疣状表皮发育不良并发鲍恩样丘疹病

报告1例疣状表皮发育不良并发鲍恩样丘疹病.患者女,39岁.面部、四肢出现褐色斑片26年,大、小阴唇及肛周出现深竭色丘疹、斑块2年.面部皮损组织病理检查示表皮呈网篮状角化过度,表皮上部可见凹空细胞,其细胞核固缩,符合疣状表皮发育不良组织病理改变.会阴部皮损经组织病理检查确诊为鲍恩样丘疹病.     

疣状表皮发育不良少见皮损1例

报告１例疣状表皮发育不良少见皮损，患者女性，３６岁，躯干，四肢疣状皮疹不断增多２４年，出现褐色斑片１年，除扁平疣样和寻常疣样皮损外，出现类似连圈状糠秕疹和脂溢性角化样的皮损。     

疣状表皮发育不良并发鳞状细胞癌

报告1例表现为脂溢性角化病样皮损的疣状表皮发育不良并发鳞状细胞癌.患者男,52 岁.四肢皮肤丘疹、斑块20余年,右手背溃疡2 个月.右前臂斑块组织病理检查:同时有疣状表皮发育不良及脂溢性角化病的表现.右手背溃疡组织病理表现符合高分化鳞状细胞癌.     

疣状表皮发育不良伴Bowen病1例临床分析

目的：报道1例花斑癣型疣状表皮发育不良伴外阴部鲍温病,并对患者两处皮损的临床特点、病因及相关性进行分析。方法：将腰背部及外阴部皮损的石蜡包埋组织切片提取DNA后,使用凯普HPV37型基因分型试剂盒以及PCR扩增方法进行检测,同时对患者进行治疗。结果：两者试验结果未能体现两处皮损相关性,推测外阴皮损不是疣状表皮发育不良发展而来,为单独起病。患者T淋巴细胞明显降低。采用ALA-光动力治疗外阴皮损,三次光疗后皮损变化不明显,予以局部肿物完整切除术后,随访半年无复发。采用维A酸治疗疣状表皮发育不良皮损,治疗4个月后四肢疣状增生样皮损较前稍许变平,色素脱失斑片部分融合、边界较前模糊。结论：此病例伴发的鲍温病与疣状表皮发育不良无相关性;T淋巴细胞等因素可能在疣状表皮发育不良发病机制中占有作用。     

疣状表皮发育不良并发多发皮角

报告1例疣状表皮发育不良并发多皮角损害.患者男,36岁.四肢多发疣增生物24年,无自觉症状.皮肤科检查:双手、前臂、双足及小腿密布淡黑褐色疣状增生物,疣体表面形成多个巨大坚硬的皮角.皮损组织病理学改变符合疣状表皮发育不良和皮角.给予阿维A口服,联合抗病毒、免疫调节剂等治疗后,病情明显好转.     

阿维A治疗疣状表皮发育不良1例

疣状表皮发育不良是由人类乳头瘤病毒（HPV）感染导致的与遗传有关的少见皮肤病,临床上可分为扁平疣型、花斑癣型及点状瘢痕型。花斑癣型疣状表皮发育不良较少见,临床上表现为泛发性花斑癣样皮损,治疗较困难。笔者采用阿维A治疗1例泛发性花斑癣型疣状表皮发育不良,取得较好疗效,现报告如下。[第一段]     

阿维A治疗疣状表皮发育不良1例

报告1例疣状表皮发育不良。患者男,57岁。下腹、前臂、会阴和大腿近端出现乳头瘤样增生物7年,躯干部泛发扁平疣样皮损,手、足部出现寻常疣样皮损5年。给予小剂量阿维A治疗6个月取得满意疗效,随访7个月皮损无复发。     

点状瘢痕型疣状表皮发育不良1例

报告1例以少见的点状瘢痕为表现的疣状表皮发育不良。患者男,17岁。面颈、躯干、上肢大量点状轻微凹陷的斑疹12年。皮损组织病理示:表皮中上部有明显的弥漫性细胞空泡化。诊断:疣状表皮发育不良(点状瘢痕型)。予重组人α-2b干扰素凝胶外搽治疗。     

疣状表皮发育不良1例报告

疣状表皮发育不良又称泛发性疣病,为一种少见的泛发性、多形性由人乳头瘤病毒感染所致的疣皮肤病.现将我们发现的1例具有两种皮损表现的病例报告如下.临床资料患者,男,17岁,学生,莒县人.双手背、面、颈部扁平疣状皮疹12年.患者于12年前不明原因的在双手背开始出现暗红色扁平疣状丘疹,无自觉症状,未在意.     

手术治疗人乳头瘤病毒感染皮损

目的分析手术治疗人乳头瘤病毒感染所致的巨大或广泛性皮损的疗效。方法对有巨大或广泛性皮损的10例寻常疣、20例尖锐湿疣、8例疣状表皮发育不良难治性病例进行外科手术治疗。结果术后6个月,10例寻常疣患者中,有2例部分原位复发。20例尖锐湿疣患者,5例复发,复发率为25%。8例疣状表皮发育不良患者经手术将严重皮损去除,所有病例肢体功能均恢复正常,但并不能完全彻底根治,后经长期给予外用维A酸类等药物,病情得以控制,增生皮损均未超出原病变皮损,肢体功能无障碍。结论外科手术是治疗巨大或广泛性人乳头瘤病毒感染皮损可选择的手段。     

Autosomal Dominant Epidermodysplasia Verruciformis Lacking a Known EVER1 or EVER2 Mutation

Abstract:  Epidermodysplasia verruciformis is a rare genodermatosis characterized by abnormal susceptibility to infection with specific human papillomavirus serotypes. Epidermodysplasia verruciformis is a genetically heterogeneous disease, and autosomal recessive and X-linked inheritance patterns have been reported. Nonsense mutations in the genes EVER1 and EVER2 have been identified in over 75% of cases. We present epidermodysplasia verruciformis in a father and a son with typical histologic and clinical findings that occur in the absence of mutations in EVER1 or EVER2. Epidermodysplasia verruciformis in this father/son pair in a nonconsanguinous pedigree is consistent with autosomal dominant inheritance. This is the first report of autosomal dominant transmission of epidermodysplasia verruciformis, providing further evidence of the genetic heterogeneity of epidermodysplasia verruciformis.     

Die Epidermodysplasia verruciformis Lewandowsky-Lutz in licht- und elektronenoptischem Vergleich mit den übrigen Papova-Virus-Akanthomen

Zusammenfassung Aufgrund histologischer und elektronenmikroskopischer Vergleichsuntersuchungen wird das gesamte Material von cytologisch veränderten Papova-Virus-Akanthomen (300 Warzen und Condylomata acuminata; Primärefflorescenzen von 7 typischen und 7 fraglichen Epidermodysplasia verruciformis-Kranken) in vier cytologische Typen als Ausdruck morphologisch unterschiedlicher cytopathogener Viruseffekte unterteilt. Das unter Typ 4 gruppierte Kollektiv (basophile schaumige Riesenkeratinocyten) scheint für die Epidermodysplasia verruciformis spezifisch zu sein, womit eine histologische Abgrenzung gegenüber den üblichen Warzen (Typ 1–3) möglich wird.

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Comparison of the epidermodysplasia verruciformis lewandowsky-lutz with the other papova virus acanthomas by light and electron microscopy

Summary Based on histology and electron microscopy, a series of Papova virus acanthomas consisting of 300 common warts and Condylomata acuminata as well as primary efflorescences of 7 typical and 7 questionable cases of Epidermodysplasia verruciformis have been classified. Four cytological types expressing different cytopathogenic viral actions were established. Typ 4 (basophilic foamy giant keratinocytes) seems to be specific for Epidermodysplasia verruciformis which thus can be differentiated histologically against ordinary warts (type 1–3).

     

勒-雪病1例

患儿男,10个月。全身泛发皮疹8月余,腹部包块伴发热半月。皮疹细胞印片可见大量泡沫样网状细胞,组织病理显示真皮浅层组织样细胞浸润。     

Treatment of a patient with epidermodysplasia verruciformis carrying a novel EVER2 mutation with imiquimod

Epidermodysplasia verruciformis (EV) is a rare disorder characterized by widespread human papillomavirus infection and malignant transformation. EV may be caused by mutations of the genes EVER1 or EVER2, which are located on the EV1 locus, 17q25. We describe a patient with EV and a novel homozygous gene mutation of EVER2 gene who was treated successfully with topical imiquimod.     

Epidermodysplasia verruciformis.

Epidermodysplasia verruciformis is a rare skin disease characterized by the disseminated, flat, wart-like lesions caused by human papillomavirus and a high frequency of various skin cancers. The clinical aspects, histological findings, genetic and immunological factors, and human papillomavirus types found in the disease and their roles in skin cancers are reviewed.     

过敏性紫癜肾脏损伤相关因素分析

目的探讨过敏性紫癜肾脏损伤的相关因素。方法回顾性分析过敏性紫癜248例患者的临床及实验室资料,进行统计学分析,建立回归方程。结果腹痛、上呼吸道感染、潜血、补体C3、性别、类风湿因子、血小板计数对患者尿白蛋白有影响。腹痛、尿潜血、年龄、类风湿因子、血小板计数、皮疹持续时间对患者尿球蛋白有影响。关节痛、肾区叩击痛、腹痛对患者尿微蛋白有影响。结论腹痛是肾脏损伤的重要相关因素,尿潜血则是肾脏发生较为严重损伤的实验室指标,性别、血小板计数、感染因素、皮疹持续时间、年龄、关节痛、肾区叩击痛与肾脏损伤的发生存在一定相关性。     

婴幼儿Kaposi水痘样疹2例并文献复习

例1女,头面部起疹伴痒4个月,加重伴起水疱、发热3d。例2男,全身起疹3个月,头面部起水疱伴发热3d。均诊断为Kaposi水痘样疹。2例患儿均予更昔洛韦联合人免疫球蛋白治疗后痊愈。     

Novel dermoscopic features of pityriasis versicolor–like macules in epidermodysplasia verruciformis

Epidermodysplasia verruciformis (EV) manifests early in childhood as pityriasis versicolor (PV)–like macules on sun-exposed sites such as the face. These hypopigmented lesions closely resemble commoner pediatric dermatoses such as PV or pityriasis alba. In this report of two cases, we describe the distinguishing dermoscopic features of PV-like macules in EV. Unfocused dotted vessels in a hypopigmented or erythematous background with whitish scales and pigment diluted vellus hairs on dermoscopy should raise the suspicion of EV in children presenting with PV-like lesions.     

结节性硬化病伴巨细胞型星形细胞瘤1例

患者男，11岁。出生后前额有一黄色包块，脐旁有一灰白色状白斑。继而鼻梁下方出现小圆红点向面部扩散且长大，波及躯干四肢。2年前开始有癫痫发作，6个月前出现头痛、呕吐、抽搐，一过性神志丧失。颅脑MRI：左侧脑室有肿物。面部皮疹病理诊断：结节性硬化病；巨细胞型星形细胞瘤。