| 人微小DNA病毒B19与人类疾病 |
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| 引用本文： | 唐青 阙飙. 人微小DNA病毒B19与人类疾病[J]. 疾病监测, 1995, 10(5): 154-158. DOI: 10.3784/j.issn.1003-9961.1995.5.154 |
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| 作者姓名： | 唐青 阙飙 |
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| 作者单位： | 1.中国预防医学科学院流研所 102206 |
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| 摘 要： | 人微小ＤＮＡ病毒Ｂ１９是１９７４年偶然发现的一种不同于已知的动物微小ＤＮＡ病毒的病毒。这种平均直径为２３ｎｍ、单链线状ＤＮＡ病毒感染人后常呈隐性感染，故在发现后数年内并未引起人们的注意。直至检测该病毒特异性诊断方法的建立和应用才逐渐明确了Ｂ１９与人类疾病的关系，也才使我们对一些不明原因的疾病有了新的认识，目前已明确Ｂ１９感染可以造成:一些慢性溶血性贫血尤其是镰形细胞贫血病人发生再障危象；传染性红斑及其并发病──多发性关节炎或关节病；妊娠妇女流产、死胎或胎儿畸形。呼吸道是Ｂ１９最常见的传播途径。此外，经血和胎盘也可造成Ｂ１９感染。鉴于Ｂ１９感染范围广泛，且各国报告的流行情况无明显差异，考虑在我国也有可能存在Ｂ１９感染，故建议在我国开展该项调查。
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| 关 键 词： | 微小DNA病毒 B19 疾病 流行 |
| 收稿时间： | 1995-01-15 |
Human Parvovirus B19 and Human Disease |
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| Affiliation: | 1.lnstitute of Epidemiology and Microbiology;Chinese Academy of Preventive Medicine;Beijing |
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| Abstract: | Human Parvovirus B19 was discovered by Chance in 1974.The Virus is different from the other animal Parvovirus already Known todoy.Its average diameter is 23nm.It is a single-strand- ed DNA virus.After its discovery,it was neglected for many years because it often caused human la- tent infection.It has not been realized that B19 has relation to some human diseases untill the specific diagnostic methods for this virus are establishes.With the help of those methods,the scientists have got- ten some new knowledge about the causes of the disease which are not known previously.Now it is clear that B19 infection can give rise to the following health probemms:chronis hemolytic anemias,espe-cially sickle cell anemia developing into aplastic crises;erythema infectiosun and its complication-poly-arthralgias or arthritis;abortion,stillbirth and malformation.Respiratory tract is the most likely portal of entry.It can also be transmitted by blood and placenta.Because of the wide-range infection of B19and ther is a little difference about the properties of its epidemic amng various countries,so it is thought that the virus mayalso circulate in China.The auhors suggest that sonme investigation of the virus should carry out in China. |
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