64层灌注CT评价兔VX2体部肿瘤模型氧分压的实验研究

目的:利用64层灌注CT评价兔VX₂肿瘤模型氧分压并与氧微电极法对照。方法:对45只成功建模兔VX₂脑瘤模型行灌注CT检查。测量脑瘤兴趣区灌注值（perfusion）、血容量（blood volume,BV）、达峰时间（time to peak TTP）、最大峰值（peak enhancement intensity,PEI）。结果与该兴趣区氧微电极法测得氧分压（PO₂）对照。结果:45例成功建模兔VX2脑瘤兴趣区灌注值范围为1.3 ml/min～127.0 ml/min,平均为27.102 ml/min±26.723 ml/min;BV为1.2 ml/100g～53.1ml/100g,平均为22.196 ml/100g±13.680ml/100g,PEI为8.7 HU～124.6HU,平均为43.456 HU±28.73 HU;TTP为8.2 sec～62.5 sec,平均为38.823 sec±14.759 sec;对应区域PO₂为0.14 mmHg～46.70mmHg,平均为15.981 mmHg±14.815mmHg。灌注值与对应区域PO₂相关系数为0.673,有统计学意义（P=0.00）。BV、PEI、TTP与与对应区域PO₂相关系数分别为0.271、0.253、-0.18,均无统计学意义（P=0.071,P=0.094,P=0.237）。结论:64层灌注CT有预测肿瘤氧分压的能力。     

兔VX2脑瘤血管生成的灌注CT研究

Objective： To study the perfusion CT features of rabbit VX2 brain tumor with correlation to MVD and VEGF, and to validate perfusion CT for reflection of tumor angiogenesis. Methods： Rabbit VX2 brain tumor model was established by injection of 100 μL viable tumor cells （10qmL） through a 2 mm-hole 5 mm to the right of the sagittal suture and 5 mm posterior to the coronal suture bored by dental drill. MRI was performed every 2 days after seven days of implantation to evaluate the growth of the tumor. Twenty New Zealand White rabbits with tumor size over 3 mm in diameter were randomly divided into 2 groups according to the tumor growth time with those less than 3 weeks as group 1 and those more than 3 weeks as group 2, and perfusion CT were performed accordingly. CT measurements of BV, BF and PS from tumor, peritumor and contralateral normal tissue regions were obtained. After that the animals were sacrificed and 2% Evans blue （2 mL/kg） was given intravenously in 16 of these animals 1 h prior to sacrifice to detect breakdown of the blood brain barrier. VEGF and MVD were evaluated in immunohistochemical examination of the specimens. Results： Tumor had significantly higher BV, BF and PS （P=0.000） than peritumor and normal tissue region. Tumor BV, BF and MVD in group 2 were significantly higher than that in group 1 （P〈0.01）. Significant linear correlation was found between MVD and BV （t=-0.915, P=-0.000）, MVD and BF （t=0.901, P=-0.000）, and MVD and PS （t=-0.459, P=0.042）. We also found a rank correlation between PS and blue stain of tumor （rs=0.861, P=0.000）. Conclusion： Perfusion CT can distinguish tumor from peritumor and normal tissue clearly, reflect tumor angiogenesis accurately, and provide useful information for the evaluation of brain tumor.     

经肝动脉灌注重组人血管内皮抑制素联合TACE治疗兔VX 2肝癌及肿瘤血管生成的评估

目的：经肝动脉灌注重组人血管内皮抑制素（recombinant human endostatin，rh-endostatin）联合经导管动脉内化疗栓塞术（transcathet artefial chemoembolization，TACE）治疗兔VX2肝癌后，对其疗效进行评估，并分析肿瘤周边CT灌注特征及微血管密度（microvascular density，MVD）、血管内皮生长因子（vascular endothelial growth factor，VEGF）表达的变化，探讨CT灌注参数、MVD及VEGF之间的相关性。方法：30只VX2肝癌兔随机分为3组，每组10只。A组：rh-endostatin＋TACE；B组：单纯TACE；C组：对照组。3组于治疗前均行CT平扫，治疗后2周行CT灌注成像，获取肿瘤周边血流量（blood flow，BF），血容量（blood volume，BV）；毛细血管表面渗透面积（permeability surface area product，PS）值。扫描后立即处死动物，组织切片用于免疫组织化学法检测MVD、VEGF表达。结果：A、B组肝癌生长率均明显低于C组（P〈0．01）；A组肿瘤BF、BV、PS值较B、C组明显增高（P〈0．05），MVD、VEGF较B、C组明显减低（P〈0．01）。B、C组之间BF、BV、PS、MVD及VEGF差异均无统计学意义（P〉0．05）。在3组中，肿瘤VEGF与MVD之间均呈显著正相关（P〈0．01），A组中BF、BV、PS分别与MVD、VEGF呈线性正相关（P〈0．05），而B、C组中BF、BV、PS与MVD、VEGF无线性相关性（P〉0．05）。结论：肝动脉灌注rh-endostatin联合TACE治疗肝癌能减慢肿瘤的生长速度，显著地抑制治疗后肿瘤新生血管的形成。肿瘤CT灌注参数不总是能反映其病理参数MVD、VEGF的变化。     

MSCT灌注成像在肺鳞癌诊断中的临床价值

目的：通过肺癌MSCT灌注成像及相关灌注参数分析,研究MSCT灌注成像在肺鳞癌诊断中的应用价值。方法：对32例肺癌患者,先行常规CT扫描,确定肿瘤的中心层面,然后采用电影技术对肿瘤中心层面进行连续扫描,以获得该层面内组织的时间-密度曲线,计算出血流量（BF）、血容量（BV）、平均通过时间（MTT）、表面渗透性（PS）,以此评价肿瘤灌注情况,并与病理分型进行对比分析。结果：分别以BF≤37.51ml/（min×100g）、BV≤7.59ml/100g、PS≤8.43ml/（min×100g）为肺鳞癌的诊断阈值,则其灵敏度分别为69.23%、69.23%、76.92%,特异度分别为73.68%、78.94%、84.21%。结论：当BF≤37.51ml/（min×100g）、BV≤7.59ml/100g且PS≤8.43ml/（min×100g）综合判定时,肺鳞癌的诊断特异度明显提高达93.75%。     

宫颈癌CT灌注参数变化对放疗敏感性的评估分析

目的探讨宫颈癌CT灌注参数变化对放疗敏感性的评估价值。 方法收集2014年2月至2016年7月宫颈癌患者120例,均进行CT灌注扫描并计算相关参数［血流量（BF）、血容量（BV）、表面通透性（PS）和平均通过时间（MTT）］;同时给予调强放疗,盆腔照射每次18～20 Gy,每周5～6次,总照射剂量40～45 Gy。放疗4周后评价疗效。采用Logistic回归模型分析影响放疗敏感性的因素。 结果120例患者均按计划完成放疗,获完全缓解34例,部分缓解46例,稳定20例和进展20例,放疗敏感率为667％（80/120）。敏感组年龄、体重指数、肿块直径、病理类型、FIGO分期和分化程度与不敏感组的差异无统计学意义（P＞005）,两组淋巴结转移的差异有统计学意义（P＜005）。敏感组BF低于不敏感组［（5922±1630）ml／（min·100 g） vs.（7204±1294）ml／（min·100 g）］,而BV［（1214±281）ml／100 g vs.（568±193）ml／100 g］、PS［（2056±852）ml／（min·100 g） vs.（910±184）ml／（min·100 g）］与MTT［（1172±448）s vs.（1034±622）s］高于不敏感组,差异均有统计学意义（P＜005）。Logistic多因素分析显示,BV为影响宫颈癌放疗敏感性的独立因素（P＜005）。 结论宫颈癌CT灌注参数能反映和评估调强放疗的敏感性,BV为影响放疗敏感性的主要因素。     

宫颈癌CT灌注参数变化对放疗敏感性的评估分析

目的探讨宫颈癌CT灌注参数变化对放疗敏感性的评估价值。 方法收集2014年2月至2016年7月宫颈癌患者120例,均进行CT灌注扫描并计算相关参数［血流量（BF）、血容量（BV）、表面通透性（PS）和平均通过时间（MTT）］;同时给予调强放疗,盆腔照射每次18～20 Gy,每周5～6次,总照射剂量40～45 Gy。放疗4周后评价疗效。采用Logistic回归模型分析影响放疗敏感性的因素。 结果120例患者均按计划完成放疗,获完全缓解34例,部分缓解46例,稳定20例和进展20例,放疗敏感率为667％（80/120）。敏感组年龄、体重指数、肿块直径、病理类型、FIGO分期和分化程度与不敏感组的差异无统计学意义（P＞005）,两组淋巴结转移的差异有统计学意义（P＜005）。敏感组BF低于不敏感组［（5922±1630）ml／（min·100 g） vs.（7204±1294）ml／（min·100 g）］,而BV［（1214±281）ml／100 g vs.（568±193）ml／100 g］、PS［（2056±852）ml／（min·100 g） vs.（910±184）ml／（min·100 g）］与MTT［（1172±448）s vs.（1034±622）s］高于不敏感组,差异均有统计学意义（P＜005）。Logistic多因素分析显示,BV为影响宫颈癌放疗敏感性的独立因素（P＜005）。 结论宫颈癌CT灌注参数能反映和评估调强放疗的敏感性,BV为影响放疗敏感性的主要因素。     

肺癌患者放疗前后CT灌注成像相关研究

目的 分析肺癌患者放疗前灌注状态及其放疗前后CT灌注成像参数改变与放疗疗效关系。方法 以28例临床及病理确诊肺癌患者为研究对象,CT灌注成像扫描并计算灌注值:血流量(BF)、血容量(BV)、平均通过时间(MTT)及表面通透性(PS)。肺癌患者放疗前CT灌注成像值与靶体积相关性采用线性相关分析,缓解组与未缓解组差异行独立样本t检验,放疗前后CT灌注成像值比较行配对样本t检验。结果 28例肺癌患者放疗缓解组16例、未缓解组12例。放疗前后缓解组病灶体积明显缩小[(58.72±22.95) cm³∶(24.53±13.79) cm³,P=0.000],但放疗前靶体积与各灌注值无明显相关(P=0.628)。放疗前缓解组与未缓解组BF、BV值不同(1.23±1.36∶6.42±2.57,P=0.024与1.23±0.31∶0.59±0.18,P=0.041),MTT、PS差异未达统计学水平(0.93±0.58∶0.93±0.66,P=0.851与1.46±0.83∶1.17±0.56,P=0.141)。放疗前后BF、BV、MTT、PS值不同(9.81±3.56∶7.48±3.31,P=0.006;0.96±0.41∶0.64±0.38,P=0.003;0.93±0.60∶0.53±0.30,P=0.007;1.34±0.73∶0.74±0.44,P=0.001)。结论 CT灌注成像能预测肺癌放疗后的疗效,在一定程度能指导肺癌精确放疗的计划及实施。     

经肠系膜上动脉行门静脉血管成像及CT灌注成像评价肝转移癌血供

背景与目的:肝转移癌的血供来源关系到血管介入治疗的给药途径和栓塞靶血管的选择.本研究探讨经肠系膜上动脉(superior mesenterica arterial,SMA)CT门静脉血管造影(CT arterial portography,CTAP)和多层螺旋CT灌注成像方法两种技术相结合评价肝转移癌的血供来源.方法:选取20例肝转移癌患者,采用经肠系膜上动脉间接门静脉血管造影(CTAP)及肝脏单纯门静脉灌注成像,观察血管走行与肿瘤的关系,通过时间密度曲线判断20例患者的33个转移灶肿瘤强化前后CT值变化特点,同时使用单血供灌注软件测量转移灶及瘤周正常肝组织的血流量(blood flow,BF)、血容量(blood volume,BV)、平均通过时间(mean transit time,MTT)、毛细血管表面通透性(capillary vessel permeability surface,PS),并进行统计学分析.结果:33个结节直径0.8～3.5 cm,所有病灶通过时间-密度曲线观察强化后CT值增量均不超过10 Hu.经SMA注射造影剂后肝内肿块内部无肿瘤血管.以门静脉作为单血供肝脏灌注扫描后得到肝内转移灶及瘤周正常肝组织各项灌注参数值,转移癌组织的BF、BV、MTT、PS的平均值分别为(17.15±11.38)ml·min-1·100 ml-1、(1.62±0.97)ml·100 g-1、(9.47±2.78)s、(3.97±3.44)ml·min-1·100 ml-1.33个转移癌的BF值均小于30 ml·min-1·100 ml-1.瘤周正常肝组织的BF、BV、MTT、PS的平均值分别为(133.43±67.17)ml·min-1·100 ml-1、(16.56±11.15)ml·100 g-1、(9.52±2.84)s、(35.16±14.03)ml·min-1·100 ml-1.其中BF、BV和PS两者之间差异有显著性(P值均＜0.001),MIT两者比较差异无显著性(P=0.96).结论:经肠系膜上动脉动脉插管门静脉造影CT灌注成像可以准确测量纯门静脉血流量.门静脉未参与肝转移癌的血液供应,肝转移癌主要由肝动脉供血.     

肺癌灌注成像参数与患者生存期的关系

目的:分析不同病理类型肺癌CT灌注参数与患者生存期的相关性。方法:对58例病理证实为肺癌的患者行螺旋CT灌注成像,量化分析灌注参数血容量(blood volume,BV） 、血流量(blood flow,BF） 、对比剂到达峰值时间(time to peak,TTP) 、强化峰值(peak enhance -mentimage,PEI),与患者生存期做相关性分析。结果:肺鳞癌BV为47.90±20.50,BF为27.75±11.75,TTP 29.65±29.05 PEI为44.50±25.35,鳞癌 BV与患者生存期成负相关(P<0.05);肺腺癌BV为36.32± 32.15,BF为75.00±25.70,TTP为 20.98±16.62, PEI为52.05±21.57,肺腺癌 BV与患者生存期成负相关(P<0.05)。结论:肺癌部分灌注参数与患者的生存期有关,对临床预后评估具有较大价值。     

重组人血管内皮抑制素单药对非小细胞肺癌肿瘤血管微环境影响的初步研究

背景与目的：临床数据显示对于局部晚期或晚期非小细胞肺癌(non-small cell lung cancer,NSCLC),重组人血管内皮抑制素(恩度)联合放疗或化疗较传统化放疗可能更具优势,但其机制,特别是对血管微环境的影响依旧不甚明确。该研究通过CT灌注成像技术(dynamic contrast-enhanced perfusion computed tomography,CT perfusion)对NSCLC肿瘤局部血流灌注进行定量分析,评估恩度单药对NSCLC肿瘤血管微环境的影响。方法：经细胞学或组织学确认的初治Ⅲ_B/Ⅳ期NSCLC患者可入组本研究。全部患者接受7.5 mg⁄m²恩度单药治疗14 d,于基线期及治疗后分别接受CT灌注成像检查,获取灌注图像并定量分析血流灌注参数：血流量(blood flow,BF)、血容量(blood volume,BV)以及血管表面通透性(permeability surface,PS)。结果：7例患者(4例为Ⅲ_B期,3例为Ⅳ期)入组,均完成基线期及恩度单药治疗后CT灌注扫描。血流灌注参数BF、BV、PS的中位值于治疗前后分别为27.1/48.9 mL·(100 mL·min)-1、86.8/84.8 mL·100 mL^-1以及45.0/54.0 mL·(100mL·min)^-1。经过14 d恩度单药治疗,肿瘤BF值较治疗前显著上升(P=0.028),而BV值与PS值变化无统计学意义(BV：P=0.398;PS：P=0.237)。结论：恩度单药治疗局部晚期或晚期NSCLC后,可导致肿瘤局部灌注血流量明显上升而通透性和血容量则变化不明显。     

A Controlled Study on Comparing Differences in CT Perfusion Imaging between Rabbits inoculated with VX2 Lung Tumor and Patients with Squamous Cell Carcinoma of the Lung

OBJECTIVE By analysis and evaluation of the perfusion images and perfusion parameters of the rabbits with VX2 lung tumor,the association between the perfusion parameters and tumor angiogenesis of patients with squamous cell carcinoma of the lung has been studied in order to establish a non-invasive and effective way to detect tumor blood supply, which is be able to exhibit hemodynamic data in tumors during cancer treatments.METHODS Fifteen Netherlands rabbits inoculated with VX2 lung tumor (rabbit group) and 25 patients with squamous cell carcinoma of the lung (patient group) received a multi-slice spiral CT perfusion imaging test using the Netherlands PHILIPS Brilliance 16-slice spiral CT and a U.S. MEDRAD binocular highpressure syringe. Image postprocessing was done using the special perfusion software and EBW 4.0 Workstation. Perfusion volume (PV), peak enhanced increment (PEI), transit time peak (TTP), and blood volume (BV) were measured and analyzed.RESULTS In the rabbit group, the values of the PV, PEI, TTP,and BV of the tumor margin were (53.89 ± 13.38) mL/(min·mL),(45.71 ± 15.52) Hu, (39.29 ± 10.10) sec, and (31.45 ± 18.19) mL/100 g,respectively; these values of the tumor center were (36.57 ± 14.17)mL/(min·mL), (28.64 ± 11.74) Hu, (39.00 ± 9.78) sec, and (19.76± 13.95) mL/100 g, respectively; the values of the muscles were (12.45 ± 4.38) mL/(min·mL), (10.98 ± 5.03) Hu, (38.86 ± 10.04) sec,and (5.38 ± 2.87) mL/100 g, respectively. The values of the relative perfusion volume (RPV), relative peak enhanced increment (RPEI),and relative blood volume (RBV) of the tumor margin were 4.38 ± 1.45, 3.96 ± 1.45, 9.99 ± 11.7, respectively; these values of the tumor center were 2.14 ± 1.08, 1.83 ± 1.45, 4.17 ± 3.39, respectively. The values of the PV, PEI, BV of the tumor margin vs. the values of the muscles developed t-values, which were 15.028, 10.79, and 5.88,respectively (P ≤ 0.01), with statistical significance; the values of the PV, PEI, BV of the tumor center vs. the values of the muscles produced t-values, which were 8.67, 7.49, and 4.55, respectively (P≤ 0.01), with statistical significance. The values of the TTP of the tumor margin vs. TTP values of the muscles, and the TTP values of the tumor center vs. TTP values of the muscles developed t-values, which were 1.7 and 0.806, respectively (P ≥ 0.05), without statistical significance. In the patient group, the values of the PV, PE, TTP, and BV of the tumor margin were (88.95 ± 30.89)mL/(min·mL), (61.87 ± 27.31) Hu, (37.72 ± 12.53) sec, and (18.38± 7.2) mL/100 g, respectively; these values of the tumor center were (39.77 ± 18.29) mL/(min·mL), (14.57 ± 8.1) Hu, (35.64 ± 12.41)sec, and (11.22 ± 6.02) mL/100 g, respectively; these values of the muscles were (12.45 ± 6.5) mL/(min·mL), (6.14 ± 2.66) Hu, (35.68± 12.35) sec, and (2.23 ± 1.11) mL/100 g, respectively. The values of the RPV, RPEI, and RBV of the tumor margin were 8.05 ± 5.04, 8.87 ± 4.32, and 12.16 ± 8.49, respectively;these values of the tumor center were 2.39 ± 1.68, 2.97± 2.1, 3.53 ± 2.82, respectively. The values of the PV,PEI, BV of the tumor margin in the patient group vs. the values of the muscles produced t-values,which were 13.8, 10.85, and 12.22, respectively (P <0.01), with significant differences; these values of the tumor center vs. the values of the muscles developed t-values, which were 9.158, 6.26, 8.654, respectively (P < 0.01), with significant differences. The TTP value of the tumor margin vs. that of the muscles produced t-value, which was 0.371, and the TTP value of the tumor center vs. that of the muscles developed t-value, which was 1 (P > 0.05), without statistical difference. CONCLUSION CT perfusion imaging technics demonstrates directly dynamic changes of blood flow to tumors, which assists in identifying tumor growth and necrosis, therefore, this research provides an evidence-based guidelines for the treatment of human lung squamous cell carcinoma and has far-reaching clinical significance.     

胃肿瘤CT灌注成像的临床研究

Objection: The purpose of this study is preliminarily to discuss stomach perfusion imaging technique with Multi-slice CT and its clinical application value in stomach neoplasm. Methods: Fifteen patients with known stomach neoplasm performed perfusion imaging with 4 or 16 slice CT. Performing peffusion imaging in central slice of neoplasm, using CT cine scan, slice thick 10 mm/2i; with high pressure syringe, injecting quickly from right elbow-front vein, dosage 45-50 mL, injec-tion rate 3.5-4.0 mL/s, scanning delay time 5 s, scanning total time 45 s. We performed perfusion CT post-processing using pancreatic mode of perfusion CT software. Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) of gastric wall and tumor were computed for every case. Results: BF, BV, MTT and PS of gastric tumor were 116.68±90.09 mL/(min .100 g), 9.57±8.12 mL/100 g, 10.07± 7.74 s, 20.78±19.68 mL/ (min .100 g), respectively. The P values for each CT perfusion parameters between gastdc tumor and normal gastric wall were 0.001,0.021, 0.155 and 0.031,respectively. Conclusion: Perfusion CT can provide hemodynamics of gastdc tumors and play a key role in the diagnosis of gastric tumors. It's clinical application prospect will be fully broad.     

64排螺旋CT灌注成像技术在直肠癌术前评估中的应用价值

目的探讨CT灌注成像的各项参数对直肠癌的术前评估价值。方法选经根治性手术治疗且病理证实的30例直肠癌患者为研究对象,所有患者于术前行CT灌注成像扫描,准确记录血容量(blood volume,BV)、强化峰值(peak enhancement image,PEI)、强化峰值达到时间即达峰时间(time to peak,TTP)、血流量(perfusion,PF),并在术后确定pTNM分期,并对TNM分期中各CT灌注参数值进行统计学比较。结果直肠癌组织中的PF、BV明显高于正常组织,差异有统计学意义(均P<0.01),而PEI、TTP的差异无统计学意义(均P>0.05)。在T分期的各组中,PF、TTP、BV的差别有统计学意义(均P<0.01),而PEI的差异无统计学意义(P>0.05);在淋巴结是否转移的分组中,无淋巴结转移组的PF、BV要高于有淋巴结转移组,差异有统计学意义(均P<0.05),TTP及PEI则无统计学差异(均P>0.05)。在是否远处转移各分组中,同时肝转移组的PEI、PF要低于无远处转移组,差异有统计学意义(均P<0.05),TTP、BV则无统计学差异(均P>0.05);肿瘤的分化程度分组中,分化程度越高,其PF、TTP渐次升高,差异有统计学意义(均P<0.05);靶淋巴结灌注的表现为转移淋巴结的PF要多于反应性增生的淋巴结(P=0.000 1),而TTP、BV、PEI无统计学意义(均P>0.05)。结论直肠癌患者CT灌注成像中的各项参数对直肠癌进行术前分期有一定的应用价值,可以使术前分期更加准确,进而采取更合理的治疗策略。     

去卷积CT灌注成像鉴别原发性良恶性骨肿瘤

目的：探讨宫颈上皮内瘤样病变（CIN）Ⅱ～Ⅲ宫颈环形电刀切除术（LEEP）治疗的有效性。方法：回顾分析浙江省舟山市妇幼保健院2002年6月至2007年9月因CINⅡ～Ⅲ行LEEP手术的168例患者临床资料，对手术前后病理、术后患者的治愈率、病变持续存在及复发等情况进行分析总结。结果：手术前后病理诊断符合率64.3%（108/168），升级占12.5%（21/168），降级占23.2%（39/168）。剔除LEEP术后切缘阳性或宫颈癌再次手术者19例，接受6～69个月随访者149例，总治愈率96.0%（143/149），病变持续存在率4.0%（6/149），复发率12.1%（18/149）。LEEP术后CINⅡ41例，6个月治愈率95.1%（39/41），病变持续存在率4.9%（2/41），1年复发率为7.3%（3/41），2年复发率为7.3%（3/41）；CINⅢ81例，6个月治愈率95.1%（77/81），病变持续存在率4.9%（4/81），1年复发率为6.2%（5/81），2年复发率为7.4%（6/81），3、4、5年均无复发。CINⅡ、CINⅢ在治愈率、病变持续存在率、复发率方面比较差异无显著性（P=0.963）。LEEP术后病理切缘阳性者、阴性者复发率分别为33.3%（3/9）、10.7%（15/140），两者比较差异无显著意义（P=0.065）；病变持续存在率分别为22.2%（2/9）、2.9%（4/140），两者比较差异有显著意义（P=0.040）。病变持续存在与术后病理切缘是否受累有关，与病变级别无关。结论：对于阴道镜下点状活检诊断为CINⅡ～Ⅲ适宜行LEEP，不仅达到治疗目的，而且能进一步明确宫颈病变程度，但术后应密切随访，尤其术后前2年。     

多层螺旋CT灌注成像诊断周围型肺癌及其微血管密度对照研究

Objective： To investigate the clinical diagnostic value of peripheral lung cancer using multi-slice CT （MSCT） perfusion imaging and the relationship with microvessel density （MVD）. Methods： 38 patients with pulmonary masses proved by pathology including 25 cases of peripheral lung cancer and 13 cases of benign masses were studied prospectively with GE Lightspeed Qx/I plus 16-slice helical CT perfusion imaging, and 25 patients with lung cancer were comparative studied with its MVD calculated using LSAB. With the CT perfusion 2-body tumor software, the parameters of CT perfusion including blood value （BV）, blood flow （BF）, mean transit time （MTT） and permeability surface （PS） were analyzed. Results： The four parameter values in lung cancer were all higher than that in pulmonary benign masses, and there were significant differences among BV, MTT and PS （P〈0.05）, especially in BV （P〈0.01）. The MVD value of lung cancer was higher than that of pulmonary benign masses （P〈0.05）, and the MVD of adenocarcinoma was higher than that of squamous cell carcinoma （P〈0.05）. In 25 cases with lung cancer, there was positive correlation only between BV and MVD value （r=0.852, P〈0.01）. Conclusion： It is helpful to diagnose the peripheral lung cancer with MSCT perfusion imaging and to differentiate from pulmonary benign masses, its bases are MVD pathologically.