Use of monoclonal antibodies to protein F of Pseudomonas aeruginosa as opsonins for phagocytosis by macrophages. |
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| Authors: | J L Battershill D P Speert R E Hancock |
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| Affiliation: | Department of Microbiology, University of British Columbia, Vancouver, Canada. |
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| Abstract: | Five protein F-specific monoclonal antibodies were found to opsonize Pseudomonas aeruginosa for complement-independent phagocytosis by unelicited mouse peritoneal macrophages, mouse macrophage cell line P388D1, and human monocyte-derived macrophages. Immunoglobulin G1 antibodies seemed to be a preferred isotype. |
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