血塞通颗粒联合阿达帕林凝胶治疗痤疮临床观察

目的观察口服血塞通颗粒联合外用阿达帕林凝胶治疗痤疮的临床疗效及安全性。方法随机将81例痤疮患者分为两组,治疗组42例,予口服血塞通颗粒联合外用阿达帕林凝胶;对照组39例,仅予外用阿达帕林凝胶。疗程6周,分别于2周、4周、6周记录皮损评分及不良反应。结果 6周的疗程后,治疗组和对照组的有效率分别为80.95%和51.28%,两组痤疮患者治疗2周、4周、6周时有效率差异均有统计学意义(χ~2=4.58,χ~2=7.10和χ~2=8.01,P 0.05)。所有患者均未发生明显不良反应。结论口服血塞通颗粒联合阿达帕林凝胶外用治疗痤疮患者的临床疗效好,不良反应小,值得临床医生选择。     

复方倍他米松穴位注射联合口服阿维A及抗结核药物治疗皮肤结核8例

目的探讨复方倍他米松穴位注射联合口服阿维A及抗结核药物治疗皮肤结核的疗效。方法运用复方倍他米松穴位注射联合口服阿维A及抗结核药物治疗8例皮肤结核。结果4例患者4周皮损基本消退;3例患者6~8周皮损基本消退,仅1例患者11周皮损基本消退。结论复方倍他米松穴位注射联合口服阿维A及抗结核药物是治疗皮肤结核的一种有效的方法。     

毛发红糠疹28例临床分析

目的:分析毛发红糠疹的临床特点和疗效。方法:回顾性分析28例毛发红糠疹患者的临床症状和治疗。结果:28例毛发红糠疹皮损表现为毛囊角化性丘疹和掌跖角皮症。给予阿维A 10mg每日2次口服,配合甘草酸二胺150 mg静滴及0.1%维A酸乳膏外用治疗2周后,皮损好转,4周后皮损明显消退。结论:毛发红糠疹临床表现及组织病理学检查有特征性改变。阿维A治疗有效。     

阿维A联合他扎罗汀治疗斑块状银屑病疗效观察

目的评价阿维A胶囊联合他扎罗汀凝胶治疗斑块状银屑病的临床疗效。方法172例患者随机分为治疗组及对照组,治疗组采用阿维A和维生素E口服,外用他扎罗汀凝胶;对照组采用迪银片和维生素E口服,外用蒽林霜。结果两组有效率分别为72.09%和31.40%,治疗组皮损改善优于对照组(P<0.01)。结论阿维A与他扎罗汀联合治疗斑块状银屑病有显著的疗效。     

普济消毒饮加减联合外用阿达帕林凝胶治疗寻常型痤疮疗效观察

目的观察普济消毒饮加味联合外用阿达帕林凝胶治疗寻常痤疮的临床疗效。方法将60例患者随机分成观察组和对照组,观察组采用口服中药普济消毒饮加减,睡前外用阿达帕林凝胶;对照组仅睡前外用阿达帕林凝胶,观察临床疗效及不良反应。结果中药普济消毒饮加减联合外用阿达帕林凝胶治疗寻常痤疮,治疗8周有效率70.00%,明显优于对照组(对照组40.00%);治疗12周,观察组有效率83.33%,与对照组(有效率60.00%)相比,差异有统计学意义(P0.05)。结论中药普济消毒饮加减联合外用阿达帕林凝胶治疗寻常痤疮疗效显著。     

阿维A酯治疗胶样婴儿2例报告

2例胶样婴儿采用口服阿维A酯犤1mg/(kg.d)犦治疗,患儿连续服药3～4周后全身皮损大部分消退,近期随访皮损未再复发。     

复方多粘菌素B软膏联合阿达帕林凝胶治疗中度痤疮疗效观察

目的观察复方多粘菌素B软膏联合阿达帕林凝胶治疗寻常型痤疮的疗效和安全性。方法将101例中度痤疮患者随机分为两组,治疗组55例采用复方多粘菌素B软膏联合阿达帕林凝胶治疗,阿达帕林凝胶每晚1次,复方多粘菌素B软膏2次/d,疗程为4周;对照组46例,每晚1次外用阿达帕林凝胶,莫匹罗星乳膏2次/d,连续4周为一个疗程。结果治疗组和对照组有效率分别为83.6%和65.2%,有效率存在明显差异(P0.05)。治疗组不良反应明显少于对照组。结论复方多粘菌素B软膏联合阿达帕林凝胶治疗寻常型痤疮可明显提高疗效,减少不良反应,值得临床推广。     

夫西地酸乳膏联合阿达帕林凝胶治疗寻常痤疮的临床观察

目的评价2%夫西地酸软膏联合0.1%阿达帕林凝胶治疗轻、中度寻常痤疮的临床疗效及安全性。方法寻常痤疮246例,随机分为3组,治疗组98例,采用2%夫西地酸软膏联合0.1%阿达帕林凝胶治疗;对照A组81例,采用1%克林霉素磷酸酯凝胶联合0.1%阿达帕林治疗;对照B组67例,单独使用0.1%阿达帕林凝胶治疗。均连用8周,分别在治疗后第2,4,8周末观察疗效并评价安全性。结果在治疗后第8周,治疗组有效率93.88%,与对照A组(81.48%)相比差异有统计学意义(P=0.010);治疗组Ⅲ级痤疮的有效率93.02%,与对照A组(69.70%)相比差异有统计学意义(P=0.007);疗程结束后,治疗组复发5例,复发率5.10%,远低于2个对照组。单独外用阿达帕林疗效均欠佳,且复发率较高。在治疗过程中,3组均未见明显不良反应。结论 2%夫西地酸软膏联合0.1%阿达帕林凝胶治疗轻、中度寻常痤疮具有疗效较好、复发率低、不良反应少等优点,是较理想的治疗方案。     

疣状汗孔角化症1例

报告1例疣状汗孔角化症。患者男，53岁。25岁始双下肢出现黄豆大丘疹并逐渐增多、增大、波及全身。臀部和双下肢皮损呈高度疣状增殖性斑块。临床症状和皮损组织病理学改变符合疣状汗孔角化症。给予角质剥脱剂外用及阿维A口服治疗2周后，疣状皮损全部消退。     

自制复方烟酰胺沙星软膏联合阿达帕林凝胶治疗寻常痤疮的疗效观察

目的:观察自制复方烟酰胺沙星软膏联合0.1%阿达帕林凝胶治疗寻常痤疮的临床疗效。方法:将按入选标准入选的90例寻常痤疮患者随机分为2组,每组45例。治疗组每天早晨、中午各点涂复方烟酰胺沙星软膏1次,晚上薄涂0.1%阿达帕林凝胶1次;对照组每晚薄涂0.1%阿达帕林凝胶1次,疗程均为8周,治疗结束后观察疗效并进行比较。结果:治疗8周疗程结束时治疗组有效率为91.1%,明显高于对照组(71.1%),差异有统计学意义(2=4.66,P0.05)。结论:自制复方烟酰胺沙星软膏联合0.1%阿达帕林凝胶治疗Ⅰ~Ⅱ级轻中度寻常痤疮,可协同作用于炎症性和非炎症性皮损,疗效显著。     

A case of early onset confluent and reticulated papillomatosis with an unusual localization

Confluent and reticulated papillomatosis is a relatively rare dermatosis of unknown origin. It is characterized by papules that become confluent in the center and reticulated at the periphery. The sites of predilection are the neck, interscapular region, inframammary area and abdomen. In a 15-year-old girl diagnosed with confluent and reticulated papillomatosis, the lesions first appeared on her knees and elbows when she was 4-years-old, and on the interscapular area when she was 13. Similar lesions arose on the left hand a few weeks previous to her visit. Two biopsy specimens were taken from the interscapular and elbow areas. The histopathological findings of this case fit the diagnosis of confluent and reticulated papillomatosis. We expect good results from azithromycin therapy.     

Treatment of confluent and reticulated papillomatosis with azithromycin

Confluent and reticulated papillomatosis (CRP) is a relatively rare disorder of unknown origin, mostly affecting young female adults. We here present the case of a 21-year-old male patient with confluent and reticulated papillomatosis. Skin examination revealed brownish, verrucous, hyperkeratotic, 2 to 5 mm papules, which formed confluent patches and plaques with a reticulate network on the interscapular area. The patient was initially treated with ketoconazole cream for two weeks without improvement. The disease can be rather persistent and resistant to topical therapy. Our case showed a satisfactory response to treatment with azithromycin. Although this treatment is known to be effective in some cases, the action mechanism of azithromycin on CRP is not fully understood.     

Multicenter randomized controlled trial on combination therapy with 0.1% adapalene gel and oral antibiotics for acne vulgaris: comparison of the efficacy of adapalene gel alone and in combination with oral faropenem

We conducted a randomized controlled trial in patients with acne vulgaris with moderate to severe inflammatory lesions. The patients were assigned to the following three treatment groups: group A received monotherapy with 0.1% topical adapalene gel for 4 weeks; group B received combination therapy with 0.1% topical adapalene gel and 600 mg oral faropenem for 2 weeks followed by 0.1% topical adapalene gel alone for 2 weeks; and group C received combination therapy with 0.1% topical adapalene gel and 600 mg oral faropenem for 4 weeks. The result of the analysis indicated that the percentage reduction in inflammatory lesion counts after 2 weeks of treatment was significantly higher in groups B and C than in group A (P < 0.05). After 4 weeks of treatment, group C showed significantly higher percentage reduction in inflammatory lesion counts than in groups A and B (P < 0.05), whereas no significant difference was noted between the latter two groups. Adverse reactions included dryness and irritation at the adapalene application sites that were observed in 10.1% of cases (16/158 patients) and diarrhea and loose stool because of oral faropenem that were observed in 7.5% of cases (8/106 patients). Taken together, our results suggest that combination therapy with oral antibiotics and adapalene results in earlier improvement in patients with moderate to severe inflammatory acne compared to the application of adapalene alone, and that 4 weeks of the combination therapy is preferable to 2 weeks of treatment.     

Six cases of confluent and reticulated papillomatosis alleviated by various antibiotics

Confluent and reticulated papillomatosis (CRP) is a relatively rare disorder manifested by persistent papules that are confluent in the center and reticulated at the periphery with a characteristic distribution. Recently, many cases of CRP treated with minocycline have been reported, and their effect seems to be derived from their antibiotic properties. We report 6 cases of CRP alleviated by various antibiotics. The patient described in case 1 is a 16-year-old girl whose disease was alleviated by oral minocycline, 100 mg daily for 8 weeks. Cases 2 and 3 describe an 18-year-old woman and a 17-year-old male adolescent whose disease was reduced by oral fusidic acid, 1000 mg daily for 4 weeks. Case 4 describes a 14-year-old girl who received oral clarithromycin, 500 mg daily for 5 weeks. Case 5 describes a 22-year-old woman whose disease was reduced by oral erythromycin, 1000 mg daily for 6 weeks. Case 5 reports a 24-year-old man who received oral azithromycin, 500 mg daily 3 times per week for 3 weeks. Complete clearing after treatment with antibiotics raises the possibility that CRP is triggered by a bacterial infection and that antibiotics are the treatment of choice for CRP.     

Confluent and reticulated papillomatosis Gougerot‐Carteaud successfully treated with minocycline

Confluent and reticulated papillomatosis is a rare dermatosis of unknown etiology mostly affecting young males and females most common in adolescence. The eruption consists of confluent, flat, brown papules forming a pigmented reticulated pattern. It occurs primarily in the intermammary and epigastric regions but may spread to the axillae. A 27‐yearold patient with typical clinical and histologic features of confluent and reticulated papillomatosis responded well to oral minocycline.     

Confluent and reticulated papillomatosis associated with tinea versicolor in three siblings

We describe three teenage siblings with confluent and reticulated papillomatosis, all presenting during a 6-month period. Two of the three patients had confirmed tinea versicolor, with positive potassium hydroxide scrapings, in association with this entity. This is the largest series of siblings with confluent and reticulated papillomatosis, and the only report describing family members having both confluent and reticulated papillomatosis and tinea versicolor. This report lends further evidence to the hypothesis that confluent and reticulated papillomatosis may be etiologically linked to tinea versicolor, and also suggests a genetic predisposition for it.     

Is confluent and reticulated papillomatosis without papillomatosis early or late stage of confluent and reticulated papillomatosis?

Abstract:  The histologic findings of confluent and reticulated papillomatosis include papillomatosis, hyperkeratosis, and minimal or no acanthosis. We present a patient with the clinical findings of confluent and reticulated papillomatosis who responded dramatically to azithromycin, but histologic examination did not reveal papillomatosis. We observed invagination of basket-weave hyperkeratosis through the epidermis. We considered this finding may give a clue for the diagnosis of confluent and reticulated papillomatosis.     

Use of methotrexate in an exuberant case of confluent and reticulated papillomatosis of Gougerot and Carteaud in a teenager

Confluent and reticulated papillomatosis of Gougerot and Carteaud is a rare dermatosis with onset during puberty, more prevalent in females than in males. The pathogenesis is unknown, but some theories suggest either a keratinization or endocrine disorder. The lesions are verrucous, brownish, hyperkeratotic papules or spots that coalesce in a confluent and/or reticulated pattern. This report presents a case with extensive cutaneous involvement associated with acanthosis nigricans and good response to treatment with methotrexate.     

Concomitant confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl with insulin resistance successfully treated with oral minocycline: Case report and published work review

Concomitant confluent and reticulated papillomatosis (CRP) and acanthosis nigricans (AN) is rare. We present a case of concomitant CRP and obesity‐associated AN in a 12‐year‐old obese Japanese girl. Curiously, oral minocycline therapy, which has been shown to be effective for CRP, was effective against both CRP and AN. Possible mechanisms by which minocycline could have improved skin lesions of CRP and obesity‐associated AN are discussed. In addition, reports of concomitant CRP and obesity‐associated AN are reviewed. CRP and obesity‐associated AN share common clinicopathological features and some reports have described concomitant CRP and obesity‐associated AN. Together with the observation that skin lesions of CRP and obesity‐associated AN in the present case responded to oral minocycline therapy, these facts suggest a tight relationship or a common pathogenetic pathway between these pathologies.     

Papilomatosis confluente y reticulada con pseudoestrías lineales: descripción de 20 casos

Confluent and reticulated papillomatosis, also known as Gougerot-Carteaud Syndrome, is a rare chronic disease typically affecting young adults. Of unknown etiology, the condition is characterised by oval grayish-brown or erythematous papules that coalesce to form a reticular pattern, usually on the trunk, especially in the intermammary or interscapular region and on the neck. Diagnosis is primarily clinical, based on the appearance of the lesions, the areas affected, and the response to treatment with minocycline. We report 20 cases of patients with histologically confirmed confluent and reticulated papillomatosis who presented linear pseudo-striae, a little known diagnostic sign.