黄芪注射液联合普米克令舒雾化吸入治疗小儿毛细支气管炎疗效观察

目的 探讨黄芪注射液联合普米克令舒雾化吸入治疗小儿毛细支气管炎疗效。方法 将107例毛细支气管炎患儿随机分为两组，在常规治疗的基础上，治疗组加用黄芪注射液联合普米克令舒雾化吸入，2次／d，共5d；对照组加用病毒唑注射液联合普米克令舒雾化吸入，2次／d，共5d。结果 治疗组患儿咳嗽、喘憋、紫绀、肺部哆音吸收时间均明显短于对照组；治疗组临床控制率明显高于对照组（χ^2=9．697，P〈0．01），差异有统计学意义。结论 黄芪注射液联合普米克令舒雾化吸入治疗小儿毛细支气管炎疗效满意，值得临床推广。     

普米克令舒雾化佐治毛细支气管炎50例

目的:观察普米克令舒压缩雾化吸入辅助治疗毛细支气管炎的临床疗效。方法:将101例描写毛细支气管炎患儿随机分成两组,在这综合治疗基础上加用普米克令舒压缩雾化吸入,对照组用生理盐水雾化吸入1个疗程均为5d。结果:总有效率治疗组92%,对照组64%,两组比较差异有显著性(P<0.01)。结论:普米克令舒压缩雾化吸入治疗毛细支气管炎疗效确切,方法简便副作用小,值得临床推广。     

普米克令舒、万托林联合雾化吸入治疗毛细支气管炎42例疗效观察

目的探讨普米克令舒、万托林雾化吸入治疗毛细支气管炎的临床疗效。方法对住院42例毛细支气管炎患儿采用普米克令舒、万托林雾化吸入治疗。方法和剂量为普米克令舒1ml（0．5mg）、万托林0．5ml（0．25mg）加入生理盐水20ml雾化吸入,每天2次,进行临床疗效评价。结果有效率92．9％,无不良反应。结论普米克令舒、万托林联合雾化吸入能迅速改善毛细支气管炎症状,缩短疗程。     

普米克令舒雾化吸入治疗毛细支气管炎疗效观察

目的:探讨普米克令舒雾化吸入治疗毛细支气管炎患儿的疗效。方法:将符合诊断标准毛细支气管炎患儿60例随机分为治疗组30例、对照组30例。两组均予抗感染、止咳化痰、补液、吸氧等治疗。治疗组给予普米克令舒加入微量气泵雾化吸入,2次/日。结果:治疗组疗效明显,总有效率与对照组比较差异有统计学意义(χ2=5.963,P<0.05)。结论:普米克令舒雾化吸入治疗毛细支气管炎疗效可靠,值得临床推广。     

普米克令舒与沐舒坦治疗毛细支气管炎疗效观察

目的观察普米克令舒和沐舒坦雾化吸入治疗毛细支气管炎的疗效。方法将80例毛细支气管炎患儿随机分为2组,2组均采用综合治疗。治疗组40例,给予雾化吸入普米克令舒和沐舒坦;对照组40例,采用α糜蛋白酶＋α干扰素＋地塞米松雾化吸入治疗。观察2组患儿用药前后症状、体征改善情况。结果治疗组使用普米克令舒和沐舒坦雾化吸入,体征改善,疗程缩短,总有效率为87.5%,对照组总有效率为62.5%.结论对毛细支气管炎患儿采用普米克令舒和沐舒坦雾化吸入疗效好,方便安全。     

普米克令舒、沙丁胺醇吸入治疗毛细支气管炎疗效观察

目的探讨普米克令舒、沙丁胺醇氧气雾化吸入治疗毛细支气管炎的疗效。方法将68例毛细支气管炎患儿随机分为治疗组及对照组各34例，两组均采用综合治疗，治疗组加用普米克令舒、沙丁胺醇雾化液氧气雾化吸入，对两组治疗后的临床症状、体征改善及疗效进行比较。结果治疗组在缓解喘憋、缩短哮鸣音及住院时间与对照组差异有显著性（P〈0．05）；治疗组总有效率高于对照组，有显著性差异（P〈0．01）。结论普米克令舒、沙丁胺醇雾化液氧气雾化吸入治疗毛细支气管炎有明显疗效，且安全方便，可作为佐治毛细支气管炎的主要方法之一。     

博利康尼和普米克令舒雾化吸入佐治毛细支气管炎疗效观察

目的 观察博利康尼和普米克令舒雾化吸入佐治毛细支气管炎疗效.方法 将61例毛细支气管炎的患儿分为治疗组31例,给予博利康尼和普米克令舒雾化吸入治疗;对照组30例,给予常规抗病毒、吸氧、止咳、化痰、镇静等对症治疗,分别观察疗效.结果 治疗组疗效优于对照组.结论 博利康尼和普米克令舒雾化吸入佐治毛细支气管炎可以缩短毛细支气管炎的病程及住院时间.     

氧驱雾化吸入普米克令舒佐治婴幼儿毛细支气管炎疗效观察

目的观察普米克令舒氧驱雾化吸入佐治婴幼儿毛细支气管炎的临床疗效.方法70例毛细支气管炎患儿随机分为两组,治疗组35例在常规治疗的基础上辅以普米克令舒氧驱雾化吸入,对照组35例仅进行常规治疗.结果治疗组和对照组两组疗效采用行×列x2检验比较,P＜0.01.结论普米克令舒氧驱雾化吸入佐治婴幼儿毛细支气管炎疗效显著,方便安全.     

氧气驱动雾化吸入普米克令舒及博利康尼治疗毛细支气管炎42例疗效观察

目的探讨普米克令舒及博利康尼混悬液氧气驱动雾化吸入治疗毛细支气管炎的疗效。方法将82例毛细支气管炎患儿随机分为两组，两组均采用综合治疗，观察组用普米克令舒及博利康尼混悬液雾化吸入，对照组采用病毒唑＋α-靡蛋白酶＋地塞米松雾化吸入。对治疗后症状体征持续时间，病情治愈好转率进行比较。结果观察组治愈率、缓解咳嗽、喘憋及缩短哮鸣音持续时间均明显优于对照组（P〈0．01）。结论氧气驱动雾化吸入普米克令舒及博利康尼混悬液治疗毛细支气管炎疗效好、方便、安全。     

氧驱雾化吸入普米克令舒佐治婴幼儿毛细支气管炎疗效观察

目的:观察普米克令舒氧驱雾化吸入佐治婴幼儿毛细支气管炎的临床疗效。方法:70例毛细支气管炎患儿随机分为两组,治疗组35例在常规治疗的基础上辅以普米克令舒氧驱雾化吸入,对照组35例仅进行常规治疗。结果:治疗组和对照组两组疗效采用行×列x2检验比较,P<0.01。结论:普米克令舒氧驱雾化吸入佐治婴幼儿毛细支气管炎疗效显著,方便安全。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.