Mutational analysis of metronidazole resistance in Helicobacter pylori |
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| Authors: | Moore Jill M Salama Nina R |
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| Affiliation: | Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle WA 98109-1024, USA. |
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| Abstract: | Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance. |
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