Comparison of gene expression profiles in core biopsies and corresponding surgical breast cancer samples |
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| Authors: | Rosanna Zanetti-Dällenbach Vincent Vuaroqueaux Edward Wight Martin Labuhn Gad Singer Patrick Urban Urs Eppenberger Wolfgang Holzgreve Serenella Eppenberger-Castori |
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| Affiliation: | Rosanna Zanetti-Dällenbach, Vincent Vuaroqueaux, Edward Wight, Martin Labuhn, Gad Singer, Patrick Urban, Urs Eppenberger, Wolfgang Holzgreve, and Serenella Eppenberger-Castori |
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| Abstract: | Introduction Gene expression profiling has been successfully used to classify breast cancer into clinically distinct subtypes, and to predict the risk of recurrence and treatment response. The aim of this study was to investigate whether the gene expression profile (GEP) detected in a core biopsy (CB) is representative for the entire tumor, since CB is an important tool in breast cancer diagnosis. Moreover, we investigated whether performing CBs prior to the surgical excision could influence the GEP of the respective tumor. |
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