Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor |
| |
| Authors: | Hess J Werner A Wirth T Melchers F Jäck H M Winkler T H |
| |
| Affiliation: | Institut für Medizinische Strahlenkunde und Zellforschung (MSZ), University of Würzburg, Versbacher Strasse 5, D-97078 Würzburg, Germany. |
| |
| Abstract: | The assembly of a pre-B cell receptor (pre-BCR) composed of an Ig mu heavy chain (mu H-chain), the surrogate light (SL) chain, and the Ig alpha/beta dimer is critical for late pro-B cells to advance to the pre-B cell stage. By using a transgenic mouse model, in which mu H-chain synthesis is solely driven by a tetracycline-controlled transactivator, we show that de novo synthesis of mu H-chain in transgenic pro-B cells not only induces differentiation but also proliferation. This positive effect of mu H-chain synthesis on proliferation requires the presence of SL chain and costimulatory signals provided by stromal cells or IL-7. We conclude that pre-BCR signaling induces clonal expansion of early pre-B cells. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
