雅皓丁硼乳膏治疗固定矫治中的牙龈炎的疗效观察

目的 :探讨雅皓丁硼乳膏对固定矫治中的牙龈炎的治疗效果。方法 :将 4 8例 (12 2 0岁 )临床正畸患者随机分成实验组 (使用雅皓丁硼乳膏刷牙 )和对照组 (使用普通牙膏刷牙 ) ,分别记录治疗前、治疗后 2周、治疗后 4周的牙周指数 (牙龈指数、菌斑指数、简易牙石指数 ) ,并进行相互比较。结果 :使用雅皓丁硼乳膏受试者的牙龈指数、菌斑指数治疗后 2周、4周分别降低 2 6 .7%、2 8.6 %和37%、36 .5 % ,而简易牙石指数变化不显著。对照组无明显变化。与对照组相比 ,雅皓丁硼乳膏受试者的牙龈指数、菌斑指数治疗后 2周、4周均有显著降低 ,结论 :雅皓丁硼乳膏治疗固定矫治中的牙龈炎有显著疗效。     

雅皓丁硼乳膏治疗固定矫治中牙龈炎的疗效观察

目的：探讨雅皓丁硼乳膏对固定矫治中牙龈炎的治疗效果。方法：将48例(12—20岁)临床固定矫治患者随机分成实验组(使用雅皓丁硼乳膏刷牙)和对照组(使用普通牙膏刷牙)，分别记录治疗前、治疗后2周、4周的牙周指数(牙龈指数、菌斑指数、简易牙石指数)，并进行相互比较。结果：使用雅皓丁硼乳膏受试者的牙龈指数、菌斑指数治疗后2周、4周分别降低26．7％、28．6％和37％、36．5％，而简易牙石指数变化不显著。对照组无明显变化。与对照组相比，雅皓丁硼乳膏受试者的牙龈指数、菌斑指数治疗后2周、4周均有显著降低。结论：雅皓丁硼乳膏治疗固定矫治中的牙龈炎有显著疗效。     

雅皓乳膏治疗人工冠和固定义齿引起的牙龈炎疗效观察

目的 :评价雅皓丁硼乳膏治疗人工冠和固定义齿引起的牙龈炎的疗效。方法 :将 5 6例由人工冠和固定义齿引起的牙龈炎患者随机分成实验组 (雅皓丁硼乳膏刷牙 )和对照组 (普通牙膏刷牙 ) ,分别记录治疗前和治疗后 4周的牙周指数 (牙龈指数、菌斑指数、龈沟出血指数 ) ,并进行统计分析。结果 :牙龈指数、菌斑指数、龈沟出血指数治疗 2周后分别降低 2 6.6% ,40 .2 % ;2 6.7% ,4周后分别降低 41.4% ;2 0 .3 % ,3 0 .7%。对照组无明显变化。实验组与对照组相比有显著性差异。结论 :雅皓丁硼乳膏治疗人工冠和固定义齿引起的牙龈炎有显著疗效。     

定期牙周洁治对固定正畸治疗中牙周健康的影响

目的:观察洁治和使用雅皓乳膏对正畸患者牙周健康状况的影响。方法:选择全身及牙周健康因错牙合畸形需固定矫治的患者48例(男28例,女20例),随机分为对照组和治疗组(洁治及用雅皓乳膏刷牙)2组。治疗组用雅皓乳膏(主要成分是丁香酚和硼砂)每天早晚各刷牙1次,每次不少于3m in。对照组用普通市售牙膏。于治疗前和治疗后3个月检测牙龈指数(GI)、菌斑指数(PLI)和龈沟出血指数(SBI),比较检测指标在治疗前后的变化,数据以t检验和χ2检验进行统计学处理。结果:治疗前2组间无显著差异(P>0.5),而治疗后存在显著性差异(P<0.01),表明洁治和用雅皓乳膏刷牙在固定矫治过程中能有效降低牙龈炎的发生率。结论:治疗组患者在矫治过程中牙周指数升幅和牙龈炎发生率明显低于对照组,说明牙周洁治和用雅皓乳膏刷牙能降低固定矫治治疗导致的牙周组织的不良反应。     

雅皓乳膏对正畸治疗引起牙龈炎症的缓解作用

目的 :观察雅皓乳膏能否对正畸治疗中出现的牙龈炎症起到控制和缓解作用。方法 :(1)选择在我科进行正畸治疗的健康状况的患者 2 8名 ,随机分为两组 ,要求牙龈有不同程度的炎症表现 ,6个月内未服用过任何药物也未接受过牙周治疗。其中实验组使用雅皓乳膏 ,对照组使用同一种普通市售牙膏进行刷牙。两组均观察两周 ,两周内禁服任何药物且不进行正畸加力。 (2 )选取牙位上颌 5 5及下颌 5 5 ,对两组患者分别于实验前后测定牙龈指数 (GI)和菌斑指数 (PⅡ )。结果 :统计学分析表明 (1)在实验后 ,经用雅皓乳膏刷牙的实验组GI和PⅡ都明显减小 ,差异有显著性 (P <0 .0 1)。 (2 )应用雅皓乳膏刷牙组实验前后GI和PⅡ的变化明显大于对照组 ,差异有显著性 (P <0 .0 1)。结论 :本实验应用的雅皓乳膏其主要成分是丁香酚和硼砂。酚类药物对各种细菌都有不同程度的抑制或杀灭作用 ,因此在使用两周后 ,各项牙周临床指标都明显下降 ,牙龈的炎症状况得到有效的缓解。说明在正畸期间让患者坚持使用对牙周有治疗性作用的牙膏的确能对牙周炎症起到缓解作用。     

局部涂抹雅皓乳膏对重症龈炎的临床疗效

目的:探讨雅皓乳膏对重症龈炎的疗效.方法:选择临床诊断为重度菌斑相关性牙龈炎的患者10例,随机分为实验组和对照组,每组30个牙.采取直接将乳膏涂抹患处的方法,2次/d,受试者治疗全程统一使用不含任何抗菌斑药物成分的爽箭牙膏和欧乐-B牙刷刷牙,在实验的第1、3、5天对龈炎指数、龈沟出血指数、菌斑指数进行检查,同时在第1、5天取患牙龈缘菌斑样本,进行微生物学观察.结果:实验组的临床指标明显改善,且与对照组相比有显著的统计学差异(P＜0.001),实验组的疗效优于阴性对照组.刚果红涂片染色显示实验组球菌数量增加,螺旋体、弯曲菌和杆菌数量下降,菌斑中细菌组成趋于正常,表明雅皓乳膏对牙周致病菌有抑制作用.结论:雅皓乳膏局部涂抹并配合刷牙等机械口腔清洁措施对于重症龈炎有一定的疗效.     

雅皓乳膏对菌斑相关性牙龈炎的临床疗效评价

目的 :评价雅皓乳膏对菌斑相关性牙龈炎的临床疗效。方法 :选择临床诊断为菌斑相关性牙龈炎患者 90例 ,随机分为实验组、阳性对照组 (全效高露洁 )和阴性对照组 (爽箭牙膏 ) 3组 ,每组 30例。分别在实验前和实验后的第 4、8、12周对牙龈指数、龈沟出血指数和菌斑指数进行检查 ,同时测量患者口气中挥发性硫化物的含量。结果 :实验组和阳性对照组随着疗程的进行临床指标明显改善 ,挥发性硫化物 (VSCs)的含量明显减少 ,两组间差别无统计学意义 (P >0 .0 5 ) ,而实验组和阴性对照组间的临床指标、VSCs含量差别在统计学上均有显著性意义 (P <0 .0 0 1)。结论 :雅皓乳膏作为牙周病常规治疗后的维护期口腔保洁用品对于维持疗效 ,减轻口臭 ,有一定的临床意义。     

百蕊牙周康药物牙膏治疗牙龈炎临床效果观察

目的 观察百蕊牙周康药物牙膏治疗牙龈炎的临床效果。方法 随机选择６０名单纯性牙龈炎病人,分成实验组和对照组。观察用药前后临床症状和菌斑指数、牙龈指数、龈沟出血指数的变化。结果 两组用药前牙周各项指数的平均值无明显差异（Ｐ〉０．０５）,用药１０天后有显著性差异（Ｐ〈０．０１）。结论 百蕊牙周康药物牙膏对牙龈炎症有一定的疗效。     

二氧化氯含漱液治疗牙龈炎、控制牙菌斑的临床效果

目的：评价二氧化氯含漱液治疗牙龈炎、控制牙菌斑的临床效果。方法：采用双盲对照方法，选择100名患有牙龈炎的17～20岁的健康男女学生作为研究对象，随机分成两组，每组50人，男女均等。实验组给以口腔爽（有效成份是二氧化氯）含漱液，对照组给以口泰含漱液，观察使用含漱液7d后两组受试者前后的牙龈指数和菌斑指数的变化，依此来评价口腔爽的临床效果。结果：使用口腔爽含漱液受试者的平均牙龈指数和菌斑指数分别减少0.66和0.91，均有统计学显著性意义（P〈0.001）；与对照组（0.64、1.06）相比，差异无显著性（P〉0.5）。结论：二氧化氯含漱液对治疗牙龈炎、控制牙菌斑有明显效果，与口泰相比无显著差异，临床上未发现任何副作用。     

正畸牙龈炎患者龈沟液中牙龈卟啉单胞菌及致病岛rag基因的研究

目的探讨正畸过程中牙龈卟啉单胞菌及致病岛rag基因与牙龈炎症程度的相关关系,分析其在正畸牙龈炎发生发展中的作用。方法收集102例来自济南市口腔医院正畸科和口腔内科患者组成正畸牙龈炎组（57例）、对照组（20例）、牙周炎组（25例）,并记录其各临床指标,分别采集牙周袋最深处或龈沟液标本,采用16SrDNAPCR和多重PCR对牙龈卟啉单胞菌及致病岛rag基因进行检测,分析其与临床指标的关系。结果102例患者临床标本,共扩增出牙龈卟啉单胞菌65株,其中正畸牙龈炎组35株;对照组7株;牙周炎组23株,经Spearman等级相关分析,牙龈卟啉单胞菌检出率与牙龈指数之间存在明显的正相关关系（P〈0．01）。正畸牙龈炎组检出率明显高于对照组,牙周炎组高于正畸牙龈炎组和对照组,三者之间有显著性差异（X2=15．918,P〈0．001）,65例牙龈卟啉单胞菌阳性患者临床标本,扩增出rag基因的有52例,其中正畸牙龈炎组29例;对照组1例;牙周炎组22例,正畸牙龈炎组明显高于对照组,牙周炎组高于正畸牙龈炎组和对照组,三者之间有显著性差异（X2=22．593,P〈0．001）。结论牙龈卟啉单胞菌致病岛rag基因与正畸治疗中牙龈炎性反应密切相关。     

双黄连牙膏对牙菌斑、牙龈炎的控制效果

目的评价含有双黄连成分的牙膏在控制菌斑及牙龈炎症方面的效果。方法选取符合纳入标准的25名牙龈炎患者,随机分为2组。采用双盲法实验,一组使用含双黄连成分牙膏,另一组使用不含双黄连其它成分相同的牙膏。记录使用牙膏前及使用牙膏1、4、12周菌斑指数、牙龈指数、探诊出血情况,比较2组数据,评价含有双黄连成分的牙膏在控制菌斑及牙龈炎症方面的效果。结果双黄连组与对照组菌斑指数、牙龈指数、探诊出血均有改善,双黄连组疗效持续时间更长久。结论使用含双黄连成分牙膏可更好、更持久的消除菌斑,减少菌斑再附着,减轻牙龈炎症。     

中药含漱液治疗固定矫治患者牙龈炎的临床研究

目的：：研究中药含漱液用于治疗固定矫治患者牙龈炎的临床疗效。方法：采用随机分组的方法将入选的60例固定矫治的牙龈炎患者分为氯己定含漱液组(氯己定组)和中药含漱液组(中药组),每组各30例。使用常规方法检测每个患者的牙龈指数( GI)和龈沟出血指数( SBI),随后给予每个患者洁治和刮治等牙周的基础治疗,嘱患者于刷牙后使用相应的含漱液,3次/d,用药7 d后及14 d后复诊,分别检测GI和SBI,进行统计学分析。结果：治疗7 d后2组GI和SBI各自与治疗前相比均有明显改善(P<0.05),组间比较无统计学差异(P>0.05)。用药14 d后中药组GI、SBI下降程度均高于氯己定组(P<0.05)。结论：该中药含漱液用于固定矫治时期的牙龈炎患者,疗效确切。     

The plaque and gingivitis reducing effect of a chlorhexidine and aluminium lactate containing dentifrice (Lacalut aktiv) over a period of 6 months

AIM: The aim of the study was to determine the plaque and gingivitis reducing effect of a dentifrice containing chlorhexidine and aluminium lactate compared with a control toothpaste during the course of 6 months. MATERIAL AND METHODS: This randomized, double-blind study looked prospectively at participants over a 6-month period. Plaque, gingivitis, calculus formation and tooth staining were assessed in 59 participants, who were divided into parallel groups. The participants used either a chlorhexidine and aluminium lactate-containing toothpaste (test group) or a minus active control toothpaste (control group). Parameters were assessed at baseline and again after 1, 3 and 6 months. RESULTS: After 6 months of product use, both groups had less gingivitis compared with the baseline evaluation (p<0.001). At this time point, the test group showed a statistically significant lower gingival index values compared with the control group (p=0.001). No statistically significant differences between either the groups or time points were detected with regard to plaque index and the development of calculus and staining. CONCLUSION: Although there was a statistically significant difference at 6 months between test and control groups, this difference was too small to be considered clinically meaningful.     

Modulation of clinical expression of plaque-induced gingivitis. III. Response of "high responders" and "low responders" to therapy

AIM: The aim of the present study was to characterize the subject-based clinical behavior of the gingiva in response to a tooth-cleaning regimen in two subpopulations, "high-responder" (HR) and "low-responder" (LR) groups, presenting a different inflammatory response to plaque accumulation. MATERIAL AND METHODS: The study population comprised of 96 systemically and periodontally healthy subjects, 46 males and 50 females, non-smokers, enrolled in an experimental gingivitis trial. At completion of the experimental gingivitis period (day 21), all subjects were prescribed the same 21-day treatment regimen of amine/stannous fluoride (AmF/SnF(2))-containing toothpaste and mouthrinse. Plaque index (PlI), gingival index (GI), gingival crevicular fluid volume (GCF), and angulated bleeding score (AngBS) were recorded on three selected teeth. Treatment efficacy was evaluated in the overall population as well as in HR and LR groups, separately. RESULTS: A statistically significant decrease of PlI was observed after treatment (p<0.001), with PlI reversing to baseline levels. Changes in PlI revealed the same trend in both HR and LR groups, without differences between groups. Treatment also resulted in a significant decrease of all gingivitis parameters (p<0.001 for all comparisons). After treatment, GI, AngBS, and GCF were comparable with baseline condition. However, when the two groups were compared, day 42-GCF was significantly higher in the HR group than the LR group. CONCLUSIONS: A treatment regimen based on mechanical plaque control supplemented with AmF/SnF(2)-containing toothpaste and mouthrinse is effective in reducing plaque accumulation and re-establishing healthy gingival conditions after experimentally induced gingivitis, even in subjects with different inflammatory response to plaque accumulation.     

Effect of amine fluoride-stannous fluoride containing toothpaste (Meridol) on plaque and gingivitis in adults: a six-month clinical study

Treatments that aim to reduce the accumulation of bacteria on dental surfaces are considered today as the most efficient way of treating gingivitis and the resultant destruction of periodontal tissues. Mechanical plaque removal was found to be very effective in the control of gingival inflammation for most patients, but the supplement of toothpastes and mouthwashes with anti-plaque properties may benefit individuals with unperfected plaque control. The aim of the present study was to investigate the long-term effect of amine fluoride/stannous fluoride (AmF/SnF2) toothpaste on plaque levels and gingivitis in adults, as an additional measure to standard oral hygiene. One hundred and three adult subjects with gingivitis were divided into two randomised groups. One group used NaF toothpaste (control) and the second group AmF/SnF2 (Meridol) toothpaste. The subjects were examined every two months under double-blind conditions. The recorded parameters were plaque index (PlI), gingival index (GI) and bleeding on probing. The differences in PlI between baseline and the end of the study were statistically significant for both treatments, and no significant differences were found between the two treatment groups. There was a significant drop in GI between baseline and the concluding examination only for the AmF/SnF2 group, but the differences between the two treatment groups were not significant. A significant reduction in the percentage of bleeding sites during the six-month study period was found in the AmF/SnF2 group, but not in the control group. The results of the present study suggest that the long-term use of AmF/SnF2 toothpaste in adults may be of benefit to gingival health.     

中药大黄对正畸固定矫治中龈炎的治疗研究

目的:评价中药大黄对正畸固定矫治中龈炎治疗的临床疗效。方法:选择牙周健康者20例(尚未矫治)和矫治6个月临床诊断为牙龈炎的患者60例为研究对象,牙周健康患者20例设为牙周健康组,60例牙龈炎患者随机分为3组:大黄组、明胶海绵组和对照组。分别于治疗前采集4组研究对象的牙周临床指数和龈沟液标本,使用ELISA法测量龈沟液中白介素-1β的含量,比较组间各项指标间的差异。对牙龈炎3组患者,其中大黄组用大黄明胶海绵药条,明胶海绵组用灭菌蒸馏水明胶海绵条,分别置于龈袋内,每周上药1次,共4次,对照组患者龈袋内不放任何药物。于4周后重新采样比较牙周治疗前后上述指标间的差异。结果:牙龈炎组治疗前牙周临床指数、龈沟液IL -1β浓度均显著高于牙周健康组(P＜0.05),大黄组、明胶海绵组与对照组比较无显著性差异。治疗后明胶海绵组上述指标与对照组比较无显著性差异,且明显高于牙周健康组(P＜0.05)。治疗后明胶海绵组和对照组分别与治疗前比较均无显著性差异。治疗后大黄组上述指标相比治疗前及对照组均明显降低(P＜0.05),与牙周健康组比较,龈沟出血指数(SBI)接近正常。结论:中药大黄对正畸固定矫治中龈炎具有明显的治疗效果。     

Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial

Background: Certain plants used in folk medicine serve as a source of therapeutic agents that have antimicrobial and other multipotential effects. This prospective, randomized, placebo, and positively controlled clinical trial was designed to evaluate the clinical and microbiologic effects of a commercially available dentifrice containing aloe vera on the reduction of plaque and gingival inflammation in patients with gingivitis. Methods: Ninety patients diagnosed with chronic generalized gingivitis were selected and randomly divided into three groups: group 1, placebo toothpaste; group 2, toothpaste containing aloe vera; and group 3, toothpaste with polymer and fluoride containing triclosan. Clinical evaluation was undertaken using a gingival index, plaque was assessed using a modification of the Quigley‐Hein index, and microbiologic counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by questionnaire. Results: Toothpaste containing aloe vera showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to those achieved with toothpaste containing triclosan. Conclusion: Toothpaste containing aloe vera may be a useful herbal formulation for chemical plaque control agents and improvement in plaque and gingival status.     

A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and initial caries lesion development in orthodontic patients

The aim of this study was to examine the effect of combined use of a toothpaste/mouthrinse containing amine fluoride/stannous fluoride (AmF/SnF2; meridol) on the development of white spot lesions, plaque, and gingivitis on maxillary anterior teeth in orthodontic patients. A prospective, randomized, double-blind study with 115 orthodontic patients (42 males and 73 females, average age 14.4 years, drop outs 18) was designed. Group A (50) brushed twice daily with an AmF/SnF2 toothpaste (1400 ppm F) and rinsed every evening with an AmF/SnF2 solution (250 ppm F). Group B (47) brushed twice daily with a sodium fluoride (NaF) toothpaste (1400 ppm F) and rinsed every evening with a NaF solution (250 ppm F). Visible plaque index (VPI), gingival bleeding index (GBI) and white spot lesion index (WSL) were recorded on the six maxillary anterior teeth at bonding and after debonding, and evaluated with t tests. In group A no significant differences between bonding and debonding were recorded for WSL (1.02 +/- 0.08 versus 1.05 +/- 0.13, P = 0.14), VPI (0.10 +/- 0.21 versus 0.12 +/- 0.21, P = 0.66) or GBI (0.13 +/- 0.21 versus 0.16 +/- 0.22, P = 0.47), whereas statistically significant differences were found in group B between bonding and debonding for WSL (1.00 +/- 0.02 versus 1.08 +/- 0.17, P = 0.01), VPI (0.06 +/- 0.13 versus 0.17 +/- 0.25, P = 0.01) and GBI (0.06 +/- 0.12 versus 0.16 +/- 0.21, P = 0.01). The increase in lesions on the upper anterior teeth was 4.3 per cent in group A and 7.2 per cent in group B. It was concluded that the combined use of an AmF/SnF2 toothpaste/mouthrinse had a slightly more inhibitory effect on white spot lesion development, plaque and gingivitis on maxillary anterior teeth during fixed orthodontic treatment compared with NaF.