阿卡波糖联合诺和锐30治疗2型糖尿病血糖控制欠佳患者的疗效观察

目的探讨阿卡波糖联合诺和锐30治疗2型糖尿病血糖控制欠佳者的临床疗效。方法南京大学医院收治的52例血糖控制欠佳的2型糖尿病患者随机分为治疗组（27例）和对照组（25例）。对照组给予诺和锐30注射液,2次／d,早晚餐前皮下注射。治疗组于三餐前口服阿卡波糖片,50mg／次,3次／d,诺和锐30注射液的用法同对照组。治疗12周后,比较两组患者治疗前后空腹血糖（FBG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbAlc）、体质量指数（BMI）、血脂变化情况及胰岛素用量。结果治疗后,两组患者FBG、HbAlc均较治疗前明显降低,治疗前后差异有统计学意义（P〈0．05）。治疗后,治疗组患者HbAlc水平明显低于对照组,两组比较差异有统计学意义（P〈0．05）。治疗后,两组全天七点血糖水平均较治疗前明显降低,同组治疗前后差异有统计学意义（P〈0．05）;同时,治疗组三餐后2hPG均显著低于对照组,两组比较差异有统计学意义（P〈0．05）。治疗组血糖达标时间明显短于对照组,两组比较差异有统计学意义（P〈0．05）。结论阿卡波糖联合诺和锐30治疗血糖控制欠佳的2型糖尿病患者具有较好的临床疗效,可有效控制餐后血糖水平,具有良好的临床应用价值。     

金芪降糖片对使用预混胰岛素2型糖尿病（气虚内热证）患者降糖疗效及血糖波动的影响

目的 观察金芪降糖片对使用预混胰岛素2型糖尿病（气虚内热证）患者降糖疗效及血糖波动的影响。方法 采用随机、双盲、安慰剂对照、多中心临床试验设计,选取预混胰岛素治疗的2型糖尿病（气虚内热证）患者60例,随机分成试验组和对照组,试验组在常规治疗基础上给予金芪降糖片（0.56 g/片,每天3次,每次3片,餐前0.5 h口服）治疗,对照组在常规治疗基础上给予金芪降糖片模拟片（每天3次,每次3片,餐前0.5 h口服）治疗。疗程均为12周。比较两组的临床疗效。观察治疗前后两组葡萄糖目标范围内时间（time in range,TIR）、平均血糖波动幅度（mean amplitude of glycemic excursion,MAGE）、糖化血红蛋白（glycosylated hemoglobin,HbA1c）、空腹血糖（fasting blood glucose,FBG）、餐后2 h血糖（2-hour postprandial blood glucose,2hPG）的变化。结果 治疗后,试验组TIR、MAGE明显改善（P<0.05）,对照组TIR、MAGE未见明显改善（P>0.05）,...     

The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose,HbA1c,lipid profile,liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double‐blind clinical trial

Diabetes mellitus is a metabolic disease that manifested as hyperglycemia due to the defect in secretion or function of insulin. Studies have shown that saffron and its derivatives cause a significant reduction in plasma glucose levels in experimental models. The purpose of this study was to investigate the effect of the saffron extract on fasting plasma glucose (FPG), glycated hemoglobin level (HbA1c), lipid profile, liver enzymes, and renal function tests in type 2 diabetic patients. In this double‐blind randomized clinical trial, 64 type 2 diabetic patients who were on oral anti‐diabetic drugs were examined. Participants received either 15 mg of saffron or placebo capsules (two pills per day) for 3 months. Anthropometric indices, dietary intake, FPG, HbA1c, lipid profiles, liver enzymes (ALT, AST, ALP), and renal function (BUN, Cr.) tests were measured pre and post intervention after 3 months. Independent t test and paired t test were used for data analysis. After 3‐months intervention, mean difference of FPG, Cholesterol, LDL‐c, and LDL/HDL ratio between two groups showed significant reduction(p < 0.0001), but HbA1c, HDL‐C, API, TG showed no significant differences (p > 0.05). In saffron group, FPG, HbA1c, cholesterol, LDL‐c, and LDL/HDL ratio decreased significantly after 3‐months intervention compare with baseline (p < 0.0001).     

八段锦对2型糖尿病患者下肢肌力与身体成分的影响

[目的]观察规律性八段锦运动对2型糖尿病患者的血糖、下肢肌力与身体成分的影响。[方法]选取60例2型糖尿病患者,年龄45~67岁之间,随机分为八段锦运动干预组与对照组,分别给予12周八段锦运动(45~50分/次,5次/周)与糖尿病的病因、防治及饮食等教育(90分/次,1次/月)。比较两组空腹血糖、餐后血糖、糖化血红蛋白、股四头肌、腘绳肌、胫骨前肌与腓肠肌最大等长肌力,体脂百分比与腰臀比。[结果]组内比较八段锦运动干预组,患者的空腹血糖、餐后血糖、糖化血红蛋白与运动前相比均降低,差异有统计学意义(P0.05);干预后与对照组相比,差异有统计学意义(P0.05)。女性体脂百分比下降,差异有统计学意义(P0.05);且与对照组相比,差异有统计学意义(P0.05)。与本组干预前相比较,双侧股四头肌、胫骨前肌、腓肠肌最大等长肌力均增长,依次平均增长6.7 kg(增长率19.8%)、6.5 kg(增长率24.3%)、6.0 kg(增长率24.7%),均P0.05,与对照组相比,干预后,股四头肌、胫骨前肌与腓肠肌肌力增加,均P0.05。[结论]12周规律性八段锦运动有效改善2型糖尿病患者的血糖、身体成分与肌肉力量,可为进一步研究传统体育运动八段锦防治糖尿病及其并发症如糖尿病足等提供基础。     

健身气功——马王堆导引术辅助治疗2型糖尿病疗效观察

目的观察健身气功马王堆导引术的长期锻炼对辅助治疗2型糖尿病的疗效,并初步探讨马王堆导引术辅助2型糖尿病患者康复的可能机制。方法 40例2型糖尿病患者随机分为2组。实验组进行1 a有组织地健身气功马王堆导引术的习练,对照组不给予运动安排。2组均在开始锻炼前及锻炼1 a后测定血糖、血脂、胰岛素、血黏度及内脂素。结果实验组实验后空腹血糖、糖化血红蛋白、三酰甘油、低密度脂蛋白水平较实验前降低,有显著性差异(P均<0.05)。实验组胰岛素敏感性指数实验后较实验前升高,有显著性差异(P<0.05)。实验组实验后三酰甘油及高密度脂蛋白水平均显著改善(P均<0.05)。实验组实验后全血高切黏度、低切黏度、血浆黏度、红细胞聚集指数、卡松黏度较实验前明显降低(P均<0.05)。实验组实验后内脂素水平较实验前降低,有显著性差异(P<0.05)。结论马王堆导引术的长期锻炼可以辅助中老年2型糖尿病患者血糖、血脂的控制,值得在2型糖尿病患者中大力推广。     

The effect of resveratrol supplementation on serum levels of asymmetric de‐methyl‐arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized,double‐blind controlled trial

The present study sought to investigate the effect of micronized resveratrol supplementation on serum levels of asymmetric de‐methyl‐arginine (ADMA) and paraoxonase‐1 (PON1) activity in patients with type 2 diabetes (T2D). In this double‐blinded randomized trial, 76 patients with T2D were recruited. Participants were randomly assigned to consume 1,000 mg resveratrol or placebo capsules (methylcellulose) per day, for 8 weeks. Serum levels of ADMA and PON1 enzyme activity were measured at the beginning and end of the intervention using the enzyme‐linked immunosorbent assay method. In total, 71 participants completed the study. Our results showed that resveratrol significantly decreased serum levels of ADMA (?0.16 ± 0.11, p < .001) and improved PON1 enzyme activity (15.39 ± 13.99, p < .001) compared with placebo, after adjusting for confounding factors (age, sex, and baseline body mass index). Our findings suggest that 8‐week resveratrol supplementation may produce beneficial effects on serum levels of ADMA and PON1 enzyme activity in patients with T2DM. However, further research is needed to confirm the veracity of these results.     

三黄化糖饮联合西药治疗痰热互结型2型糖尿病疗效研究

目的:观察三黄化糖饮联合西药治疗痰热互结型2型糖尿病临床疗效。方法:将90例痰热互结型2型糖尿病患者按照简单随机的方法分为两组,每组45例。观察组44例完成研究,对照组43例完成研究。对照组患者给予基础降糖治疗,观察组在对照组基础上给予三黄化糖饮口服。治疗4周后,观察两组治疗前后中医证候积分、症状积分、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)及血脂指标。观察并比较两组疗效。结果:观察组治疗显效率为90.91%,高于对照组的72.09%(P<0.05)。治疗后观察组多食易饥、胸闷脘痞、喜冷饮、大便异常症状积分优于对照组(P<0.05)。治疗后观察组HOMA-IR、FBG、HbA1c水平及中医证候积分均显著优于对照组(P<0.05)。治疗后两组胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平比较差异均无统计学意义(P>0.05)。结论:三黄化糖饮联合西药治疗痰热互结型2型糖尿病可明显改善患者临床症状,减轻胰岛素抵抗。     

Blood pressure lowering and anti‐inflammatory effects of hesperidin in type 2 diabetes; a randomized double‐blind controlled clinical trial

Elevated levels of reactive oxygen species under diabetic condition lead to vascular complications and inflammation. This study aimed to examine the effects of hesperidin supplement on blood pressure and inflammatory markers in type 2 diabetes. In this research, 64 patients were randomly allocated to receive 500 mg/day hesperidin or placebo capsules for 6 weeks. Data on systolic blood pressure (SBP), diastolic blood pressure, serum total antioxidant capacity (TAC), tumor necrosis factor alpha, interleukin 6 (IL‐6), and high‐sensitivity C‐reactive protein (hs‐CRP) were collected at the baseline and at the end of the study. In the hesperidin group, SBP (122.7 ± 8.5 vs. 119.0 ± 7.4; p = .005), mean arterial blood pressure (94.2 ± 5.5 vs. 91.8 ± 5.5; p = .009), IL‐6 (8.3 ± 2.1 vs. 7.4 ± 1.8; p = .001), and hs‐CRP (1.9 ± 1.2 vs. 1.1 ± 0.9; p < .000) decreased whereas TAC increased (0.74 ± 0.1 vs. 0.82 ± 0.1; p < .000) in comparison to the baseline values. There was a significant difference in mean percent change of SBP, diastolic blood pressure, mean arterial blood pressure, serum TAC, and inflammatory markers (tumor necrosis factor alpha, IL‐6, and hs‐CRP) between hesperidin and control groups following intervention in adjusted models (p < .05). These results suggest that hesperidin may have antihypertensive and anti‐inflammatory effects in type 2 diabetes.     

The effects of rutin flavonoid supplement on glycemic status,lipid profile,atherogenic index of plasma,brain-derived neurotrophic factor (BDNF), some serum inflammatory,and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind,placebo-controlled trial

This study aimed to investigate the effects of rutin flavonoid in type 2 diabetes mellitus (T2DM) patients. In this trial (double-blind, placebo-controlled), 50 T2DM patients (supplement, n = 25 and placebo, n = 25) were randomized and supplemented with 500 mg rutin or placebo per day for 3-months. At the beginning and at the end of the study, metabolic parameters including fasting blood glucose (FBG), insulin, glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMO-IR), quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment of β-cell function (HOMA-β), triglyceride (TG), total cholesterol (CHOL), high-density and low-density lipoprotein cholesterol (HDL-c and LDL-c), and atherogenic index of plasma (AIP), inflammatory and oxidative stress markers such as interleukin 6 (IL-6), total antioxidant capacity (TAC), and malondialdehyde (MDA) and brain-derived neurotrophic factor (BDNF) were assessed. The results showed a significant decrease in FBG, insulin, HbA1c, HOMO-IR, LDL-c, TG, VLDL, CHOL, LDL-c.HDL-c ratio, AIP, IL-6, and MDA and a significant increase in HDL-c, QUICKI index, BDNF, and TAC compared with the initial value (p for all <.05). In the adjusted model, the mean changes of FBG, insulin, HbA1c, HOMO-IR, LDL-c, CHOL, LDL.HDL ratio, AIP, MDA, and IL-6 were significantly lower and mean changes of QUICKI index, HDL-c, and TAC were significantly higher in the rutin group compared with the placebo group (adjusted p for all <.05). It seems that rutin may have beneficial effects on improving metabolic parameters, BDNF, and inflammatory and oxidative stress factors in T2DM patients.     

中医辨证点穴法对2型糖尿病患者血糖和胰岛功能作用的临床研究

[目的]观察中医辨证点穴法对2型糖尿病患者血糖及胰岛功能的临床效果。[方法]选择符合入选标准的160例2型糖尿病患者,按病程长短进行分层分为初发组、1~3 a组,3~5 a组,每层随机分为治疗组及对照组,对照组采用常规降糖治疗,治疗组在此基础上加用中医辨证点穴方法治疗,治疗2周后比较两组血糖、症状积分、HOMA指数、胰岛第1时相功能、胰岛第2时相功能。[结果]治疗组总有效率优于对照组,P0.05,在血糖控制、症状改善上均优于对照组(P0.05),稳态评估模型(HOMA)指数、胰岛第1时相功能明显高于对照组(P0.01或0.05)具有统计学差异。[结论]中医辨证点穴方法能有效改善2型糖尿病患者症状、有效控制血糖,对胰岛功能亦有一定恢复作用,有推广应用价值,需进一步深入研究。     

门冬胰岛素30联合二甲双胍治疗老年2型糖尿病疗效观察

目的观察农村初诊老年2型糖尿病（T2DM）患者使用门冬胰岛素30联合二甲双胍治疗后血糖、血脂及体质量的变化。方法33例农村初诊老年T2DM患者予以门冬胰岛素30联合二甲双胍口服治疗,疗程12周,观察治疗前后空腹血糖（FBG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbAlC）、TG、TC、HDL—C、LDL—C、体质量指数（BMI）等指标的变化。结果治疗12周后,FBG、2hPG、HbAlc水平均较治疗前显著降低（P均〈0．01）,TG、TC、LDL—C明显下降（P均〈0．05）,HDL—C、BMI及体质量变化不明显。结论门冬胰岛素30联合二甲双胍可有效降低农村初诊老年T2DM患者血糖、HbAlC及血脂水平,体质量增加无显著变化,无夜间低血糖及严重低血糖事件发生。     

The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial

Oxidative stresses are increasingly implicated in the pathogenesis of diabetic complications which may either cause direct pancreatic beta-cell damage or lead to metabolic abnormalities that can induce or aggravate diabetes. The valuable effect of antioxidant nutrients on the glycemic control of diabetic patients has been reported in experimental and clinical studies. The present study was designed to investigate the effects of the herbal medicine, Silybum marianum seed extract (silymarin), which is known to have antioxidant properties on the glycemic profile in diabetic patients. A 4-month randomized double-blind clinical trial was conducted in 51 type II diabetic patients in two well-matched groups. The first group (n = 25) received a silymarin (200 mg) tablet 3 times a day plus conventional therapy. The second group (n = 26) received the same therapy but a placebo tablet instead of silymarin. The patients were visited monthly and glycosylated hemoglobin (HbA(1)c), fasting blood glucose (FBS), insulin, total cholesterol, LDL and HDL, triglyceride, SGOT and SGPT levels were determined at the beginning and the end of the study. The results showed a significant decrease in HbA(1)c, FBS, total cholesterol, LDL, triglyceride SGOT and SGPT levels in silymarin treated patients compared with placebo as well as with values at the beginning of the study in each group. In conclusion, silymarin treatment in type II diabetic patients for 4 months has a beneficial effect on improving the glycemic profile.     

2型糖尿病合并大血管病变患者血浆脂联素水平变化的研究

目的探讨2型糖尿病合并大血管病变患者血浆脂联素(APN)水平的变化及意义。方法随机选取2型糖尿病合并大血管病变患者34例(A组)、单纯2型糖尿病患者34例(B组)、正常体健者20例(C组),分别检测3组患者的体质量指数(BMI)、血压、空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、血浆纤溶酶原激活剂抑制剂-1(PAI-1)水平,比较APN水平的变化,并与其他因素进行相关分析及回归分析。结果A组和B组血浆APN水平均低于C组(P<0.01),A组低于B组(P<0.01)。多元线性相关分析显示,A组APN与收缩压、BMI、FBG、FINS、TG水平呈负相关,与血浆PAI-1水平亦呈负相关。结论2型糖尿病患者中血浆APN水平显著降低,合并大血管病变者更低,脂联素与2型糖尿病及大血管病变之间存在一定相关性。     

The effects of wheat germ supplementation on metabolic profile in patients with type 2 diabetes mellitus: A randomized,double‐blind,placebo‐controlled trial

The aim of the present trial was to examine the effects of wheat germ (WG) consumption on metabolic control and oxidative stress status of type 2 diabetes mellitus (T2DM) patients. Eighty participants with T2DM were randomly allocated to receive 20‐g WG (n = 40) or placebo (n = 40) in a randomized double‐blind clinical trial for 12 weeks. Serum lipid profiles, glycaemic indices, total antioxidant capacity, and malondialdhyde (MDA) were assessed. A total of 75 subjects completed the trial. Compared with the placebo, WG consumption led to significant reduction in total cholesterol (TC) concentrations (p = .04). There was a trend regarding TC to high density lipoprotein ratio (p = .08) following 12 weeks WG consumption, although they were not statistically significant after correcting for multiple testing. In addition, within‐group comparison revealed a significant rise in total antioxidant capacity concentration (p = .001) in WG group. We observed no significant effects of WG intake on glycaemic status, blood pressure, MDA, triglyceride, and low density lipoprotein levels. WG consumption for 12 weeks could decrease serum TC levels and had no significant effects on other metabolic variables and MDA in patients with T2DM. Though observed health benefit effects were small, it might lead to a major impact on wider public health.     

2型糖尿病合并急性脑梗死患者溶血磷脂酸、超敏C反应蛋白水平的变化及其意义

目的通过观察2型糖尿病合并急性脑梗死患者血浆溶血磷脂酸(LPA)、超敏C反应蛋白(hs-CRP)水平,探讨LPA、hs-CRP与2型糖尿病及其合并缺血性脑血管病变之间的关系。方法选择2型糖尿病合并脑梗死患者42例作为DACI组,2型糖尿病且无糖尿病急慢性并发症患者41例作为T2DM组,门诊健康体检者46例作为正常对照组。所有入选者于入院后空腹取血检测血浆LPA、血清hs-CRP、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、TC、TG、LDL-C、HDL-C水平。结果 DACI组LPA、hs-CRP水平高于T2DM组和正常对照组;T2DM组LPA、hs-CRP水平高于正常对照组。DACI组各因素相关分析显示LPA与HbA1c(r=0.352,P<0.01)、hs-CRP(r=0.239,P<0.05)、TG(r=0.319,P<0.01)呈正相关,与FBG、TC、LDL-C及HDL-C无相关关系(P均>0.05);hs-CRP与TG(r=0.387,P<0.01)成正相关,与FBG、HbA1c、TC、LDL-C及HDL-C均无相关关系(P均>0.05)。结论 LPA、hs-CRP测定对预测2型糖尿病患者发生急性缺血性脑血管病变具有重要意义。LPA与HbA1c水平有关,并与体内炎症反应相关。     

The effects of curcumin supplementation on high‐sensitivity C‐reactive protein,serum adiponectin,and lipid profile in patients with type 2 diabetes: A randomized,double‐blind,placebo‐controlled trial

Diabetes mellitus is one of the most common and important metabolic diseases in human. Curcumin, which is a natural polyphenol found in turmeric, can be used in treatment of diabetes complications for its antidiabetic, anti‐inflammatory, and antioxidant properties. In this double‐blind randomized clinical trial, 44 patients with Type 2 diabetes randomly assigned to curcumin or placebo group. Patients consumed either 1,500‐mg curcumin or placebo daily for 10 weeks. Anthropometric measurements were measured at baseline and at the end of the study. Serum concentrations of triglyceride (TG), total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, high‐sensitivity C‐reactive protein, and adiponectin were determined after 12‐hr fasting at the beginning and end of study. The mean serum level of TG decreased in curcumin group compared with baseline (109 ± 36 vs. 124 ± 36; p < 0.05). At the end of study, the mean concentration of high‐sensitivity C‐reactive protein decreased in the curcumin group compared to the control (2.9 ± 2.9 vs. 3.4 ± 4.2; p < 0.05). The mean serum concentration of adiponectin increased (64 ± 3 vs. 63 ± 4; p < 0.05) in the treatment group compared with the placebo at the end of the study. The results of the current study indicate that curcumin consumption may reduce diabetes complications through decreasing TG level as well as indicators of inflammation.     

清热利湿中药对肥胖2型糖尿病患者胰岛素抵抗的影响

目的 观察清热利湿中药对肥胖2型糖尿病患者胰岛素抵抗(insulin resistance,IR)的影响。方法 采用随机数字表法将60例患者随机分为两组各30例,对照组采用西医常规降糖治疗,治疗组在对照组治疗基础上给予清热利湿中药,1剂/d,分早晚2次温服。疗程均为8周。疗程结束时比较两组患者中医证候积分变化及空腹血糖...     

丹参注射液穴位注射在2型糖尿病强化治疗中的作用

[目的]在2型糖尿病患者胰岛素强化治疗的基础上予以针灸干预治疗(丹参注射液于足三里、三阴交穴位注射),明确其在临床糖尿病治疗中的作用和地位。[方法]选择2型糖尿病患者共60例,分为治疗组和对照组,比较治疗前后生化指标、胰岛素和C-肽分泌水平的变化,评估胰岛β细胞功能和胰岛素抵抗程度,并进行治疗经济学评价。[结果]治疗组低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、餐后2 h血糖(P2hPG)、游离脂肪酸(FFA)、C反应蛋白水平(CRP)较对照组明显下降(P<0.05),静脉葡萄糖耐量试验显示治疗组各时点血糖水平下降显著(P<0.05),血清胰岛素的第一时相分泌缺陷能较好修正(P<0.05),HOMA-IR(C-P)、HOMA-islet(C-P)改善明显(P<0.05)。两组所需胰岛素用量(日用量和总用量)、住院治疗总费用及日费用比较差异无统计学意义(P>0.05),但治疗组血糖达标时间较对照组明显缩短(P<0.05)。[结论]在2型糖尿病患者进行胰岛素强化治疗的基础上辅以丹参注射液穴位注射不能获得直接的短期经济效益,然而能更加有效纠正患者糖脂代谢紊乱状况,改善第一时相胰岛素分泌及胰岛β细胞功能、恢复机体对胰岛素的敏感性方面具有积极作用。     

The effect of saffron (Crocus sativus L.) on glycemia,lipid profile,and antioxidant status in patients with type-2 diabetes mellitus: A randomized placebo-controlled trial

In the current study, we aimed to investigate the effect of saffron supplementation on glycemic status, lipid profile, atherogenic indices, and oxidative status in patients with type-2 diabetes (T2DM). In a randomized, double-blind controlled trial, 70 patients were randomly allocated into two groups (n = 35, each) and received 100 mg/day of saffron or placebo for eight weeks. Dietary intake, weight, body mass index (BMI), waist and hip circumferences (WC and HC), waist to hip ratio (WHR), fasting blood sugar (FBS), hemoglobin A1c (HbA1c), insulin, and Homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile, atherogenic indices, oxidative status, and liver enzymes were determined before and after the intervention. At the end of the eighth week, saffron intervention could significantly reduce FBS (7.57%), lipid profile (except high-density lipoprotein cholesterol [HDL-C]), atherogenic indices, and liver enzymes (p < .05). Moreover, saffron could improve oxidative status (nitric oxide [NO] and malondialdehyde [MDA] reduced by 26.29% and 16.35%, respectively). Catalase (CAT) concentration remained unchanged. Saffron supplementation may alleviate T2DM by improving glycemic status, lipid profile, liver enzymes, and oxidative status. Further investigation is necessary to assess possible side effects and confirm the positive effect of saffron as a complementary therapy in clinical recommendations for T2DM.     

2型糖尿病患者胰岛素、血脂变化与冠心病的关系研究

目的通过对2型糖尿病患者的胰岛素、血脂等指标的检测来观察、比较、分析其与冠心病的关系。方法检测已确诊为2型糖尿病(T2DM)伴冠心病(CHD)患者56例的空腹血糖(FBG)、餐后2 h血糖(P2BG)、空腹胰岛素(FI NS)、餐后2 h胰岛素(PI NS2)、糖化血红蛋白(HbA1C)、24 h尿微量白蛋白(UMA)、三酰甘油(TG)、胆固醇(CHO)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算胰岛素抵抗指数(HOMA-IR),并与单纯2型糖尿病患者35例作对照。结果2型糖尿病伴冠心病患者在病程、HOMA-IR、TG、CHO和LDL-C水平均比对照组高(P0.01或0.05),HDL-C水平低于对照组(P0.05),FI NS、PI NS2、FBG、P2BG、HbA1C、UMA等均无显著性差异(P均0.05)。结论2型糖尿病伴冠心病患者存在明显胰岛素抵抗、脂代谢紊乱。控制血糖、改善脂代谢异常、减少胰岛素抵抗对预防和治疗2型糖尿病并发冠心病有指导意义。