色素性基底细胞癌

报告1例色素性基底细胞癌。患者女,68岁。右侧腋下黑色条状斑块10余年。皮肤科检查:右侧腋下约3.0 cm×0.2 cm大黑色斑块,边界尚清,其上散在分布数个米粒大黑色丘疹,斑块中部可见糜烂、渗液,渗液周边可见炎症性红斑,无触痛。皮损组织病理检查:表皮层局灶瘤细胞巢,表皮至真皮层可见一肿块,由嗜碱性基底样细胞组成,可见细胞异形性及有丝分裂象,在肿块周边细胞呈栅栏状排列,可见收缩间隙。诊断:色素性基底细胞癌。     

甲下鳞状细胞癌1例

患者男，50岁，右手第4指甲下肿物伴糜烂3年，既往银屑病史20余年。查体：右手第4指甲下黄豆大小红色肿物，表面糜烂伴少量渗液。皮损组织病理示：与表皮相连的鳞状细胞向真皮内浸润生长，细胞异型性，核分裂象增加。病理诊断：甲下鳞状细胞癌。治疗上予局部组织切除。     

手术联合光动力治疗外伤后瘢痕继发鳞状细胞癌2例

病例1,女,49岁,右膝盖内侧瘢痕继发斑块伴渗液、结痂8个月。病例2,女,56岁,右足跟部瘢痕继发斑块伴糜烂、渗液2个月。组织病理检查示:瘢痕组织中异型鳞状上皮呈舌状或不规则浸润性生长。诊断:高分化鳞状细胞癌。治疗上均予手术扩大切除后+光动力治疗。两例患者术后创面逐渐愈合,随访半年无复发。     

银屑病伴发多发Bowen病及鳞状细胞癌1例

患者女,50岁。周身反复出现鳞屑性红斑伴瘙痒30年,右臀出现菜花状肿物1年。有银屑病病史30年,予UVA照射治疗70余次。手术切除右臀肿物,组织病理示鳞状细胞癌和Bowen病。诊断:银屑病;鳞状细胞癌;Bowen病(多发)。     

面部寻常狼疮50年继发低分化鳞状细胞癌

报告1例寻常狼疮继发低分化鳞状细胞癌。患者女,79岁。左侧面部及颈部红斑及结节50年,溃疡2年。皮肤科检查:左侧面、颈部及下颌部弥漫暗红色结节及斑块,其上可见溃疡。皮损组织病理检查:真皮内肿瘤细胞团块形成,细胞异形性明显,偶见角化不良细胞,未见角珠,真皮内可见结核样肉芽肿结构。诊断:寻常狼疮继发低分化鳞状细胞癌。     

红皮病型银屑病并发鳞状细胞癌1例

患者男,57岁.周身反复鳞屑性红斑丘疹伴瘙痒30年,左下肢外伤后溃疡半年.溃疡处组织病理示:表皮增生,灶性角化不全,真皮全层可见大量鳞状细胞团,角珠易见,伴有较多炎性细胞浸润.诊断:红皮病型银屑病;鳞状细胞癌(SCC).     

小汗腺汗孔癌1例

 报告1例小汗腺汗孔癌。患者女，56岁，头部结节30余年，破溃、渗液2个月。皮损病理检查示：真皮内可见瘤细胞团呈巢状分布，部分瘤细胞巢与表皮相连，瘤细胞以不典型嗜伊红鳞状细胞样细胞为主，细胞核大，深染，形态不规则，核分裂相增多，瘤细胞巢内可见管腔样结构。诊断为小汗腺汗孔癌。予扩大手术切除，现随访中。     

肛周HPV18阳性鲍温病1例

患者男,58岁,肛周红斑,逐渐隆起,伴糜烂、渗液、疼痛1年。肛周见一类圆形暗红色斑块,边界清楚,大部分不规则隆起,部分疣状增生,呈鲜红色,表面湿润,少许糜烂。触之较硬。皮损处活检组织病理示:肛周原位鳞状细胞癌(鲍温病)。人乳头状瘤病毒分型检测:HPV18阳性。治疗:广泛的病灶切除。     

上唇粘液表皮癌1例

报告1例上唇粘液表皮癌。患者男,42岁。因上唇反复溃烂渗液10年余就诊。患者上唇唇中线处可见一大小约0.8 cm×1.0 cm的创面,表面可见黑色痂皮覆盖,中间有裂口深及唇肌,挤压有少量渗液,创缘界限清楚,稍高出创面,创周组织肉芽无明显异常。皮肤镜下可见创面血管粗大丰富,创缘有扩张的毛细血管。皮肤病理显示:真皮内可见较多大小不一的鳞状上皮细胞瘤团,其上见粘液细胞,并见粘液腔内较多粘液和粘液细胞,少许中间细胞,少许细胞呈异型;间质浆细胞、淋巴细胞、嗜酸性白细胞浸润,病变浸润性生长到横纹肌。诊断:上唇粘液表皮癌。     

上唇粘液表皮癌1例

报告1例上唇粘液表皮癌。患者男,42岁。因上唇反复溃烂渗液10年余就诊。患者上唇唇中线处可见一大小约0.8 cm×1.0 cm的创面,表面可见黑色痂皮覆盖,中间有裂口深及唇肌,挤压有少量渗液,创缘界限清楚,稍高出创面,创周组织肉芽无明显异常。皮肤镜下可见创面血管粗大丰富,创缘有扩张的毛细血管。皮肤病理显示:真皮内可见较多大小不一的鳞状上皮细胞瘤团,其上见粘液细胞,并见粘液腔内较多粘液和粘液细胞,少许中间细胞,少许细胞呈异型;间质浆细胞、淋巴细胞、嗜酸性白细胞浸润,病变浸润性生长到横纹肌。诊断:上唇粘液表皮癌。     

Tinea of the glans penis: report of a case presenting as a crop of papules

A 27-year-old Japanese male student with tinea of the glans penis was described. The lesion on the glans penis was unique; it developed as a crop of papules.     

Penile metastasis from adenocarcinoma of the prostate in a patient with colorectal carcinoma

Skin metastasis secondary to cancer of the prostate is rare and the prognosis is poor. A 65-year-old male patient diagnosed with metastatic colon carcinoma presented with polyuria and subcutaneous nodular mass on dorsal side of the corpus penis. The serum prostate specific antigen (PSA) level was 111.1 ng/mL and therefore the patient underwent transperineal prostate biopsy. Pathology reported adenocarcinoma of the prostate. The subcutaneous nodular lesion on the penis was totally excised and removed. Immunohistochemical examination of the excised mass was carcinoembryonic antigen (CEA) negative and PSA positive. Taking all these findings into consideration, the patient was diagnosed with prostate cancer that had metastasized to the penis. FOLFOX-4 chemotherapy regime in addition to bicalutamide and goserelin acetate was administered to the patient who also had metastatic colon cancer.     

Penile lichen sclerosus: follow-up study

INTRODUCTION: The aim of this work was to study the long-term course of patients with penile lichen sclerosus and atrophicus. PATIENTS AND METHODS: We reviewed the files of 16 patients followed at our university center from 1982 to 1997 for pathologically proven penile lichen sclerosus and atrophicus. Age at disease onset, duration of the disease course, presence of a triggering factor, initial localization, signs and symptoms, treatment given and its efficacy were recorded. RESULTS: Mean age at diagnosis was 52 years. Inaugural prepuce localizations were observed in 6 cases, involving the distal part of the penis and the glan in 3 cases. Concomitant involvement of the glan and the balanopreputial groove were seen in 6 cases. The localization was limited to the glan in one case. Six patients underwent posthectomy and one had dorsal plasty of the prepuce. The 9 other patients were treated medically with topical corticosteroids and/or androgens. One patient had died prior to evaluation. Among the 9 patients given medical treatment, lichen sclerosus persisted in 7, one developed a squamous cell carcinoma of the penis and one was cured. Among the 6 cases of surgical treatment, 5 were cured and 1 had persistent lesions. Considering the initial localization, long-term course showed that 7 of the 8 patients with a prepuce localization (alone or in association with glan involvement) were cured while the 7 patients with a lesion of the balanopreputial groove (alone or in association with glan involvement) or a lesion of the glan alone still had lichen sclerosus and atrophicus. The non parametric Fischer test showed that the chances of cure were better for preputial localizations than for balanopreputial localizations (p = 0.001) and that surgical treatment was more effective than medical treatment. DISCUSSION: This study of a small number of patients highlighted two points: prepuce localizations of lichen sclerosus and atrophicus cure better than balanopreputial localizations, and that medical treatment is partially effective in balanopreputial localizations. One patient developed squamous cell carcinoma of the penis. As the level of the cancer risk remains unknown, it would be important to provide the most effective treatment in all cases of penis lichen sclerosus and atrophicus.     

浆细胞性龟头炎一例

患者,男,64岁。阴茎、包皮内侧浸润性红斑5个月,组织病理:真皮浅中层淋巴细胞及浆细胞为主的带状炎性浸润。诊断为浆细胞性龟头炎。外用0.1%他克莫司软膏,皮损减轻。     

Localised genital Norwegian scabies in an AIDS patient

OBJECTIVES: We present a case of an AIDS patient with Norwegian scabies manifest by a single, crusted plaque localised to the glans penis. METHODS: A 45 year old man with AIDS presented to our clinic complaining of a red papular pruritic rash on his abdomen and anterior thighs and a single, thick, crusted, non-pruritic lesion on the penis. He had been treated with lindane topically prior to the development of the penile lesion without resolution of the pruritus or red papular lesions. A mineral oil preparation was obtained from the hyperkeratotic penile lesion and revealed numerous mite eggs and faeces. RESULTS: The diagnosis of localised, genital Norwegian scabies was made. The patient was treated with ivermectin 200 micro g/kg per dose taken as two doses, 14 days apart, with complete resolution of both pruritus and skin lesions. CONCLUSIONS: This patient is the first known report of Norwegian scabies localised as a single lesion on the penis. He was successfully treated with oral ivermectin monotherapy.     

Kissing nevus of the penis. Report of two cases and review of the literature

Kissing nevus is a curious type of nevus that was first described on the eyelids and rarely described on the penis. We report two cases of kissing nevus of the penis and review previously reported cases. The lesions of the kissing nevus of the penis showed characteristic mirror-image symmetry relative to the coronal sulcus. On histopathology, the lesion showed a compound nevus.     

Bowen's disease of the glans penis (erythroplasia of Queyrat) in plasma cell balanitis

We report a case of a persistent penile plaque on the glans penis of allegedly more than 20 years' duration, which was refractory to circumcision and local treatment. Over the years, the patient repeatedly presented with a circumscribed inflammatory lesion of the glans penis, diagnosed as Zoon's balanitis on the basis of clinical aspects and two biopsies. Because of unresponsiveness of the lesion to circumcision and focal steroid infiltration, repeated biopsies were performed in an attempt to rule out malignancy. Two further biopsies were carried out. One again showed the features of a plasmacellular inflammation, while the other finally revealed the histopathologic features of erythroplasia of Queyrat (carcinoma in situ or Bowen's disease of the glans penis). We assume that either the former biopsy specimens were taken from a plasma cell-rich reactive infiltrate around the neoplastic lesion, or that carcinoma in situ may have arisen due to the chronic inflammation of Zoon's balanitis plasmacellularis. Radiotherapy was performed with good clinical response and subsequent histopathologic proof of complete remission of the lesion.     

Basal cell carcinoma of penis: case report.

Basal cell carcinoma of the penis is rare. A patient who presented with a penile and scrotal ulcer due to basal cell carcinoma is reported. Wide local excision and split skin grafting were performed to excise the lesion completely.     

浅表性阴茎癌保留阴茎完整性切除术的可行性以及对患者及配偶性心理影响(附3例报告)

目的:探讨浅表性阴茎癌保留阴茎完整性手术的可行性以及术后对患者及配偶的心理生理学影响。方法:3例患者术前均行必要体检确定肿瘤未侵及白膜,常规术前病理活检证实为阴茎鳞癌,常规检查胸片、髂血管走行区超声及盆腔CT未发现局部淋巴结转移及远处转移。切除肿瘤组织及远端0.5cm包皮组织,深达白膜层,近端切除多余包皮内板及适当外板包皮组织连同阴茎筋膜达白膜层,术中冰冻病例证实切缘阴性。术后1周预防性加用双侧腹股沟区放疗治疗。结果:3例患者均按时复诊,随诊18个月~3年,局部无肿瘤复发,腹股沟区及腹膜后淋巴结未见转移。术后生殖器外观满意,排尿正常,性欲及性生活满意度为满意。结论:浅表性阴茎肿瘤保留阴茎完整性阴茎切除术从手术方案方面是可行的,从手术效果上看,可使患者更好的保持良好的性自信、性功能和性生活满意度,使患者夫妇对生活充满希望及保持幸福。     

Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5‐fluorouracil and liquid nitrogen

Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86‐year‐old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with thin mica‐like scales involving his glans penis. Histology of the lesion showed hyperkeratosis, parakeratosis, epidermal acanthosis and papillomatosis with no evidence of dysplasia. Immunohistochemistry for human papillomavirus was negative. The patient was treated with topical 5‐fluorouracil and liquid nitrogen with clinical improvement. He is now under long‐term surveillance for verrucous carcinoma and squamous cell carcinoma.