18F-FDG PET/CT评价兔VX2移植瘤对顺铂化疗的早期反应

目的 探讨18F-FDG PET/CT评价兔VX2移植瘤顺铂化疗早期反应的最佳时间,观察移植瘤摄取FDG的变化规律及其与病理变化的相关性.方法 将30只VX2荷瘤兔按随机数字表法分为5组,每组6只.化疗组在按体质量静脉注射顺铂(7 mg/kg)化疗前和化疗后6、12、24及36h分别行18F-FDG PET/CT显像;对照组用等体积的生理盐水进行干预;勾画ROI,计算SUVmax、T/NT.采用HE染色观察肿瘤细胞坏死率,TUNEL法检测细胞凋亡.统计学分析采用配对t检验、Games-Howell检验及曲线相关分析.结果 对照组干预后SUVmax为9.77±2.45,明显高于干预前(6.58±1.67;t=-5.480,P＜0.05),干预后T/NT为29.34±3.31,明显低于干预前(52.93±3.90;t=17.593,P＜0.05).化疗组化疗后6 h 18F-FDG摄取减低,SUVmax平均减低率为(11.83±8.89)％,T/NT平均减低率为(59.00±8.22)％,与对照组间的差异有统计学意义(均P＜0.05).化疗后24 h 18F-FDG摄取减低最明显,SUVmax平均减低率为(42.33±33.80)％,T/NT平均减低率为(83.50±7.69)％,与对照组和化疗后6h显像组间的差异均有统计学意义(均P＜0.05).SUVmax和T/NT变化率与凋亡指数呈正相关(r=0.750、0.794,均P＜0.05),与肿瘤细胞坏死率亦呈正相关(r=0.804、0.874,均P＜0.05).结论 18F-FDG PET/CT能够灵敏检测早期化疗反应,化疗后24 h是最佳早期化疗反应评价时间点.     

CT导向下射频消融治疗不能手术切除肺癌患者的临床分析

目的:探讨CT导向下射频消融对不能手术切除肺癌治疗的有效性及安全性。方法:回顾性分析23例经CT导向下射频消融治疗的肺癌患者,其中原发性肺癌患者17例,肺癌术后转移6例,评价其治疗局部有效率和1年无进展生存期。结果:本组共23例患者共行33次射频消融治疗,手术均顺利完成。平均随访时间18.3月(13～30个月),局部控制率在3月、6月及1年分别是96.8%、93.5%及86.7%,1年无进展生存率73.9%。余发生与手术相关的严重并发症。结论:CT导向下射频消融在肺癌治疗中是一种安全有效的局部治疗方法。     

PET/CT及DWI-MRI早期评估兔VX2肉瘤射频消融效果

目的：探讨弥散加权(DWI)-MRI和18F-FDG-PET/CT评估兔VX2肉瘤射频消融(RFA)治疗早期效果的价值。方法14只新西兰白兔双侧后肢接种VX2肉瘤建模,一侧后肢VX2肉瘤接受超声引导下RFA治疗(RFA组),对侧后肢不进行射频治疗(对照组)。 RFA治疗后2 d行DWI-MRI检查,治疗后3 d行PET/CT检查。分别计算肿瘤病灶和消融灶表观弥散系数(ADC)值和标准摄取值(SUV)值。根据外科切除病灶组织病理学检查结果金标准,分别对DWI-MRI、PET/CT及两者联合等3种方法评估RFA瘤灶行临床诊断一致性Kappa检验。结果 VX2肉瘤RFA前,DWI-MRI显示T1低信号,T2高信号,T1加权像环状强化,PET/CT显示18F-FDG呈结节状或环状聚集;消融后DWI-MRI显示T1高信号, T2轻度高密度,T1加权像轻度强化,PET/CT显示18F-FDG浓聚程度减低。消融瘤灶ADC值为(1．52±0．24)×10－3 mm2/s,明显高于未消融瘤灶(1．09±0．12)×10－3 mm2/s(P<0．05);SUV值为(0．60±0．30),明显低于未消融瘤灶(9．60±3．20)(P<0．05)。单独DWI-MRI与单独PET/CT评估结果的敏感性、特异性及准确性与组织病理学诊断结果的一致性Kappa值分别为0．357和0．428,无显著性差别(P>0．05),DWI-MRI联合PET/CT评估结果与组织病理学诊断结果的一致性Kappa值为0．786,与前两者均有显著性差别(P<0．05)。结论 DWI-MRI显像ADC值和FDG-PET/CT显像SUV值是评估RFA治疗早期效果的有临床应用价值的指标。DWI-MRI与FDG-PET/CT诊断肿瘤病灶治疗效果各具优势,两者联合应用可有效提高疗效评估的准确性。     

18F-FDG PET/CT in evaluation of radiofrequency ablation of liver metastasis

Image-guided radiofrequency ablation (RFA) is a minimally invasive therapy option in the treatment of primary and secondary hepatic malignancies, which are not suitable for surgery/chemotherapy, and more recently, for tumors with limited hepatic involvement and solitary liver metastasis. Accurate assessment of treatment response after RFA remains a concern. Conventional imaging modalities have limitations of differentiation between residual/recurrence from post-RFA changes. We illustrate images of 3 patients in whom (18)F-FDG PET/CT was used for response assessment and restaging after RFA in liver tumors.     

Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG.

Recently, the thymidine analog 3'-deoxy-3'-(18)F-fluorothymidine (FLT) was suggested for imaging tumoral proliferation. In this prospective study, we examined whether (18)F-FLT better determines proliferative activity in newly diagnosed lung nodules than does (18)F-FDG. METHODS: Twenty-six patients with pulmonary nodules on chest CT were examined with PET and the tracers (18)F-FDG and (18)F-FLT. Tumoral uptake was determined by calculation of standardized uptake value (SUV). Within 2 wk, patients underwent resective surgery or had core biopsy. Proliferative activity was estimated by counting nuclei stained with the Ki-67-specific monoclonal antibody MIB-1 per total number of nuclei in representative tissue specimens. The correlation between the percentage of proliferating cells and the SUVs for (18)F-FLT and (18)F-FDG was determined using linear regression analysis. RESULTS: Eighteen patients had malignant tumors (13 with non-small cell lung cancer [NSCLC], 1 with small cell lung cancer, and 4 with pulmonary metastases from extrapulmonary tumors); 8 had benign lesions. In all visible lesions, mean (18)F-FDG uptake was 4.1 (median, 4.4; SD, 3.0; range, 1.0-10.6), and mean (18)F-FLT uptake was 1.8 (median, 1.2; SD, 2.0; range, 0.8-6.4). Statistical analysis revealed a significantly higher uptake of (18)F-FDG than of (18)F-FLT (Mann-Whitney U test, P < 0.05). (18)F-FLT SUV correlated better with proliferation index (P < 0.0001; r = 0.92) than did (18)F-FDG SUV (P < 0.001; r = 0.59). With the exception of 1 carcinoma in situ, all malignant tumors showed increased (18)F-FDG PET uptake. (18)F-FLT PET was false-negative in the carcinoma in situ, in another NSCLC with a low proliferation index, and in a patient with lung metastases from colorectal cancer. Increased (18)F-FLT uptake was related exclusively to malignant tumors. By contrast, (18)F-FDG PET was false-positive in 4 of 8 patients with benign lesions. CONCLUSION: (18)F-FLT uptake correlates better with proliferation of lung tumors than does uptake of (18)F-FDG and might be more useful as a selective biomarker for tumor proliferation.     

Four-dimensional transcatheter intraarterial perfusion MRI monitoring of radiofrequency ablation of rabbit VX2 liver tumors

Purpose:

To investigate the hypothesis that four‐dimensional (4D) transcatheter intraarterial perfusion (TRIP) magnetic resonance imaging (MRI) can quantify immediate perfusion changes after radiofrequency (RF) ablation in rabbit VX2 liver tumors.

Materials and Methods:

Nine New Zealand White rabbits were used to surgically implant VX2 liver tumors. During ultrasound‐guided RF ablation, tumors received either a true or sham ablation. After selective catheterization of the left hepatic artery under x‐ray fluoroscopy, we acquired pre‐ and post‐RF ablation 4D TRIP MR images using 3 mL of 2.5% intraarterial gadopentetate dimeglumine. Two regions‐of‐interest were drawn upon each tumor to generate signal‐intensity time curves. Area under the curve (AUC) was calculated to provide semiquantitative perfusion measurements that were compared using a paired t‐test (α = 0.05). Ablated tissue was visually confirmed on pathology using Evans blue dye.

Results:

Mean AUC perfusion of VX2 tumors for the true ablation group decreased by 92.0% (95% confidence interval [CI]: 83.3%–100%), from 1913 (95% CI: 1557, 2269) before RF ablation to 76.6 (95% CI: 18.4, 134.8) after RF ablation (a.u., P < 0.001). Sham‐ablated tumors demonstrated no significant perfusion changes.

Conclusion:

4D TRIP MRI can quantify liver tumor perfusion reductions in VX2 rabbits after RF ablation. This MRI technique can potentially be used to improve tumor response assessment at the time of RF ablation. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.     

Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques.

The rupture of atherosclerotic vulnerable plaques and subsequent formation of thrombi are the main factors responsible for myocardial and cerebral infarctions. Because macrophage infiltration plays an essential role in plaque rupturing, pharmacologic therapy that reduces macrophage infiltration is required to stabilize the vulnerable plaques. The monitoring of therapeutic effect is important in assessing the therapeutic effects of drugs for individual patients. We previously reported that (18)F-FDG accumulates in macrophage-rich plaques. The present study was undertaken to investigate the usefulness of (18)F-FDG PET for monitoring therapies that target vascular inflammation. METHODS: Myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits were used in this study. The antioxidant probucol was included in the diet fed to 4 rabbits starting at 10 mo of age (probucol group). In a control study, 4 rabbits received standard rabbit chow (control group). (18)F-FDG PET experiments were performed on both groups before the study and at 1, 3, and 6 mo after treatment. After the last imaging session, the rabbits were sacrificed at 3 h after injection of (18)F-FDG, and the aortas were removed. The accumulated radioactivity was then measured, and the number of macrophages was determined by examination of stained sections. RESULTS: At the age of 10 mo, before the treatment, the aorta could be imaged by (18)F-FDG PET in all rabbits. The aorta could not be imaged after 6 mo of probucol treatment, whereas intense radioactivity was observed in the control rabbits throughout the investigation. The standardized uptake values (SUVs) of the aorta were decreased significantly in the probucol group after 3 mo of intervention as compared with the pretreatment period. The SUVs of the control group were increased gradually at 6 mo. Radioactivity in the aorta was significantly lower in the probucol group than that in the control group. Macrophages were already present at the beginning of the study, and probucol treatment for 6 mo resulted in a significant reduction of macrophage infiltration. CONCLUSION: (18)F-FDG PET was able to image the reduction of inflammation by probucol. (18)F-FDG PET should be useful for evaluating the therapeutic effect of drugs clinically and for the development of new drugs that can stabilize vulnerable plaques. (18)F-FDG PET should be useful for evaluating the therapeutic effect of drugs clinically and for the development of new drugs that can reduce inflammation of vulnerable plaques.     

肺肿瘤CT引导下经皮射频消融后的影像评估进展

近年来,CT引导下经皮射频消融术在无法手术切除或转移性肺肿瘤的治疗中备受推崇。但因术后病理改变的复杂性,不同影像检查的表现既存在重叠,又存有差异,使得评估充满挑战。就不同影像方法(CT、PET/CT、MRI)对肺肿瘤病人术后不同时期的评估进展予以综述,以期更好地指导临床。     

Spillover and partial-volume correction for image-derived input functions for small-animal 18F-FDG PET studies.

We present and validate a method to obtain an input function from dynamic image data and 0 or 1 blood sample for small-animal 18F-FDG PET studies. The method accounts for spillover and partial-volume effects via a physiologic model to yield a model-corrected input function (MCIF). METHODS: Image-derived input functions (IDIFs) from heart ventricles and myocardial time-activity curves were obtained from 14 Sprague-Dawley rats and 17 C57BL/6 mice. Each MCIF was expressed as a mathematic equation with 7 parameters, which were estimated simultaneously with the myocardial model parameters by fitting the IDIFs and myocardium curves to a dual-output compartment model. Zero or 1 late blood sample was used in the simultaneous estimation. MCIF was validated by comparison with input measured from blood samples. Validation included computing errors in the areas under the curves (AUCs) and in the 18F-FDG influx constant Ki in 3 types of tissue. RESULTS: For the rat data, the AUC error was 5.3% +/- 19.0% in the 0-sample MCIF and -2.3% +/- 14.8% in the 1-sample MCIF. When the MCIF was used to calculate the Ki of the myocardium, brain, and muscle, the overall errors were -6.3% +/- 27.0% in the 0-sample method (correlation coefficient r = 0.967) and 3.1% +/- 20.6% in the 1-sample method (r = 0.970). The t test failed to detect a significant difference (P > 0.05) in the Ki estimates from both the 0-sample and the 1-sample MCIF. For the mouse data, AUC errors were 4.3% +/- 25.5% in the 0-sample MCIF and -1.7% +/- 20.9% in the 1-sample MCIF. Ki errors averaged -8.0% +/- 27.6% for the 0-sample method (r = 0.955) and -2.8% +/- 22.7% for the 1-sample method (r = 0.971). The t test detected significant differences in the brain and muscle in the Ki for the 0-sample method but no significant differences with the 1-sample method. In both rat and mouse, 0-sample and 1-sample MCIFs both showed at least a 10-fold reduction in AUC and Ki errors compared with uncorrected IDIFs. CONCLUSION: MCIF provides a reliable, noninvasive estimate of the input function that can be used to accurately quantify the glucose metabolic rate in small-animal 18F-FDG PET studies.     

MRI-guided radiofrequency thermal ablation of implanted VX2 liver tumors in a rabbit model: demonstration of feasibility at 0.2 T.

Successful radiofrequency (RF) thermal ablation was performed on VX2 tumors implanted in 23 rabbit livers under magnetic resonance (MR) guidance using a C-arm-shaped low-field 0.2 T system. RF application and immediate postprocedure MRI of all animals was performed [T2-weighted, turbo short tau inversion recovery (STIR), T1-weighted before and after gadopentetate dimeglumine administration). Follow-up MRI with a superparamagnetic iron oxide (SPIO) contrast medium was performed in nine rabbits at 2 weeks and in four rabbits at 1 month post RF ablation. All livers were harvested for pathologic examination. T2-weighted and turbo-STIR images demonstrated the highest tumor-to-RF-thermal lesion contrast-to-noise ratios (CNRs; means 4.5 and 3.8, respectively) on postprocedure images; this was redemonstrated at 2- and 4-week follow-up imaging. T2-weighted imaging never overestimated pathologic lesion size by more than 2 mm, and the radiologic-pathologic correlation coefficient was not less than 0.90. In conclusion, MRI-guided RF thermal ablation in implanted liver tumor is feasible using a C-arm-shaped low-field 0.2 T system. The thermal lesion size can be most accurately monitored with T2-weighted and turbo-STIR images.     

Evaluation of liver metastases after radiofrequency ablation: utility of 18F-FDG PET and PET/CT

OBJECTIVE: Our objective was to review the CT appearance of liver metastases after radiofrequency ablation and to describe the imaging findings of and utility of (18)F-FDG PET and PET/CT in assessing tumor recurrence after ablation. CONCLUSION: (18)F-FDG PET and PET/CT can provide added diagnostic information compared with conventional imaging in patients after radiofrequency ablation of liver metastases and can be useful in guiding repeat ablation procedures.     

射频消融联合骨水泥对兔VX2椎旁肿瘤的杀伤作用

目的 探讨射频消融(RFA)联合聚甲基丙烯酸甲酯骨水泥对兔VX2腰椎旁肿瘤的杀伤作用.方法 CT导引下经皮穿刺成功构建兔VX2腰椎旁移植瘤模型48只,随机分为4组,每组12只.A组兔模型瘤灶中心先行RFA,后注入骨水泥0.5 ml;B组单纯注入骨水泥0.5 ml;C组单纯RFA;D组注入生理盐水0.5 ml,作为对照组.术后24 h处死全部4组模型兔,分别在瘤灶中心或距骨水泥边缘5、10、15、20 mm处不同方向各取2 mm大小组织块4块,检测肿瘤细胞凋亡指数.结果 A、B、C组手术成功率均为91.7％(11/12),D组为100％(12/12).A、C组瘤灶中心半径10 mm范围内肿瘤细胞呈大片状凝固性坏死,细胞形态消失,几乎检测不出凋亡存在.A组距骨水泥边缘10、15、20 mm处平均肿瘤细胞凋亡率分别为(69.48±1.27)％、(59.05±3.02)％、(21.03±2.20)％,与对照组(10.25±0.79)％相比差异均有统计学意义(p＜0.01);B组距骨水泥边缘5、10、15 mm处平均肿瘤细胞凋亡率分别为(62.52±2.07)％、(45.07±3.14)％、(17.41±1.12)％,与对照组相比差异均有统计学意义(P＜0.01),而20 mm处平均肿瘤细胞凋亡率为(11.15±0.97)％,与对照组相比差异无统计学意义(P＞0.01);C组距瘤灶中心10、15、20 mm处平均肿瘤细胞凋亡率分别为(67.74±3.33)％、(56.36±3.63)％、(20.71±1.11)％,与B组、D组相比差异有统计学意义(P＜0.01),与A组相比差异无统计学意义(P＞0.01).结论 RFA和骨水泥均可促进肿瘤细胞凋亡,RFA杀伤肿瘤范围更大,RFA联合骨水泥对肿瘤杀伤作用无明显增强.     

18 F-FDG PET-CT在肺癌疗效监测中的临床应用价值

目的:探讨18F-FDG PET-CT对可疑复发和转移的肺癌患者的诊断和临床应用价值。方法:对17例经临床、生化指标和影像学检查可疑复发的肺癌患者行18F-FDG PET-CT检查,并将结果与同期CT检查结果相比较。最终复发的诊断经外科手术、穿刺活检或经进一步的临床和影像学随访证实,评价PET-CT对制订患者治疗计划的价值。结果:8例经证实为复发或转移的患者PET-CT全部显示为阳性。8例证实为无复发的患者PET-CT阴性,1例PET-CT诊为复发的患者,经1年后随访证实为假阳性。9例无复发的患者CT仅肯定正确诊断4例,另5例CT假阳性患者皆由于CT无法鉴别复发与放疗后反应或术后疤痕所致,PET-CT改变了6例患者的最初治疗计划。结论:对治疗后可疑复发和转移的肺癌患者,PET-CT是有效的检查手段,与CT相比具有明显的优越性,对临床治疗计划的制定有较高的指导价值。     

Assessment of a chemically induced model of lung squamous cell carcinoma in mice by 18F-FDG small-animal PET

BACKGROUND: Small-animal imaging has become a relevant research field in pre-clinical oncology. In particular, metabolic information provided by small-animal positron emission tomography (PET) is very useful to closely monitor tumour growth and assess therapy response in murine models of human disease. There are various murine models for human lung adenocarcinoma, but those for squamous cell lung carcinoma, the most common form of human cancer, are lacking. AIM: To assess the feasibility of 18F-FDG small-animal PET to monitor tumour growth in a chemically induced model of squamous cell carcinoma of the lung. MATERIALS AND METHODS: Nineteen NIH Swiss mice were skin painted by N-nitroso-tris-chloroethylurea (NTCU) twice a week, with a 3 day interval, for 8 months and 10 NIH Swiss mice skin painted with NTCU solvent (acetone) were used as controls. 18F-FDG PET was performed under sevofluorane anaesthesia and oxygen supplementation at 2, 4, 6 and 8 months from initial treatment. Images were assessed by visual analysis and semi-quantitatively. When a diffuse distribution of tumour was noted, the mean of the counts/pixel measured at three lung levels, corrected for the effective dose injected and for decay, was used for comparison between mutagen-painted and control mice. Pathological evaluation was carried out from the time of the first positive PET results in a subgroup of the whole population to assess correlation with PET findings. Small animal CT was performed at 8 months in another subgroup. RESULTS: In both terms of visual analysis and measurement of total lung activity, 18F-FDG PET at 2 and 4 months from initial treatment were comparable in mutagen-painted and controls. At 6 months, PET images showed a faint and diffuse uptake over both lung fields in mutagen-painted mice with multiple focal areas of increased tracer uptake that merged into confluent masses at 8 months and seriously subverting lung architecture on computed tomography. Total lung activity was significantly higher in mutagen-painted versus control mice at 6 (P=0.00000668) and 8 months (P=0.00000043) from initial treatment and paralleled the progressive lung involvement and histological severity. CONCLUSIONS: 18F-FDG PET may be useful in the assessment of this chemically induced murine model of lung squamous cells carcinoma. The total lung activity may be used as a measure of tumour metabolic activity of the tumour-bearing animals and may be useful in new drug testing studies.     

兔肺VX2移植瘤放疗前后~（18）F-FDG PET及CT观察

目的：探讨兔肺VX2移植瘤模型用于评估肺部肿瘤放射治疗效果的可行性。方法：12只兔肺VX2移植瘤模型行短期大剂量放疗,放疗前及放疗后第7天行18F-FDGPET及CT检查,以常规病理作为金标准。结果：兔肺VX2移植瘤放疗前PET显像,常规SUVmax为2.95±1.04,延迟SUVmax为3.58±1.32;放疗后第7天PET显像,常规SUVmax为1.47±0.36,延迟SUVmax为1.88±0.44。放疗后PET常规显像较放疗前18F-FDG代谢变化百分率下降60.48±5.66,PET延迟显像18F-FDG代谢变化百分率下降57.18±6.79。兔肺VX2移植瘤放疗前后PET常规显像SUV改变与放疗前后PET延迟显像的SUV改变均以t检验分析,放疗前后SUV变化有统计学意义。病理检查见肿瘤组织内大片凝固坏死。结论：兔肺VX2移植瘤模型短期大剂量放疗后行18F-FDGPET显像,其SUV显著降低,可在兔肺VX2移植瘤出现CT形态学改变之前早期评估兔肺VX2移植瘤对放射治疗的反应。     

兔VX2肝癌射频消融后CT与病理对照分析

射频消融(RFA)作为肝癌局部治疗的常用方法,已取得了显著疗效[1-3].影像检查作为随访判断肝癌RFA后疗效的常用手段之一,对于肿瘤的残存和复发、肿瘤浸润的早期发现具有非常重要的作用.笔者旨在通过对兔VX2肝癌RFA后病灶的CT影像和病理的对照分析,以早期鉴别肿瘤残存与术后炎性反应.     

Diagnostic accuracy of 18F-FDG PET/CT for assessing response to radiofrequency ablation treatment in lung metastases: a multicentre prospective study

Purpose

To assess diagnostic accuracy of ¹⁸F-FDG PET/CT at 3 months for the detection of local recurrence after radiofrequency ablation (RFA) of lung metastases.

Methods

The PET/CT scan at 3 months was compared with a baseline PET/CT scan from a maximum of 2 months before RFA, with the reference standard as recurrence diagnosed by CT during a 12-month follow-up. Local recurrence was diagnosed on the PET/CT scan if lesional uptake was greater than the mediastinal background. Maximum standardized uptake values (SUVmax) were recorded. ROC curve analysis for SUVmax was performed. Overall survival (OS) and time to local relapse were computed from the date of RFA using the Kaplan-Meier method (www.clinicaltrials.gov: NCT 00382252).

Results

Between 2005 and 2009, 89 patients (mean age 65 years) underwent RFA for 115 lung metastases (mean size 16.2 ± 6.9 mm). The median SUVmax before RFA was 5.8?±?4. PET/CT at 3 months and the reference standard were available in 77 patients and 100 lesions. Accuracy was 66.00 % (95 % CI 55.85–75.18 %), sensitivity 90.91 % (95 % CI 58.72–99.77 %), specificity 62.92 % (95 % CI 52.03–72.93 %), PPV 23.26 % (95 % CI 11.76–38.63 %), and NPV 98.25 % (95 % CI 90.61–99.96 %). One-year OS was 94.2 % (95 % CI 86.6–97.5 %) and the probability of being free of local recurrence 1 year after RFA was 84.6 % (95 % CI 75.0–90.8 %).

Conclusion

The specificity of PET/CT at 3 months is low because of persistent inflammation, especially when the lesion is close to the pleura. This technique is useful for its negative predictive value, but positive findings need to be confirmed by histology before new treatment is planned.     

18F-FDG PET显像在肺癌中的应用

18F-FDG(18F-氟代脱氧葡萄糖)PET可以反映正常机体组织和肿瘤细胞的功能状态,在对肺部病变的定性诊断、肺癌的临床分期、疗效评价、复发监测以及预后估计上都明显优于CT、MRI等形态解剖学检查,而且能间接提供瘤组织细胞分化程度和增殖潜能的判断依据,具有重要的临床应用价值。由于PET在空间分辨率上存在不足,应与其他影像学检查相结合,以提高其准确性。     

A pilot study of early 18F-FDG PET to evaluate the effectiveness of radiofrequency ablation of liver metastases

OBJECTIVE: The objective of our study was to collect pilot data about the use of FDG PET within hours after radiofrequency ablation (RFA) of liver metastases. CONCLUSION: Total photopenia on early PET can potentially be regarded as a macroscopic tumor-free margin; focal uptake can be regarded as macroscopic residual tumor.