共查询到20条相似文献，搜索用时 15 毫秒
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Shen KR Wain JC Wright CD Grillo HC Mathisen DJ 《The Journal of thoracic and cardiovascular surgery》2008,135(6):1210-1219
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Richard C. Gilmore Vinod H. Thourani Hanna A. Jensen Jose Condado José Nilo G. Binongo Eric L. Sarin Chandan M. Devireddy Bradley Leshnower Kreton Mavromatis Amjad Syed Robert A. Guyton Peter C. Block Amy Simone Patricia Keegan James Stewart Mohammad Rajaei Brian Kaebnick Stamatios Lerakis Vasilis C. Babaliaros 《The Annals of thoracic surgery》2015,100(6):2167-2173
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Hiroaki Nomori Atsushi Shiraishi Yue Cong Kazufusa Shoji Masafumi Misawa Hiroshi Sugimura Yu Oyama 《The Journal of thoracic and cardiovascular surgery》2018,155(5):2129-2137.e1
Objective
Our study aim was to determine whether there are differential changes in whole-lung and regional lung functions after lobectomy for lung cancer between propensity score-matched patients treated with and without induction chemoradiotherapy, by using single-photon emission computed tomography lung perfusion.Methods
This study was a retrospective matched cohort study of consecutively acquired data. Pulmonary function test and perfusion scintigraphy were conducted before lobectomy and 6 months after lobectomy in patients treated with induction therapy (n = 72) and in those not treated (n = 170), for measuring functional changes of whole lung, contralateral lung, and lobes. After exact matching on resected lobe site, propensity scores for age, smoking status, preoperative pulmonary functions, and predicted postoperative pulmonary function were used to match the groups.Results
After the matching, 46 patients were selected from the groups. Standardized mean differences of the 5 matched variables were <0.1. Whole lung function significantly decreased after lobectomy in the induction therapy group than in the noninduction therapy group (P < .001). Although ipsilateral preserved lobe function before surgery was not different between the groups (P = .33), postoperative value was significantly lower in the induction therapy group than in the noninduction therapy group (P < .001). Although both groups showed a significant increase of contralateral lung function after lobectomy (P < .01), the increases were not significantly different between the groups (P = .81).Conclusions
Induction chemoradiotherapy was associated with reduced pulmonary function after lobectomy because of a decrease in ipsilateral preserved lobe function, which could be caused by the chronic effects of the induction chemoradiotherapy. 相似文献17.
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