北京地区中老年人同型半胱氨酸参考区间的建立及与尿酸相关性分析

目的:建立北京地区中老年人群同型半胱氨酸(HCY)的参考区间,并分析其与尿酸(UA)的相关性。方法:筛选在本院体检的2752例50岁以上表观健康中老年人,采用罗氏Cobas c702全自动生化分析仪检测其血清HCY和UA水平,分析不同性别年龄组的HCY水平差异及HCY与UA的相关性,建立适用于本地区中老年人群的HCY参考区间。结果:本研究中2752例表观健康中老年人血清HCY数据呈偏态分布,浓度为11.41(4.62)μmol/L。中老年男性血清HCY水平明显高于女性(Z=20.51,P<0.05)。血清HCY水平随年龄呈上升趋势：50～59岁组最低：男性11.75(4.00)μmol/L,女性9.36(4.05)μmol/L;80岁以上组最高：男性13.41(6.06)μmol/L,女性10.42(3.98)μmol/L,不同年龄组差异有显著性(P<0.05)。血清UA和HCY呈正相关(r=0.312,P<0.05)。血清HCY 95%参考区间按年龄组50～59岁、60～79岁、≥80岁,男性分别为7.63～24.82μmol/L、7.62～25.71μmol/L、...     

老年人群血清清蛋白参考范围及其分布

目的研究连云港地区正常老年人群血清清蛋白的参考范围及其分布。方法对连云港地区60岁以上无严重疾病的老年人进行体检,4 242名符合条件者被纳入研究,通过溴甲酚紫法检测血清清蛋白值,并按年龄、性别分组分析比较。采用95%CI确定参考范围。结果 4 242名60岁以上老年人男女总体清蛋白值呈偏态分布(Z=3.312,P=0.000),中位数为37.7 g/L,采用偏态分布双侧95%CI确定参考范围为:31.5～45.8 g/L。60～、65～、70～、75～、80～、85～、90岁以上组双侧95%CI参考范围分别为:男性为34.5～46.9 g/L、33.4～45.9 g/L、33.2～46.2 g/L、33.0～44.6 g/L、30.9～45.4 g/L、31.1～42.9 g/L、25.6～42.9 g/L;女性为35.7～47.1 g/L、34.8～45.7 g/L、34.4～45.8 g/L、33.7～45.4 g/L、30.9～44.2 g/L、29.7～41.9 g/L、25.7～42.3 g/L。60～79岁的老年人,女性清蛋白水平显著高于男性(均有P<0.05)。85～89岁组男性清蛋白水平高于女性(P<0.05),80～84岁组及90岁以上组男女间差异无统计学意义。清蛋白在男性组、女性组及总体组分析中,均与年龄呈负相关,回归系数有显著意义(均P<0.05)。在60岁以上老年人中,年龄每增加1岁,清蛋白值减少0.183 g/L。清蛋白随增龄下降程度女性(0.218 g/L)高于男性(0.155 g/L)。结论正常老年人血清清蛋白参考范围是31.5～45.8 g/L,血清清蛋白性别之间存在差异且与年龄呈负相关。在临床应用时应按不同年龄段及性别选用合适的参考范围。     

北京地区体检中老年男性下尿路症状与年龄的关系

目的 调查北京市中老年人群下尿路症状(LUTS)随年龄分布的状况. 方法 对2010年1月至2010年7月在北京医院体检中心常规单位体检的40岁以上男性进行问卷调查,了解其LUTS的发生状况并对结果进行分析. 结果 2357例男性接受调查,LUTS的出现频率随年龄的增长而增加,而对于排尿症状的满意程度随年龄的增加而降低.40～49岁年龄组中44.94%具有至少1种症状,71.47%对于排尿症状满意.而80～岁年龄组94.97%具有至少1种症状,仅27.67%对于目前排尿症状满意.各种排尿症状均和患者对排尿的满意程度相关.在各个年龄段中夜尿均为最常见的症状. 结论 LUTS是中老年男性中常见症状,随年龄增长而增加,其中夜尿是最为常见的症状.     

北京地区体检中老年男性下尿路症状与年龄的关系

目的 调查北京市中老年人群下尿路症状(LUTS)随年龄分布的状况. 方法 对2010年1月至2010年7月在北京医院体检中心常规单位体检的40岁以上男性进行问卷调查,了解其LUTS的发生状况并对结果进行分析. 结果 2357例男性接受调查,LUTS的出现频率随年龄的增长而增加,而对于排尿症状的满意程度随年龄的增加而降低.40～49岁年龄组中44.94%具有至少1种症状,71.47%对于排尿症状满意.而80～岁年龄组94.97%具有至少1种症状,仅27.67%对于目前排尿症状满意.各种排尿症状均和患者对排尿的满意程度相关.在各个年龄段中夜尿均为最常见的症状. 结论 LUTS是中老年男性中常见症状,随年龄增长而增加,其中夜尿是最为常见的症状.     

2009年宁夏婴幼儿尿碘监测结果分析

目的 了解宁夏0～30个月婴幼儿的碘营养水平,为是否有必要开展特需人群强化补碘和下调盐含碘量提供参考依据.方法 采用二阶段抽样法,在全区22个县(市、区)的664个行政村中抽取1483名婴幼儿,用砷铈催化分光光度法检测其尿碘并进行相关影响因素调查.结果 全区婴幼儿的尿碘中位数为216.5μg/L,<100μg/L所占比例为19.1%(283/1483),100～300 μg/L所占比例为49.3%(731/1483),>300μg/L所占比例为31.6%(469/1483);各县尿碘中位数在130.6 ～328.4μg/L,均>100μg/L以上;尿碘中位数男性略高于女性,分别为223.2、210.2 μg/L,两者比较差异无统计学意义(Z=-1.76,P>0.05);1岁以内尿碘几乎无变化(Z=-0.624,P>0.05),1岁后开始逐渐下降(χ2=13.59,P<0.05),随着月龄的增加,尿碘<100μg/L的比例逐渐增多;母亲服用过碘油的婴幼儿,尿碘高于未服用者,分别为257.5、22 1.2μg/L,两者比较差异有统计学意义(Z=-2.54,P<0.05).1岁以内接受母乳喂养的婴幼儿尿碘高于未服用者,分别为239.1、204.2μg/L,两者比较差异有统计学意义(Z=-2.74,P<0.05).结论 现行的食盐加碘量对宁夏婴幼儿可能造成其碘营养超过适宜量,故宁夏居民盐碘总体上有下调的空间.宁夏除西吉县外,其他山区县可不必对特需人群再进行强化补碘.     

沿海产盐区与非产盐区18～45岁人群碘营养状况及甲状腺功能水平研究

目的掌握厦门市沿海产盐区与非产盐区居民盐碘、18～45岁人群碘营养和甲状腺功能水平状况,为采取针对性的防治措施提供依据。方法选择沿海产盐区翔安区和非产盐区集美区为调查点,调查居民合格碘盐食用率、18～45岁育龄期妇女和男性尿碘水平、甲状腺激素水平和海带、紫菜的摄入习惯。结果产盐区和非产盐区盐碘中位数均为27.21 mg/kg,合格碘盐食用率分别为95.33%和96.33%;18～45岁男性尿碘中位数分别为206.55μg/L和232.95μg/L,尿碘<100μg/L的比例分别为20.97%和10%;18～45岁育龄期妇女尿碘中位数分别为176.95μg/L和227.70μg/L,尿碘<100μg/L的比例分别为21.67%和25%;产盐区和非产盐区18～45岁男性和育龄期妇女的甲状腺激素TSH、Tg、FT3、FT4、TPOAb、TT3、TT4中位数均在正常值范围内;产盐区18～45岁男性的甲状腺功能亢进阳性率为3.4%、育龄期妇女的甲状腺功能减退和亚临床甲状腺减退症的阳性率均为1.67%,而非产盐区均为0。产盐区和非产盐区18～45岁男性和育龄期妇女中均有一定比例易患甲状腺免疫性疾病的人群。每月食用海带、紫菜的次数≥4次、1～3次和<1次的人尿碘组间比较无统计学差异。结论产盐区和非产盐区18～45岁男性和育龄期妇女碘营养总体处于适宜状态,应坚持食盐加碘措施,对育龄期妇女在婚前体检时开展常规碘营养水平和甲状腺功能检测。     

内蒙古自治区特需人群碘营养状况调查

目的了解全民食盐加碘及新的盐碘标准实行后特需人群碘营养状况.方法通过人群尿液碘含量水平对特需人群碘营养状况进行分析.结果新的盐碘标准实行后2001年妇女组的尿碘中位数为217.78μg/L,＜100μg/L的比例是16.79%;0～2岁婴儿组尿碘中位数为229.54μg/L,＜100μg/L的比例是13.34%,＞1000μg/L的比例是1.67%;8～10岁儿童组尿碘中位数为271.77μg/L,＜100μg/L的比例是6.43%,＞1000μg/L的比例是0.5%.新的盐碘标准实行前1998年妇女组尿碘中位数为304.32μg/L,尿碘值集中在200～800μg/L范围内,＜100μg/L的比例是9.10%;＞1000μg/L的比例是4.16%;0～2岁婴儿组尿碘中位数为360.90μg/L,尿碘值集中在100～800μg/L范围内,＜100 μg/L的比例是8.00%;＞1000μg/L的比例是10.00%;8～10儿童组尿碘中位数为439.50μg/L,尿碘值集中在200～800μg/L范围内,＜100 μg/L的比例是5.00%;＞1000μg/L的比例是7.70%.结论调查结果反映了碘盐干预的有效性,也反映出特需人群中仍存在碘摄入不足的现象,新的盐碘标准实行后人群尿碘中位数处于一个比较合理的范围,但人群中碘摄入不足的状态有所加重;同时,由于食盐加碘标准的调整及宣传教育的深入开展,人群碘摄入过多及补碘措施不当的问题得到了纠正.所以今后针对特需人群的碘营养监测应加强,并适当加强辅助性措施的实施.     

怀化市区41岁以上部分人群血脂水平调查

目的调查怀化市区41岁以上部分人群血脂现状及血脂异常情况。方法以2004至2005年来本院健康体检41岁以上的中老年人群4219例为观察对象,测定项目包括总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及甘油三酯。结果本组人群血脂水平随年龄增加而升高。总胆固醇和低密度脂蛋白胆固醇51岁以后女性高于男性;高密度脂蛋白胆固醇各年龄组女性均高于男性;各年龄组高胆固醇血症多于高甘油三酯血症。高胆固醇血症41～60岁年龄组男性为29.5%,女性为36.3%,60岁以上年龄组男性为41.0%,女性为50.6%。高甘油三酯血症41～60岁年龄组男性为28.4%,女性为10.9%,60岁以上年龄组男性为19.5%,女性为15.5%。高密度脂蛋白胆固醇降低者男性约15%,女性约5.2%。高密度脂蛋白胆固醇高水平者男性约22%,女性约37%。结论怀化市区41岁以上的中老年人群血脂异常比例较高,预示动粥样硬化性心血管病的发病风险增加。必须向居民大力宣传饮食结构的合理安排,防止血脂异常势在必行。     

老年人N端B型利钠肽参考值范围的初步观察

目的观察60岁以上健康老年人N端B型利钠肽(NT-proBNP)水平的参考值范围。方法将107例健康老年人根据年龄、性别分组,空腹采血,采用电化学发光法测定其血清NT-proBNP水平,将结果进行统计分析,NT-proBNP的参考值取97．5%可信限的上限。结果老年人NT-proBNP水平随年龄增长而增高,70～92岁组为(92．3±60．8)μg/L显著高于60～69岁组的(59．6±35．1)μg/L,(P＜0．05),其平均水平约是60～69岁组的1．5倍;老年女性NT-proBNP水平为(128．5±61．3)μg/L,显著高于老年男性的(78．5±39．7)μg/L(P＜0．05)。取第97．5百分位数为参等值上限,老年男性为202．5μg/L,老年女性为319．3μg/L。结论NT-proBNP水平与受试者年龄、性别、种族等生理因素密切相关。各临床实验室应根据受试者不同年龄、性别分别建立实验室内NT-proBNP的参考值范围。     

2008年广西沿海地区碘缺乏病重点人群碘营养状况调查

目的 调查2008年广西沿海5个县(区)碘缺乏病重点人群碘营养状况,提出相应防治措施.方法 在广西碘盐监测中碘盐覆盖率、碘盐合格率和居民合格碘盐食用率一直处于全区低水平的北海市海城区、铁山港区、银海区、合浦县以及钦州市钦南区5个沿海县(区),采用随机抽样的方法,合浦县抽取6个乡(镇),其余县(区)各抽取3个乡(镇),每个乡(镇)抽取2个行政村,每个行政村抽取40名8～10岁学龄儿童及10名18～42岁育龄妇女(要求包括有半数比例的妊娠妇女和哺乳期妇女),用砷铈催化分光光度法(WS/T 107-2006)检测尿碘.结果 共采集8～10岁儿童尿样1437份,尿碘中位数为191.0μg/L,<20μg/L的比例为1.4%(20/1437),<50μg/L的比例为5.4%(77/1437),<100μg/L的比例为20.3%(292/1437);5个县(区)儿童尿碘中位数为134.5～220.0μg/L,其中海城区、合浦县儿童尿碘中位数>200 μg/L(分别为220.0、209.5μg/L),其他3个县(区)儿童尿碘中位数均在100～200μg/L适宜范围内(分别为134.5、162.4、199.3μg/L);8、9岁组儿童尿碘中位数(192.3、206.7μg/L)均高于10岁组(157.2μg/L,χ2值分别为19.644、41.997,P均<0.017).共采集妇女尿样365份,5个县(区)妇女尿碘中位数为88.2～195.6μg/L,其中海城区和合浦县妇女尿碘中位数>150 μg/L(分别为195.6、156.5μg/L),铁山港区妇女尿碘中位数最低(88.2μg/L)且<100μg/L;在妊娠妇女、哺乳期妇女、育龄妇女中,育龄妇女尿碘中位数最高,为152.6μg/L,哺乳期妇女尿碘中位数为131.9μg/L,妊娠妇女尿碘中位数最低(89.4 μg/L)且<100μg/L,仅有6.7%(2/30)的妊娠妇女尿碘水平处于150～250μg/L适宜范围.结论 广西沿海5个县(区)8～10岁儿童碘营养状况良好,育龄妇女和哺乳期妇女尿碘水平在碘营养适宜范围内,妊娠妇女整体上未达碘营养适宜水平.建议将妊娠妇女碘营养监测纳入常规监测,进一步落实碘盐防治措施,加强健康教育宣传,提高碘盐覆盖率.     

Age-Related Prostate Specific Antigen Reference Ranges in Healthy Northern Iranian Men

Background: Prostate cancer is the third most common malignancy in men worldwide. Despite being a helpful biomarker in prostate cancer, prostate specific antigen (PSA) is affected by different factors including age, lifestyle, geographical region and ethnicity. Objective: To determine the age specific serum PSA level among healthy Northern Iranian men and to compare the results of our study with the findings of other populations in the world. Methods: A total of 1271 men who were referred for routine check-up in a multispecialty hospital in the city of Rasht, in Northern Iran, were evaluated for their PSA levels by commercial ELISA method. Results: The normal age related prostate specific antigen range (0-95th percentile) in our study was 0.0-0.62 in men younger than 40 yrs; 0.0-0.75 ng/ml in 40-49 yrs; 0.0-0.91 ng/ml in 50-59 yrs; 0.0-1.33 ng/ml in 60-69 yrs; 0.0-1.45 ng/ml in 70-79 yrs group and 0.0-1.93 in subjects older than 80 yrs. Conclusion: The present study revealed the lowest upper limit of PSA level in all age groups in comparison to populations from different countries.     

Age Specific Reference Levels of Serum Prostate-Specific Antigen,Prostate Volume and Prostate Specific Antigen Density in Healthy Iranian Men

Background: It is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum PSA in Iranian population. Objective: To determine age-specific reference ranges for serum prostate-specific antigen (PSA) concentration and PSA density (PSAD) and prostate volumes in a population of healthy Iranian men. Methods: Nine-hundred and thirteen healthy Iranian men, aged 50-79 years, underwent a detailed clinical evaluation including a digital rectal examination, a serum PSA determination (DRE) and transrectal ultrasound (TRUS). PSA test was performed on 666 of the subjects and TRUS was done on 633 of them. None of the subjects had any evidence of prostate cancer by any one of the three diagnostic tests and had no history of Lower Urinary Tract Symptoms (LUTS). Age specific ranges for PSA levels, PSA density and prostate volume were determined. Results: The serum PSA concentration correlated directly with the subjects’ age (r=0.280; p<0.001) and prostatic volume (r=0.327; p<0.001). Also prostatic volume was directly proportional to age (r=0.197; p<0.001).The serum PSA ranges (95th percentile) for each age range in Iranian men were: 0.00-2.61 ng/ml for 50-59 years; 0.00-3.59 ng/ml for 60-69 years; and 0.00- 4.83 ng/ml for 70-79 years. The respective prostate volumes were: 14-59, 16-66 and 18- 73ml. Also respective PSA densities were: 0.00-0.076, 0.00-0.10 and 0.00-0.14 ng/ml/ml. Conclusion: The present study confirms earlier reports that serum PSA levels and prostate volume and PSAD are age- and race- dependent, so it is appropriate to have age- specific reference ranges for these variables in various communities around the world. This will increase the positive predictive value of PSA estimation in the diagnosis of prostate cancer in different communities.     

Haemoglobin concentrations appear to be lower in indigenous Greenlanders than in Danes: assessment of haemoglobin in 234 Greenlanders and in 2804 Danes

OBJECTIVE: To compare haemoglobin concentrations in Greenlanders and Danes. METHODS: Haemoglobin was measured in a population survey in 1993-1994 comprising 234 indigenous Greenlandic individuals (115 men) aged 19-82 yr. and in Copenhagen County 1983-1984 comprising 2804 Caucasian Danes (1444 men) aged 30-60 yr. The Greenlandic participants were residents in the capital Nuuk (n=70), the town Ilulissat (n=74), and four settlements in the Uummannaq district (n=90). The significance of differences was assessed by Student's t-test, and the xi2-test. Correlations were assessed by Spearman's correlation coefficient (rs). RESULTS: Greenlanders: Haemoglobin levels were not correlated with age or consumption of traditional foods, and were not significantly different in the three residential areas. Mean haemoglobin was higher in men, 146+/-9.6 (SD) g/L, than in women, 132+/-9.6 g/L (p<0.0001). Mean haemoglobin in iron-replete men with serum ferritin >32 microg/L (n=104) was 146+/-9.3 g/L, and in iron-replete women (n=68) 133+/-10.4 g/L (p<0.0001). The 5th percentile for haemoglobin in iron-replete men was 133 g/L (8.3 mmol/L) and in women 118 g/L (7.3 mmol/L). The prevalence of iron deficiency anaemia (i.e. ferritin <13 microg/L and Hb <5th percentile for iron-replete men and women) was 0% in men, 2.78% in women < or =50 yr of age and 0% in women >50 yr of age. Danes: Mean haemoglobin in men was 154+/-10.0 g/L and in women 138+/-10.4 g/L (p<0.0001). Haemoglobin in iron-replete men (n=1379) (i.e. serum ferritin >32 microg/L) was 154+/-10.7 g/L, and in iron-replete women (n=1003) 140+/-9.6 g/L (p<0.0001). Mean haemoglobin was lower in premenopausal than in postmenopausal women (p<0.0001). The 5th percentile for haemoglobin in iron-replete men was 137 g/L (8.5 mmol/L) and in women 124 g/L (7.7 mmol/L). The prevalence of iron deficiency anaemia (i.e. ferritin <13 microg/L and Hb <5th percentile for iron replete men and women) was 0% in men, 1.92% in women < or =50 yr of age and 0% in women >50 yr of age. CONCLUSION: Haemoglobin concentrations in Greenlanders were significantly lower than in Danes both in men (p<0.0001) and in women (p<0.0001). Delta(mean haemoglobin) in men was 8.0 g/L (0.5 mmol/L) and in women 6.2 g/L (0.4 mmol/L). Variations in haemoglobin levels may be due to genetic differences.     

血清β淀粉样蛋白含量与年龄关系的研究

目的探讨我国成人血清β淀粉样蛋白(A1β-28)含量与年龄之间的关系,为研究Aβ1-28与阿尔茨海默病(AD)的关系奠定基础。方法采用平衡饱和竞争放射免疫分析法,检测智能正常成人人群中血清A1β-28含量,其中青年组(20~35岁)100例、中年组(36~59岁)100例、老年组(60~79岁)100例与高龄老年组(80~94岁)35例。结果青年组、中年组、老年组、高龄老年组血清A1β-28含量分别为(0.77±0.16)μg/L、(0.77±0.17)μg/L(、0.68±0.20)μg/L、(0.67±0.25)μg/L。结论我国智能正常成人人群中血清A1β-28水平与年龄无直接关系。     

ROC曲线评价血清骨桥蛋白对冠脉钙化的诊断价值

目的:应用受试者工作特征曲线(ROC)评价血清骨桥蛋白(OPN)对冠状动脉钙化(CAC)的诊断价值,确定血清OPN诊断CAC的最佳临界值。方法:据64层螺旋CT冠脉造影结果将54例患者分为CAC组(32例)和非CAC组(UCAC组,22例),用酶联免疫吸附测定法(ELISA)检测血清OPN水平;应用ROC对血清OPN水平进行分析评价。按年龄受试者被分为<50岁组(16例)、50～60岁组(20例)、>60岁3组(18例),分别评价各年龄组血清OPN对CAC的诊断价值。结果:(1)CAC组血清OPN水平显著高于UCAC组[(40.281±11.997)μg/L比(23.682±5.760)μg/L],P<0.01;(2)按ROC曲线分析和Youden′s指数最大的截断点作为临床诊断界点,血清OPN诊断CAC的ROC曲线下面积为0.947,最佳分界值为32μg/L,以血清OPN≥32μg/L来预测CAC,敏感度和特异性分别为81.3%和95.5%;(3)<50岁组、50～60岁组、>60岁组OPN诊断CAC的ROC曲线下面积分别为0.991、0.958和0.889;敏感度和特异性分别100%、90.9%,83.3%、100%,73.3%、100%;最佳分界值分别为31μg/L,33μg/L,34μg/L。结论:(1)血清OPN水平升高可作为CAC形成的标志之一;(2)血清OPN≥32ug/L对CAC的诊断有较高的敏感性和特异性;(3)各年龄组血清OPN对CAC诊断的特异性都较高,OPN的诊断价值在于对CAC的排除。     

Age-specific relationship between blood pressure and the risk of total and cardiovascular mortality in Japanese men and women.

To examine the impact of age on the relationship between blood pressure (BP) levels and each of cardiovascular disease mortality and all-cause mortality, a total of 30,226 men and 58,798 women aged 40-79 years who had no history of stroke or heart disease underwent health checkups in Ibaraki-ken, Japan, in 1993 and were followed through 2002. Risk ratios for mortality by BP category based on the 1999 WHO-ISH guidelines were calculated by age subgroups (40-59 years, 60-79 years) using a Cox proportional hazards model. Compared with optimal BP levels, the multivariate risk ratios of cardiovascular mortality for stage 2 or 3 hypertension were 5.99 (95% confidence interval: 2.13-16.8) in middle-aged men and 4.09 (1.70-9.85) in middle-aged women. These excess cardiovascular mortality risks were larger in the 40-59 years age group than in the 60-79 years age group for both genders (p for interaction = 0.01 for both). In men, the population attributable risk percents of cardiovascular mortality were 60% for younger men and 28% for older men, while for women they were 15% for younger women and 7% for older women. Weaker but significant excess risks of total mortality were observed for stage 2 or 3 hypertension in men of both age groups and in the older age group for women. The impact of BP on the risk of cardiovascular mortality was larger among middle-aged persons than among the elderly in both men and women. Our findings indicate the importance of BP control to prevent cardiovascular disease among middle-aged individuals.     

Prevalence and characteristics of anemia in the elderly: cross-sectional study of three urban Korean population samples

We conducted a prospective study to assess the prevalence and clinical characteristics of anemia and to define the risk factors for anemia in older Koreans. From October 2002 to November 2002, 1,254 subjects over the age of 60 years were selected from a cross-sectional study. All subjects underwent a complete medical history taking and laboratory testing, which included; a complete blood cell count, reticulocyte, liver and renal function tests, lipid profiles, and iron profiles. The median age was 70 years old (range, 60-95 years). The mean levels of hemoglobin (mean +/- SD) were 14.5 +/- 1.4 g/dL in men and 13.0 +/- 1.1 g/dL in women, and the overall prevalence of anemia was 13.6% (171/1,254): 9.9% (27/273) in men and 14.7% (144/981) in women. We found that the prevalence of anemia differed significantly between those of age 60-69 and 70-79 years (P < 0.0001), those of age 60-69 and > or =80 (P < 0.0001), and those of age 70-79 and > or =80 (P = 0.0474). Hemoglobin levels were significantly lower in subjects > or =80 years old. By logistic regression testing, female sex, old age, lower albumin level, higher creatinine level, and lower body mass index were identified as independent risk factors of anemia in elderly Koreans. In conclusion, the overall prevalence of anemia in our study group was 13.6% (171/1,254), and this increased with age.     

前列腺特异性抗原在老年男性的分布及与空腹血糖、血脂的相关性研究

目的 了解老年男性前列腺特异性抗原(PSA)的分布情况,并探讨空腹血糖(FBG)、血脂与PSA的相关性.方法 回顾2010年来我院体检的2903名60岁及以上老年男性的PSA、FBG、血脂包括三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)的水平资料,按照年龄分为6组,分析不同年龄组之间PSA的差异;并用多元线性回归分析各组FBG、TG、LDL-C、HDL-C与PSA的相关性.结果 PSA水平随年龄增高呈上升趋势;60～64岁组的TG和LDL-C与PSA正相关,HDL-C与PSA负相关(r=0.10,0.15,0.12,P＜0.05),其余各组上述指标与PSA不相关(P＞0.05);65～69岁组FBG与PSA负相关(r=0.10,P＜0.05),其余各组FBG与PSA不相关(P＞0.05).结论 PSA随年龄增长而升高,暂不能认为空腹血糖、血脂与PSA相关.     

中青年男性血清睾酮与代谢综合征的关系

目的 探讨中青年男性血清睾酮与代谢综合征(MS)的关系.方法 选取85例20～50岁男性为研究对象,分为MS组(n=36)和对照组(n=49).应用放射免疫分析法测定血清睾酮水平.结果 MS组血清睾酮水平低于对照组[(20.06±5.31)nmol/L vs.(25.02±6.97)nmol/L](P＜0.01).睾酮...     

Serum prostate-specific antigen levels in older men with or at risk of HIV infection

OBJECTIVES: The aim of the study was to determine the rate of, and factors associated with, elevated prostate-specific antigen (PSA) levels in older men with or at risk of HIV infection. METHODS: Using a cross-sectional analysis, we interviewed 534 men > or =49 years old at risk for HIV infection on demographics, behaviours and medical history. Laboratory testing included serum PSA level and HIV serology, and T-cell subsets for those who were HIV seropositive. Elevated PSA level was defined as >4.0 ng/mL, and men with elevated PSA levels were referred for urological evaluation. RESULTS: Fifteen per cent of men were white, 55% black, and 23% Hispanic; median age was 53 years (range 49-80 years); 74% were sexually active; 65% currently smoked cigarettes; and 16% had taken androgens. Among 310 HIV-positive men, CD4 counts were >500 cells/microL in 31%, 200-500 cells/microL in 51%, and <200 cells/microL in 19%. Twenty men (4%) had elevated PSA. On univariate analysis, only older age was significantly associated with elevated PSA, and there was no significant difference in the number of men with elevated PSA between HIV-positive and HIV-negative men (nine of 310 vs 11 of 224; P = 0.28). On multivariate analysis, older age remained the only variable associated with elevated PSA level [reference group < or =50 years; adjusted odds ratio (OR(adj)) 1.0 for age 51-60 years; OR(adj) 5.9 (95% confidence interval 1.2-30.1) for age > or =61 years] adjusted for HIV status, family history of prostate cancer, and androgen use. CONCLUSIONS: Among older men, PSA levels increased with age but did not differ by HIV status. The clinical use of PSA levels in older men currently do not need to be modified for those with HIV infection.