瘦素、胰岛素抵抗与阻塞性睡眠呼吸暂停低通气综合征关系的研究

目的 探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea and hypopnea syndrome,OSAHS)患者血清瘦素水平与胰岛素抵抗的关系,以及2者与睡眠呼吸监测各指标的相关性.方法 选择未接受任何治疗的OSAHS患者69例,健康体检者20例为对照组,记录睡眠呼吸监测各项指标,计算体块指数(BMI),同步检测空腹血糖(FBG)、空腹血清瘦素及空腹胰岛素水平,以HOMA-IR评价胰岛素抵抗.(1)据AHI分为正常对照组(10例),轻度OSAHS组(19例),中度OSAHS组(26例),重度OSAHS组(24例);(2)据BMI及AHI分为A组(正常对照10例),B组(单纯肥胖10例),C组(非肥胖OSAHS27例),D组(肥胖OSAHS 42例).分别比较各组间空腹血清瘦素水平、空腹血糖、空腹胰岛素、HOMA-IR的差异; (3)分析OSAHS患者血清瘦素水平与HOMA-IR的相关性,以及2者与空腹血糖、空腹胰岛素、睡眠呼吸监测各项指标的相关性.结果 (1)空腹血清瘦素水平、空腹胰岛素水平、HOMA-IR:重度OSAHS组高于轻中度OSAHS组及正常对照组(P＜0.01),B、C、D3组高于A组(P＜0.05),D组高于B、C组(P＜0.05); (2)空腹血糖:重度OSAHS组高于轻度OSAHS组及正常对照组(P＜0.05),B、C、D3组高于A组(P＜0.05),D组高于B、C组(P＜0.05); (3)轻中度OSAHS组间及B、C组间以上指标差异不明显(P＞0.05); (4) OSAHS患者血清瘦素水平与HOMA-IR呈正相关;血清瘦素水平、HOMA-IR与空腹血糖水平、空腹胰岛素、AHI、BMI、ESS呈正相关,与平均血氧饱和度及最低血氧饱和度呈负相关.结论 OSAHS患者血清瘦素及胰岛素抵抗增高,与睡眠呼吸紊乱及低氧存在相关性,胰岛素抵抗与血清瘦素水平的增高有关,OSAHS病情严重度可影响瘦素分泌及胰岛素抵抗.     

胰岛素抵抗、瘦素和阻塞性睡眠呼吸暂停低通气综合征的关系

目的探讨胰岛素抵抗（IR）、瘦素和阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的关系。方法检测并分析对照组、肥胖的轻度OSAHS组、肥胖的中重度OSAHS组、非肥胖的轻度OSAHS组和非肥胖的中重度OSAHS组的体重指数、颈围、腰围、HOMA2-IR、血清瘦素水平和血脂系列。结果（1）肥胖的轻度、中重度OSAHS组和非肥胖的中重度OSAHS组的HOMA2-IR、瘦素高于对照组（P〈0．01）。肥胖和非肥胖的中重度OSAHS组的HOMA2-IR、瘦素均高于相应的轻度OSAHS组（P〈0．01）。（2）瘦素与HOMA2-IR、AHI、BMI、颈围、腰围、TG呈正相关（P〈0．05—0．001），与HDL—C呈负相关（P〈0．05）。HOMA2-IR与瘦素、BMI、颈围、腰围、AHI呈正相关（P〈0．001），与HDL—C呈负相关（P〈0．05）。（3）多元逐步回归分析，得出影响瘦素的因素依次是AHI、BMI、CH；影响HOMA2-IR的因素依次是瘦素、BMI和AHI。结论OSAHS是影响IR、血清瘦素水平的独立危险因素，高瘦素水平是影响IR的重要危险因素。     

阻塞性睡眠呼吸暂停低通气综合征与血清瘦素水平的关系探讨

目的 :探讨阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)与血清瘦素水平的关系。方法 :选择 2 2例 OSAHS患者和 13例正常对照者行多导睡眠图 (PSG)检测和昼夜血清瘦素水平测定 ,分析比较两组血清瘦素水平。结果 :OSAHS组患者 (9∶ 0 0 )血清瘦素水平 [(13.79± 9.0 0 ) μmol]比对照组 [(8.5 9± 4 .6 8) μm ol/ L]增高 (P <0 .0 5 ) ;正常体重组、超重组和肥胖组的血清瘦素水平似有随着体重指数 (BMI)增大逐渐增高的趋势。不同时段血清瘦素水平均与 BMI呈正相关 (r =0 .4 32和 r =0 .4 0 4 ,P <0 .0 5 )。结论 :OSAHS与肥胖和血清瘦素水平关系密切 ,夜间睡眠异常和肥胖可能是血清瘦素水平增高的重要原因。     

阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素及瘦素受体水平的变化

目的探讨血清瘦素（leptin）及瘦素受体（leptin R）水平在不同严重程度及肥胖程度的阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者中的变化。方法应用酶联免疫吸附法（ELISA）测定71例OSAHS患者和14名正常对照者血清leptin及leptin R水平,同时计算体质量指数（BMI）、监测呼吸暂停低通气指数（AHI）等指标。结果 （1）AHI与BMI成显著正相关（r=0.4711,P〈0.01）。（2）AHI≤20次/h组中,肥胖组leptin R水平明显高于非肥胖组（P〈0.05）,leptin水平的差异无统计学意义（P〉0.05）;AHI〉20次/h组中,肥胖组的leptin水平明显高于非肥胖组（P〈0.01）,leptin R水平的差异无统计学意义（P〉0.05）。结论 OSAHS与肥胖关系密切。中、重度肥胖OSAHS患者leptin R水平不再明显升高,提示leptin-leptin R调节系统已基本失去调节代偿作用,必须予以积极治疗以改善预后。     

阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素水平及与胰岛素抵抗的相关性研究

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清瘦素水平及与胰岛素抵抗的相关性.方法选择OSAHS患者和健康者(对照组)各50例,分别行多导睡眠图检查,并测定空腹血糖、瘦素和胰岛素水平.结果 (1)OSAHS患者组的血清瘦素、空腹胰岛素水平及胰岛素抵抗指数(HOMA-IR)与对照组间差别均有显著性意义(P＜0.01).(2)OSAHS患者组血清瘦素水平、空腹胰岛素水平、HOMA-IR均与呼吸暂停低通气指数(AHI)、呼吸障碍事件最长时间、微觉醒指数呈正相关,与最低血氧饱和度呈负相关.(3)OSAHS患者血清瘦素水平与空腹胰岛素水平、HOMA-IR呈正相关.结论 (1)OSAHS患者的空腹血清瘦素水平升高,且与OSAHS病情严重程度有关.(2)OSAHS独立于肥胖等混淆因素与胰岛素抵抗存在相关性.(3)OSAHS患者血清瘦素水平与胰岛素抵抗存在相关性.     

阻塞性睡眠呼吸暂停低通气综合征肥胖患者血清瘦素和胰岛素的变化

根据睡眠呼吸暂停低通气指数和体重指数将56例研究对象分为4组，测定血瘦素和胰岛素水平。结果显示，阻塞性睡眠呼吸暂停低通气综合征（OSAHS）肥胖组、非肥胖组及单纯肥胖组空腹胰岛素、瘦素水平较正常对照组显著升高，且OSAHS肥胖组胰岛素、瘦素显著高于OSAHS非肥胖组及单纯肥胖组。提示OSAHS肥胖患者体内存在瘦素抵抗和胰岛素抵抗，瘦素和胰岛素与OSAHS有独立的相关陛。     

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)和胰岛素抵抗的关系

目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的睡眠呼吸紊乱指标与其血清瘦素水平和胰岛素抵抗程度的关系。方法选择未接受任何治疗、经多导睡眠监测仪8 h睡眠监测确诊为OSAHS的男性患者54例,参照OSAHS诊治指南按睡眠暂停低通气指数(AHI)进行病情分度,其中轻-中度组(轻度9例,中度18例)和重度OSAHS组各27例,次日监测结束后空腹外周血瘦素、空腹胰岛素和血糖水平,计算体重指数(BMI)(体重/身高2)和HOMA-IR指数[(空腹血糖×空腹胰岛素)/22.5]。结果重度OSAHS组的平均和最低SpO2皆显著低于轻-中度组,BMI、血清瘦素水平和HOMA指数则明显高于轻-中度组,上述指标在两组间比较皆有显著统计学差异(均P<0.01)。其中瘦素与BMI和AHI成正相关,与平均及最低脉氧饱和度均存在负相关。HOMA-IR指数则和BMI、AHI成正相关,和最低SpO2存在负相关。结论在OSAHS患者中,睡眠呼吸功能紊乱和肥胖、瘦素和胰岛素抵抗有关。     

阻塞性睡眠呼吸暂停低通气综合征患者血清脂联素水平的变化

目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清脂联素水平的变化并分析其影响因素。方法选取门诊和住院诊断为OSAHS的患者60例,根据睡眠呼吸暂停低通气指数(AHI)分为轻度、中度、重度三组,每组20例,另选单纯打鼾者20例为对照组。入选者均测量身高、体重、腰围、臀围,计算体重指数(BMI)和腰臀比(WHR);并行一整夜多导睡眠监测(PSG);于PSG检查次日清晨6时抽取空腹静脉血5 mL,检测血清脂联素水平、空腹血糖(FPG)和空腹胰岛素水平(FINS)。结果OSAHS各组血清脂联素水平均明显低于对照组(P<0.05),而FPG和FINS较对照组明显升高(P<0.05),轻、中、重度各组间血清脂联素水平、FPG和FINS差异有显著性(P<0.05);血清脂联素水平与BMI、WHR、AHI、SpO2<90%的时间、FPG及FINS呈显著负相关(相关系数分别为r=-0.66,P<0.01;r=-0.46,P<0.01;r=-0.61,P<0.01;r=-0.36,P<0.01;r=-0.54,P<0.01;r=-0.67,P<0.01),与最低SpO2呈显著正相关(r=0.38,P<0.01),与平均SpO2和年龄无明显相关性;控制BMI、WHR、FPG、FINS后,血清脂联素水平仍与AHI呈显著负相关,与最低SpO2呈显著正相关(相关系数分别为r=-0.38,P<0.01;r=0.23,P<0.05);多元逐步回归分析表明,在OSAHS患者中,AHI是除了FINS和BMI以外的血清脂联素水平的独立影响因子。结论OSAHS患者血清脂联素水平较对照组明显降低,且与OSAHS病情严重程度有明显相关性,AHI是导致血清脂联素水平下降的独立危险因素。     

阻塞性睡眠呼吸暂停综合征患者血清抵抗素水平与胰岛素抵抗的关系及其临床意义

目的探讨血清抵抗素水平在阻塞性睡眠呼吸暂停综合征(OSAS)患者体内的变化,分析抵抗素与胰岛素抵抗(IR)的关系。方法选择年龄、体质量指数(BMI)相匹配的OSAS患者(OSAS组,n=60)和单纯肥胖者(对照组,n=40),测定所有受试者血清抵抗素、血压、空腹血糖(FBG)、空腹胰岛素(FINS)、血脂及呼吸暂停低通气指数(AHI)及最低血氧饱和度(SaO2),计算胰岛素抵抗指数(HOMA-IR)。结果 OSAS组的抵抗素、AHI、三酰甘油(TG)及FINS及HOMA-IR水平显著高于对照组(P<0.05),最低SaO2、高密度脂蛋白显著低于对照组(P<0.05)。多元逐步回归分析显示:FBG、BMI、AHI及抵抗素是影响患者IR的独立危险因素。结论 OSAS患者存在血清抵抗素水平升高,IR及脂代谢紊乱,随着OSAS病情的加重,抵抗素可影响OSAS患者IR的程度。     

阻塞性睡眠呼吸暂停低通气综合征与高血压及瘦素的关系

目的 研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与高血压及瘦素的关系,初步探讨睡眠呼吸紊乱及瘦素在OSAHS并发高血压发病中的作用.方法 测定60例OSAHS及40例年龄、体质指数(BMI)相匹配对照组睡前及醒后血压(BP)、醒后心率(HR),血清瘦素(LEp)水平,同时测定BMI、颈围(NC)、腰臀比(WHR)、血清空腹血糖(FBG)、三酰甘油(TG)、胆固醇(Chol)、空腹真胰岛素(TI)水平.对比两组睡前、醒后BP变化;分析睡眠呼吸紊乱参数及瘦素与高血压的相关关系.结果 OSAHS组与对照组睡前血压差异无显著性(P>0.05),但醒后血压尤其是舒张压(89.75±2.04)mmHg显著高于对照组(81.63±1.91)mmHg并独立于年龄和肥胖(P<0.01);OSAHS组DBP与瘦素、呼吸暂停低通气指数(AHI)呈正相关(r=0.282,P<0.05;r=0.318,P<0.01);BMI(P=0.029)、醒后HR(P=0.030)及瘦素(P=0.049)可能是高血压发生的独立相关因素.结论 睡眠呼吸紊乱可能对醒后血压,尤其是醒后舒张压产生独立的效应;而BMI、醒后HR和瘦素可能是高血压的独立相关因素.     

81例老年阻塞性睡眠呼吸暂停低通气综合征临床特点分析

目的：探讨老年阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与中年OSAHS临床特点和多导睡眠监测特征的差异,为诊断及个体化干预老年OSA HS提供参考依据。方法分析81例老年OSA HS和123例中年OSA HS的一般情况、临床表现和多导睡眠图特点,并按BM I匹配比较两组临床表现及多导睡眠指标差异。结果老年及中年OSA HS患者均以男性居多,老年组BMI及颈腹围均小于中年组（P＜0．05）,而胸围大于中年组（P＞0．05）。老年组的临床症状如嗜睡、打鼾、晨起头痛、口干及夜间憋醒发生率均低于中年组,差异具有统计学意义（P＜0．05）,而并发症如高血压、糖尿病等患病率明显高于中年组,差异具有统计学意义（P＜0．05）。老年组OSAHS患病程度主要分布于轻中度,中年组主要分布于中重度,但差异无统计学意义（P＞0．05）。REM期AHI老年组大于中年组（P＜0．05）,AHI低于中年组（P＜0．05）;NREM Ⅰ＋Ⅱ期大于中年组,差异有统计学意义（P＜0．05）;而NREM Ⅲ＋Ⅳ期、REM期、平均SaO2（％）、MAI小于中年组,LSAT（％）大于中年组,但差异均无统计学意义（P＞0．05）。结论老年OSAHS患者典型临床表现的发生率低于中年组,然而高血压、糖尿病等并发症患病率明显高于中年组,二者OSAHS严重程度相近,PSG监测结果与中年组存在差异,且REM期AHI与中年组差异明显。     

Value of STOP-Bang questionnaire in screening patients with obstructive sleep apnea hypopnea syndrome in sleep disordered breathing clinic

Background Obstructive sleep apnea hypopnea syndrome （OSAHS） is the most common sleep-disordered breathing and is still underdiagnosed.This study was designed to evaluate the value of the STOP-Bang questionnaire （SBQ） in screening OSAHS in sleep-disordered breathing clinics in order to extend it into the general Chinese population.Methods Two hundred and twelve patients undergoing overnight polysomnography （PSG） in the sleep-disordered breathing clinic of Pecking Union Medical College Hospital between May 2011 and January 2012 were prospectively included and were asked to fill in the SBQ.A score of 3 or more of the SBQ indicated a high risk of OSAHS.We analyzed the sensitivities and specificities of SBQ in screening OSAHS.Logistic regression analysis was used to evaluate the probabilities of the severity of OSAHS based upon the apnea hypopnea index （AHI）.Results The patients at high risk of OSAHS had higher AHI,higher oxygen desaturation index （ODI）,lower pulse oxygen saturation （LSpO2） during sleep time and less sleep time in stage N3.SBQ scores were positively correlated with AHI,ODI and the ratio of SpO2 lower than 90％,and negatively correlated with LSpO2 during sleep.The sensitivities of the SBQ with AHI ≥5/h,AHI ≥15/h,AHI ≥30/h as cut-offs were 94.9％,96.5％,and 97.7％,respectively,and the specificities were 50.0％,28.6％,and 17.9％,respectively.The Logistic regression analysis showed the probability of severe OSAHS increased and the probability of normal subjects decreased with increasing SBQ score.Conclusions The STOP-Bang questionnaire has excellent sensitivity in screening OSAHS patients and can predict the severity of OSAHS.More studies will be required to determine the value of SBQ in the general Chinese population.     

阻塞性睡眠呼吸暂停低通气综合征与瘦素受体基因Pro1019 Pro变异的关系及其危险因素分析

目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与瘦素受体基因第20位外显子3057位G→A变异(Pro1019 Pro)的关系,并对OSAHS与其发病危险因素进行相关性分析.方法 采用聚合酶链反应-限制性片段多态性法(PCR-RFLP)测定360例无亲缘关系的中国北方汉族居民瘦素受体Pro1019 Pro的基因型(其中OSAHS组180例,对照组180例),比较3个基因型的颈围、腹围、腰臀比等差异并进行问卷调查.结果 GG、GA、AA3种基因型及等位基因频率分布在OSAHS组与对照组中差异均无统计学意义(P＞0.05),OSAHS组中各基因型个体比较,颈围、腹围、睡眠监测等各项指标差异均无统计学意义(P＞0.05);有吸烟史、打鼾家族史、上气道结构异常、颈围增大者在OSAHS组中比例明显高于对照组.结论 瘦素受体基因Pro1019 Pro的单一变异在北方汉族居民OSAHS的发生中可能无明显作用;年龄、男性、颈围增大、吸烟、打鼾家族史、上气道结构异常为OSAHS的易患因素,它们能增加OSAHS的患病风险.     

OSAHS患者外周血Th1/Th2细胞比例变化及临床意义

目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者外周血Th1/Th2细胞比例变化及临床意义.方法 经多导睡眠图确诊OSAHS患者60例,按照呼吸暂停低通气指数(AHI)分为轻度OSAHS组(n=18),中度OSAHS组(n=22),重度OSAHS组(n=20).对照组为年龄、性别、BMI匹配,经多导睡眠监测除外OSAHS者20例.用流式细胞术检测各组Th1/Th2细胞比例并进行各组间比较.对OSAHS患者睡眠期AHI和Th1细胞比例进行相关性分析.结果 OSAHS组Th1比例明显高于对照组[(18.2±5.4)%和(12.5±3.8)%,P<0.05],其中重度OSAHS组增高较对照组尤为明显[(21.8±4.6)%和(12.5±3.8)%,P<0.01].OSAHS患者Th1细胞比例与AHI呈正相关(r=0.668,P<0.01).Th2比例差异在各组间均无统计学意义(P>0.05).结论 OSAHS患者Th1细胞激活程度显著增高,且与OSAHS的严重程度相关.     

Correlation of obstructive sleep apnea hypopnea syndrome with metabolic syndrome in snorers

Though obstructive sleep apnea hypopnea syndrome（OSAHS） and metabolic syndrome（MS） are correlated;the contributing factors for the occurrence of MS in Chinese snorers remain largely undefined.We aimed to investigate the associated pathogenesis of coexistence of OSAHS and MS in Chinese snorers.A total of 144 Chinese habitual snorers were divided into 3 groups,the control group（simple snorers）（n = 36）,the mild OSAHS group（n= 52）and the moderate-to-severe OSAHS group（n = 56）.The incidence of MS in the moderate-to-severe OSAHS group（26.8%） was significantly higher than that in the control group（8.3%）,the mild OSAHS group（11.1%） and all the OSAHS patients（19.45%）（all P 〈 0.05）.Homeostatic model assessment（HOMA） index and proinsulin（PI） were negatively correlated with nocturnal meanSpO2 and miniSpO2.Meanwhile,nocturnal SpO2 were negatively correlated with body mass index,waist and neck circumferences and diastolic blood pressure,but positively correlated with total cholesterol and high-density lipoprotein cholesterol.The study indicated that in Chinese snorers,moderate-to-severe OSAHS was closely associated with MS via nocturnal hypoxemia.     

Serum adiponectin level in patients with obstructive sleep apnea hypopnea syndrome

Background Adiponectin, secreted by adipocytes, has been found to be associated with diabetes, obesity and some cardiovascular diseases. Obstructive sleep apnea hypopnea syndrome (OSAHS) is also closely related to obesity and easily complicated with diabetes and some cardiovascular diseases. This study was carried out to explore the change of serum adiponectin level in patients with OSAHS.Methods Polysomnography was performed in 71 patients with OSAHS (OSAHS group) and 26 simple obese controls (control group). The two groups had no significant difference in age and body mass index (BMI). Radioimmunoassy was used to test serum adiponectin level.Results Serum adiponectin level was significantly lower in OSAHS group ［(5.03±1.01) mg/L］ than that in the control group ［(7.09±1.29) mg/L, P&lt;0.05］. The differences between two groups were independent of gender. In OSAHS groups, serum adiponectin levels were negatively correlated with apnea hypopnea index (AHI) （r=-0.78, P&lt;0.01）, BMI （r=-0.13, P&lt;0.05）, waist circumsference (r=-0.36, P&lt;0.01), and neck circumference (r=-0.42, P&lt;0.01), but positively correlated with the minimal pulse oxyhemoglobin saturation （r=0.48, P&lt;0.01）. Conclusion OSAHS may contribute to the decrease of serum adiponectin level independent of obesity.     

Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome

Background  The nocturnal nondipping and elevated morning blood pressure (BP) in patients with obstructive sleep apnea syndrome (OSAS) have not yet been well investigated in Chinese patients. This study aimed to describe the BP profile, and to elucidate the relationships between daytime BP and nighttime BP, and between evening BP and morning BP in patients with OSAS.

Methods  Twenty teaching hospital sleep centers in China were organized by the Chinese Medical Association to participate in this study and 2297 patients were recruited between January 2004 and April 2006. BP assessments were made at four time points (daytime, evening, nighttime and morning) and polysomnography (PSG) was performed and subjects were classified into four groups by their apnea­hypopnea index (AHI): control, n=213 with AHI <5; mild, n=420 with AHI ≥5 and <15; moderate, n=460 with AHI ≥15 and <30; and severe, n=1204 with AHI ≥30. SPSS 11.5 software package was used for statistical analysis and figure drawing.

Results  All the average daytime, nighttime, evening and morning BPs were positively correlated with AHI and negatively correlated with nadir nocturnal oxygen saturation. The ratios of nighttime/daytime and morning/evening average BP were positively correlated with AHI. The ratio of nighttime/daytime systolic BP became a “reversed BP dipping” pattern until the classification reached severe, while the ratio of nighttime/daytime diastolic BP became reversed at moderate. Similarly, the ratio of morning/evening diastolic BP becomes reversed even at mild.

Conclusions  OSAS may result in higher BP levels at all four time points. The ratios of nighttime/daytime and morning/evening BP increase with increased AHI. The increasing of diastolic BP, which is inclined to rise more quickly, is not parallel with increasing systolic BP.

     

瘦素受体基因Lysl09Arg和Pro1019Pro多态性与阻塞性睡眠呼吸暂停低通气综合征的相关性研究

目的 观察瘦素受体基因Lysl09Arg和Pro1019Pro变异与阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的相关性.方法 对390例无亲缘关系的中国北方汉族居民(OSAHS组195例,健康对照组195例)进行了多导睡眠图监测,用聚合酶链反应-限制性片段多态性方法(PCR-RFLP)检测瘦素受体基因Lysl09Arg和Pro1019Pro的基因型.结果 Lysl09Arg和Pro1019Pro基因的AA、GA、GG三种基因型及等位基因频率分布在OSAHS组与对照组中无显著差异(P＞0.05);各基因型个体比较,颈围、腹围、PSG等各项监测指标均无显著差异(P ＞0.05);OSAHS与对照组相比,Lysl09Arg和Pro1019Pro基因不同基因型组合间比例无统计学意义(P＞0.05).结论 瘦素受体基因Lys 109Arg和Pro1019Pro单一基因的变异及两者的联合效应与我国北方汉族居民发生OSAHS之间无明显相关性.     

血清瘦素检测在阻塞性睡眠呼吸暂停低通气综合征和冠心病中的应用

[目的]探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)、冠心病(CHD)患者血清瘦素(Leptin)水平,以及血清Leptin在OSAHS和CHD中的应用.[方法]用ELISA法检测单纯OSAHS组、单纯CHD组、OSAHS合并CHD组及健康对照组的血清Leptin水平,并计算出各受试组血清Leptin的95%置信区...     

阻塞性睡眠呼吸暂停低通气综合征的治疗进展

阻塞性睡眠呼吸暂停低通气综合征是一种严重危害人们身体健康的疾病。手术与非手术两种治疗方案越来越受到人们的关注。笔者就该病的目前治疗状况作一综述。