Clinical studies on treatment of acute cerebral infarction with Xueshuantong injection

Objective: To observe the effect of Xueshuantong injection (XST, with its ingredient as Notoginseng saponin, on acute cerebral infarction (ACI) and on blood coagulation and fibrinolysis, so as to comprehensively analyse the mechanism of XST.Methods: Fifty ACI patients were randomly divided into 2 groups, and XST group (30 patients) was treated with XST, and the control group (20 patients) given low molecular dextrose, as well as low molecular heparin calcium. The course of treatment for both groups was 15 days. The changes of effective rate, score of neurologic impairment, tissuetype plasminogen activator (tPA), inhibitor of plasminogen activator (PAI), D-D dimmer, antithrombinIII (AT-III), and fibrinogen (Fbg) were all observed.Results: The total effective rate of XST group was 73.33%, that of the control group 65. 00%. After the therapy, plasma level of tPA, ratio of tPA/PAI, and AT-III content were increased obviously, while the plasma level of PAI and D-D dimmer were decreased significantly (all P<0.01). But there was only insignificant difference between the 2 groups (P> 0.05).Conclusion: XST injection could be effective to ACI, the mechanism of which is probably related to improving the balance between plasminogen activator and its inhibitory factor, increasing the activity of fibrinolysin, inactivating thrombin, inhibiting platelet aggregation induced by thrombin, and decreasing blood coagulation.     

Clinical observation of the effect of Xuesaitong soft capsule on post-hepatitis fibrosis

Objective: To study the effect of Xuesaitong soft capsule (XST) on liver fibrosis criteria in patients with post-hepatitis fibrosis.Methods: Sixty-four patients with such fibrosis were randomly divided into the treated group and control group. They were treated with XST and Dahuang Zhechong pill for 3 months respectively. Their liver fibrosis criteria were examined before and after treatment.Results: The levels of serum procollagen III, hyaluronic acid, collagen IV, laminin in the two groups were significantly lower (P<0. 01) than those before treatment. The differences between the two groups were insignificant (P>0.05).Conclusion: XST could recover liver dysfunction and had anti-liver fibrosis function.     

Comparative study on the effects of small dose of aspirin combined with Ginkgo-damole injection and the effects of conventional dose of aspirin in treating senile unstable angina pectoris

Objective: To evaluate the therapeutic and adverse effect of small dose of aspirin (Asp) combined with Ginkgo-damole injection (GDI) in treating senile unstable angina pectoris (UA).Methods: One hundred and twenty old in-patients of coronary heart disease with UA were randomly divided into two groups. The 60 patients in the treated group were treated with oral administration of enteric soluble 50 mg Asp once a day and GDI 20 ml per day by intravenous dripping, with 14 days as one therapeutic course, while the other 60 in the control group were treated with enteric soluble Asp 100 mg alone once a day orally. Besides, isosorbide-5-mononitrate 20 mg twice a day was applied to both groups, and the β-adrenoceptor blocker, blood lipids regulatory agents and nitroglycerin (10 mg by intravenous dripping) were given accordingly. The angina total improving rate, hemorrheologic indexes (whole blood viscosity, plasma viscosity, fibrinogen, platelet aggregation rate), comprehensive clinical terminal event and the total occurrence rate of adverse reaction in the two groups were observed.Results: After treatment, comparison between the two groups showed insignificant difference in aspects of angina total improving rate (75.00% vs 65.00%), hemorrheological indexes and comprehensive clinical terminal event rate (25.00% vs 31.67%),P>0.05, and the hemorrheological indexes were improved in both groups (P<0.05), but the total occurrence rate of adverse reaction in the treated group was lower than that in the control group (6.67% vs 25.00%), showing significant difference (P<0.05).Conclusion: In treatment of senile UA, small dose of Asp combined with GDI showed therapeutic effect similar to that of conventional dose of Asp, but it has lower adverse reaction.     

Clinical study on effect of Xiaoyao Nose Drops in stopping episode of Migraine

Objective: To observe the effect of Xiaoyao Nose Drops (XYND) in stopping episode of migraine.Methods: Adopted was the randomized double-blinded placebo-controled method, with the 126 patients equally assigned to two groups, the treated group treated with XYND and the control group with placebo, and the therapeutic course was 30 days for all. The clinical total effective rate and effect in alleviating headache were observed. And hemorrheological parameters as well as the blood flow of the anterior cerebral artery (ACA), median cerebral artery (MCA) and posterior cerebral artery (PCA) were measured before and after treatment.Results: The clinical total effective rate and headache alleviating rate in the treated group were 93. 33% and 96. 67% respectively, while those in the control group were 18. 33% and 20.00% respectively, and comparison between the two groups showed significant difference (allP< 0.01). The blood viscosity (high, middle and low shear), plasma viscosity and fibrinogen got lowered significantly in the treated group after treatment, showing significant difference in comparison either with those before treatment or with those in the control group after treatment (P< 0.05 orP< 0.01). The velocity of blood flow in all cerebral arteries lowered significantly, also showing significant difference in comparison either with those before treatment or with those in the control group after treatment (P< 0.05 orP< 0.01).Conclusion: XYND is effective in stopping the headache of patients with migraine, and worth applying in clinical practice. Supported by Shandong Provincial Administration of Traditional Chinese Medicine (No. 200310)     

Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a

Objective: To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).Methods: Forty-five patients with CCA were assigned into two groups, the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA), and the 19 patients in the control group were treated with androgen alone, with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture, and the colony productivity of burst forming unit-erythroid (BFU-E), colony forming unit-erythroid (CFU-E) and colony forming unit-granulocyte macrophage (CFU-GM) in bone marrow were observed before and after 3 months treatment. The amount of erythrocyte and platelet infusion, frequency of infection, condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.Results: The total effective rate in the treated group was 84.6%, which was significantly higher than that in the control group (52.6 %,P< 0.05). Levels of hemoglobin, reticulocyte, neutrophil and platelet increased after treatment in the treated group, as compared with those before treatment, with significant difference (P< 0.05), and the colony productivity of BFU-E, CFU-E and CFU-GM in bone marrow also got significantly increased (P< 0.01), and showed significant difference from those in the control group (P< 0.05).Conclusion: Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA.     

维奈克拉联合小剂量阿柔比星、阿糖胞苷方案治疗老年急性髓系白血病的疗效观察

目的 探讨维奈克拉联合小剂量阿柔比星、阿糖胞苷(AA)方案治疗老年急性髓系白血病(AML)的疗效。方法 回顾性分析2017年2月—2020年12月青海省人民医院治疗的83例老年AML患者的临床资料。其中,62例采用小剂量阿柔比星、阿糖胞苷治疗作为对照组,21例采用维奈克拉联合小剂量AA方案治疗作为研究组。比较两组近期疗效、外周血p53含量,观察两组不良反应及血制品输注情况,分析两组治疗期间药物安全性及治疗后6个月生存情况。结果 研究组客观缓解率高于对照组(P <0.05)。研究组治疗前后p53的差值高于对照组(P <0.05)。研究组粒细胞缺乏时间、血小板计数<20×10⁹/L时间短于对照组(P <0.05),细胞输注量、血小板输注量少于对照组(P <0.05)。两组感染、皮疹、肝功能损伤、胃肠道反应发生率比较,差异均无统计学意义(P>0.05)。研究组死亡1例,对照组死亡7例;两组患者总存活率曲线比较,差异无统计学意义(P>0.05)。结论 维奈克拉联合小剂量AA方案治疗老年AML疗效显著,且安全可靠。     

奥扎格雷钠治疗急性脑梗死60例疗效观察

目的观察奥扎格雷钠治疗急性脑梗死(ACI)的疗效和不良反应。方法 108例ACI分为治疗组(60例)和对照组(48例),治疗组静脉滴注奥扎格雷80 mg,1次/d;对照组静脉滴注维脑路通600 mg,1次/d,疗程均为14 d,观察两组患者治疗前后临床神经功能缺损程度评分,血流变学及血脂变化,进行自身比较和相互比较。结果治疗组总有效率为93.3%;明显高于对照组的73%(P<0.05)。治疗组全血高切粘度(HSR)、血浆粘度(HP)、红细胞聚集指数、红细胞压积(HCT)、甘油三酯(TG)比治疗前明显降低(P<0.01),并低于对照组(P<0.05),两组血小板计数(PLT)、血胆固醇(TC)与治疗前相比差异无统计学意义(均P>0.05),两组均无明显不良反应。结论奥扎格雷是治疗急性脑梗死(ACI)的有效药物,值得临床推广使用。     

Study of interference treatment by Xuesaitong soft capsule on patients of nephrosis syndrome with Qi deficiency and blood stasis during dose reducing stage of corticosteroid

Objective: To observe the effect of Xuesaitong (XST) soft capsule in interference treatment on patients of nephrosis syndrome (NS) during corticosteroid (CS) dose reducing stage.Methods: Seventy-one NS patients applying prednisone and initiating dose reducing stage were randomized into trial group and control group. On the basis of conventional prednisone dose reduction of both groups, the trial group was given additionally XST, and the treatment course ended with the reduction to maintenance dose. In the course of observation, those who did not comply with the criteria of observation were excluded. Before and after the dose reduction, TCM syndrome scoring, 24 hrs urinary protein amount, blood β₂-microglobulin (β₂-MG), urinary β₂-MG, blood fibrinogen (Fbg), plasma prothrombin time (PT), blood lipid, etc. were observed.Results: The trial group of XST could obviously lower their urinary protein amount and blood lipid level (P<0.05 orP<0.01), markedly improve the blood coagulation parameters (P<0.01), improve the TCM syndrome and CS induced adverse reaction (P<0.05 orP<0.01), also obviously reduced the recurrence rate of NS (P<0.05).Conclusion: XST could obviously improve the clinical symptoms and renal impairment parameters in NS patients during CS dose reduction stage, improve the CS induced adverse reaction and prevent the recurrence of NS.     

Efficacy observation on Yunnan Baiyao () combined with antibiotics in treating Helicobacter pylori related duodenal ulcer) combined with antibiotics in treating Helicobacter pylori related duodenal ulcer

Objective: To observe the clinical efficacy of Yunnan Baiyao ( , YNBY) combined with antibiotics in treating Helicobacter pylori (HP) related duodenal ulcer (DU).Methods: Eighty-two HP positive DU patients were randomly divided into two groups: Treated group (44 cases) used YNBY plus amoxicillin and metronidazole; control group (38 cases) used de-nol plus amoxicillin and metronidazole).Results: After a 2-week treatment course, the effect of epigastric pain relief was 68.3% in treated group, and 44.4% in control group, the difference between them was significant (P < 0.05). Marked effect in acid regurgitation and belching relief was observed in both groups. The rate of DU healing in treated and control group was respectively 88.6% and 89.5%; the clearance of HP 84.1% and 89.5%; and the side-effects 4.5% and 13.5%, with insignificant difference between these two groups.Conclusion: YNBY combined with antibiotics in treating DU, and clearance of HP is an economic, safe and effective therapy.     

Study on Tongkuaixiao Babu plaster in treating cancer pain

Objective: To explore the efficacy of Tongkuaixiao Babu plaster (TKXBBP) in treating cancer pain.Methods: In the clinical observation, sixty-five patients with moderate or severe cancer pain were randomly divided into two groups: 32 in the treated group (TKXBBP group) and 33 in the control group (Bucinnazine group). The therapeutic effects in relieving pain, improving quality of life (QOL), and the rate of satisfaction the patients felt of the two groups were compared respectively. Results: TKXBBP was effective in treating cancer pain. There wasn’t any statistically significant difference in total effective rate (P>0.05), but the statistical difference was significant in obvious remission rate (P<0.05) between the treated and control group, and the effect on serious pain shown in the treated group was better than that of the control group (P<0. 05). The difference in the initiation time of relieving cancer pain was insignificant (P>0.05), while in the remission period, the treated group showed its treatment was obviously superior to that of the control group (P<0.05). TKXBBP showed better effect in the improvement of QOL (P<0.05) and satisfaction rate, with significant difference between the treated and the control groups (P<0.01).Conclusion: TKXBBPs effect in treating cancer pain was obvious, its application was safe and convenient. It was shown that the external treatment with this kind of Chinese medicine had great advantage in treating cancer pain.     

急性脑梗死患者颈动脉内膜中层厚度性别差异性研究

目的 探究急性脑梗死患者颈动脉内膜中层厚度(intima-media thickness,IMT)的性别差异,为脑梗死患者诊断和防治的性别差异提供参考。方法 选择急性脑梗死患者193例,依据性别将193例急性脑梗死患者分为两组:男性急性脑梗死组94例,女性急性脑梗死组99例。检测两组受试者血浆同型半胱氨酸(homocysteine,Hcy)、总胆固醇(total cholesterol,TC)、甘油三酯(triglycerides,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,HDL-C)水平,采用彩色多普勒超声测定两组受试者颈动脉IMT,比较两组间各指标的差异,分析颈动脉IMT性别差异性原因。结果 男性急性脑梗死患者组颈动脉IMT较女性急性脑梗死组厚,差异有统计学意义(P<0.05);男性急性脑梗死组血浆Hcy水平、LDL-C水平及吸烟率均高于女性急性脑梗死组,差异有统计学意义(P<0.05);女性急性脑梗死组HDL-C水平高于男性急性脑梗死组,差异有统计学意义(P=0.000);多变量Logistic回归显示血浆高Hcy、LDL-C水平,高吸烟率以及低血浆HDL-C与男性显著相关(P<0.05);多元线性回归分析进一步揭示男性、年龄、Hcy、吸烟与颈动脉IMT独立相关。结论 男性急性脑梗死患者组颈动脉IMT较女性急性脑梗死组厚,这可能与血浆Hcy水平、吸烟不良行为密切相关。     

肺癌相关肺动脉高压患者临床特点及相关因素分析

目的 通过病例对照研究了解肺癌相关肺动脉高压患者临床特点,并对其相关因素进行分析。方法 随机选取肺癌伴发肺动脉高压患者128例作为病例组,选取128例性别相同、年龄相差3岁以内的肺癌不伴发肺动脉高压患者进行1∶ 1病例对照研究,采用SPSS19.0统计学软件进行单因素和多元Logistic回归分析。结果 两组在临床症状上差异有统计学意义;肺癌伴发肺动脉高压易于发生于腺癌患者（P=0.019）,肿瘤转移患者（68.75% vs 45.31%）,肺内肿瘤转移患者（39.06% vs 3.91%）;肿瘤淋巴结转移患者（P=0.000）;容易表现出出血倾向（27.34% vs 1.56%）;D-二聚体和纤维蛋白原定量升高;血小板升高（34.38% vs 15.67%）;肺动脉主干内径增宽（24.22±2.59mm vs 20.75±2.09mm）;肺部磨玻璃样改变;对抗癌治疗的效果差。多元Logistic回归分析显示纤维蛋白原定量升高（OR=2.524,95% CI：1.171~5.441,P=0.000）及血小板计数升高（OR=3.21,95% CI：1.509~6.832,P=0.003）是危险因素,而治疗后呼吸困难等临床表现好转（OR=0.038,95% CI：0.014~0.107,P=0.000）是保护因素。结论 肺癌伴发肺动脉高压好发于腺癌、肿瘤细胞转移和淋巴结肿瘤细胞转移患者;易发生出血倾向、D-二聚体升高、纤维蛋白原计量升高、血小板计数升高、右心衰竭、肺部磨玻璃样间质改变。纤维蛋白原定量升高、血小板计数升高是肺癌伴发肺动脉高压的独立危险因素,治疗后呼吸困难好转是保护因素。     

Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis

Objective: To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXGs therapeutic mechanism.Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group (n = 60) and control group (n = 30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest, low purine diet, sufficient water drinking and urine alkalization, etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models.Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won, insignificant difference (P>0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group was 10.0%, with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice.Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects, proving to be superior to single drugs. Supported by Project of Science and Technology Commission Foundation of Jiangsu Province in 1998;     

尤瑞克林联合阿替普酶静脉溶栓对急性脑梗死患者神经功能及血液流变学的影响

目的 探究尤瑞克林联合阿替普酶静脉溶栓对急性脑梗死患者神经功能及血液流变学的影响。方法 选取2018年1月—2021年12月萍乡矿业集团有限责任公司总医院收治的126例急性脑梗死患者作为研究对象。将患者分为研究组和对照组,每组63例。对照组予以阿替普酶静脉溶栓,研究组在对照组基础上联合尤瑞克林治疗,两组患者均于治疗14 d后检测血液流变学指标,评估神经功能、日常生活能力、临床疗效及药物毒性。结果 研究组治疗前后全血黏度、血浆黏度、血小板聚集率及红细胞压积的差值高于对照组（P <0.05）。研究组治疗后NIHSS评分低于对照组（P <0.05）。研究组MRS评分评估预后良好率,治疗前后ADL、BI的差值高于对照组（P <0.05）。研究组临床有效率高于对照组（P <0.05）。两组不良反应发生率比较,差异无统计学意义（P>0.05）。结论 尤瑞克林联合阿替普酶有助于改善急性脑梗死患者血液流变学状态和神经功能,提升治疗后患者日常生活能力且安全性良好。     

Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel

Objective: To study the clinical effect of Fuzheng Jiedu granule (FJG) and its influence on serum nitric oxide (NO), nitric oxide synthase (NOS) and microelements in patients with coronary heart disease who are in long-term contact with nickel.Methods: Sixty patients were randomly divided into two groups, the treated group and the control group, 30 in each group. Conventional Western medicinal treatment was applied to both groups, but to the treated group, FJG was given additionally by oral intake, and the therapeutic course for both groups was 4 weeks. Besides, a health control group was set up with 15 healthy subjects selected from the same area, who had no history of contact with nickel. Clinical symptoms of the patients and changes in their electrocardiogram (ECG) and serum levels of NO, NOS and microelements were observed before and after treatment.Results: The total effective rate on clinical symptoms in the treated group was 93.3% and that in the control group 63.3%, comparison between the two showing significant difference (P<0.05); the total effective rate on ECG in the two groups was 90.0% and 56.7% respectively, which also showed significant difference (P<0.05). After treatment, levels of serum NO, NOS, Mg, Zn and Ca increased and those of Ni, Mn and Fe decreased significantly (P<0.05 orP<0.01) in the treated group, while in the control group, changes in these laboratory indexes were insignificant.Conclusion: FJG could lower the blood nickel level and regulate the unbalance of microelements, help restore serum NO and NOS in persons exposed to nickel and improve the clinical symptoms of patients with coronary heart disease and in long-term contact with nickel. Project supported by Scientific Research Fund Item of Gansu Provincial Education Department (No. 023-01)     

制霉菌素联合光动力抗菌疗法治疗口腔念珠菌病的疗效及安全性分析

目的探讨制霉菌素联合光动力抗菌疗法治疗口腔念珠菌病的疗效及安全性。方法选取2018年3月—2020年4月新疆医科大学第五附属医院口腔科收治的86例口腔念珠菌病患者,按照随机分组方法分为对照组和研究组,每组43例。对照组接受制霉菌素口服50万u/次,3次/d,研究组在对照组基础上联合光动力抗菌疗法,每隔24 h光疗1次,均治疗1周。对比两组临床疗效、安全性、治疗前后念珠菌菌数、复发率。结果研究组总有效率高于对照组(P <0.05)。治疗前两组念珠菌菌数比较,差异无统计学意义(P>0.05);治疗后研究组念珠菌菌数低于对照组(P <0.05)。治疗后两组念珠菌菌数均低于治疗前(P <0.05)。研究组复发率低于对照组(P <0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论制霉菌素联合光动力抗菌疗法治疗口腔念珠菌病疗效显著,可降低复发率及念珠菌菌数,且安全可靠。     

Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura

Objective: To observe the clinical effect of Shengxueling (SXL) on idiopathic thrombocytopenic purpura (ITP), and study the possible mechanism.Methods: Eighty-six cases of ITP were randomly divided into two groups. The SXL group, 56 patients treated with SXL, a traditinal Chinese medicine and 30 patients administered with prednisone were taken as control. Each group took drugs for 3 months and was under follow-up observation.Results: In the SXL group, the total effective rate was 85. 71%, similar to prednisone 83. 33%(P>0. 05) for 3 months, but the total effective rate of SXL (91.07%) were obviously better than that of the control group (53. 33%) (P<0.01) for 6 months and had no obvious adverse reaction. The patients bleeding was alleviated or stopped, the general condition was improved. At the same time, blood platelet count (PLT) was increased, platelet associated immunoglobulin (PAIg) and interleukin-4 (IL-4) were markedly dropped, the level of natural killers cells activity (NKa) increased, the rate of T lymphocyte subsets gradually returned to normal level. Megakaryocyte tended to maturation on bone marrow smear after treatment. All differences above were statistically significant.Conclusion: SXL is an effective and safe medicine for ITP. Its mechanism could regulate cytoimmune, inhibit platelet antibody to reduce the destruction of platelet, increase the number of platelet, promote the division and maturation of megakaryocyte, facilitate the production and release of platelet, lower the fragility of capillary, prevent and cure hemorrhagic tendency.     

血府逐瘀胶囊治疗血瘀型肺心病的临床疗效

目的:观察血府逐瘀胶囊对血瘀型肺心病的治疗效果。方法:40例血瘀型肺心病患者随机分为两组,在常规治疗同时,治疗组使用血府逐瘀胶囊,对照组使用肠溶阿斯匹林,28～30d为1个疗程,将治疗前后症状、体征及血常规、血流变检查进行记录。结果:治疗组总有效率为95%,对照组总有效率为70%,两组比较有显着性差异,P<0.05.两组血流变、血小板、纤维蛋白原均有改善,两组比较有显着性差异,P<0.05。结论:血府逐瘀胶囊为治疗血瘀型肺心病提供了有效的方法,且安全、有效、不良反应少。     

Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV

Objective: To observe and compare the effect of traditional Chinese medicine (TCM) combined with chemotherapy (CT) on immune function and quality of life (QOL)of patients with non-small cell lung cancer (NSCLC) in stage III-IV.Methods: One hundred cases with stage III-IV NSCLC were randomly divided into two groups. The treated group (n = 50) received CT combined with TCM, and the control group received CT alone. The percentage of T lymphocyte subset in peripheral blood and the change of natural killer (NK) cell count were observed after treatment. The QOL and tolerance of CT were also compared between the two groups after treatment. Results: In the treated group, CD₃ cell count, CD₄ cell count, CD₄/ CD₈ ratio and NK cell activity were higher than those in control group, while CD₈ cell count in the treated group was lower than that in the control group (P<0.05), and QOL and tolerance of CT in the treated group were also better (P<0.05).Conclusion: TCM combined with CT could raise the patients’ ability in tolerating CT in stage III-IV NSCLC.     

法安明联合阿司匹林治疗不同类型高凝状态复发性流产疗效

目的 研究法安明联合阿司匹林在治疗高凝状态复发性流产中的价值,探讨不同类型高凝状态的疗效和并发症差异。方法 选取2011年5月~2014年5月高凝状态[D-二聚体升高和（或）血小板聚集率升高]复发性流产患者283例,均推荐采用法安明联合阿司匹林治疗。剔除随访失败患者16例,共267例患者纳入研究,其中同意采用的患者共216例,拒绝采用该方案的患者共51例。此外根据高凝状态指标差异,将同意治疗患者分为D-二聚体升高组（HD）、血小板聚集率升高组（HP）、D-二聚体和血小板聚集率均升高组（HD+HP）。同意治疗的患者,在排卵期准备同房前一天开始采用法安明（5000IU）联合小剂量阿司匹林（25mg）治疗。比较治疗组与对照组患者的妊娠结局的差异,同时分析治疗组患者各亚组间的妊娠结局和并发症的差别。结果 治疗组和对照组的的妊娠成功率分别86.11%和43.13%,两组相比差异有统计学意义（P<0.05）。治疗组组内比较发现,HD和HP组的妊娠成功率为91.25%和88.89%,两组比较差异有统计学意义（P>0.05）。HD+HP组的妊娠成功率为76.56%,与HD及HP组相比,差异有统计学意义（P<0.05）。结论 法安明联合阿司匹林是治疗高凝状态复发性流产的安全有效方法,其单纯D-二聚体升高或血小板聚集率升高患者的疗效优于两者均升高的患者。