光学相干断层扫描评价高度近视黄斑裂孔伴视网膜脱离的玻璃体手术疗效

目的 光学相干断层扫描(Optical Coherence Tomography，OCT)评价高度近视黄斑裂孔伴视网膜脱离行玻璃体手术的疗效。方法 回顾性分析17例(17眼)高度近视黄斑裂孔伴视网膜脱离行玻璃体切除术的住院病史资料，术后平均随访10月，所有病例均行以下检查：OCT、裂隙灯生物显微镜、三面镜、90D前置镜、验光。结果 术后OCT表现有3种：黄斑裂孔闭合2眼(11．8％)，黄斑裂孔未闭合但视网膜复位12眼(70．6％)，黄斑裂孔未闭合伴视网膜浅脱离3眼(17．6％)。预后情况与黄斑区色素上皮和脉络膜的健康状况以及黄斑裂孔的大小有关。结论 高度近视黄斑裂孔伴视网膜脱离行玻璃体手术的裂孔闭合率低。OCT是术后随访的有效手段。     

Reorganization of photoreceptor layer on optical coherence tomography concurrent with visual improvement after macular hole surgery

To report three cases in which reorganization of the photoreceptor layer on optical coherence tomography (OCT) was concurrent with long-term visual recovery after macular hole surgery. Serial OCT scans of three eyes in which visual acuity continued to improve for 1 or more years after successful macular hole surgery were reviewed. Case 1. At postoperative four weeks, visual acuity was 20/100 with disorganized photoreceptor layer on OCT. The photoreceptor layer had been reorganized and visual acuity had improved to 20/25 by 1 year. Case 2. Two weeks after the operation, visual acuity was 20/125 and disorganization of the photoreceptor layer was noted. Visual acuity improved to 20/50 by four months. The photoreceptor layer had been partly reorganized and had appearance of a broken line. Visual acuity had improved to 20/40 and the photoreceptor layer had been reorganized further with a residual defect on OCT by 15 months. Case 3. Visual acuity at two weeks was 20/100. OCT revealed disorganization of the photoreceptor layer. Six months after the operation, the partly reorganized photoreceptor layer appeared as a broken line and visual acuity had reached 20/80. Visual acuity had improved further to 20/40 by 1 year, concurrent with improved organization of the photoreceptor layer. The reorganization of the photoreceptor layer plays a part in long-term improvement of visual acuity after macular hole surgery.     

抗血管内皮生发因子治疗后湿性AMD患者的OCT特征与视力相关性分析

目的 评价湿性年龄相关性黄斑变性(AMD)患者抗血管内皮生长因子(VEGF)治疗后术眼OCT参数与视力之间的相关性.方法 32例32只眼湿性AMD患者接受抗VEGF治疗后5-6月,记录患者最佳矫正视力,同一天进行频域OCT扫描,对黄斑中心凹厚度(FT),黄斑中心区厚度(CST),黄斑区容积(CV),黄斑区平均厚度(CAT),视网膜下液(SRF),视网膜内液(IRF),脉络膜新生血管膜厚度(CN-VMT)等参数进行分析,并根据成像质量进行手动校正,探讨术眼最佳矫正视力与OCT各参数之间的关系.结果 对32例患者的结果分析显示,在CST>210um的患者中,术眼最佳矫正视力(LogMar视力)与校正前后的FT、CV及CAT均无相关性;与校正前后的CST有相关性,相关系数分别为r=0.396,P=0.041;r=0.447,P=0.019,校正后的相关性更强.有视网膜内液组和无视网膜内液组的LogMar视力分别为1.14±0.54和0.64.4±0.49,两组差异有统计学意义(t=2.66 P=0.012). CNV显著组和CNV不显著组的LogMar视力分别0.98 4±0.61,0.57 4±0.34,两组差异有统计学意义(t=2.205 P=0.035).结论 湿性AMD患者抗VEGF治疗后最佳矫正视力(LogMar视力)与校正后的中心区厚度呈正相关.手动校正中心凹位置对正确判断AMD患者抗VEGF治疗的效果十分必要.     

A study of macular hole formation by serial spectral optical coherence tomography

Background:  The purpose of this paper is to evaluate changes of the vitreoretinal interface in fellow eyes of eyes with a macular hole and to study early stages of macular hole formation by spectral optical coherence tomography (SOCT).
Methods:  A prospective study of 131 consecutive patients with history of macular hole. Serial SOCT examinations were performed on the fellow eyes four times during a 6-month observation period. Progression of foveal changes and formation of macular hole in the fellow eyes were studied.
Results:  Seven distinct abnormalities in the foveal region were noted in 70 of the fellow eyes (53.4%). Additionally in 18 patients (13.6%) other defects typical for the older population were noted. Gradual evolution to full-thickness macular holes during the 6-month observation period was noted in five eyes. One of these eyes had a previously detected cyst, and four eyes had elevation of the photoreceptor layer.
Conclusions:  The high prevalence of macular abnormalities in the fellow eyes particularly epiretinal membranes and vitreous traction with schizis as well as the evolution of these abnormalities over time suggest that diseases of the vitreomacular interface may have similar pathogenesis. Macular hole formation often starts as a triangular elevation of the photoreceptor layer. In some cases, a cyst in the inner retinal layers can be an early step in macular hole formation.     

外伤性黄斑裂孔的光学相干断层成像特征

目的 :分析外伤性黄斑裂孔的光学相干断层成像特征。方法 :18例黄斑裂孔患者 (18眼 )行OCT检查。结果 :17例外伤性黄斑裂孔均未见玻璃体后脱离 (PVD) ,裂孔边界整齐 ,无明显视网膜脱离。 7例裂孔边缘可见神经上皮脱离的轮化 ,10例未见晕轮。结论 :年轻的外伤性黄斑裂孔患者不易发生视网膜脱离 ,定期检查OCT有助于外伤性黄斑裂孔治疗方式的选择。     

光学相干断层成像对黄斑裂孔的诊断意义

目的　评价光学相干断层成像 (optical coherence tomography,OCT)对黄斑裂孔的诊断价值。方法　自 1999年 10月至 2 0 0 0年 2月我院 40例 45只眼临床诊断为黄斑裂孔的患者在双眼散瞳后行 OCT检查 ,并对图像进行测量和分析。结果　 10例 (13只眼 ) OCT显示为板层裂孔 ,其黄斑中心凹处神经上皮厚度平均为 110μm,标准差为 41。全层黄斑裂孔 30例 (32只眼 ) ,5例为双眼黄斑全层或板层裂孔 ,平均裂孔直径为 6 2 1.2μm,标准差为194.1。全层裂孔者 OCT表现为黄斑中心凹处边界清晰的全层神经上皮缺失 ,裂孔周围视网膜增厚为 393.4±10 0 .7μm,并见无反射的暗腔。 5例行手术后裂孔封闭 ,黄斑中心凹正常反射曲线恢复。结论　 OCT是一种非接触性、非侵入性、高分辨率的检测技术 ,临床上对于黄斑裂孔的定性及定量诊断具有非常重要的应用价值。     

光学相干断层扫描对特发性黄斑裂孔玻璃体手术解剖疗效的评价

目的 探讨光学相干断层扫描(optical coherence tomography,OCT)图像在评价特发性黄斑裂孔(idiopathic macular hole,IMH)手术疗效中的作用。 方法 用OCT检测19例IMH患者19只眼手术前、后的裂孔直径、孔晕直径、孔缘厚度及裂孔形态变化特征。 结果 OCT定量检测显示,裂孔直径平均由术前(570.95±264.59)μm减少到术后(337．05±335.95)　μm,孔晕直 径平均由术前(1043．53±278.80)　μm减少到术后(695．00±483.00)　μm,孔缘厚 度平均由术前(389.78±60．58)　μm减少到术后(298.78±109．80)　μm。裂孔闭合、 缩小,孔晕缩小,孔缘厚度减少共17只眼,手术解剖成功率为89%。结论OCT能客观、精确、有效地判断IMH手术的解剖疗效。（中华眼底病杂志,2000,16：71-138）     

Evolution of lamellar macular hole studied by optical coherence tomography

Purpose  To study the natural course of lamellar macular hole (LMH) as examined by optical coherence tomography (OCT) in a noncomparative observational case series. Methods  Forty-one eyes of 41 patients with LMH were included in this analysis. Baseline and final OCT findings related to LMH diameter, foveal thickness and visual acuity (VA) were collected and compared. Mean follow-up was 37.1 months. Main outcome measures were best-corrected visual acuity (BCVA), diameter of the LMH opening, foveal thickness, epiretinal membrane (ERM), posterior vitreous detachment (PVD) and vitreoretinal traction. Results  The diameter of the LMH increased by an average of 13.7%. A statistically significant association was found between the LMH diameter increase and the presence of ERM. The mean foveal thickness depicted a statistically significant decrease between the initial and the final examination. The decrease of the foveal thickness showed to correlate with visual acuity deterioration. BCVA was stable in 30 (78%) and deteriorated in 11 (22%) cases. In eight of the 11 cases, the visual acuity deterioration ranged from 2 to 15 letters. Conclusion  We identified an increase of LMH diameter related to the presence of ERM and a decrease of the foveal thickness within a period of observation which ranged from 24 to 54 months (mean 37.1 months). The study is not related with any proprietary or commercial interests. No sponsoring organizations have been involved and no grants were received from any organization or institution.     

白内障术前频域相干光断层扫描对黄斑疾病诊断价值的探讨

目的探讨白内障术前频域相干光断层扫描（SD-OCT）对黄斑疾病的诊断价值。方法随机选取2012年1～10月在本院准备行白内障超声乳化联合人工晶状体植入手术患者共418例（418眼）,分别采用双目间接检眼镜及海德堡公司生产的Spectralis OCT对所有患者进行术前黄斑区视网膜检查,判断黄斑疾病。术后1～2d再行检眼镜及OCT检查随访,阳性病例及疑似病例于术后1周进行荧光素眼底血管造影（FFA）或吲哚青绿血管造影（ICGA）检查。对比检眼镜与OCT2种检查方法在白内障术前对黄斑疾病的检出率。结果术后最终确诊为黄斑疾病42例。白内障术前,289例成功获取OCT图像,占总数69．14％,其中36例显示有不同类型的黄斑疾病,检出率为85．71％;206例通过双目间接检眼镜可查见眼底,其中14例显示有黄斑病变,检出率为33．33％。2种方法在白内障术前对黄斑疾病检出率差异有统计学意义（P〈0．01）。结论与传统的双目间接检眼镜相比,SD-OCT可以大大提高白内障术前黄斑疾病的检出率,有利于对白内障术后预后效果的判断。SD．OCT在白内障术前对黄斑疾病的诊断具有较高的临床价值,可广泛应用于白内障术前检杏。     

Stargardt病的频域相干光断层扫描图像分析

目的 应用频域相干光断层扫描(OCT)技术评价Stargardt病患者黄斑区视网膜容积与中心视力之间的关系.方法 回顾性病例系列研究.收集10例(20只眼)Stargardt病的临床资料进行回顾性分析.所有患者均使用频域OCT分别测量黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节缺失宽度、黄斑中心凹区直径3 mm和1 mm范围内的视网膜容积.运用线性回归分析法,比较最小分辨角对数(logMAR)视力与黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节(IS/OS)缺失宽度、黄斑中心凹区直径3 mm和1 mm范围内视网膜容积的关系.结果 18只眼的logMAR视力为0.30～1.22,黄斑中心凹区光感受器细胞内外节缺失宽度为847～5306μm,黄斑中心凹区视网膜厚度为20～126 μm,黄斑中心凹区直径3 mm和1 mm范围内的视网膜容积分别为1.06～1.76 mm3、0.06～0.13 mm3.logMAR视力与黄斑中心凹区光感受器细胞内外节缺失宽度呈正相关(r=0.695,P＜0.05),与黄斑中心凹区视网膜厚度呈负相关(r=-0.601,P＜0.05),与黄斑中心凹区直径3 mm范围内的视网膜容积呈负相关(r=-0.725,P＜0.05),与黄斑中心凹区直径1 mm范围内的视网膜容积无相关性(r=-0.364,P＜0.05).结论 频域OCT技术可以清晰观察Stargardt 病患者各层视网膜结构,频域OCT检测获得的黄斑区视网膜容积与中心视力间存在一定的相关性.

Abstract：

Objective To assess the relationship between central visual acuity and retinal volume of macular fovea in patients with Stargardt disease by spectral-domain optical coherence tomography ( SD OCT). Methods It was a retrospective case series study. Twenty eyes of 10 patients with Stargardt disease were investigated by three-dimensional spectral-domain optical coherence tomography. SD OCT images were obtained and retrospectively analyzed. The retinal volumes of macular fovea were measured by SD OCT,whose diameters were set as 3 mm and 1 mm separately ( volume 3 and volume 1). The retinal thickness of macular fovea (macular thickness) and the width of IS/OS conjunction loss of macular fovea (IS/OS loss)were also measured by SD OCT. We correlated the logMAR BCVA with IS/OS loss, macular thickness,volume 3 and volume 1 by linear regression analysis. Results LogMAR BCVA was from 0. 3 to 1. 22.IS/OS loss was from 847 μm to 5306 μm. Macular thickness was from 20 μm to 126μm. Volume 3 and volume 1 was from 1. 06 to 1. 76 mm3 and 0. 06 to 0. 13 mm3. LogMAR BCVA correlated with the IS/OS loss (r = 0.695,P＜0. 05) , macular thickness (r= - 0. 601 ,P ＜ 0. 05), and volume 3 ( r = -0.725,P＜0. 05 ). LogMAR BCVA did not correlate with volume 1 ( r = - 0. 364, P ＞ 0. 05). Conclusions SD OCT could demonstrate the retinal structure of Stargardt disease clearly. The retinal volume of macular fovea accessed by SD OCT correlated with the visual acuity of Stargardt disease.     

Spectral-domain optical coherence tomography images of inner/outer segment junctions and macular hole surgery outcomes

Background  To evaluate the ability of spectral-domain optical coherence tomography (SD-OCT) images of the inner/outer segment (IS/OS) junction to predict macular hole surgery outcomes. Methods  Fifty-four eyes in 53 patients with idiopathic macular holes were studied. Postoperative visual acuity and SD-OCT images of the fovea were examined before and 12 months after surgery. The total area and the maximum length of the IS/OS junction defect were measured. Results  The macular holes were successfully closed in all the eyes included in this series. The mean logMAR visual acuity improved significantly from 0.67 ± 0.25 preoperatively to 0.16 ± 0.22 postoperatively (p < 0.001). The mean total area and maximum length of the IS/OS junction defect at 12 months after surgery were 10,185 ± 1,537 μm² and 100.5 ± 10.4 μm respectively; these values were significantly negatively correlated with the postoperative visual acuity. Conclusion  SD-OCT is useful for quantitatively measuring IS/OS junction defects. The postoperative IS/OS junction may play an important role in visual recovery after macular hole surgery. Financial support None. The authors have no proprietary interest in the material used in this study.     

频域OCT检查对黄斑水肿特点的分析

目的 通过频域OCT对黄斑水肿形态进行观察,了解水肿程度及分布情况,并分析水肿与视力的相关性.方法 选取患黄斑水肿患者25例29只眼,病例包括视网膜中央静脉阻塞所致为8例8只眼,视网膜分支静脉阻塞7例7只眼,葡萄膜炎4例4只眼,糖尿病性视网膜病变6例10只眼.年龄52-83(64.76±8.30)岁.最佳矫正视力(BCVA)0.05～1.0(0.35±0.12).利用最新一代频域RTVueFD-OCT对黄斑区进行扫描.结果 黄斑区15°范围内神经上皮厚度(453.00±103.12)μm,其中各区域神经上皮层厚度为:中心凹(533.10±115.23)μm,旁中心区(488.93±89.71)μm,中心凹边缘区(397.05±83.52)μm.不同区域神经上皮层厚度比较差异有统计学意义(F=2.937,P<0.01),黄斑区中心凹区神经上皮层厚度与中心凹边缘区神经上皮层厚度比较差异有统计学意义(与上、下、鼻、颞侧比较结果P<0.01,以中心凹区最厚,依次为下、上、颞、鼻侧边缘区).而中心凹神经上皮层厚度与旁中心凹区神经上皮层厚度比较差异无统计学意义与上、下、鼻、颞侧比较结果P>0.05.患者BCVA与中心凹神经上皮层厚度间存在负相关关系(r=-0.784,P<0.01),与旁中心凹区神经上皮层厚度间无相关关系(r=-0.134,P>0.05),与中心凹边缘区神经上皮层厚度间无相关关系(r=.275,P>0.05).结论 频域OCT能够精确地对黄斑水肿进行活体组织学成像,具有简便、非侵入性、重复性好等特点.     

3D光学相干断层扫描在特发性黄斑前膜诊治中的应用

目的应用3D光学相干断层扫描（OCT）观察特发性黄斑前膜（IMEM）的形态特征及其对视力的影响。方法应用3D—OCT观察42例（46只眼）IMEM患者的OCT图像,分析黄斑中心凹形态、中心凹厚度与视力的关系。结果在42例（46只眼）IMEM患者的3D-OCT图像中表现为黄斑区视网膜表面厚薄不一的高反光带,绝大多数伴不同程度的黄斑中心凹厚度增加,黄斑中心凹越厚,视力越差。34只眼（73．9％）OCT图像表现为与视网膜内层局灶性粘附的条带状强反光,大部分与视网膜内层分离,另12只眼（26．1％）表现为与视网膜内层完全紧密粘连的增强增宽的反光带。结论3D-OCT可以精确测量黄斑视网膜厚度,客观而全面地提供视网膜各层之间以及厚度变化的信息,从而初步评价IMEM与视力的关系,为IMEM提供更有参考价值的手术指征并指导手术操作。     

外伤性黄斑全层裂孔的OCT观察

目的 观察外伤性黄斑伞层裂孔的光学相干断层成像特征及转归.方法 对15例(15只眼)黄斑全层裂孔患者采用OCT检查观察两周至2年,分析其图像特征.结果 15只眼OCT图像均表现为黄斑区全层视网膜神经上皮缺失;15只眼中11例未进行手术治疗,其中4例在2周至8个月(36.4%)自然愈合,视力平均提高3.3行.6例(54.5%)观察了6个月至2年未愈合,视力提高1～2行者5例,下降者1例.1例(9.1%)在受伤后1～7个月期间发展成为全层裂孔,视力无明显变化;15只眼中4例进行了手术治疗,术后2个月至1年OCT显示裂孔愈合,2例视力提高了3行,2例视力无明显改善.结论 外伤性黄斑全层裂孔是有可能自然愈合的,采用OCT保守观察是外伤性黄斑裂孔治疗的一种选择.     

特发性黄斑裂孔的光学相干断层成像分析

目的：采用光学相干断层扫描（optical coherence tomography,OCT）观察特发性黄斑裂孔（idiopathic macular hole,IMH）各期的图像特征及演变过程。方法：对199只眼（170例，其中29例双眼患者）IMH的OCT图像进行回顾性观察分析，进行随访观察。结果：Ⅰ期裂孔１６只眼（８％），表现为黄斑中心凹视网膜不同程度的囊样变性（７５％）或浅脱离（１５％）；Ⅱ期裂孔２０只眼（１０%）,OCT示黄斑中心凹旁中心破裂（８５％）和中心破裂（１５％）；Ⅲ期裂孔１２１只眼（６１％），表现为黄斑中心凹神经上皮层全层缺失；Ⅳ期裂孔、板层裂孔及双眼黄斑裂孔分别为２３只眼（１２％）、１９只眼（１０％）、２９只眼（１７％）。结论：OCT图像对观察IMH各期特征及演进过程具有重要的临床应用价值。     

Morphological and functional changes in spectral domain optical coherence tomography and microperimetry in macular microhole variants: spectral domain optical coherence tomography and microperimetry correlation

Purpose:

To evaluate the relationship between the morphology and retinal function of macular microhole (MMH) variants.

Materials and Methods:

We evaluated 12 eyes of 11 patients with defects in the IS/OS junction of photoreceptor layer with SD-OCT. All patients underwent comprehensive ophthalmic examination including spectral domain optical coherence tomography (SD-OCT) and microperimetry.

Results:

The mean logMAR visual acuity in the affected eye was 0.15 ± 0.17 (range 0.00–0.5). Mean horizontal diameter of the MMH was 163 ± 99 μm; the mean retinal sensitivity in the area corresponding to the MMH was 13.79 ± 4.6 dB. Negative correlation was found between the MMH diameter and the retinal sensitivity (r = -0.65, p = 0.02). Three morphological patterns of MMH variants were recognized on SD-OCT, which did not differ in retinal sensitivities.

Conclusion:

We described and classified the MMH variants and made an assessment on the physiological functions using microperimeter.     

Long-term functional outcome of macular hole surgery correlated to optical coherence tomography measurements

OBJECTIVE: Evaluation of long-term functional outcome after macular hole surgery and its correlation with postoperative optical coherence tomography (OCT). METHODS: Before and after surgery a complete clinical examination and OCT were performed in 38 patients. Best corrected postoperative visual acuity (VA) was correlated to the following OCT parameters: preoperative base and minimum diameter of the hole, hole height, hole form factor, retinal thickness and nerve-fibre layer measurements postoperatively, postoperative foveal contour, appearance of retinal pigment epithelium layer and photoreceptor layer. RESULTS: Over a mean follow up of 67 months, VA improved significantly (P=0.01). Retinal thickness and retinal thickness and nerve-fibre layer measurements of the operated eye did not differ from fellow eye. A negative correlation was seen between final VA and preoperative base diameter of the hole (r=-0.41, P=0.02) and hole height (r=-0.45, P=0.01). The correlation between hole form factor values and final VA (r=0.36, P=0.04) was weak. Appearance of the photoreceptor band was the only OCT parameter significantly correlating with final VA (r=-0.42, P=0.01) and explaining the observed increase (r=-0.32, P=0.05) in VA. CONCLUSION: Appearance of the photoreceptor layer on postoperative OCT correlates to functional outcome and may help to explain cases of unsatisfactory postoperative VA despite successful hole closure.     

Posterior chamber compartments demonstrated by optical coherence tomography, in silicone-filled eyes, following macular hole surgery

PURPOSE: To report visualization with optical coherence tomography of a prefoveal space in silicone oil-filled eyes following surgery for idiopathic macular hole. METHODS: Seven eyes of seven consecutive patients undergoing macular hole surgery with silicone oil tamponade were prospectively evaluated with optical coherence tomography preoperatively, on the first postoperative day, after 6 weeks and before removal of silicone oil. RESULTS: In all seven eyes the posterior face of the silicone oil bubble was visualized with optical coherence tomography. In all of these patients, who had a silicone oil fill of over 90%, the silicone oil bubble in the upright position did not conform to the foveal depression. Closure of the macular hole was achieved in all seven eyes after one operation. CONCLUSIONS: Macular hole closure can occur without complete tamponade of the central fovea. A prefoveal space can be visualized in silicone oil-filled eyes. Concentration of growth factors, adjuvants and indocyanine green in this compartment may influence postoperative visual outcome, as may changes in retinal homeostasis induced by removal of silicone oil.     

视网膜色素变性的相干光断层成像

目的 通过相干光断层成像（optical coherence tomography,OCT）观察原发性视网膜色素变性（retinitis pigmentosa,RP）患者的视网膜黄斑区图像特征.方法 对临床诊断为原发性视网膜色素变性的25例50只眼进行相干光断层成像检查,观察形态特点并进行厚度测量.结果 原发性视网膜色素变性患者黄斑区的相干光断层图像,通常有6种表现：1.神经上皮层弥漫性增厚即水肿（厚度＞170μm）,13只眼（26%）.2.黄斑囊样水肿8只眼（16.7%）.3.神经上皮层萎缩薄变（＜120μm）,18只眼（36%）.4.视网膜色素上皮层和脉络膜毛细血管层萎缩薄变,见于所有患者.5.黄斑前膜4只眼（8%）.6.黄斑正常厚度.结论 相干光断层成像有助于较早地发现RP的各种黄斑病变,是很有用的检查方法.     

Glaucoma and optical coherence tomography changes in migraine: A comparative cross-sectional study

Purpose:To study the prevalence of glaucoma among adults with migraine and the effect of migraine on peripapillary retinal nerve fiber layer (pRNFL) and central macular thickness (CMT) using optical coherence tomography (OCT) compared to those without migraine headache, i.e. in tension-type headache (TTH) and normal group.Methods:One hundred and eleven patients (222 eyes) were recruited in three groups. migraine, TTH, and normal subjects visiting hospital outpatient services. After noting demographic details and pertinent history, ophthalmological evaluation including optic disc for glaucomatous changes along with computerized visual field testing and OCT for pRNFL thickness and CMT was performed in all eyes. Continuous variables were compared using ANOVA or Kruskal–Wallis test, while categorical variables including the association of glaucoma with migraine were analyzed using Chi-square or Fisher’s exact test.Results:Prevalence of glaucoma in migraine group (12.2%) was more than in comparison groups (6.8% in TTH, 4.1% in normal) which was however not significant (Fisher’s exact P = 0.207). Average pRNFL thickness (103.59 ± 12.82 μm) and thickness in nasal (90.49 ± 19.19 μm) and temporal quadrants (70.58 ± 16.13 μm) and CMT (213.78 ± 19.81 μm) were significantly reduced (ANOVA P < 0.05) in migraine patients when compared to the other groups and this was independent of the presence of glaucoma.Conclusion:Prevalence of glaucoma is not significantly higher in migraine patients. However, migraine causes thinning of retinal layers on OCT that is statistically significant.