2011年郑州市中老年人糖化血红蛋白水平及与代谢综合征及各种代谢紊乱的相关性

目的 探讨中老年社区居民糖化血红蛋白(hemoglobin A1c, HbA1c)水平与代谢综合征(metabolic syndrome, MS)及各种代谢紊乱的相关性。 方法 2011年7月,对郑州市四个社区8 237名社区居民进行问卷调查、体格检查和实验室检查,按照HbA1c＜5.7%,5.7%～,6.5%～分组后调查MS及各种代谢紊乱的患病率,采用Pearson相关分析探讨HbA1c与MS及各项代谢指标的相关性。 结果 中老年社区居民HbA1c水平较高, MS和各种代谢紊乱随着HbA1c水平的升高而升高,当HbA1c≥6.5%时,MS、中心性肥胖、高甘油三酯(high triglyceride,H-TG)血症、低高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)血症的患病率分别为81.7%、78%、50.8%、58%。HbA1c与HDL-C呈负相关;与腰围、体重指数、舒张压、胆固醇、甘油三酯、低密度脂蛋白胆固醇、糖耐量试验2h血糖呈正相关。 结论 2011年郑州市社区中老年人群HbA1c水平较高,HbA1c≥6.5%时MS和各种代谢紊乱的患病率较高,HbA1c与MS和各种代谢紊乱有较强相关性。     

Relationship between dietary habits and urinary concentrations of 3-phenoxybonzoic acid in a middle-aged and elderly general population in Japan

Objectives  The ingestion of pesticides in the daily diet is assumed to be the main modality of pesticide exposure for most people. A widely used class of pesticides in agricultural or residential settings is pyrethroid. We have examined the relationship between the intake frequency of selected items of vegetables and fruits and urinary metabolites of pyrethroid pesticides in a healthy general population. Methods  A total of 535 residents (184 men and 351 women) who attended a healthcare checkup program conducted in a rural area of Hokkaido, Japan, in August 2005 provided informed consent for their spot urine samples to be used for the determination of 3-phenoxybenzoic acid (3-PBA) levels. They also completed a self-administered questionnaire regarding the intake frequency of 12 food items. The concentrations of creatinine-corrected 3-PBA were predicted by the intake frequency of each item, using analysis-of-covariance models to adjust for age, sex, body mass index, and drinking and smoking status. Results  Both a significant association between the 3-PBA concentration and the frequency of tomato consumption and a significant positive linear trend was found in female subjects. In contrast, no such association was found in the male subjects. Conclusions  The frequency of tomato consumption was confirmed to strongly predict the urinary pyrethroid metabolite levels in the general population—presumably because tomatoes are most often consumed raw and unpeeled (more so than all other vegetables and fruits analyzed in the current study). However, it should be noted that the 3-PBA levels, even among those subjects with the highest consumption of tomatoes, were far below the levels of toxicological significance, although the health consequences from long-term low-level exposure to pyrethroid requires further exploration.     

代谢综合征对中国中老年人日常生活活动能力影响的前瞻性队列研究

目的:探讨我国中老年人代谢综合征（MS）与日常生活活动能力（ADL）受损的关联,为提高人口健康预期寿命提供依据。方法:采用前瞻性队列研究设计,利用2011-2018年中国健康与养老追踪调查数据,以2011年数据为基线,分别在2013、2015和2018年随访ADL结局,且以2013年和2015年新进入队列的人群作为基线...     

2型糖尿病患者高尿酸血症的临床特征及血尿酸与代谢综合征组分数目的关系

目的分析2型糖尿病（T2DM）高尿酸血症的临床及生化特征，并探讨血尿酸（UA）与代谢综合征（MS）组分数目的关系。方法采用横断面研究方法，将547例T2DM患者按UA分为高尿酸血症组和正常尿酸组；按具有代谢综合征组分的数目不同分为4组（MS1，MS2,MS3及MS4），分析临床资料。结果T2DM并高尿酸血症组的体重指数（BMI）、收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）、肌酐（Cr）、甘油三酯（TG）、总胆固醇（TC）、糖化血红蛋白（HbAlc）明显高于正常尿酸组（P〈0．05，P〈0．01），高密度脂蛋白胆固醇（HDL-C）明显低于正常尿酸组（P〈0．05），低密度脂蛋白胆固醇（LDL-C）2组间差异无统计学意义（P〉0．05）；MS1—4组间UA、BMI、SBP、DBP、Cr、TG、TC、LDL—C、HDL-C差别均有统计学意义（P均〈0．05），年龄、FPG差别无统计学意义；UA与性别、TG、HbAlc、HDL-C、Cr有线性回归关系（P〈0．05，P〈0．01），其中与HbAlc、HDL-C负相关，TG对UA影响最大。结论随着代谢综合征组分数目的增加，T2DM患者UA增加，异常TG对UA影响最大，因此UA水平升高是代谢综合征的危险因素。     

Effect of soy product kinako and fish oil on serum lipids and glucose metabolism in women with metabolic syndrome

ObjectivesAt the doses typically used to treat hypertriacylglycerolemia, fish oil may increase low-density lipoprotein (LDL) cholesterol and blood glucose levels. The aim of the present study was to verify whether soy could attenuate the effects of fish oil on blood lipids and carbohydrate metabolism in patients with metabolic syndrome.MethodsSixty-five women (47.9 ± 9.98 y) were studied with the use of a parallel, randomized design. The control group maintained the usual diet; the second group received 29.14 g/d of soy (kinako); the third group received 3 g/d of fish oil n-3 fatty acids; and the fourth group received fish oil (3 g/d) and kinako (29.14 g/d). Assessments were performed at baseline and after 45 and 90 d.ResultsIn relation to baseline values, fish oil increased (P < 0.05) total and LDL cholesterol, glucose, insulin, and homeostasis model assessment of insulin resistance levels after 90 d. Comparisons among groups demonstrated a decrease (P < 0.05) in total cholesterol in the fish oil and kinako group after 90 d as compared with the fish oil group. LDL cholesterol decreased (P < 0.01) in the kinako group as compared with the fish oil group. Blood glucose and homeostasis model assessment of insulin resistance levels decreased after 90 d (P < 0.01 and P < 0.05, respectively) and insulin levels decreased (P < 0.05) after 45 d when the kinako group was compared with the fish oil group.ConclusionsThe present study showed that kinako moderates the adverse effects of high doses of fish oil on LDL cholesterol, total cholesterol, and glucose metabolism levels.     

钢铁工人血常规指标及尿酸水平与代谢综合征发病风险的相关性

目的研究钢铁工人血常规指标和尿酸水平与代谢综合征(MS)的关联。方法采用病例对照研究方法,选取内蒙古某钢铁企业接触噪声和高温危害因素的男性作业人员607人作为接害组,该企业不接触噪声与高温的行政和管理岗位的男性作业人员312人作为对照组。采集两组血标本,检测血常规和尿酸水平,分析接害组与对照组血常规指标[白细胞计数(WBC)、红细胞计数(RBC)、血小板计数(PLT)、红细胞分布宽度(RDW)及血红蛋白含量(Hb)]和尿酸水平(UA)与MS的相关性。结果接害组和对照组间吸烟、饮酒、腰围(WC)、收缩压(SBP)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、WBC、RBC、PLT、Hb、RDW、体质量指数(BMI)及UA方面比较差异均有统计学意义(均P<0.05)。接害组MS总体患病率为39.04%,高于对照组的23.08%,差异有统计学意义(P<0.05)。两组MS患者和非MS患者WBC、RBC、PLT、RDW及UA比较差异均有统计学意义(均P<0.05)0多因素logistic回归分析发现WBC、RBC、RDW、PLT及UA是接害组MS的危险因素(均P<0.05)。结论钢铁工人MS患病率较高,红细胞计数增高、红细胞分布宽度增大及血小板计数升高是MS发生的危险因素。     

IGF-1基因启动子区CA重复序列多态性与代谢综合征关系研究

目的 探讨胰岛素样生长因子1（IGF-1）基因启动子区CA重复序列多态性与代谢综合征（MS）的关系.方法 收集北京市东城区常住人口1047例,采用2005年国际糖尿病联盟标准诊断代谢综合征.将受试者的基因组DNA应用聚合酶链反应扩增,再通过选择不同长度的纯合子样本测序确定CA重复的次数,以确定等位基因.同时测量身高、体重、腰围、血糖、血脂、胰岛素及血IGF-1.结果 （CA）19纯合组MS患病率显著低于不携带（CA）19组（9.1% vs 24.0%,Х^2=18.05,P＜0.01）及（CA）19杂合组（9.1% vs 18.3%,Х^2=8.55,P＜0.01）;三组间血IGF-1水平差异有统计学意义[（114.0±52.6）μg/L vs（136.6±80.5）μg/L vs（129.2±49.1）μg/L,F=3.16,P＜0.05],（CA）19纯合组血IGF-1水平低于不携带（CA）19组及（CA）19杂合组.三组间体重指数（BMI）、腰围（WC）、甘油三酯（TG）、空腹胰岛素（Fins）、2hIns及胰岛素敏感性指数（ISI）差异均有统计学意义（P＜0.05）,（CA）19纯合组的BMI、WC、TG、FIns、2hIns均低于另两组,而ISI高于另两组.结论 IGF-1基因启动子区CA重复序列多态性与汉族人群MS发病有关.     

阻塞性睡眠呼吸暂停低通气综合征患者卵泡抑素样蛋白1测定及临床意义

目的 研究卵泡抑素样蛋白1(FSTL1)在不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清中的变化及其意义。方法 随机抽样选取本院2019年2月—2020年5月70例OSAHS 患者,分为轻度24例、中度26例、重度20例,同时选取22名健康体检者为对照组。采用酶联免疫吸测定(ELISA)患者血清FSTL1的水平,分析其与病情轻重的相关性。采用SPSS 16.0软件对结果进行统计分析。结果 轻、中、重度OSAHS 患者血清FSTL1分别(122.6±26.5)ng/mL、(182.1±39.5)ng/mL、(249.8±52.3)ng/mL,均高于对照组的(95.3±5.2)ng/mL (P<0.05),且随病情的加重逐渐升高, 不同程度OSAHS患者血清FSTL1水平的差异有统计学意义(P<0.05)。并且,患者血清FSTL1水平与其呼吸暂停低通气指数(AHI)呈正相关(r=0.526,P<0.001),与夜间最低血氧饱和度(LSaO2)呈负相关(r=-0.687,P<0.001)。结论 FSTL1在OSAHS患者血清中显著升高,并与疾病严重程度呈正相关,提示它们与OSAHS的发生和发展密切相关,可反映病情的严重程度。     

Association between serum levels of vascular endothelial growth factor,macrophage inhibitory cytokine and markers of oxidative stress,with the metabolic syndrome and its components in obese individuals

Aim

Metabolic syndrome (MetS) is a clinical disorder with widespread prevalence. In the current study, we aimed to investigate the serum values of macrophage inhibitory cytokine (MIC)-1, vascular endothelial growth factor (VEGF) and markers of oxidative stress among patients with metabolic syndrome.

Association of homocysteinemia with high concentrations of serum insulin and uric acid in Brazilian subjects with metabolic syndrome genotyped for C677T polymorphism in the methylenetetrahydrofolate reductase gene

Information on plasma homocysteine concentrations and their associated factors in Brazilian subjects with metabolic syndrome (MS) is nonexistent. Therefore, a cross-sectional study was conducted to investigate the association of homocysteinemia with MS components; folate and cobalamin biochemical and dietary indices of nutritional status; and genetic, anthropometric, and lifestyle factors in Brazilian subjects with MS. Waist circumference; body fat; body mass index; insulin resistance; lipid profiles; glycemia; uricemia; insulinemia; erythrocyte folate and plasma homocysteine; folate and cobalamin concentrations; C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene; coffee and alcohol intake; and smoking were determined in 63 subjects (24 males and 39 females) with MS. No difference in homocysteine plasma was observed between sexes. Hyperhomocysteinemia (Hhcy) frequency was 49.2% (n = 31) in the group studied. The distribution of MTHFR genotypes was as follows: CC, 64% (n = 42); CT, 32% (n = 19); and TT, 4% (n = 2). No association was found between Hhcy and C677T polymorphism in the MTHFR gene. Plasma homocysteine concentrations showed no association with age; blood pressure; dietary intakes of folate, cobalamin, and pyridoxine; body mass index; waist circumference; body fat; glycemia; lipid profile; insulin resistance; and concentrations of folate erythrocyte and plasma folate and cobalamin. Also, there was no correlation between Hhcy, sex, and lifestyle factors. In this study, the variables uricemia (C = 0.67, χ² = 2.23, P = .27) and insulinemia (C = 0.86, χ² = 2.98, P = .07) were positively associated with homocysteinemia. In conclusion, our results suggest that high concentrations of serum insulin and uric acid are associated with an increased risk of developing Hhcy in subjects with MS.     

Urinary phthalate metabolites and metabolic syndrome in U.S. adolescents: Cross-sectional results from the National Health and Nutrition Examination Survey (2003–2014) data

Objective

There is limited research on the association between phthalates and metabolic syndrome (MetS). Among adolescents, phthalate exposure, which can occur from multiple sources, has been linked to several risk factors for MetS. The objective was to investigate the association between urinary phthalate metabolite concentrations (i.e., mono-ethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), mono-benzyl phthalate (MBzP), mono-(3-carboxylpropyl) phthalate (MCPP), and di(2-ethylhexyl phthalate (DEHP)) and MetS in adolescents aged 12–19 years using the National Health and Nutrition Examination Survey (NHANES) data (2003–2014). A secondary aim was to assess if observed associations varied by a measure of socioeconomic status, economic adversity, which was defined using parental income and educational attainment as well as household food security.