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1.
Yu. O. Fedotova N. P. Goncharov N. S. Sapronov 《Bulletin of experimental biology and medicine》2004,138(7):54-57
We studied the effect of repeated intraperitoneal treatment with dehydroepiandrosterone in doses of 0.1 and 0.7 mg/kg on conditioned-response
activity and behavior of adult male rats. The effect of dehydroepiandrosterone on learning was estimated in conditioned active
and passive avoidance response paradigms. Chronic administration of dehydroepiandrosterone in low and high doses had no effect
on retention of conditioned passive avoidance response in adult male rats 24 h after learning. However, chronic administration
of dehydroepiandrosterone in low dose impaired acquisition of the conditioned active avoidance response. It should be emphasized
that chronic administration of dehydroepiandrosterone in high dose did not modulate acquisition and retention of this reaction.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 7, pp. 63–67, July, 2004
This work was supported by the Regional Social Foundation for Russian Medicine. 相似文献
2.
Obut TA Ovsyukova MV Cherkasova OP 《Bulletin of experimental biology and medicine》2006,141(5):571-573
In male rats exposed to repeated stress, the decrease in stress reactivity produced by subcutaneous injection of dehydroepiandrosterone
sulfate (recorded by the decrease in stress-induced concentrations of corticosterone and adrenocorticotropic hormone in blood
plasma) was observed 1–6 days postinjection and involved central regulatory mechanisms.
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Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 141, No. 5, pp. 507–510, May, 2006 相似文献
3.
Obut TA Ovsyukova MV Cherkasova OP 《Bulletin of experimental biology and medicine》2004,138(2):137-139
Acute stress was accompanied by reduction of 11-dehydrocorticosterone to corticosterone in male rats. The reverse reaction predominated during repeated stress and increased after administration of dehydroepiandrosterone sulfate. Treatment with mu-opioid receptor antagonist naltrexone in a dose of 0.1 mg/kg 20 min before administration of dehydroepiandrosterone sulfate abolished this effect. 相似文献
4.
T. A. Obut M. V. Ovsyukova T. Yu. Dement’eva O. P. Cherkasova S. K. Saryg T. A. Grigor’eva 《Neuroscience and behavioral physiology》2009,39(7):695-699
In male rats, repeated but not single exposures to stress increased the conversion of corticosterone (CS) to 11-dehydrocorticosterone
(11-DHCS), particularly on the background of administration of dehydroepiandrosterone sulfate (DHEAS). Naltrexone given 20
min before DHEAS at a dose of 0.1 mg/kg, at which it selectively blocks μ opioid receptors, prevented this effect of DHEAS,
which is evidence that it is mediated by μ opioid receptors. This action of DHEAS involved endogenous ACTH and was thus mediated
by central regulatory mechanisms. Our results, along with published data, lead to the first proposed scheme for the physiological
regulation of the interconversion of CS and 11-DHCS in conditions of repeated stress with the involvement of DHEAS and μ opioid
receptors.
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 94, No. 8, pp. 945–951, August, 2008. 相似文献
5.
The effect of the neurosteroid dehydroepiandrosterone sulfate on inhibitory synaptic transmission was studied in area CA1 of the rat hippocampus using an in vitro hippocampal slice preparation. Synaptic responses elicited by stimulation of Schaffer collateral fibers were recorded extracellularly as population spikes in the somatic region and as synaptic field potentials in the dendritic region. Bath application of dehydroepiandrosterone sulfate (10 μM) enhanced the synaptically evoked somatic population spike with no effect on the dendritic synaptic potential. Isolation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor-mediated component of the synaptic response by addition of antagonists of N-methyl-
-aspartate and GABA receptors to the perfusion saline demonstrated that dehydroepiandrosterone sulfate had no effect on this component of the dendritic synaptic potential. In contrast, dehydroepiandrosterone sulfate antagonized GABA receptor-mediated inhibitory effects in the somatic region, resulting in an augmentation of the somatic population spike amplitude. Paired-pulse facilitation was unaltered by dehydroepiandrosterone sulfate, thus arguing against possible presynaptic sites of dehydroepiandrosterone sulfate's actions.These results indicate that dehydroepiandrosterone sulfate can alter synaptic transmission in the hippocampus through selective postsynaptic actions on inhibitory synaptic transmission. A synaptic effect of dehydroepiandrosterone sulfate is consistent with a neuromodulatory role for this neurosteroid in the central nervous system, and may contribute to the reported effects of dehydroepiandrosterone sulfate on cognitive processes such as learning and memory. 相似文献
6.
Interleukin-2 concentration in hypothalamic structures of rats receiving peptides during mild stress
Barabanova SV Artyukhina ZE Kazakova TB Khavinson VKh Malinin VV Korneva EA 《Bulletin of experimental biology and medicine》2006,141(4):390-393
The number of hypothalamic IL-2-containing cells changed in rats receiving Vilon and Epithalon during mild stress (handling).
The number of IL-2-positive cells in hypothalamic structures decreased 24 h after intramuscular injection of Epithalon and
2 h after intranasal administration of the test peptides. Adaptation of animals to experimental conditions prevented the decrease
in the number of IL-2-positive cells in the supraoptic nucleus after intranasal administration of Epithalon.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 371–374, April, 2006 相似文献
7.
The rats were divided into groups demonstrating extremely high and low stress reactivity depending on the results of testing
for the nociceptive threshold and thermolability in response to bacterial lipopolysaccharide administration. Specific structural
features of the nucleus and mitochondria were revealed in neurons of the hypothalamic suprachiasmatic nucleus in rats with
constitutionally high reactivity, which reflects high functional activity and stress-induced lability of these structures.
Ultramicroscopic study revealed phenotypic differences in one of the key hypothalamic nucleus, which enables potent and rapid
neurogenic response of the stress system in animals with high stress reactivity.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 578–581, November, 2007 相似文献
8.
Goncharova ND Shmaliy AV Marenin VY Smelkova SA 《Bulletin of experimental biology and medicine》2007,144(5):730-733
Activity of glutathione-dependent antioxidant enzymes (glutathione peroxidase, glutathione reductase, and glutathione transferase)
in blood erythrocytes from female Macaca mulatta (6–8 and 20–26 years) was measured during activation of the hypothalamic-pituitary-adrenal system under conditions of acute
psychoemotional stress (2-h restraint stress). Glutathione reductase activity increased during stress, depended on the time
of day, and strongly correlated with blood corticosteroid level. Circadian variations in stress reactivity of glutathione
reductase during aging were accompanied by similar changes in stress reactivity of the hypothalamic-pituitary-adrenal system.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 574–577, November, 2007 相似文献
9.
S. E. Edeeva G. N. Kopylova Z. V. Bakaeva G. E. Samonina B. A. Umarova A. A. Guseva 《Bulletin of experimental biology and medicine》2008,145(3):302-306
Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4
(100 μg/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests,
and increased the level of depression of Porsolt test. Preliminary intranasal administration of glyprolines (15 min before
cholecystokinin) in a dose of 3.7 μmol/kg prevented the development of stress-induced behavioral disturbances. Administration
of peptides 30 min after cholecystokinin-4, i.e. to rats with developed behavioral disturbances, almost completely abolished these disturbances.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 3, pp. 270–274, March, 2008 相似文献
10.
Pertsov SS 《Bulletin of experimental biology and medicine》2006,141(4):383-386
We studied the role of the hypothalamic suprachiasmatic nucleus in realization of the effect of melatonin on stress marker
organs in rats under normal conditions and during acute stress. Stress induced involution of the thymus in active rats and
adrenal gland hypertrophy in active and passive animals. Electrocoagulation of the suprachiasmatic nucleus induced a more
pronounced decrease in the weight of the thymus and greater increase in the weight of the adrenal glands. Melatonin administration
after electrocoagulation of the suprachiasmatic nucleus had no effect on the relative weight of the thymus, adrenal glands,
and spleen in control and stressed animals. The influence of melatonin on the thymus, adrenal glands, and spleen is partly
mediated by this structure of the brain.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 364–367, April, 2006 相似文献
11.
Dyuzhikova NA Savenko YN Sokolova NE Savvateeva-Popova EV Vaido AI 《Bulletin of experimental biology and medicine》2006,142(2):239-241
In rats with low excitability threshold of the nervous system demonstrating significant and persistent behavioral disorders
under stress conditions, the content of methylcytosine-binding protein MeCP2 in neuronal nuclei of hippocampal field CA3 decreased
over 2 weeks after long-term emotional and pain stress. It was hypothesized that protein MeCP2 triggers epigenetic changes
in DNA that underlie “stress memory”.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 8, pp. 205–207, August, 2006 相似文献
12.
We studied the kinetics of thietazole distribution in the liver, brain, kidneys, spleen, heart, skeletal muscles, lungs, adipose
tissue, and testicles after single and repeated administration of this drug. Single and repeated administration of thietazole
was followed by elimination of this drug from the blood into organs and tissues. After repeated administration, thietazole
was selectively accumulated in the spleen.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 5, pp. 555–557, May, 2008 相似文献
13.
Short-term cold exposure improves antioxidant status and general resistance of animals 总被引:3,自引:0,他引:3
Akhalaya MY Platonov AG Baizhumanov AA 《Bulletin of experimental biology and medicine》2006,141(1):26-29
We studied the effect of short-term swimming in cold water (13°C) on parameters of the blood antioxidant system (activities
of superoxide dismutase and catalase, concentrations of ceruloplasmin and nonprotein thiols), heme oxygenase activity, and
nonprotein thiol level in mouse liver. The test parameters of antioxidant protection increased 1 h after cold exposure and
remained high 1 day after treatment. These changes were accompanied by an increase in the adaptive capacity. After swimming
in cold water the resistance of animals to another stress factor (administration of epinephrine) was higher compared to controls.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 1, pp. 31–34, January, 2006 相似文献
14.
The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system.
Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during
selective correction of the L-arginine-NO system. L-Arginine and nonselective NO synthase inhibitor had little protective
effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 368–370, April, 2006 相似文献
15.
N. D. Goncharova 《Bulletin of experimental biology and medicine》1997,124(2):804-807
Similar changes in the functioning of the adrenal glands (activation of cortisol synthesis due to a more complete utilization
of its biochemical precursors and reduced formation of dehydroepiandrosterone and its sulfate fraction) are demonstrated in
men and monkeys in hemoblastoses and during aging. It is assumed that being adaptive and nonspecific in nature, these changes
lead to hormonal imbalance promoting the development of senile involution processes in patients and animals with severe chronic
disease.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 207–210, August, 1997 相似文献
16.
M. B. Plotnikov S. V. Logvinov N. V. Pugachenko M. Y. Maslov O. I. Aliev N. A. Tyukavina N. I. Suslov A. V. Potapov 《Bulletin of experimental biology and medicine》2000,130(5):1080-1083
Electron microscopy and electrophysiological studies revealed pronounced structural and functional changes in the brain cortex
in rats with experimental cerebral ischemia. Repeated administration of diquertin and ascorbic acid significantly attenuates
ischemic damage induced by circulatory disturbances.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 543–547, November, 2000 相似文献
17.
N. A. Palchikova O. I. Kuzminova N. V. Utkina V. G. Selyatitskaya V. A. Shkurupiy 《Bulletin of experimental biology and medicine》2008,146(6):705-707
Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response
of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics
of cortisol concentration in the adrenal glands was similar, while changes in progesterone concentration were in antiphase
to those in the blood. After combined administration of both inductors of granulomatous inflammation, changes in the concentrations
of the studied hormones to a greater extent corresponded to their dynamics after injection of BCG.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Suppl. 1, pp. 20-22, 2008 相似文献
18.
E. V. Kuryanova 《Bulletin of experimental biology and medicine》2009,147(2):173-176
Effect of α-tocopherol (vitamin E) periodical administration on heart rhythm regulation was investigated in outbred white
rats. α-Tocopherol administration to males was followed by reduction of sympathetic neural influence on heart rhythm and also
by the increase of the number of individuals with high activity of autonomic regulation loop. In female rats α-tocopherol
administration modulates the activity of humoral control circuit and promotes heart rate reduction, however upon that the
percent of females with high centralization of heart rate regulation was increased.
Translated from Byulleten’ Experimental’noi Biologii i Meditsiny, Vol. 147, No 2, pp. 130–133, February, 2009 相似文献
19.
Semenova MA Klimova OA Anishchenko TG 《Bulletin of experimental biology and medicine》2006,141(3):299-301
Castration of males and females reduces the sensitivity of cardiac chronotropic function to atropine and potentiates the vascular
component in the reaction to atropine in females (during stress) and males (at rest and during stress). Our results show that
estrogens and androgens increase the sensitivity of the cardiovascular system to cholinergic influences at rest and during
stress.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 3, pp. 270–272, March, 2006 相似文献
20.
N. V. Maslennikova E. N. Sazonova S. S. Timoshin 《Bulletin of experimental biology and medicine》2008,145(2):210-212
We studied the effect of β-casomorphin-7 on DNA synthesis in cell populations of newborn albino rats. Intraperitoneal administration
of a β-casein fragment heptapeptide β-casomorphin-7 (1 mg/kg, 1 or 5 injections) activated proliferative processes in the
myocardium and ectodermal and endodermal epithelium of newborn rats.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 170–172, February, 2008 相似文献