| 丹参酮ⅡA对自发性高血压大鼠左室肥厚的作用及其机制 |
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| 引用本文： | 冯俊,郑智,熊玮. 丹参酮ⅡA对自发性高血压大鼠左室肥厚的作用及其机制[J]. 实用医学杂志, 2005, 21(17): 1869-1873 |
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| 作者姓名： | 冯俊 郑智 熊玮 |
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| 作者单位： | 430030,武汉市,华中科技大学同济医学院附属同济医院急诊科 |
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| 基金项目： | 本课题为湖北省自然科学基金资助项目（编号：2000J064） |
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| 摘 要： | 目的:观察丹参酮IIA对自发性高血压大鼠左室肥厚的作用,并研究其对心肌原癌基因c-fosmRNA表达的影响。方法:18只8周龄的自发性高血压大鼠随机分成3组:对照组于8周处死,另两组分别经腹腔注射丹参酮IIA1mL/(kg·d)(丹参组)(和蒸馏水1mL/(kg·d)(高血压组),共10周。测量大鼠尾动脉收缩压(SBP)及左心室重量指数(LVMl)。应用HE染色、VG染色、免疫组织化学的方法,结合计算机图像分析技术,检测心肌细胞的直径和面积、心肌组织胶原体积比例(CVF)、血管周围胶原面积和管腔面积比例(PVCA)。用逆转录聚合酶链反应(RT-PCR)检测心肌细胞原癌基因c-fosmRNA的表达。结果:与对照组的自发性高血压大鼠相比,高血压组大鼠的SBP、LVMI、心肌细胞的直径、面积、CVF、PVCA显著增加,c-fos表达明显,丹参酮IIA治疗可抑制左室肥厚(LVH)的发展和心肌细胞c-fosmRNA的表达,但收缩压无明显改变。结论:长期应用丹参酮IIA治疗可预防自发性高血压大鼠LVH的形成,其机制可能与丹参酮IIA抑制了心肌细胞c-fosmRNA的表达有关。
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| 关 键 词： | 高血压 丹参酮 |
| 收稿时间： | 2005-04-25 |
| 修稿时间： | 2005-04-25 |
Effect of tanshinone ⅡA in prevention of left ventricular hypertrophy in spontaneously hypertensive rats and its mechanism |
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| FENG Jun,ZHENG Zhi,XIONG Wei. Effect of tanshinone ⅡA in prevention of left ventricular hypertrophy in spontaneously hypertensive rats and its mechanism[J]. The Journal of Practical Medicine, 2005, 21(17): 1869-1873 |
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| Authors: | FENG Jun ZHENG Zhi XIONG Wei |
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| Affiliation: | FENG Jun,ZHENG Zhi,XIONG Wei. Department of Emergency Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Objective To observe the effect of tanshinone ⅡA(TSN) on preventing left ventricular hypertrophy(LVH) in spontaneously hypertensive rats. and investigate the expression of proto-oncogene c-fos mRNA. Methods Eighteen spontaneously hypertensive rats, 8 weeks old, were divided randomly into three groups: TSN and distilled water (1 mL/(kg·d) were injected intraperitoneally into two groups, respectively for 10 weeks. Systolic blood pressure (SBP) and left ventricular mass index(LVMI)were measured. Combined with ... |
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| Keywords: | Hypertension Tanshinone |
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