Q开关Nd:YAG激光治疗色素增加性皮肤病疗效分析

目的观察Q开关Nd:YAG激光治疗色素增加性皮肤病的临床疗效及治疗次数、间隔时间以及安全性。方法用Q开关Nd:YAG激光(1 064 nm,532 nm波长)治疗570例色素增加性皮肤病,观察、分析其疗效。结果 Q开关Nd:YAG激光治疗色素增加性皮肤病均有效。其中老年斑、雀斑、蓝黑纹身、雀斑样痣、褐青色痣、太田痣总有效率均达87.14%以上。黄褐斑总有效率为85.20%。咖啡斑、炎症后色素沉着总有效率分别为65.00%及60.00%。毛表皮痣总有效率为30.00%。痊愈率由高到低依次为老年斑、雀斑、雀斑样痣、蓝黑纹身、褐青色痣、太田痣、黄褐斑、咖啡斑、炎症后色素沉着、毛表皮痣。治疗次数1～13次,间隔时间1周～半年。临床疗效与治疗次数呈正相关,不良反应少。结论Q开关Nd:YAG激光治疗色素增加性皮肤病的疗效显著,安全性较好。毛表皮痣治疗效果相对较差。     

Q开关Nd:YAG激光治疗色素增加及血管增生等皮肤病的疗效分析

目的：观察Q开关Nd:YAG激光治疗色素增加及血管增生等皮肤病的临床疗效与治愈次数，以及影响疗效的有关因素。方法：用Q开关Nd:YAG激光（1064nm,532nm或585nm波长）治疗3977例色素啬及血管增生等皮肤病，观察，分析其疗效和美容效果。结果：Q形状d:YAG激光治疗色素增加及血管增生等皮肤病均有效，其中雀斑、美容文刺、文身和太田闱总有效率均达95％以上，痊愈率由高到低依次为：雀斑、美容文刺、面部色素恙、雀斑样痣、老年斑、文身、颧部褐青色痣、咖啡斑、外伤性文身、炎症后色素沉着、多毛症、太田痣、毛细血管扩张、蜘蛛痣、蓝痣、鲜红斑痣和毛表皮痣。治愈次数1－9次。结论：Q开关Nd:YAG激光治疗色素增加皮肤病的疗效及美容效果很好，而对多毛症和血管增生皮肤病疗效及美容效果相对较差。     

强脉冲光联合Q开关Nd：YAG激光治疗雀斑的疗效观察

目的：探讨强脉冲光联合Q开关Nd：YAG激光治疗雀斑的疗效。方法：将65例泛发性雀斑患者分为两组。对照组32例采用强脉冲光治疗,每3周一次,5次为一疗程。治疗组33例在疗程的第二次（术后3周）,采用Q开关Nd：YAG激光治疗,其余治疗方法、疗程同对照组。治疗后第6周及12周观察治疗效果。结果：治疗后6周及12周对照组和治疗组的疗效比较,差异有统计学意义（P〈0.05）。结论：强脉冲光联合Q开关Nd：YAG激光治疗泛发性雀斑创伤微小,治疗时间短,痛苦较轻,治愈率高;良好的护理对提高治愈率起着十分重要的作用。     

调Q开关倍频Nd：YAG激光和超脉冲CO2激光对早期脂溢性角化病的疗效比较

目的探讨两种治疗方法对于早期脂溢性角化病的临床效果。方法将患者随机分为两组,分别用调Q开关Nd：YAG激光和超脉冲CO2激光治疗,对比观察治疗效果：结果调Q开关Nd：YAG激光总有效率为96．12％,超咏冲CO2激光治疗组总有效率97．24％,没有统计学差异。术后两组色素沉着率分别为8．74％和25．35％;色素减退率分别为4．37％和7．38％;调Q开关Nd：YAG激光没有疤痕形成,超脉冲CO2激光疤痕形成率为4．15％;均有统计学差异。结论表明调Q开关Nd：YAG激光是一种理想的治疗手段。     

Q开关Nd:YAG激光和585nm脉冲染料激光治疗色素性、血管性皮肤病1686例

目的评估Q开关Nd:YAG激光和585nm脉冲染料激光治疗色素性皮肤病和血管性皮肤病的疗效。方法分别采用Q开关Nd:YAG激光治疗色素性皮肤病400例、585nm脉冲染料激光治疗血管性皮肤病1177例,并采用二者治疗病毒疣109例,观察疗效。结果Q开关Nd:YAG激光对色素性皮肤病的有效率由高到低依次为:雀斑(100%)、文身(87.50%)、脂溢性角化(84.60%)、斑痣(46.70%)、咖啡斑(40.40%);585nm脉冲染料激光对血管性皮肤病的有效率由高到低为:蜘蛛痣(98.30%)、草莓状血管瘤(91.40%)、红斑期酒渣鼻(83.30%)及颜面毛细血管扩张(80.00%);二者对病毒疣的有效率分别为:寻常疣90.10%、尖锐湿疣66.70%、扁平疣52.60%。结论Q开关Nd:YAG激光治疗色素性皮肤病、585nm脉冲染料激光治疗血管性皮肤病及二者治疗病毒疣疗效较好。     

Q开关1064 nm Nd∶YAG激光治疗睑黄瘤的疗效观察

目的:探讨Q开关1064 nm Nd:YAG激光治疗睑黄瘤的疗效及安全性。方法:应用Q开关1064 nm Nd:YAG激光治疗38例睑黄瘤患者(共68处皮损)。能量密度8.3 J/cm~2,频率10 Hz,脉宽6 ns,光斑直径3 mm。每次治疗间隔2周,所有患者在2～8周内接受1～4次激光治疗。结果采用Mantel-Haenszel卡方检验进行分析。结果:68处皮损中,1次治疗后即有70.59%的皮损治疗有效,4次治疗后77.94%的皮损治疗有效,32.35%的皮损疗效显著。结论:在8.3 J/cm~2的能量密度下,Q开关1064nm Nd:YAG激光能安全有效治疗睑黄瘤,治疗次数越多,效果越显著。     

Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑临床观察

目的探讨Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑的疗效和安全性。方法将210例黄褐斑患者随机分为3组,每组各70例。治疗组予Q开关Nd:YAG激光治疗联合红花逍遥片口服;对照1组单纯予Q开关Nd:YAG激光治疗;对照2组单纯口服红花逍遥片。Q开关Nd:YAG激光治疗每周1次连续10周,后2周1次再治疗6周,共16周。红花逍遥片口服2片,3次/d连续16周。分别于5,10和16周时评价临床疗效。结果 16周时治疗组有效率为90.00%,对照1组为80.00%,对照2组为41.00%,差异有统计学意义(P均0.01);治疗组不良反应发生率为26.00%,对照1组为21.00%,对照2组为17.00%,差异无统计学意义(P0.05)。结论 Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑比两者单独应用效果好。     

大光斑低能量Q开关1064nm Nd:YAG激光治疗雀斑

目的:评价大光斑低能量模式Q开关1064 nm Nd:YAG激光治疗雀斑的疗效和安全性。方法:应用大光斑低能量模式Q开关1064 nm Nd:YAG激光治疗15例成人女性雀斑患者。治疗参数:波长1064 nm,脉宽10 ns,光斑7 mm,能量密度1.5~2.0 J/cm2,频率10 hz,每2~3周一次,治疗3~5次。末次治疗结束后随访6个月。结果:8例患者76%~100%皮损颜色变淡,4例51%~75%皮损颜色变淡,3例26%~50%皮损颜色变淡。所有患者治疗后仅有轻微红斑,数小时内消退,治疗后无色沉发生。随访6个月后2例患者复发。结论:大光斑低能量Q开关1064 nm Nd:YAG激光治疗雀斑安全有效。     

Q开关Nd:YAG激光治疗太田痣体会

Q开关Nd:YAG激光治疗太田痣已在临床广泛开展,我科自1997年12月以来开展该疗法,现就治疗体会总结如下。1临床资料     

大光斑低能量Q开关Nd:YAG激光联合中药面膜治疗黄褐斑疗效观察

目的探讨大光斑低能量Q开关Nd:YAG激光联合中药面膜治疗黄褐斑的疗效及安全性。方法 90例患者随机分为3组。治疗组予Q开关Nd:YAG激光联合中药面膜;对照1组单纯予Q开关Nd:YAG激光治疗;对照2组单纯予中药面膜。Q开关Nd:YAG激光治疗波长1 064nm,光斑6mm,能量1.5~3.0J/cm~2,每周1次。外敷中药面膜每周2次。12周进行疗效评价。结果治疗组有效率83.33%,对照1组63.33%,对照2组50.00%,治疗组与对照1组,对照2组之间的差异具有统计学意义(P0.05),对照1组与对照2组之间的差异无统计学意义(P0.05)。结论大光斑低能量Q开关Nd:YAG激光联合中药面膜治疗黄褐斑安全、有效。     

A randomized,split-face clinical trial of Q-switched alexandrite laser versus Q-switched Nd:YAG laser in the treatment of bilateral nevus of Ota

Different types of Q-switched (QS) lasers have been used successfully to treat nevus of Ota. The purpose of this study was to compare the clinical efficacy and complication of QS alexandrite (QS Alex) laser versus QS neodymium:yttrium aluminum garnet (Nd:YAG) (QS Nd:YAG) laser for bilateral nevus of Ota. Seventeen patients with bilateral nevus of Ota were treated randomly with QS Alex in one half of face and QS Nd:YAG in the other half with an interval of at least 3 months between each. Subjective assessment was made by both patients and dermatologists. Patients were also examined for evidence of complications. All patients experienced improvement (p < 0.05). There was no statistically significant difference between the two sides (p > 0.05). The pain after a short period of laser therapy was more severe for QS Alex than for QS Nd:YAG laser. Vesicles developed in 1 patient after QS Alex therapy. Both QS Alex laser and QS Nd:YAG laser were equally effective at improving bilateral nevus of Ota. Patients tolerate QS Nd:YAG laser better than QS Alex laser.     

调Q-Nd:YAG染料700nm激光治疗太田痣130例临床评估

应用调Q-Nd：YAG染料700nm激光治疗大田痣130例，疗效随治疗次数增加而显著，治疗5次以上治愈率75%，显效率100%，随访未发现色素减退，治疗区未见皮肤纹理改变及瘢痕，疗效与其他类型或波长激光相近，具有安全性高，恢复快，痛苦小的优点。     

调QAlexandrite激光对太田痣黑素细胞作用机制的研究

目的 研究调Ｑ Ａｌｅｘａｎｄｒｉｔｅ激光对太田痣黑素细胞的作用机制。方法 在激光照射前及照射后各个阶段,对４例患者分别进行１１例次组织病理学观察和１４例次透射电镜观察。结果激光照射瞬间,真皮黑素细胞破坏,黑素小体空泡化,真皮中形成圆形人泡。表皮无明显损伤。     

A retrospective analysis of the clinical efficacies and recurrence of Q-switched Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients

Background: Nevus of Ota can be treated successfully using the Q-switched (QS) laser; but few studies are long-term retrospective of the efficacy and influencing factor, studies on the recurrence is even less. Purpose: Retrospective analysis of the clinical characteristics and recurrence of QS Nd:YAG laser treatment of nevus of Ota in 224 Chinese patients at Laser Cosmetology Center of Department of Dermatology, the Second Hospital, Xi’an Jiaotong University. Methods: The data of 224 patients with nevus of Ota were analyzed retrospectively, which included the correlation among lesion color, treatment sessions, gender, age, lesion types and effect, and all patients were followed up for 2–10 years. Results: Higher number of treatment sessions that were conducted using the QS Nd:YAG laser system was positively associated with better responses to treatment. 99.11% of patients acquired more than 75% improvement with an average of 3.7 sessions. Only eight patients (3.57%) who had been completely cleared developed recurrence at the same site as before. Conclusion: The treatment of nevus of Ota with QS Nd:YAG laser is safe and effective with rare recurrence.     

Treatment of nevus of OTA by Q-switched, frequency doubled, ND:YAG laser

Nevus of Ota is a dermal melanocytic nevus for which hitherto no effective therapy was available. Lasers have been successfully tried for ablation. But there is no Indian experience till date. Q-Switched, Frequency Doubled, Nd:YAG Laser was installed at our centre an year ago. The first operated case, which has shown near complete pigment dilution, is being presented. The patient underwent three treatments with a minimum of 2 months between sessions. Pre and post therapy photographs were taken and side effects documented. The patient has shown near complete pigment dilution after 3 treatments. Q-Switched, Frequency Doubled, Nd:YAG Laser is effective in treating Nevus of Ota in the Indian skin types. There are no complications noticed till date in our experience.     

Successful treatment of a patient with multicolored nevus of Ota using a combination of 1064 and 532 nm Q-switched Nd:YAG lasers

ABSTRACT

Nevus of Ota (NO) is a hamartoma of dermal melanocytes usually presents as unilateral blue, gray or brown macules or patches. It can impose a high burden of cosmetic and psychological disturbances in affected individuals. Q-Switched lasers appear to be an effective treatment for this kind of dermal melanocytosis. Multicolored Ota nevus is a rare variant of this kind of nevus and its treatment may be more challenging compared with unicolor lesions. Herein we report a 21-year-old woman with a multicolored nevus of Ota (blue and brown), which showed a dramatic response to a combination of 1,064 nm and 532 nm Q-Switched Nd:YAG lasers. We also discuss different aspects of the Q-switched laser application of Ota nevus treatment. We also focus on laser combination therapy to treat the nevus of Ota.     

不同波长的Q-开关激光治疗眶周色素沉着症疗效比较

目的：评价三种Q-开关激光治疗眶周色素沉着症的疗效。方法：83例患者随机分为A、B、C3组，A组和C组分别采用532nm和1064nm Q-开关Nd：YAG激光治疗，B组采用Q-开关翠绿宝石激光(755nm)治疗。结果：A组和C组疗效差，B组经4次及以上的治疗，总有效率可达82．1％，3组的总有效率的差异有显著性。结论：Q-开关翠绿宝石激光治疗眶周色素沉着症有较满意疗效，无明显副作用，可作为首选治疗方法。     

Treatment of acquired bilateral nevus of Ota‐like macules (Hori's nevus) using 1064‐nm Q‐switched Nd:YAG laser with low fluence

Background Acquired bilateral nevus of Ota‐like macules (ABNOM), or Hori's nevus, is a common dermal melanocytic hyperpigmentation in Asians. Aim To describe the effect of 1064‐nm Q‐switched Nd:YAG laser (QSNY) with low fluence in South Korean patients with ABNOM. Methods Fifteen South Korean patients (13 women and two men; mean age, 33.2 years; range, 26–52 years; Fitzpatrick skin type IV), clinically diagnosed with ABNOM, and treated using 1064‐nm QSNY with low fluence, were enrolled in this study. Patients were treated with 1064‐nm QSNY using a MedLite C6? (HoyaConBio Inc., Fremont, CA, USA) at 1–2‐week intervals. The laser settings were 2.2–2.6 J/cm² using a 6‐mm spot size, followed by 4–6 J/cm² using a 4‐mm spot size. Results The median number of QSNY treatment sessions was 11 (range, 10–15). Follow‐up results 2 months after the final treatment revealed that seven of the 15 patients (46.7%) demonstrated clinical improvement of 76–100%, and five (33.3%) of 51–75%. Three patients showed moderate clinical improvement between 26% and 50%. Post‐therapy dyschromia, including hypo‐ and hyperpigmentation, was not observed. Conclusion We suggest that QSNY with low fluence provides an easy‐to‐perform, low‐downtime, effective treatment algorithm in certain cases of ABNOM in Asian patients.     

Induction of melasma by 1064‐nm Q‐switched neodymium:yttrium–aluminum–garnet laser therapy for acquired bilateral nevus of Ota‐like macules (Hori nevus): A study on related factors in the Chinese population

Laser treatment has emerged as a common treatment modality for acquired bilateral nevus of Ota‐like macules (ABNOM). To identify the ratio of melasma induction and exacerbation before and after laser therapy for ABNOM and to observe the risk factors related to the induction and exacerbation of melasma by laser therapy, we analyzed related factors of 1268 adult Chinese patients who underwent 1064‐nm Q‐switched neodymium:yttrium–aluminum–garnet (Nd:YAG) laser (QNYL) treatment using case series and case–control studies. Overall, 24.0% of the ABNOM patients had mixed melasma. Among the ABNOM patients without melasma, after laser therapy the development of melasma was more frequently noted in patients older than 35 years (P < 0.0001), as well in patients whose ABNOM was less than 10 cm² (P = 0.027), ABNOM were light (similar to yellow‐brown) in color (P = 0.021) and skin types were closer to type IV (P < 0.0001). New melasma lesions also appeared most frequently in the zygomatic region (P < 0.0001). Among the ABNOM patients with melasma, 89.5% experienced worsening of their melasma, irrespective of their related factors above. We concluded that the risk of inducing melasma is great after 1064‐nm QNYL treatment in ABNOM patients, and particularly in the patients with both ABNOM and melasma. ABNOM patients should be treated as early as possible and before the age of 35 years.