Ticlopidine-induced subacute cutaneous lupus erythematosus: A case report and literature review

Many drugs have been reported to induce lupus in a minority of patients. Ticlopidine hydrochloride inhibits platelet aggregation and is widely used for the prevention of thrombosis. There have been only a few reports of ticlopidine-induced lupus. Here, we review 13 previously reported cases and describe the case of a 71-year-old man with ticlopidine-induced subacute cutaneous lupus erythematosus. His diagnosis was supported by the appearance of papulosquamous skin lesions on sun-exposed areas and detectable anti-Ro/SS-A antibodies, shortly after drug initiation as well as the gradual resolution of these symptoms after the discontinuation of ticlopidine. Our case highlights that when a patient presents with subacute cutaneous lupus erythematosus-like skin lesions, ticlopidine should be considered as a potential causative agent.     

Subacute cutaneous lupus erythematosus induced by terbinafine: case report and review of literature

Systemic lupus erythematosus and subacute cutaneous lupus erythematosus (SCLE) occasionally evolve as adverse reactions to a large variety of chemically different drugs. We here report on a 76‐year‐old woman who developed SCLE within 10 days after initiation of oral terbinafine. Analysis of the 27 cases of terbinafine‐induced SCLE in the literature revealed that this disorder has been reported 6 times more often in females than in males. Skin lesions evolved on average around 7 weeks after starting the drug. In 79% of the cases ANA could be detected while antibodies against Ro/SS‐A and La/SS‐B were found in 86% and 39%, respectively. Remarkably, anti‐histone antibodies were present in only 29%. In all cases terbinafine‐induced SCLE resolved after discontinuation of the triggering agent. Systemic treatment with anti‐malarials and/or corticosteroids does not appear to be mandatory.     

新生儿红斑狼疮三例并文献复习

报道3例新生儿红斑狼疮并对相关文献进行复习。3例患儿皮损表现为红斑、丘疹,以面部为主,第2例患儿母亲有干燥综合症6年,第1例及第3例患儿母亲无结缔组织病史。患儿及其母亲抗核抗体、抗Ro/SSA抗体、抗La/SSB 抗体、抗Ro-52抗体均阳性。3例心电图检查均未见心脏传导阻滞,2例患儿伴肝损伤。均予泼尼松及对症治疗后病情好转。     

Sweet's syndrome associated with systemic lupus erythematosus: A case report and review of the literature

A 35‐year‐old Japanese female patient with systemic lupus erythematosus (SLE) presented with fever, erythematous papules and nodules, and polyarthralgia. Skin biopsy of a nodule was compatible with Sweet's syndrome. The papules/nodules were well treated with an oral glucocorticoid. Thirty cases of Sweet's syndrome associated with lupus erythematosus (LE) have been reported in the published work. The mean age was 34.2 years. They showed a higher male ratio (male : female, 1:2) compared with patients with SLE (1:9) and Sweet's syndrome (1:3.7). Sweet's syndrome may occur as a manifestation of LE, and a moderate dose of an oral glucocorticoid will result in a good response.     

Congenital and neonatal lupus erythematosus: two case reports

Neonatal lupus erythematosus is an autoimmune disease produced by the passage of maternal antinuclear antibodies and extractable nuclear antigen antibodies through the placenta. At the moment of the diagnosis, the mothers are asymptomatic in 40 to 60% of cases. The most common manifestations are cutaneous lesions and congenital heart block. The cutaneous findings are variable and usually begin within the first weeks or months of life. Congenital lupus erythematosus is a congenital variant of neonatal lupus erythematosus. We present one case of congenital lupus erythematosus and one case of neonatal lupus erythematous, showing the variability of this disease.     

先天性黏液型隆突性皮肤纤维肉瘤一例并文献复习

先天性DFSP临床罕见,其临床表现可类似血管性病变。黏液型先天性隆突性皮肤纤维肉瘤(congenital dermatofibrosarcoma protuberans,DFSP)是DFSP独特而罕见的亚型,具有其特征性病理组织学改变,生物学行为属交界恶性/潜在低度恶性。先天性黏液型DFSP更为罕见,国外仅有2例散发病例报道。本文报道一例并回顾相关文献。患儿,女,1岁9个月。出生后即有背部肿物,曾于外院误诊为血管瘤,予盐酸噻吗诺尔眼药水外敷治疗1年余,效果不佳。肿物不断增大,就诊我科后,予手术切除肿物并行病理组织学及免疫组织化学检查,诊断为先天性黏液型隆突性皮肤纤维肉瘤。考虑病理回报底切缘最近距离仅0.25 mm,根据指南行肿瘤边缘1 cm扩大切除治疗,随访2年未发现复发及转移。     

Childhood discoid lupus erythematosus: report of five new cases and review of the literature

Discoid lupus erythematosus (DLE) is an uncommon disease in childhood. In this paper we present five new cases of childhood DLE. Two of them are identical twin brothers, who developed similar lesions during an interval of 5 years. This is in favour of the hypothesis that both genetic factors and somatic mutations, due to environmental factors, are implicated in the pathogenesis. A review of the English language literature is also presented. In order to have better epidemiological data on this disease, all cases of childhood DLE, including those published in non-English literature and those not yet published, should be placed together and analysed.     

Atypical fibroxanthoma in a young female patient with systemic lupus erythematosus: A case report and literature review

A 23-year-old woman presented with an asymptomatic erythematous subcutaneous nodule on her right shin that had been present for the preceding 6 months. She had been diagnosed with systemic lupus erythematosus (SLE) and Sjogren's syndrome 6 years ago and was controlled with prednisolone and hydroxychloroquine. The nodule was excised and the pathologic diagnosis was atypical fibroxanthoma. This case is reported because this tumor occurred in an atypical site in a young female patient with SLE. The occurrence of this unusual atypical fibroxanthoma is believed to be related to altered immunity.     

Congenital lupus erythematosus

Neonatal lupus erythematosus (NLE) is an autoimmune disease affecting the fetus as a result of transplacental transfer of anti-Ro autoantibodies. Typically, it presents in the first few months of life with an annular form of subacute cutaneous lupus erythematosus. We report an unusual case of NLE presenting at birth with scaly erythematous telangiectatic patches and macules with skin atrophy involving the face, head, and upper trunk. Thrombocytopenia was discovered on laboratory investigations. Histopathology of skin biopsy was consistent with subacute cutaneous lupus. The mother was clinically free of disease and had no family history of autoimmune disease. Serology (extra-nuclear antigens) was positive in both the baby and the mother. This is a rare presentation of a rare disease.     

Sarcoidal alopecia mimicking discoid lupus erythematosus: Report of a case and review of the literature

Sarcoidal alopecia is a subtype of plaque-forming cutaneous sarcoidosis that may resemble discoid lupus erythematosus (DLE). Because the clinical appearance of the two lesions is similar, the correct diagnosis may be missed. The systemic involvement and progressive nature of sarcoidosis, make it important to differentiate sarcoidal alopecia from DLE, so that proper treatment can be initiated and potential long-term sequelae avoided. We present the case of a 57-year-old Taiwanese woman with sarcoidal alopecia of the scalp that mimicked DLE.     

Coexistence of systemic lupus erythematosus with psoriasis vulgaris: a case report and reviewof the literature

报告l例系统性红斑狼疮并发寻常性银屑病.患者女,25岁.因面部红斑,伴乏力8个月,皮疹日晒后加重.既往患寻常性银屑病病史13年,实验室检查:抗核抗体阳性(1:640),抗Sm抗体(+++),抗SSA抗体(+++),抗ds-DNA抗体(+).诊断:①系统性红斑狼疮;②寻常性银屑病.     

Congenital reticular ichthyosiform erythroderma--ichthyosis variegata: a case report and review of the literature

We present a 32-year-old white patient with congenital reticular ichthyosiform erythroderma, also known as ichthyosis variegata. The patient had typical clinical features with areas of normal appearing skin surrounded by erythematous hyperkeratotic patches. The smaller "confetti-like" patches were mostly present on the trunk, while the larger areas forming a reticular pattern predominated on the extremities. Ultrastructural findings demonstrated perinuclear vacuolization, binuclear cells and filamentous deposits compatible with congenital reticular ichthyosiform erythroderma. Besides presenting the case, we review the literature on this rare disorder of keratinization.     

Congenital midline cervical cleft: case report and review of the English language literature

Congenital midline cervical cleft is a rare anomaly of the ventral neck that heretofore has not been reported in the dermatology literature. We present a case of a midline cervical cleft that was diagnosed and managed at an early age. We also review the literature and discuss its clinical and histologic features, treatment, and possible embryology.     

Subacute cutaneous lupus erythematosus with positive anti-Ro antibodies following palbociclib and letrozole treatment: A case report and literature review

Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is an uncommon but well-described phenomenon, most often seen in association with antihypertensives and antifungal medications. In recent years, rare reports of DI-SCLE have been described in patients being treated with targeted therapies. Herein, we describe a case of DI-SCLE in association with palbociclib and letrozole treatment for metastatic breast cancer. This report is the first known case of DI-SCLE with positive anti-Ro antibodies in this setting. We also summarize the literature describing DI-SCLE in association with targeted therapies to date and its possible association with dysregulation of the vascular endothelial growth factor pathway.     

Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review

Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent candidal infections of the mucous membranes, nails, and skin. Systemic involvement is rare. CMC in adults with coexistent thymoma, benign or malignant, is well-known and is often associated with hypogammaglobulinemia. There is an unusually high frequency of thymoma and systemic lupus erythematosus (SLE). I present a case of a patient with a history of malignant thymoma, SLE, and hypergammaglobulinemia who was found to have CMC. Discussion of the relationship of these findings is presented.     

线状盘状红斑狼疮

报告1例发生于额部的线状盘状红斑狼疮.患儿女,15 岁.左额部带状红斑伴瘙痒3 年.皮肤科检查:左侧发际、额部、左上眼睑有一纵行走向的带状红斑,呈S 形分布,表面可见萎缩及毛细血管扩张.组织病理检查:毛囊角栓形成、基底层液化变性、基膜带增宽、真皮血管和附属器周围淋巴细胞呈片状或团块状浸润,符合盘状红斑狼疮组织病理学改变.     

大疱性系统性红斑狼疮一例

<正>临床资料患者,女,16岁。因全身反复发生皮疹伴痒4月,复发2周,收入院。患者4个月前无明显诱因出现鼻腔、口腔糜烂,当地诊所予"抗病毒治疗"(具体用药不详),疗效欠佳,躯干、四肢、颜面逐渐出现红斑,手背、面颈部出现大小不一的水疱、血