Molecular diversity through sugar scaffolds

Monosaccharides provide an excellent platform to tailor molecular diversity by appending desired substituents at selected positions around the sugar scaffold. The presence of five functionalized and stereo-controlled centres on the sugar scaffolds gives the chemist plenty of scope to custom design molecules to a pharmacophore model. This review focuses on the peptidomimetic developments in this area, as well as the concept of tailoring structural and functional diversity in a library using carbohydrate scaffolds and how this can lead to increased hit rates and rapid identification of leads, which has promising prospects for drug development.     

身体动起来，血糖静下来

生命在于运动。对糖尿病病人来说，这句话还可以说得“严重”一点：寿命在于运动。动得好，能帮助控制病情．延长寿命。不动或瞎动，都可能会让生命长度打折扣。     

糖尿病患者围手术期的血糖控制及其疗效分析

目的探讨糖尿病患者围手术期血糖控制及其疗效影响因素.方法回顾分析8年间收治79例并发糖尿病的腹部外科手术患者的临床资料.结果79例糖尿病患者经积极有效的血糖控制,术前血糖为7.0～11.0mmol/L,术中血糖为8.3～13.9mmoL/L,术后血糖控制在7.8mmoL/L以下.术后切口感染2例,肺部感染3例,泌尿系统感染3例,所有病例未发生酮症酸中毒和死亡.结论糖尿病患者围手术期只要对血糖进行有效的控制和选择合理的麻醉方式,以防治感染,促进伤口愈合,完全可以达到理想的治疗效果.     

Dietary myo-inositol effect on sugar cataractogenesis

The lens myo-inositol (MI) content is known to be depleted during initial cataractogenesis in both streptozocin (STZ)-induced diabetic and 50% galactose-maintained rats. The objective of this study is to establish whether dietary MI supplementation protects lens transparency, MI content and individual fiber cell ultrastructure is both model systems of sugar cataract. In the diabetic study, after induction with STZ, rats were immediately placed on normal chow supplemented with 2% MI for 14 weeks while additional age-matched control and diabetic rats remained untreated. Within 14 weeks, untreated diabetic rat lenses were totally opaque with undetectable MI content; MI was undetectable by 1 month. These opaque lenses were devoid of fiber cells and exhibited only acellular, amorphous cortical regions between 0 and 500 microns from the capsule. In contrast, 14-week, MI-treated diabetic rat lenses exhibited only cortical vacuolation indicative of initial cataractogenesis; MI content was 0.41 +/- 0.26 mumol/g wet weight of lens. Scanning electron micrographs indicated a granulated, acellular region subadjacent to the capsule and confirmed the presence of cortical fiber cells, approximately 100 microns from the capsule. In 50% galactose-maintained rats, daily administration of MI for 1 month was unable to prevent total opacification or reverse initial cataractogenesis indicating that in rapidly progressing galactose cataracts, MI was unable to protect lens transparency, MI content and cortical fiber ultrastructure. The combined results suggest that MI may exert a protective effect on the slowly developing diabetic cataract. Of the 2 models, the time course and polyol content in STZ diabetic lenses more closely correlate to the human diabetic lens which has a low activity of aldose reductase; therefore, it is possible that MI may exert a protective effect in human diabetic cataract.     

红糖能补血吗？

“红糖补血”是一个流传很广的说法。如果一定要跟“血”联系的话，可能就是红糖中含有铁。其实，这又是一个误导。     

身体动起来,血糖静下来

生命在于运动。对糖尿病病人来说,这句话还可以说得"严重"一点:寿命在于运动。动得好,能帮助控制病情,延长寿命。不动或瞎动,都可能会让生命长度打折扣。     

把吃上去的血糖走下来

得了糖尿病,您就害怕运动了?专家认为,走路可是有奇效的。请看看李可基老师给出的糖尿病运动处方。