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Development of quality indicators to evaluate antibiotic treatment of patients with community‐acquired pneumonia in Indonesia
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Helmia Farida Angelique Rondags M. Hussein Gasem Katharina Leong A. Adityana Peterhans J. van den Broek Monique Keuter Stephanie Natsch 《Tropical medicine & international health : TM & IH》2015,20(4):501-509
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Participation in medical research as a resource‐seeking strategy in socio‐economically vulnerable communities: call for research and action
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Raffaella M. Ravinetto Muhammed O. Afolabi Joseph Okebe Jennifer Ilo Van Nuil Pascal Lutumba Hypolite Muhindo Mavoko Alain Nahum Halidou Tinto Adamu Addissie Umberto D'Alessandro Koen Peeters Grietens 《Tropical medicine & international health : TM & IH》2015,20(1):63-66
The freedom to consent to participate in medical research is a complex subject, particularly in socio‐economically vulnerable communities, where numerous factors may limit the efficacy of the informed consent process. Informal consultation among members of the Switching the Poles Clinical Research Network coming from various sub‐Saharan African countries, that is Burkina Faso, The Gambia, Rwanda, Ethiopia, the Democratic Republic of Congo (DRC) and Benin, seems to support the hypothesis that in socio‐economical vulnerable communities with inadequate access to health care, the decision to participate in research is often taken irrespectively of the contents of the informed consent interview, and it is largely driven by the opportunity to access free or better quality care and other indirect benefits. Populations' vulnerability due to poverty and/or social exclusion should obviously not lead to exclusion from medical research, which is most often crucially needed to address their health problems. Nonetheless, to reduce the possibility of exploitation, there is the need to further investigate the complex links between socio‐economical vulnerability, access to health care and individual freedom to decide on participation in medical research. This needs bringing together clinical researchers, social scientists and bioethicists in transdisciplinary collaborative research efforts that require the collective input from researchers, research sponsors and funders. 相似文献
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Caleb D. Ebert Tigist Astale Eshetu Sata Mulat Zerihun Andrew W. Nute Aisha E. P. Stewart Demelash Gessese Gedefaw Ayenew Zebene Ayele Berhanu Melak Melsew Chanyalew Bizuayehu Gashaw Zerihun Tadesse E. Kelly Callahan Samuel M. Jenness Scott D. Nash 《Tropical medicine & international health : TM & IH》2019,24(4):493-501
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Lisa F. Langhaug Lorraine Sherr Frances M. Cowan 《Tropical medicine & international health : TM & IH》2010,15(3):362-381
Objectives To systematically review comparative research from developing countries on the effects of questionnaire delivery mode. Methods We searched Medline, EMbase and PsychINFO and ISSTDR conference proceedings. Randomized control trials and quasi‐experimental studies were included if they compared two or more questionnaire delivery modes, were conducted in a developing country, reported on sexual behaviours and occurred after 1980. Results A total of 28 articles reporting on 26 studies met the inclusion criteria. Heterogeneity of reported trial outcomes between studies made it inappropriate to combine trial outcomes. Eighteen studies compared audio computer‐assisted survey instruments (ACASI) or its derivatives [personal digital assistant (PDA) or computer‐assisted personal interview (CAPI)] against another self‐administered questionnaires, face‐to‐face interviews or random response technique. Despite wide variation in geography and populations sampled, there was strong evidence that computer‐assisted interviews lowered item‐response rates and raised rates of reporting sensitive behaviours. ACASI also improved data entry quality. A wide range of sexual behaviours were reported including vaginal, oral, anal and/or forced sex, age of sexual debut, condom use at first and/or last sex. Validation of self‐reports using biomarkers was rare. Conclusions These data reaffirm that questionnaire delivery modes do affect self‐reported sexual behaviours and that use of ACASI can significantly reduce reporting bias. Its acceptability and feasibility in developing country settings should encourage researchers to consider its use when conducting sexual health research. Triangulation of self‐reported data using biomarkers is recommended. Standardizing sexual behaviour measures would allow for meta‐analysis. 相似文献
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Alexander K. Rowe Dawn M. Osterholt Julien Kouamé Emily Piercefield Karen M. Herman Faustin Onikpo Marcel Lama Michael S. Deming 《Tropical medicine & international health : TM & IH》2012,17(4):438-446
Objective Training health workers to use Integrated Management of Childhood Illness (IMCI) guidelines can improve care for ill children in outpatient settings in developing countries. However, even after IMCI training, important performance gaps exist. One potential reason is that the effect of training can rapidly wane. Our aim was to determine if the performance of IMCI‐trained health workers deteriorated over 3 years. Methods We studied two departments in Benin. First, we performed a record review of 32 IMCI‐trained health workers during the first year of IMCI implementation (2001–2002). Second, we analysed data from cross‐sectional health facility surveys from 2001 to 2004 that represented the entire study area. Primary outcomes were the proportion of children under 5 years old with potentially life‐threatening illnesses who received either recommended or adequate treatment, and among all children, an index of overall guideline adherence. Secondary outcomes reflected the treatment of individual diseases. Outcomes were calculated monthly, and time trends were evaluated with regression modelling. Results The record review included 9393 consultations, and the surveys included 411 consultations performed by 105 health workers. For both data sources, performance trends were essentially flat for nearly all outcomes. Absolute levels of performance revealed substantial performance gaps. Conclusions We found no evidence that performance declined over 3 years after IMCI training. However, important performance gaps found immediately after IMCI training persisted and should be addressed. 相似文献
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Vincent De Brouwere Fabienne Richard Sophie Witter 《Tropical medicine & international health : TM & IH》2010,15(8):901-909
The huge majority of the annual 6.3 million perinatal deaths and half a million maternal deaths take place in developing countries and are avoidable. However, most of the interventions aiming at reducing perinatal and maternal deaths need a health care system offering appropriate antenatal care and quality delivery care, including basic and comprehensive emergency obstetric care facilities. To promote the uptake of quality care, there are two possible approaches: influencing the demand and/or the supply of care. Five lessons emerged from experiences. First, it is difficult to obtain robust evidence of the effects of a particular intervention in a context, where they are always associated with other interventions. Second, the interventions tend to have relatively modest short‐term impacts, when they address only part of the health system. Third, the long‐term effects of an intervention on the whole health system are uncertain. Fourth, because newborn health is intimately linked with maternal health, it is of paramount importance to organise the continuum of care between mother and newborn. Finally, the transfer of experiences is delicate, and an intervention package that has proved to have a positive effect in one setting may have very different effects in other settings. 相似文献
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Edward Fottrell Kathleen Kahn Nawi Ng Benn Sartorius Dao Lan Huong Hoang Van Minh Mesganaw Fantahun Peter Byass 《Tropical medicine & international health : TM & IH》2010,15(10):1256-1265
Objective To demonstrate the viability and value of comparing cause‐specific mortality across four socioeconomically and culturally diverse settings using a completely standardised approach to VA interpretation. Methods Deaths occurring between 1999 and 2004 in Butajira (Ethiopia), Agincourt (South Africa), FilaBavi (Vietnam) and Purworejo (Indonesia) health and socio‐demographic surveillance sites were identified. VA interviews were successfully conducted with the caregivers of the deceased to elicit information on signs and symptoms preceding death. The information gathered was interpreted using the InterVA method to derive population cause‐specific mortality fractions for each of the four settings. Results The mortality profiles derived from 4784 deaths using InterVA illustrate the potential of the method to characterise sub‐national profiles well. The derived mortality patterns illustrate four populations with plausible, markedly different disease profiles, apparently at different stages of health transition. Conclusions Given the standardised method of VA interpretation, the observed differences in mortality cannot be because of local differences in assigning cause of death. Standardised, fit‐for‐purpose methods are needed to measure population health and changes in mortality patterns so that appropriate health policy and programmes can be designed, implemented and evaluated over time and place. The InterVA approach overcomes several longstanding limitations of existing methods and represents a valuable tool for health planners and researchers in resource‐poor settings. 相似文献
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Chronic hepatitis C virus infection affects around 150 million persons, and 350,000 persons worldwide die of this disease each year. Although the data on its natural history are incomplete, after the acute infection, most patients develop chronic forms of hepatitis C with variable stages of fibrosis. In these patients, continual inflammatory activity can cause significant fibrosis, cirrhosis, decompensation of the liver disease, or hepatocarcinoma. In the next few years, it is expected that hepatitis C virus infection and its complications will significantly increase, as will the incidence of hepatocarcinoma in Spain. This review presents the data on the natural history of hepatitis C virus infection and discusses the potential impact of antiviral therapy on the distinct stages of the disease. 相似文献
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Equity dimensions of the availability and quality of reproductive,maternal and neonatal health services in Zambia
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Lily D. Yan Jonas Mwale Samantha Straitz Godfrey Biemba Zulfiqar Bhutta Julia F. Ross Lawrence Mwananyanda Mary Nambao Paul Ngwakum Eleonora Genovese Bowen Banda Nadia Akseer Kojo Yeboah‐Antwi Peter C. Rockers Davidson H. Hamer 《Tropical medicine & international health : TM & IH》2018,23(4):433-445
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Rosanne W. Wieten Wytze Vlietstra Abraham Goorhuis Michèle van Vugt Caspar J. Hodiamont Tjalling Leenstra Peter J. de Vries Saskia Janssen Pieter P. van Thiel Kees Stijnis Martin P. Grobusch 《Tropical medicine & international health : TM & IH》2012,17(8):1023-1030
Objectives The aim of this study was to assess the applicability and benefits of the new WHO dengue fever guidelines in clinical practice, for returning travellers. Methods We compared differences in specificity and sensitivity between the old and the new guidelines for diagnosing dengue and assessed the usefulness in predicting the clinical course of the disease. Also, we investigated whether hypertension, diabetes or allergies, ethnicity or high age influenced the course of disease. Results In our setting, the old classification, compared with the new, had a marginally higher sensitivity for diagnosing dengue. The new classification had a slightly higher specificity and was less rigid. Patients with dengue who had warning signs as postulated in the new classification were admitted more often than those who had no warning signs (RR, 8.09 [1.80–35.48]). We did not find ethnicity, age, hypertension, diabetes mellitus or allergies to be predictive of the clinical course. Conclusions In our cohort of returned travellers, the new classification system did not differ in sensitivity and specificity from the old system to a clinically relevant degree. The guidelines did not improve identification of severe disease. 相似文献