Akutes Koronarsyndrom und Entzündung

Inflammation plays a pivotal role in atherosclerosis and coronary heart disease. Inflammatory processes of the coronary arterial wall are involved in plaque formation, progression and, finally, plaque instability consecutively leading to the clinical manifestations of stable coronary artery disease or acute coronary syndromes (unstable angina, non-ST elevation and ST elevation myocardial infarction). Acute coronary syndromes result from plaque rupture or erosion leading to local thrombus formation with consecutive necrosis of myocytes due to ischemia, which is associated with widespread and diffuse pancoronary and panmyocardial inflammation. Accordingly, markers of myocardial necrosis (e. g., cardiac troponins) do have crucial diagnostic and prognostic value. In case of troponin-negative acute coronary syndromes, however, markers of inflammation emerged as potentially useful tools for risk stratification. C-reactive protein has been shown to serve as a powerful predictor of future cardiovascular events following acute coronary syndromes, even if troponins are not (yet) positive. Moreover, a variety of pro- (soluble CD40 ligand, placental growth factor, interleukin-6, pregnancy-associated plasma protein A, myeloperoxidase, monocyte chemoattractant protein-1) and anti-inflammatory markers (interleukin-10, activin A) have been suggested to provide relevant prognostic information in patients with acute coronary syndrome. However, the clinical utility of these novel markers has not been established so far.     

Entzündung und Ernährung bei Mukoviszidose

Mucoviscidosis or cystic fibrosis (CF) is the most common life-shortening autosomal recessive disorder with a significantly reduced average life expectancy. In most cases, the mortality in CF is due to respiratory insufficiency. The early nutritional status in CF is directly associated with the progression of lung disease. However, the impact of dietary interventions on pulmonary and intestinal inflammation to prevent disease progression remains a matter of debate. Growing evidence shows that bioactive food components, such as polyunsaturated fatty acids (PUFA), probiotics, vitamins and antioxidants, have beneficial effects on the inflammation in CF. This review article focuses on anti-inflammatory nutritional strategies in cystic fibrosis.     

Das Verhalten des Kernplasmas als Bindeglied zwischen Entzündung und Geschwulstentwicklung

Zusammenfassung Es wird auf Verschiebungen im Verhalten des Kernplasmas als den direkten Anlaß für den Umschlag der Zelle zur malignen Zelle hingewiesen (und nicht als ihre Folge, wie mißverständlich behauptet worden ist, da die Ratio der malignen Zelle [Kernplasmaverhalten] die gleiche wie bei der normalen Zelle ist, aber die weist jetzt, wohlbemerkt,gleichzeitig andere Dimensionen auf, nimmt ein anderes Größenniveau an).Analogie zu den größeren Dimensionen und der größeren Wachstumsenergie der veränderten Zelle (mit einer polyploiden Chromosomenzahl) findet man am spontanen und arteficiellen Vorkommen in vielen verschiedenen Beobachtungen innerhalb der Biologie, auch innerhalb somatischer Zellen, nicht allein innerhalb Generationszellen.     

Experimentelle Untersuchungen über das Verhalten zwischen Entzündung und Wachstum der Impfgeschwülste

Ohne ZusammenfassungHerrn Prof. Dr.A. Fujinami zum 60. Geburtstage.     

Pathophysiologie der diabetischen Neuropathie (DN), Rolle von Entzündung und Eisenstoffwechsel

Die Diabetologie - Die Pathogenese der diabetischen Neuropathie ist komplex und bisher nicht eindeutig geklärt. Ein besseres Verständnis derselben wäre jedoch Voraussetzung für...     

MicroRNAs in B- und T-Zellen als Regulatoren der Entz��ndung

MicroRNAs are small non-coding RNAs which are crucial for the fine regulation of gene expression. Recent results suggest that these molecules display multifaceted functions in B-cells and T-cells in rheumatic inflammatory diseases.     

Entzündliche Herzerkrankungen

Ohne Zusammenfassung     

Entzündliche Muskelkrankheiten

Dermatomyositis, polymyositis, inclusion body myositis and myositis overlap syndromes are systemic immune disorders of unknown origin with muscle weakness and elevated values of creatinkinase in the serum. Muscle biopsy is pivotal for a proper clinical diagnosis. Extramuscular findings at the skin, the joints or internal organs (lung, heart) are characteristic for the different clinical presentations of dermato- or polymyositis and are usually absent in inclusion body myositis. With the exception of inclusion body myositis myositis-associated autoantibodies are frequently present and associated with distinct clinical manifestations (e. g. antisynthetase syndrome). The rate of malignancy is elevated for several years after onset of myositis. Especially in polymyositis an appropriate differential diagnosis of infectious, endocrine, metabolic or neuromuscular causes of muscle disease is necessary. Glucocorticosteroids are the first choice of treatment in dermato- or polymyositis. Methotraxate, azathioprine, cyclophosphamamide, i.v. immunoglobulins and other drugs are used in diseases courses with continuous high dose requirement of corticosteroids.     

Gründung eines jugoslavischen Komitees für Krebsforschung und -bekämpfung

Ohne Zusammenfassung     

Kompetenznetz Entzündlich-Rheumatische Erkrankungen

The foundation of the competence network for rheumatology, which is funded by the "Bundesministerium für Bildung und Forschung" (BMBF) since 1999, succeeded to create a unique research structure in Germany: medical doctors and scientists from six university rheumatology centres (Berlin, Düsseldorf, Erlangen, Freiburg, Hannover und Lübeck/Bad Bramstedt) work closely together with scientists doing basic research at the Deutsches Rheuma-Forschungszentrum (DRFZ), with rheumatological hospitals, reha-clinics, and rheumatologists. Jointly they are searching for causes of systemic inflammatory rheumatic diseases and try to improve therapies-nationwide and with an interdisciplinary approach. The primary objective of this collaboration is to transfer new scientific insights more rapidly in order to improve methods for diagnosis and patients treatment.