Unique features of a highly pathogenic Campylobacter jejuni strain |
| |
| Authors: | Hofreuter Dirk Tsai Jennifer Watson Robert O Novik Veronica Altman Bill Benitez Michelle Clark Christina Perbost Clotilde Jarvie Thomas Du Lei Galán Jorge E |
| |
| Affiliation: | Section of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, Connecticut 06536, USA. |
| |
| Abstract: | Campylobacter jejuni, a major human enteric pathogen, exhibits significant strain-to-strain differences which result in differences in pathogenic potential. C. jejuni 81-176 is a highly virulent strain that exhibits unique pathogenic features and is used by many research laboratories. We have determined the nucleotide sequence of its genome and compared it to the genomes of other sequenced C. jejuni strains. We identified a number of unique genetic features which may confer specific metabolic and pathogenic properties on this strain. We have also identified regions of the C. jejuni genome that are hot spots for the integration of horizontally acquired genetic material. This information should help the understanding of the pathogenesis of C. jejuni and, in particular, the unique features of this highly pathogenic strain. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
