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1.
Prognostic factors for survival after pulmonary resection of metastatic renal cell carcinoma 总被引:11,自引:0,他引:11
Pfannschmidt J Hoffmann H Muley T Krysa S Trainer C Dienemann H 《The Annals of thoracic surgery》2002,74(5):1653-1657
BACKGROUND: Pulmonary resection in metastatic renal cell carcinoma is an accepted method of treatment. The purpose of this study was to determine the clinical course, outcome, and prognostic factors after surgery. METHODS: Between 1985 and 1999, 191 patients (145 men, 46 women) with pulmonary metastases from a renal cell carcinoma underwent surgical resection. Inclusion criteria for the study were the absence of primary tumor recurrence and other extrapulmonary metastases. Complete resection (CR) was achieved in 149 patients. RESULTS: The overall 5-year survival rate was 36.9%. The 5-year survival rate after complete metastasectomy and incomplete resection was 41.5% and 22.1%, respectively. In patients with pulmonary or mediastinal lymph node metastases, we observed after complete resection a 5-year survival rate of 24.4%, whereas the rate was 42.1% in patients without lymph node involvement. A significantly longer survival was observed for patients with fewer than seven pulmonary metastases compared with patients with more than seven metastases (46.8% vs 14.5%). For surgically rendered complete resection (CR) patients with a disease-free interval of 0 to 23 months, the 5-year survival rate was 24.7% compared with 47% for those with more than a 23-month disease-free interval. By multivariate analyses, we showed that the number of pulmonary metastases, the involvement of lymph node metastases, and the length of the disease-free interval were all predictors of survival after complete resection. CONCLUSIONS: We conclude that pulmonary resection in metastatic renal cell carcinoma is a safe and effective treatment that offers improved survival benefit. Prognosis-related criteria are identified that support patient selection for surgery. 相似文献
2.
Results after pancreatic resection for metastatic lesions 总被引:9,自引:0,他引:9
Background Unlike primary pancreatic carcinoma, isolated metastatic lesions to the pancreas are uncommon. Although the value of surgical
resection is poorly documented, resection may be deemed appropriate in selected cases. The aim of this study was to review
our experience with the operative management of pancreatic metastases
Methods Sixteen patients who underwent pancreatic resection for the treatment of metastatic disease were identified from a prospective
pancreatic database. The clinical features of and results after resection were examined.
Results Renal cell carcinoma was the most frequent primary histopathology (10 of 16; 62%). In the remaining patients, the primary
histopathology was non-small-cell lung cancer (n=3), sarcoma (n=1), melanoma (n=1), or transitional cell carcinoma of the
bladder (n=1). A prolonged disease-free interval (median, 7.5 years) was characteristic of most patients. Operative procedures
performed included eight pancreaticoduodenectomies, seven distal pancreatectomies, and one total pancreatectomy. The operative
mortality was 6%, and the morbidity was 25%. The overall 2- and 5-year actuarial survival rates were 62% and 25%, respectively.
A trend toward improved survival was observed in the renal cell carcinoma patients, but this finding was not statistically
significant.
Conclusions Long-term survival after pancreatic resection for metastatic disease is achievable, and patients with primary renal cell carcinoma
seem to have a more favorable prognosis. Surgical resection should thus be offered to selected patients with isolated metastatic
disease to the pancreas. 相似文献
3.
Renal cell carcinoma involving penis and testis: unusual initial presentations of metastatic disease 总被引:1,自引:0,他引:1
Solitary parenchymal metastases of renal cell carcinoma to the penis or testis are rare. We report 1 case of each: in one instance the patient presented with priapism and an asymptomatic primary tumor; in the other, the metastasis presented as an acute change in a long-standing hydrocele more than one year after nephrectomy. Both patients had either positive margins at resection or recurrence after resection of the metastasis. While long-term, disease-free survival has been reported after orchiectomy for isolated metastatic disease, penile involvement appears to carry a very poor prognosis. 相似文献
4.
Chen F Fujinaga T Shoji T Miyahara R Bando T Okubo K Hirata T Date H 《Interactive Cardiovascular and Thoracic Surgery》2008,7(5):825-828
The treatment of metastatic renal cell carcinoma still represents a widely debated issue due to the introduction of several immunotherapies. To confirm again a role for resection of pulmonary metastases for such tumors, we reviewed our institutional experience. Between 1992 and 2007, eight patients with pulmonary metastases from renal cell carcinoma underwent complete pulmonary resection. All patients had undergone curative resection of their primary renal cell carcinomas and also had obtained or had obtainable locoregional control of their primaries. Various perioperative variables were investigated retrospectively. Disease-free interval varied from 25 to 156 months, with a median of 73 months. In three patients, lung metastases were found to be unilateral and solitary. Four patients presented two metastases in the unilateral lungs. One patient showed five metastases in the bilateral lungs. Six patients underwent wedge resection or segmentectomy, while two patients underwent more than lobectomy. Five patients showed recurrence after pulmonary metastasectomy. Five-year and 10-year overall survival rate was 83.3% and 41.7%, respectively, while 3-year and 5-year disease-free survival rate was 35.0% and 17.5%, respectively. Our study suggested that pulmonary metastasectomy for renal cell carcinoma might be well justified. 相似文献
5.
Pancreatic metastases from renal cell carcinoma are rare. In most cases metastases occur many years after nephrectomy. Solitary pancreatic metastases of renal cell cancer can be the only manifestation of tumor dissemination. Between 1995 and 2005 five patients after nephrectomy due to renal cell cancer were suspected of having malignant pancreatic tumor and underwent an operation. The histology revealed metastases of renal cancer. The intervals from primary renal tumor resection to recognition of metastases in the pancreas varied from 6-17 years. The prognosis of metastatic invasion to the pancreas is better than that of primary pancreatic carcinoma. Radical resection of the tumor is the treatment of choice for isolated solitary late metastases of renal cell cancer in the pancreas. 相似文献
6.
Thelen A Jonas S Benckert C Lopez-Hänninen E Rudolph B Neumann U Neuhaus P 《World journal of surgery》2007,31(4):802-807
Background This study was conducted to evaluate the safety and efficacy of liver resection in patients with hepatic metastases from renal
cell carcinoma and to identify selection criteria for patients suitable for resection.
Methods Between January 1988 and March 2006, 31 patients underwent liver resection for metastases from renal cell carcinoma. Patients
were identified from a prospective database and retrospectively reviewed. Patient, tumor, and operative parameters were analyzed
for their influence on long-term survival.
Results The overall 1-, 3- and 5-year survival rates were 82.2%, 54.3%, and 38.9%, respectively. One patient was deceased and 4 developed
complications during the postoperative course. In the univariate analysis, site of the primary tumor (P = 0.013), disease-free interval (P = 0.012), and resection margins (P = 0.008) showed significant influence on long-term survival. In the multivariate analysis, only the resection margins were
identified as an independent prognostic factor after liver resection.
Conclusions Liver resection is effective and safe in the treatment of patients with hepatic metastases from renal cell carcinoma and offers
the chance of long-term survival and cure. Achieving a margin-negative resection is the most important criterion in the selection
of suitable patients for liver resection. However, the number of patients in the present study was small, and investigations
of larger series may provide further prognostic parameters in these patients. 相似文献
7.
Philip C. Kierney MD Dr. Jon A. van Heerden MB FRCS Joseph W. Segura MD Amy L. Weaver MS 《Annals of surgical oncology》1994,1(4):345-352
Background: Solitary metastases from a primary renal cell carcinoma (RCC) occur in <10% of patients with metastatic RCC. To date, the
benefit of surgically resecting such apparently solitary lesions has not been well documented.
Materials and Methods: Forty-one patients (25 men, 16 women) with metastatic renal cell carcinoma treated by surgical excision of solitary metastases
(1970–1990) were retrospectively reviewed. They comprised 9% of patients with metastatic hypernephroma seen during this period.
All patients had undergone previous curative nephrectomy with a median disease-free interval of 27 months. Patients with skeletal,
spinal cord, and lymph node metastases were excluded.
Results: Mevtastases were intrathoracic (n=20), intracranial (n=7), and intraabdominal or in the extrapleural chest wall soft tissue
(n=10). Three patients had metastases to the thyroid gland and one had a solitary metastasis to an index finger. Median follow-up
was 3.2 years. Complete resection was possible in 36 patients (88%) with a single lesion excised in 23 of these 36 patients
(64%). There was no operative mortality. Predicted survival from the date of complete resection of metastases was 77%, 59%,
and 31% at 1, 3, and 5 years, respectively, with a median survival of 3.4 years. One patient is alive without evidence of
recurrent tumor 93 months from the first of 12 complete surgical resections. Varying adjuvant therapy was used in 50% of the
patients. An increased histological tumor grade of the metastatic lesion relative to the original RCC was the only significant
prognostic indicator identified. Disease-free interval and number of resected lesions were not significantly associated with
patient survival.
Conclusion: A small fraction of renal cell carcinoma patients are candidates for potentially curative surgical resection of solitary
metastatic lesions. Excision of such lesions may contribute to prolonged survival in selected instances.
The results of this study were presented at the 46th Annual Cancer Symposium of The Society of Surgical Oncology, Los Angeles,
California, March 18–21, 1993. 相似文献
8.
Jung ST Ghert MA Harrelson JM Scully SP 《Clinical orthopaedics and related research》2003,(409):223-231
The records of 99 patients treated at one institution for osseous metastases secondary to renal cell carcinoma were reviewed. Patients were followed up for at least 24 months or until death. Survival was analyzed with respect to age, gender, disease-free interval, location of osseous metastases, number of osseous metastatic sites, resection of osseous metastases, and primary tumor resection. The mean age of the 72 men and 27 women was 60 years (range, 34-82 years) and the mean followup was 20 months (range, 2-81 months). Twenty-six patients (26%) had a solitary osseous metastasis, 47 patients (48%) had multiple osseous metastases, and 26 patients (26%) had additional visceral involvement such as the lung and brain at the time of diagnosis. In 49 patients (49%), the renal cell carcinoma was diagnosed concurrently with detection of the osseous metastasis. The presence of one osseous renal carcinoma metastasis, wide resection of the lesion, and a history of nephrectomy were identified as independent predictors of survival in patients with renal cell carcinoma. The eight patients who had wide resection of a solitary osseous metastasis in combination with a nephrectomy had a disease-specific survival rate of 100% (mean followup, 69 months; range, 24-76 months). Patients who present with these characteristics are candidates for aggressive surgical treatment with curative intent. 相似文献
9.
Taylor A. Sohn M.D. Charles J. Yeo M.D. John L. Cameron M.D. Attila Nakeeb M.D. Keith D. Lillemoe M.D. 《Journal of gastrointestinal surgery》2001,5(4):346-351
Metastatic tumors to the pancreas are uncommon. Renal cell carcinoma is one of the few tumors known to metastasize to the
pancreas. The purpose of the current report is to evaluate the surgical management and long-term outcome of patients with
metastatic renal cell carcinoma. A retrospective review of patients undergoing pancreatic resection for renal cell carcinomas
metastatic to the pancreas or periampullary region between April 1989 and May 1999, inclusive, was performed. Time from initial
presentation, other metastatic sites, surgical outcomes, and long-term survival were evaluated. During the 10-year time period,
10 patients underwent pancreatic resection for renal cell carcinoma metastases. Ofthose, six underwent pancreaticoduodenectomy
and two underwent distal pancreatectomy, whereas the two remaining patients underwent total pancreatectomy for extensive tumor
involvement throughout the entire gland. The mean time from nephrectomy for resection of the primary tumor to reoperation
for periampullary recurrence was 9.8 years (median 8.5 years). The range was 0 to 28 years, with one patient presenting with
a synchronous metastasis. The mean age of the patients was 61.2 years with 60% of patients being male and 90% being white.
Pathologic findings included histologically negative lymph nodes and negative surgical margins in all patients. One patient
had tumor involving the retroperitoneal soft tissue, but final margins were negative. The mean live patient follow-up was
30 months (median =1.5 months), with eight patients remaining alive. The Kaplan-Meier actuarial 5-year survival was 75%, with
the longest survivor still alive 117 months following resection. The patient with retroperitoneal soft tissue involvement
died 4 months after resection. The pancreas is an uncommon site of metastasis for renal cell carcinoma, typically occurring
years after treatment of the primary tumor. When the metastatic focus is isolated and the tumor can be resected in its entirety,
patients can experience excellent S-year survival rates. The current report suggests that pancreatic metastases from renal
cell carcinoma should be managed aggressively with complete resection when possible.
Presented at the Forty-First Annual Meeting of The Society for Surgery of the Alimentary Tract, San Diego, Calif., May 2l–24,
2000. 相似文献
10.
Imamura H Sano K Harihara Y Noie T Hasegawa K Minagawa M Takayama T Makuuchi M 《Journal of Hepato-Biliary-Pancreatic Surgery》2003,10(4):321-324
Although liver resection is accepted as the only available treatment that regularly produces long-term survival with possible cure in patients with colorectal carcinoma metastatic to the liver, controversy appears to exist regarding the surgical indication for patients with more than four nodules. Similarly, it may be arguable to perform a repeated hepatic resection for a patient who developed multiple recurrent liver metastases with a short disease-free period after the initial liver resection. During the last 7 years, we have adopted constantly the aggressive surgical approach to patients with colorectal carcinoma metastatic to the liver if the number of tumor nodules identified preoperatively were less than ten and irrespective of the length of disease-free period after the previous resection. Here we report on a patient who underwent hepatic resection twice at an interval of 3 months and in whom a total of 22 metastatic nodules (6 in the initial hepatic resection and 22 in the repeated resection) were removed. The patient is now alive and remains disease-free, 5 years after the first liver resection. 相似文献
11.
Chen F Sonobe M Sato K Fujinaga T Shoji T Sakai H Miyahara R Bando T Okubo K Hirata T Date H 《World journal of surgery》2008,32(8):1657-1662
BACKGROUND: Pulmonary metastasectomy has become the standard therapy for various metastatic malignancies to the lungs; however, little data have been available about lung metastasectomy for head and neck cancers. To confirm a role for resection of pulmonary metastases for such tumors, we reviewed our institutional experience. METHODS: Between 1991 and 2007, 20 patients with pulmonary metastases from head and neck cancers underwent complete pulmonary resection. All patients had obtained or had obtainable locoregional control of their primary head and neck cancers. Various perioperative variables were investigated retrospectively to analyze the prognostic factors for overall survival and disease-free survival after metastasectomy. RESULTS: Of the 20 patients, 10 (50%) had squamous cell carcinoma, 7 (35%) had adenoid cystic carcinoma, and 3 had miscellaneous carcinomas. The median disease-free interval from the time of treatment of the head and neck primary cancers to the development of pulmonary metastases was 27 months. Overall survival rate after metastasectomy was 59.4% at 5 years and 47.5% at 10 years, respectively. Disease-free survival rate was 25.0% at 5 years after pulmonary resection. A disease-free interval equal to or longer than 12 months was a significantly favorable prognostic factor for both overall survival and disease-free survival (p = 0.02 and 0.01, respectively). Patients with squamous cell carcinoma and male sex showed a worse overall survival (p = 0.04 and 0.03, respectively). CONCLUSION: The current practice of pulmonary metastasectomy for head and neck cancers in our institution was well justified. A disease-free interval equal to or longer than 12 months, nonsquamous cell carcinoma, and female sex might be relevant to a better prognosis. 相似文献
12.
Pulmonary resection for metastatic laryngeal carcinoma 总被引:3,自引:0,他引:3
E A Rendina M de Vincentiis G Primerano T Claudio Mineo C Ricci 《The Journal of thoracic and cardiovascular surgery》1986,92(1):114-117
In a 5 year period, 11 patients were referred to our department as candidates for resection of pulmonary metastases from laryngeal carcinoma. At thoracotomy, a second primary tumor of the lung was discovered in three patients (27%). The other eight were considered eligible for thoracotomy and were subsequently proved to have metastases. Two of these patients (Group I) refused surgical treatment and died after 10 and 12 months; histologic diagnosis was obtained at autopsy. Six patients (Group II) underwent curative resection: Two of them have died (26 and 34 months) and four are alive and free of disease 40, 43, 46, and 55 months after thoracotomy. The disease-free interval, stage of primary tumor at laryngectomy, and single versus multiple metastases do not seem to affect survival. We conclude that lung resection increases survival in patients with pulmonary metastases from laryngeal carcinoma. 相似文献
13.
Experience with fossa recurrence of renal cell carcinoma. 总被引:2,自引:0,他引:2
We describe the surgical management and followup of 11 patients with local recurrence of renal cell carcinoma in the renal fossa, 10 of whom demonstrated no evidence of distant metastatic disease at the time of recurrence. Average interval to recurrence was 31 months from nephrectomy, with the majority of patients presenting with symptoms of weight loss, fatigue and lumbar discomfort. A total of 13 resections of recurrent carcinoma was performed with 3 immediate postoperative complications, including a retroperitoneal abscess, jejunal necrosis requiring resection and a duodenal obstruction requiring duodenojejunostomy. There were 2 postoperative deaths, 2 patients died of disseminated disease at 8 and 22 months, and 3 died of causes unrelated to cancer recurrence at 4 months, 6 months and 10 years. Four patients were without disease at a followup of 35, 46, 48 and 211 months. We include in this review a report on 1 patient who maintains a disease-free survival of 17 years after resection of a recurrent spindle cell carcinoma. We conclude that an aggressive surgical approach to recurrent renal cell carcinoma within the renal fossa can produce long-term disease-free survival and is justified when compared to the results reported for chemotherapy. 相似文献
14.
Primary mucinous carcinoma of the skin: a case of metastasis after 10 years of disease-free interval
M. Miyasaka R. Tanaka K. Hirabayashi A. Yamazaki H. Shinohara H. Taira T. Akamatsu 《European journal of plastic surgery》2009,32(4):189-193
Primary mucinous carcinoma of the skin (MCS) is a rare neoplasm. Clinically, it has a high local recurrence rate, but it is
known to be a slow-growing benign tumor with a rare incidence of distant metastases. We present a case of primary MCS on the
jaw that underwent tumor resection twice and was disease-free for 10 years after the second surgery. The patient had no evidence
of local recurrence and distant metastasis until his 11th year follow-up. At that time, he was diagnosed with lung and bone
metastasis and died 3 years after this. To our knowledge, this is the first case of MCS that presented with metastasis with
more than 10-year disease-free interval. Since MCS is a slow-growing asymptomatic tumor, distant metastasis is difficult to
diagnose without detailed radiological examination. We believe that computed tomography and resonance imaging should be performed
for early diagnosis of metastasis even for cases with long-term disease-free interval, especially cases of local recurrence. 相似文献
15.
Benoit L Favoulet P Arnould L Margarot A Franceschini C Collin F Fraisse J Cuisenier J Cougard P 《Annales de chirurgie》2004,129(4):218-223
PURPOSE: The aim of this study was to retrospectively report clinical manifestations, type of treatment, survival rate of thyroid metastases from renal carcinoma. PATIENTS AND METHODS: Seven patients were retrospectively collected from files of different Burgundy's hospitals. All renal and thyroid gland specimens were controlled by the anatomopathologist. RESULTS: Tumors occurred in four women and three men (mean age: 66 years). Symptoms were generally a solitary mass. The metastatic tumor to the thyroid gland was the initial presentation of renal carcinoma in one case. In the other cases, patients had documented previous evidence of renal carcinoma as remotely 8.1 years before the thyroid metastases. Thyroglobulin immunohistochemistry was always negative in the foci of metastatic renal carcinoma. All patients had surgical resection of there metastasis. The majority of patients died with disseminated malignancies (mean: 38.1 months after there thyroid resection). Three patients are still alive, one after a complementary pancreatic resection for a secondary pancreatic metastasis and one other with cervical and mediastinal lymph node recurrence. CONCLUSIONS: Surgical treatment of the metastatic disease is suggested, as this may prolonged patient survival. 相似文献
16.
Aaron S. Estrera Melvin R. Platt Lawrence J. Mills Robert R. Shaw 《The Annals of thoracic surgery》1981,31(3):244-250
At our institution, 3 patients with pulsatile sternal tumor have been seen. Although ascending aortic aneurysm frequently is high on the list of differential diagnoses, the likelihood that this tumor is metastatic from either a primary renal or thyroid neoplasm is overwhelming. Of the 15 patients reported, 11 had metastases from a primary renal cell carcinoma, including all 3 of our patients. There were 2 patients with primary myeloma, the only histologically proved primary pulsatile sternal tumor.From the surgical standpoint, only the patient with metastatic renal cell carcinoma has a chance of cure. With the recent report of 2 5-year survivors and our own experience of 1 patient with a long asymptomatic interval following resection of the primary kidney tumor and the secondary sternal metastasis, the attitude of hopelessness for these patients should be challenged and an aggressive approach considered. 相似文献
17.
The results of pulmonary resection for metastatic pulmonary lesions in our institution are reviewed. Over the period of ten years 43 patients underwent 46 thoracotomies with a 5 years survival rate of 40.8%. The most significant predictors of survival were type of primary tumor, number of lesions removed and disease-free interval, while there were no statistically significant difference in survival rates between partial resection and lobectomy. Recurrence in the early postoperative period was often observed in the patients with bilateral pulmonary metastases and their 5 years survival rate was as low as 21.9%. Though multiple lung metastases is not contraindication for pulmonary resection, we should be prudent to operate for those patients with multiple lung metastases. Our results suggest that the patient with solitary lesion, long disease-free interval and no metastases to mediastinal lymph nodes is the best candidate for resection of the metastatic pulmonary lesions. 相似文献
18.
OBJECTIVE: In 60-70% of patients with renal cell carcinoma (RCC), metastases develop in the course of the disease. In the present analysis, the surgical management of metastases is described, and survival data are presented. This retrospective analysis may help in the management of future cases. Due to the retrospective nature of the data, no comparison between surgical and nonsurgical management is possible. METHODS: Between 1985 and 1995, 152 resections of RCC metastases were performed in 101 patients at four Dutch Hospitals. Thirty-five and 6 patients had metastases resected 2 and 3 times, respectively. In most patients, the primary tumor was resected (n = 95). Resections were performed for metastases at different locations: lung n = 54, bone n = 42, lymph nodes n = 18, cerebrum n = 12 and locations in the spinal canal, thyroid, bowel, and testis. Skin excisions were excluded from the analysis. Solitary metastases were resected in 40 patients. RESULTS: Median survival after the initial metastasectomy was 28 months. Initial tumor stage, grade, or size were not related to metastasis location or survival. The number of initially resected pulmonary metastases was of no influence on survival, however, multiple consecutive resections were related with longer survival. Patients with solitary metastases (n = 40) did not show longer survival after the first metastasectomy compared to no solitary lesions. Better survival was found for lung metastases compared to other tumor locations (p = 0.0006, log rank test) and for patients that were clinically tumor free after metastasectomy (p = 0.0230, log rank test). Additional immuno- or radiotherapy did not independently influence survival. Time interval between primary tumor resection and metastasectomy correlated positively with survival: a tumor-free interval of more than 2 years between primary tumor and metastasis was accompanied by a longer disease-specific survival after metastasectomy. Eleven patients were free of disease after metastasectomy with a median time of 47 (14-65) months. The median time of hospital admittance for metastasectomy was 9 days (4-64). Lethal complications were found in 2 patients. Long-term (>5 years) disease-free survival was achieved in 7% of patients whereas 14% of patients were free of disease with a minimal follow-up of 45 months. CONCLUSIONS: (1) Surgical management of metastases could be performed with short hospital stay, and low complication rates were found. (2) Disease-free survival was found in 14 and 7%, with follow-ups of at least 45 and 60 months, respectively. (3) The longest survival was found after surgery for pulmonary lesions. (4) Resection of solitary metastases did not result in longer survival compared to resection of nonsolitary lesions. (5) An interval shorter than 2 years between primary tumor and metastases was correlated with a shorter disease-specific survival. 相似文献
19.
Partial hepatectomy for metastases from noncolorectal, nonneuroendocrine carcinoma 总被引:9,自引:0,他引:9
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Weitz J Blumgart LH Fong Y Jarnagin WR D'Angelica M Harrison LE DeMatteo RP 《Annals of surgery》2005,241(2):269-276
OBJECTIVE: To define perioperative and long-term outcome and prognostic factors in patients undergoing hepatectomy for liver metastases arising from noncolorectal and nonneuroendocrine (NCNN) carcinoma. SUMMARY BACKGROUND DATA: Hepatic resection is a well-established therapy for patients with liver metastases from colorectal or neuroendocrine carcinoma. However, for patients with liver metastases from other carcinomas, the value of resection is incompletely defined and still debated. METHODS: Between April 1981 and April 2002, 141 patients underwent hepatic resection for liver metastases from NCNN carcinoma. Patient demographics, tumor characteristics, treatment, and postoperative outcome were analyzed. RESULTS: Thirty-day postoperative mortality was 0% and 46 of 141 (33%) patients developed postoperative complications. The median follow up was 26 months (interquartile range [IQR]) 10-49 months); the median follow up for survivors was 35 months (IQR 11-68 months). There have been 24 actual 5-year survivors so far. The actuarial 3-year relapse-free survival rate was 30% (95% confidence interval [CI], 21-39%) with a median of 17 months. The actuarial 3-year cancer-specific survival rate was 57% (95% CI, 48-67%) with a median of 42 months. Primary tumor type and length of disease-free interval from the primary tumor were significant independent prognostic factors for relapse-free and cancer-specific survival. Margin status was significant for cancer-specific survival and showed a strong trend for relapse-free survival. CONCLUSIONS: Hepatic resection for metastases from NCNN carcinoma is safe and can offer long-term survival in selected patients. Hepatic resection should be considered if all gross disease can be removed, especially in patients with metastases from reproductive tract tumors or a disease-free interval greater than 2 years. 相似文献
20.
Pancreatic late recurrence of bilateral renal cell carcinoma after conservative surgery 总被引:2,自引:0,他引:2
The appearance of solitary late metastases of renal cell carcinoma has seldom been documented. A female patient, who 13 years previously underwent left radical nephrectomy and right lower polar resection for bilateral simultaneous renal cell carcinoma, presented with a solitary pancreatic metastasis which was successfully treated with pancreaticoduodenectomy. The major points of interest of this report are the occurrence of a primary bilateral tumor, the initial treatment with conservative surgery and the site of late recurrence. The diagnostic and prognostic implications of late metastases of renal tumors are discussed. 相似文献