无缝隙护理在妇科恶性肿瘤术后深静脉血栓预防中的应用

目的 探讨无缝隙护理在妇科恶性肿瘤术后深静脉血栓预防中的应用。方法 选取86例妇科恶性肿瘤患者作为研究对象,按照入院先后顺序分为观察组和对照组,各43例。对照组开展常规护理,观察组在常规护理的基础上融入无缝隙护理。比较2组患者干预后护理满意度、凝血功能及深静脉血栓发生率。结果 干预后,观察组的护理满意度为(90.45±5.67)分,高于对照组的(81.23±5.89)分,差异有统计学意义(P<0.05);干预后2组患者的凝血功能指标有所改善,从高凝向低凝状态转变,且观察组的各项指标优于对照组,差异有统计学意义(P<0.05);观察组术后深静脉血栓发生率为4.65%,低于对照组的23.26%,差异有统计学意义(P<0.05)。结论 针对行手术治疗的妇科恶性肿瘤患者,将无缝隙护理融入临床护理中不仅可以改善患者的凝血功能指标,减少术后深静脉血栓发生率,还可提升患者护理满意度。     

妇科盆腔手术围术期对下肢深静脉血栓的预防护理措施

目的对妇科盆腔手术围术期下肢深静脉血栓的预防护理措施进行探讨。方法选取100例妇科盆腔手术患者作为研究对象,进行随机分组,分为观察组与对照组,两组各有患者50例。对照组患者给予常规护理,观察组患者给予综合护理,对两组患者护理后下肢深静脉血栓的发生率进行比较。结果对照组患者下肢深静脉血栓发生率为8.0%,观察组患者下肢深静脉血栓发生率为2.0%,与对照组相比,观察组患者的下肢深静脉血栓发生率明显更低,两组患者下肢深静脉血栓发生率的差异具有统计学意义(P0.05)。结论在妇科盆腔手术围术期对下肢深静脉血栓的预防护理中采用综合护理,可取得较好的护理效果,使患者下肢深静脉血栓的发生率有效降低。     

整体护理干预在盆腔手术围手术期下肢深静脉血栓预防中的应用效果

目的探讨整体护理干预在盆腔手术围手术期下肢深静脉血栓预防中的应用效果。方法选取淅川县人民医院妇科2013年1月至2014年12月收治的180例盆腔手术患者,采用随机抽签法将其分为对照组和干预组,各90例。对照组给予常规护理,干预组行整体护理,对比分析两组患者下肢深静脉血栓发生率。结果干预组下肢深静脉血栓发生率为1.25%(1/80),对照组为8.75%(7/80),组间差异有统计学意义(χ2=4.737,P<0.05)。结论整体护理在妇科盆腔手术围手术期的应用可有效预防下肢深静脉血栓的形成,具有较高的应用价值。     

预防性护理干预对老年骨折下肢深静脉血栓形成的影响

目的：探讨预防性护理干预对老年骨折下肢深静脉血栓形成的影响。方法选取老年髋部骨折患者120例,采用随机抽样法分为对照组和预防护理干预组各60例,分别给予常规护理干预和预防性护理干预。比较2组患者下肢深静脉血栓发生率,术后15 d下肢周径差及护理满意度等。结果预防护理干预组患者下肢深静脉血栓发生率显著低于对照组,差异有统计学意义（P<0.01）;对照组和预防护理干预组患者术后15 d下肢周径差分别为（3.25±0.93）cm、（2.08±0.61）cm,预防护理干预组患者术后15 d下肢周径差显著低于对照组,差异有统计学意义（P<0.05）;对照组和预防护理干预组患者护理满意度分别为76.67%,96.67%,预防护理干预组患者护理满意度显著高于对照组,差异有统计学意义（P<0.01）。结论预防性护理干预可降低老年骨折患者下肢深静脉血栓形成风险,减轻术后下肢肿胀程度,提高护理服务满意度。     

集束化护理在预防老年患者骨科术后下肢深静脉血栓中的效果观察

目的:观察集束化护理在预防老年患者骨科术后下肢深静脉血栓中的效果。方法:选取126例行骨科手术的老年患者作为观察对象,采用随机数字表法将其分为对照组65例和观察组61例。对照组给予常规护理,观察组在对照组基础上给予集束化护理。比较两组下肢深静脉血栓发生率及护理满意度。结果:观察组下肢深静脉血栓发生率为8.20%(5/61),明显低于对照组的24.62%(16/65),差异有统计学意义(P<0.05);观察组护理满意度为95.08%(58/61),明显高于对照组的78.46%(51/65),差异有统计学意义(P<0.05)。结论:集束化护理可有效预防老年患者骨科术后发生下肢深静脉血栓,提高患者护理满意度。     

护理干预对骨科术后下肢深静脉血栓形成的预防作用研究

目的:探究护理干预对骨科术后下肢深静脉血栓形成的预防作用。方法:选取2015年1月至2016年4月期间本院收治的80例骨科手术患者,采用随机分组方式,将其分为研究组与对照组,各40例。对照组,给予常规护理,研究组,在常规护理基础上,给予护理干预,对比两组患者下肢深静脉血栓发生情况和护理满意度。结果:研究组下肢深静脉血栓发生率为5%,对照组为15%,研究组明显低于对照组,差异显著,具有统计学意义(P0.05)。研究组护理满意度为92.5%,对照组为80%,研究组明显高于对照组,差异具有统计学意义(P0.05)。结论:针对骨科手术患者,实施护理干预措施,有助于减少下肢深静脉血栓,效果显著,值得广泛推广。     

优质护理干预对预防骨科术后下肢深静脉血栓形成的影响研究

目的探讨优质护理干预在预防骨科术后下肢深静脉血栓形成方面的影响。方法选取98例骨科手术患者作为研究对象,将其随机均分为两组,观察组给予优质护理干预,对照组给予常规护理干预,各组49例,比较两组护理效果及在下肢深静脉血栓发生率。结果观察组下肢深静脉血栓形成率为4.08%,对照组下肢深静脉血栓形成率28.57%,两组对比,差异有统计学意义,(P0.05)。另外,观察组以97.96%的护理满意度显著高于对照组的79.59%,差异有统计学意义(P0.05)。结论骨科术后,对患者实施优质护理干预,可大大提升护理满意度,降低下肢深静脉血栓形成率,促进患者的康复。     

早期护理干预对老年腹部术后下肢深静脉血栓的预防效果

目的探讨早期护理干预对老年患者腹部术后下肢深静脉血栓的预防效果。方法将126例老年择期腹部手术患者随机分为观察组和对照组,各63例。对照组给予围手术期常规护理,观察组在常规护理基础上加用早期护理干预。观察两组患者术后2周内下肢胀痛及下肢深静脉血栓发生情况;出院前采用问卷法调查患者护理满意度,并进行比较。结果观察组术后2周内下肢胀痛发生率6.3%,下肢深静脉血栓发生率1.6%;对照组下肢胀痛发生率14.3%,下肢深静脉血栓发生率7.9%;观察组护理满意度96.8%,对照组82.5%,组间比较差异均有统计学意义(P<0.05)。结论护理干预可有效预防和减少老年患者腹部术后下肢深静脉血栓发生,提高护理满意度,促进康复。     

老年股骨干骨折术后下肢深静脉血栓的的预防

目的:探讨护理干预对老年股骨干骨折术后下肢深静脉血栓的预防作用。方法:2012年1月至2014年1月期间,我院60例老年股骨干骨折患者,根据随机数字法,将其分为对照组和观察组,分别给予常规护理和护理干预,每组各30例,对两组下肢深静脉血栓、下肢肿痛的发生情况、护理满意度,进行观察和比较。结果:与对照组相比,观察组下肢深静脉血栓、下肢肿痛的发生率显著降低,护理满意度明显提高,差异有统计学意义(P0.05)。结论:护理干预能够有效预防老年股骨干骨折患者术后下肢深静脉血栓,提高患者及其家属对护理服务的满意度,值得临床推广。     

围术期预见性护理降低下肢骨折患者下肢深静脉血栓发生率的效果分析

目的 下肢深静脉血栓多发生在下肢骨折患者中,有效的护理干预,能够降低患者发生下肢深静脉血栓的几率,进而改善患者预后。本研究主要探讨围术期预见性护理在下肢深静脉血栓预防中的效果。 方法 选择2015年10月-2017年10月蚌医一附院收治的下肢骨折患者102例作为研究对象,使用随机数字表法分为对照组(48例)和观察组(54例)。对照组给予常规护理,观察组采用围术期预见性护理干预。统计并记录2组患者手术后下肢深静脉血栓发生率;比较2组患者术前、术后15 d的D-二聚体水平;采用彩色多普勒检测患者下肢静脉血流速度,比较2组患者下肢深静脉血栓发生率、凝血功能指标、血流速度。 结果 观察组围术期预见性护理后下肢深静脉血栓发生率为1.85%,低于对照组的18.75%(P<0.05);2组患者手术前D-二聚体水平比较差异无统计学意义(P>0.05);术后15 d观察组D-二聚体水平低于对照组(P<0.05);2组患者术前血流速度比较差异无统计学意义(P>0.05);术后15 d观察组血流速度水平低于对照组(P<0.05)。 结论 围术期预见性护理有助于降低下肢深静脉血栓发生率,能改善患者凝血指标及血流速度,值得推广应用。      

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.