米索前列醇的临床药理作用

米索前列醇(misoprostol)商品名喜克溃(cytotec),是美国西尔公司研制的一种类似前列腺素E1的药物,用于治疗十二指肠溃疡和胃溃疡,以及因服用非甾体类抗炎药(NSAID)诱发的消化性溃疡,亦用于耳呜及终止早期妊娠.     

北京大学临床药理研究所简介

北京大学临床药理研究所(又称北京大学第一医院临床药理研究所)成立于1980年,是全国第一个创建的临床药理研究所,是我国临床药理研究高级学术机构,也是国内最早开展药物临床试验的单位之一。卫生部1983年在研究所建立临床药理基地,并指定为卫生部临床药理培训中心之一,是我国最早的卫生部抗感染药物临床药理研究基地。1995年国家科委、卫生部和国家医     

银翘散的临床药理

银翘散的药理试验研究表明具有解热镇痛、抗炎、抗过敏、抗菌、抗病毒作用。方中各组成成分的药理研究证实了银翘散的药理作用,同时也验证了银翘散组方的合理。     

伊贝沙坦的临床药理

伊贝沙坦是一种血管紧张Ⅱ受体拮抗剂,比血管紧张素转化酶抑制剂(ACEI)具有更多优点,其耐受性更佳。本文就伊贝沙坦的临床药理作一概述。     

孕激素的临床应用

新一代孕激素的开发不仅降低了传统孕激素的不良反应,而且特异性更强,临床疗效更好.本文对近年来孕激素在临床中的应用进展作一综述.     

北京大学临床药理研究所简介

北京大学临床药理研究所(又称北京大学第一医院临床药理研究所)成立于1980年,是全国第一个创建的临床药理研究所,是我国临床药理研究高级学术机构,也是国内最早开展药物临床试验的单位之一。卫生部1983年在研究所建立临床药理基地,并指定为卫生部临床药理培训中心之一,是我国最早的卫生部抗感染药物临床药理研究基地。1995年国家科委、卫生部和国家医药管理局共同确定在北京大学临床药理研究所筹建国家抗感染新药临床试验研究中心。1999年12月22日国家科技部生命发展     

临床药理教学方法问题的探讨

教学方法是教师与学生为实现教育目标、完成教学任务所运用的方式方法,它包括教和学两个方面,贯穿于整个教学过程.临床药理学是研究药物与人体相互作用规律的一门学科,它以药理学和临床医学为基础,主要研究药物代谢动力学、药物效应动力学、毒副反应性质机制以及药物间的相互作用等课题.     

Clinical pharmacology — Training and career

Summary As young physicians, attending and participating in various postgraduate clinical pharmacology training programmes, it is our experience that many of our clinical colleagues are not informed about (i) the definition or functions of a clinical pharmacologist, (ii) postgraduate education opportunities, or (iii) career prospects in this field. By reviewing the training and career opportunities in a country in which the speciality is well-developed (Great Britain) it may be possible partly to answer these points.     

左乙拉西坦的药理和临床评价

左乙拉西坦为一抗癫痫新药，其生物利用度较高，药动学呈线性，蛋白结合率低，且代谢不依赖于肝细胞色素P450等，使其成为较安全的药物。现对其药理作用、药动学、临床评价及不良反应等做一综述。     

左旋氨氯地平的临床药理及临床应用

本文综述了左旋氨氯地平的临床药理、近年来临床应用、不良反应及与其他药物联合应用的情况。     

Clinical pharmacology considerations in biologics development

Biologics, including monoclonal antibodies (mAbs) and other therapeutic proteins such as cytokines and growth hormones, have unique characteristics compared to small molecules. This paper starts from an overview of the pharmacokinetics (PK) of biologics from a mechanistic perspective, the determination of a starting dose for first-in-human (FIH) studies, and dosing regimen optimisation for phase II/III clinical trials. Subsequently, typical clinical pharmacology issues along the corresponding pathways for biologics development are summarised, including drug-drug interactions, QTc prolongation, immunogenicity, and studies in specific populations. The relationships between the molecular structure of biologics, their pharmacokinetic and pharmacodynamic characteristics, and the corresponding clinical pharmacology strategies are summarised and depicted in a schematic diagram.     

安全药理学研究的基本要求及其规范化

安全药理学是从药理学、生理学和毒理学发展而来的一门独立的综合性药理学学科。安全药理学研究之目的是识别、监控并确定非临床研究中出现潜在的不期望的药效活性。本文分析安全药理学的现状,讨论实验设计的基本要求,对中枢神经系统、心血管系统和呼吸系统实验设计的规范化提出了建议。     

Merck fellowships contribute to the continued growth of clinical pharmacology in Sweden

Since 1990, Merck, Sharpe & Dohme, Sweden, has created fellowships for physicians embarking upon a career in clinical pharmacology at Swedish medical schools. The fellowship has provided full salary at the level of a resident in clinical medicine for an average period of 1–2 years. Between 1992 and 2004, 22 fellows representing all six medical schools were selected for a fellowship. Of these, 20 have received specialties in clinical pharmacology, 11 now (2006) have positions as physicians in clinical pharmacology in university hospitals, 7 in the pharmaceutical industry, and 2 in a drug control agency. Two have not yet completed their training. The fellowships have been granted on the basis of excellence in clinical pharmacological problem-oriented research. The peer review of the applications has been performed by academic professors in clinical pharmacology and the chairperson of the Swedish Society of Clinical Pharmacology. The importance of having a donor with serious dedication to training and research and a scholarship organization that can prioritize these goals in an unbiased way are underlined. The Swedish MSD fellowships are a valuable complement to the resources provided by society to support the development of clinical pharmacology, i.e. the health care organizations, the faculties in medicine, and various research foundations.     

临床药理专业实验教学改革探索

临床药理学实验是临床药理课程的重要组成部分,随着临床药理学教材的改编和发展,实验教学改革势在必行.该文阐述了在临床药理学实验教学改革中的几点尝试,包括对增加教学内容、改变教学方式、优化考核与激励机制.     

对临床药理学一些基本问题研究的思考

临床药理学是研究药物与人体相互作用及其规律的一门学科。临床药理学基本原理在药物的临床研究与评价、药物不良反应监测等方面做了大量工作,取得了明显进展。然而,对临床药理学的共性、关键性和前沿性的基本问题研究更应给予高度关注,在进一步做好常规性临床药理学服务工作的同时,积极加强临床药理学学术问题的探索,为临床安全有效合理用药提供理论支撑。药物相互作用、多药耐药(MDR)、遗传药理学、药物基因组学、药动学/药效学(PK/PD)模型、性别药理学、基于药物作用于人体病理组织细胞的药效学和分子机制的研究等临床药理学的共性、关键性和前沿性问题已引起人们的重视。本文就临床药理学研究的一些基本问题的思考作一简述。     

Clinical pharmacology and the provision of drug information

Summary Clinical pharmacologists have a service role in the provision of drug information to individuals both in hospitals and primary health care. We present here a systematic approach in answering questions in a drug information centre (DIC), and describe the working method and the documentation of the work in a question answer (Q/A) data base.Drugline is a full-text data base offering problem-oriented drug evaluation comparable to a clinical consultation. The drug information is produced in a non-commercial drug information centre sponsored by the national health care sector and the National Corporation of Swedish Pharmacies, and run jointly by clinical pharmacologists and pharmacists.A minor part of Drugline is available in English for online searching, in parallel with Medline at the database host, the Medical Information Centre at the Karolinska Institute Library and Information Centre, and the users represent mainly medical libraries, hospital pharmacies, university clinics, and the pharmaceutical industry. A network of DICs has been organized in Swedish university hospitals with access to Drugline for searching and the storage of questions and answers.This network has the potential for expansion throughout Europe. It offers the unique possibility of complementing drug product information with problem-oriented drug information emerging from cases in the real world of prescribing.