| 单克隆抗体SC3A在胃癌及癌前病变的表达意义 |
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| 引用本文： | 吴继锋, 宋育林, 杨光霖, 董聿明, 王道斌, 刘民培. 单克隆抗体SC3A在胃癌及癌前病变的表达意义[J]. 世界华人消化杂志, 1997, 5(8): 497-499 |
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| 作者姓名： | 吴继锋 宋育林 杨光霖 董聿明 王道斌 刘民培 |
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| 作者单位： | 230032,安徽省合肥市,安徽医科大学病理学教研室. |
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| 摘 要： | 目的研究单克隆抗体ＳＣ３Ａ在胃癌及癌前病变的表达意义．方法应用免疫组化ＡＢＣ法及粘液组化染色检测１０１例胃良恶性病变组织中ＳＣ３Ａ的表达．结果胃癌７１例中ＳＣ３Ａ阳性５７例（８０３％），但与癌组织类型、分化程度、转移及术后生存率无明显关系．ＳＣ３Ａ阳性率在酸性粘液（＋）组胃癌明显高于酸性粘液（－）组（９０２％对２００％，Ｐ＜００１），硫酸粘液（＋）组胃癌明显高于硫酸粘液（－）组（９１３％对６００％，Ｐ＜００１）．而且癌旁肠化硫酸粘液阳性率明显较良性病变伴肠化高（８８９％对３５３％，Ｐ＜００１）；硫酸粘液（＋）组肠化ＳＣ３Ａ阳性率明显高于硫酸粘液（－）组（６０９％对３１３％，Ｐ＜００５）．结论单克隆抗体ＳＣ３Ａ的表达对胃癌诊断及组织发生探讨有一定意义．
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| 关 键 词： | 抗体.单克隆／代谢 胃肿瘤／免疫学 |
Significance of monoclonal antibody SC3A expression in gastric carcinoma and precancerous lesion |
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| WU Ji Feng,SONG Yu Lin,YANG Guang Lin,DONG Yu Ming,WANG Dao Bing and LIU Min Pei. Significance of monoclonal antibody SC3A expression in gastric carcinoma and precancerous lesion[J]. World Chinese Journal of Digestology, 1997, 5(8): 497-499 |
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| Authors: | WU Ji Feng SONG Yu Lin YANG Guang Lin DONG Yu Ming WANG Dao Bing LIU Min Pei |
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| Affiliation: | WU Ji Feng,SONG Yu Lin,YANG Guang Lin,DONG Yu Ming,WANG Dao Bing and LIU Min Pei Department of Pathology,Anhui Medical University,Hefei 230032,Anhui Province,China |
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| Abstract: | AIM To study the significance of monoclonal antibody SC3A expression in gastric carcinoma and precancerous lesion. METHODS Immunohistochemical staining and mucin histochemical staining were performed on paraffin embedded sections from gastric benign and malignant lesions of 101 cases. RESULTS SC3A positive rate was 80 3% (57/71) in gastric carcinoma. The expression of SC3A was not related to classification, differentiation, metastasis and survivals. The positive rate of SC3A in cancers secreting acid mucin (90 2%) or sulphomucin (91 3%) was higher than that in cancers without acid mucin (20 0%) or sulphomucin (60 0%) ( P <0 01). The positive rate of sulphomucin was higher in intestinal metaplasia with cancer (88 9%) than that of intestinal metaplasia with benign lesion (35 3%) ( P <0 01). The positive rate of SC3A with sulphomucin in intestinal metaplasia (60 9%) was higher than that without sulphomucin (31 3%) ( P <0 05). CONCLUSION SC3A monoclonal antibody might be helpful in the diagnosis of gastric cancer and discernment of histogenesis. |
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| Keywords: | Antibodies monoclonal/metabolism Stomach neoplasms/immunology |
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