心功能各指标EDV、ESV、SV、EF相关性高(r=0.702～0.898),差异无统计学意义(P>0.05)。两种方法所测冠心病合并II型糖尿病组左心功能指标EDV、ESV值均较非糖尿病组测值高,EF值较低,差异均有统计学意义(P<0.05)。结论:两种方法评价左心功能相关性好,双源CT是一种评价左心功能准确可行的方法,一次冠状动脉造影所获得的数据,不但可评价左心功能,还可评价冠脉狭窄情况,无需额外增加对比剂和辐射剂量。     

MRI心功能参数对陈旧性心肌梗死左心室重塑的评估价值

目的：观察陈旧性心肌梗死后心室形态和心功能参数的变化,探讨MRI测量心功能参数对心室重塑的评估价值。方法：纳入33例陈旧性心肌梗死患者为病变组,12例健康志愿者为对照组。病变组及对照组成员均行MRI检查。MRI测量参数包括：舒张末期客积（EDV）、收缩末期容积（ESV）、每搏输出量（SV）、左心室射血分数（LVEF）、射血率峰值（PER）、充盈率峰值（PFR）。同时测量梗死心肌面积所占的百分比,以24％为分界值,分为无重塑组（≤24％）和重塑组（〉24％）,分析各组间的心功能参数的差异,进行受试者操作特征（ROC）曲线分析,筛选能独立评估心室重塑的心功能指标。结果：病变组的EDV、ESV、SV均高于对照组,病变组的LVEF、PER和PFR低于对照组。ESV随EDV的增加而增加（P〈0．001）,PER、PFR及LVEF均随EDV的增加而下降（P〈0．05）,而SV与各参数均无相关性。PFR、EDV和ESV的ROC分析曲线下面积分别为0．725、0．741、0．764,分界值分别为2．27EDV／sec、140．23ml和79．12ml（P值分别为0．036、0．021和0．032）。结论：MRI可以从收缩和舒张功能的不同角度全面地评估心功能变化。MRI心功能指标对评估心室重塑有重要作用。PFR、EDV、ESV可以作为独立因子评估心室重塑,其中以PFR的评估效能更高。     

Assessment of global left ventricular function: comparison of cardiac multidetector-row computed tomography with angiocardiography

OBJECTIVE: Evaluation of left ventricular function using electrocardiogram (ECG)-gated multidetector row CT (MDCT) by using 3 different volumetric assessment methods in comparison to assessment of the left ventricular function by invasive ventriculography. METHODS: Thirty patients with suspected or known coronary artery disease underwent MDCT coronary angiography with retrospective ECG cardiac gating. Raw data were reconstructed at the end-diastolic and end-systolic periods of the heart cycle. To calculate the volumes of the left ventricle, 3 methods were applied: The 3-dimensional data set (3D), the geometric hemisphere cylinder (HC), and the geometric biplane ellipsoid (BE) methods. End-diastolic volumes (EDV), end-systolic volumes (ESV), the stroke volumes (SV), and ejection fractions (EF) were calculated. The left ventricular volumetric data from the 3 methods were compared with measurements from left ventriculography (LVG). RESULTS: The best results were obtained using the 3D method; EDV (r = 0.73), ESV (r = 0.88), and EF (r = 0.76) correlated well with the LVG data. The EDV volumes did not differ significantly between LVG and the 3D method (P = 0.24); however, ESV, SV, and EF differed significantly. The ESV were significantly overestimated (P < 0.01), leading to an underestimation of the SV (P < 0.01) and the EF (P < 0.01). The HC method resulted in the greatest overestimation of the volumes. The EDV and the ESV were 31.8 +/- 37.6% and 136.4 +/- 92.9% higher than the EDV and ESV volumes obtained by LVG. Bland-Altman analysis showed systematic overestimation of the ESV using the HC method. CONCLUSION: MDCT with retrospective cardiac ECG gating allows the calculation of left ventricular volumes to estimate systolic function. The 3D method had the highest correlation with LVG. However, the overestimation of the ESV is significant, which led to an underestimation of the SV and the EF.