| 浙江省湖州地区幽门螺杆菌感染及耐药研究 |
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| 引用本文： | 秦基取,钱福初,何建方,杨水新. 浙江省湖州地区幽门螺杆菌感染及耐药研究[J]. 疾病监测, 2010, 25(10): 795-798 |
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| 作者姓名： | 秦基取 钱福初 何建方 杨水新 |
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| 作者单位： | 湖州市中心医院中心实验室,浙江,湖州,313000;湖州市中心医院中心实验室,浙江,湖州,313000;湖州市中心医院中心实验室,浙江,湖州,313000;湖州市中心医院中心实验室,浙江,湖州,313000 |
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| 摘 要： | 目的探讨幽门螺杆菌(Helicobacter pylori,Hp)在浙江省湖州地区感染和耐药性情况。方法取患者胃黏膜活组织进行Hp增菌、分离培养、挑取菌落涂片镜检、生化反应鉴定;对Hp呈阳性者,采用纸片琼脂扩散法(K-B法)进行药物敏感性检测。结果 902例患者胃黏膜组织标本中检出Hp 354株,阳性率为39.25%(354/902)。胃癌、胃炎、胃溃疡和其他消化道疾病的Hp感染阳性率分别为66.67%(16/24)、40.08%(295/736)、36.58%(30/82)和21.67%(13/60),胃癌较其他疾病Hp感染率差异有统计学意义(P0.05)。男女性别总感染率分别为39.96%和37.64%,Hp感染率男女性别间差异无统计学意义(P0.05),40～50岁属于本地区Hp感染多发年龄段。药物敏感实验阿莫西林、庆大霉素和痢特灵3种药物全部敏感,左氧氟沙星的耐药率为8.19%(29/354),克拉霉素的耐药率为19.21%(68/354),甲硝唑的耐药率为100%(354/354);克拉霉素和甲硝唑双重耐药率为16.95%(60/354),左氧氟沙星和甲硝唑双重耐药率4.24%(15/354),克拉霉素、左氧氟沙星和甲硝唑多重耐药率为1.98%(7/354)。结论 Hp感染与多种胃病关系密切。40～50岁属于Hp感染多发年龄段。在治疗时应注意左氧氟沙星、克拉霉素和甲硝唑等药物耐药性,本地区可以选择阿莫西林、庆大霉素和痢特灵治疗,不宜选用甲硝唑。
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| 关 键 词： | 幽门螺杆菌 感染 耐药性 |
| 收稿时间： | 2010-07-12 |
Prevalence and drug resistance of Helicobacter pylori in Huzhou area, Zhejiang province |
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| QIN Ji-qu , QIAN Fu-chu , HE Jian-fang , YANG shui-xin. Prevalence and drug resistance of Helicobacter pylori in Huzhou area, Zhejiang province[J]. Disease Surveillance, 2010, 25(10): 795-798 |
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| Authors: | QIN Ji-qu QIAN Fu-chu HE Jian-fang YANG shui-xin |
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| Affiliation: | 1.Central laboratory of Huzhou Central Hospital, Huzhou 313000,Zhejiang, China |
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| Abstract: | Objective To understand the prevalence and drug-resistance of Helicobacter pylori （H. pylori ） in gastropathic patients in Huzhou. Methods The patients＇ gastric mucosa tissue were collected for the isolation and culture of H. pylori. The suspected bacteria colonies were microscopic examined after smearing and identified by biochemical test. The drug susceptibility test was conducted by K-B method. Results A total of 902 specimens of patients＇ gastric mucosa tissue were examined, and 354 strains of 14. pylori were detected （39. 25% ）. The positive rate was 66. 67% in gastric cancer patients （ 16/24）, 40. 08% in gastritis patients （295/736）, 36. 58% in gastric ulcer patients （30/82） ,21.67% in other gastropathic patients （13/60）. The prevalence of H. pylori in gastric cancer patients was significantly higher than others （ P 〈 0.05 ）, and the difference on the prevalence of H. pylori between males （39. 96% ） and females （37.64%） was not statistically significant. The drug susceptibility test were performed for the 354 H. pylori strains, the results indicated that the H. pylori were sensitive to amoxicillin, gentamicin and furazolidone, whereas the drug resistant rate was 8.19% to levofloxacin （29/354）, 19.21% to clarithromycin （68/354） and 100% to metronidazole （354/354）, the multi drug resistant rate was 16.95% to clarithromycin and metronidazole （60/354）, 4. 24% to levofloxacin and metronidazole （15/354） and 1.98% to clarithromycin, levofloxacin and metronidazole （7/354）. Conclusion H. pylori infection is closely related to gastric diseases and mainly occurs in age group of 45 - 55 years. Close attention should be paid to the drug-resistance of levofloxacin, clarithromycin and metronidazole. H. pylori infection in Huzhou could be treated by using amoxicillin, gentamycin and furazolidone, but not by metronidazole. |
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| Keywords: | Helicobacter pylori infection drug resistance |
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