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Real‐life 3D therapy failure: Analysis of NS5A 93H RAS plus 108 K polymorphism in complex with ombitasvir by molecular modeling |
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| Authors: | Nadia Marascio Grazia Pavia Isabella Romeo Carmine Talarico Sebastiano Di Salvo Mariaconcetta Reale Vito Marano Giorgio Settimo Barreca Fernanda Fabiani Nicola Perrotti Massimo De Siena Francesca Giancotti Tiziana Gravina Stefano Alcaro Anna Artese Carlo Torti Maria Carla Liberto Alfredo Focà |
| Affiliation: | 1. Department of Health Sciences, Unit of Clinical Microbiology, School of Medicine, University of “Magna Graecia”, Catanzaro, Italy;2. Department of Health Sciences, University of “Magna Graecia”, Catanzaro, Italy;3. Unit of Hepatology, “Mater Domini” University Hospital, Catanzaro, Italy;4. Unit of Medical Genetics, “Mater Domini” University Hospital, Catanzaro, Italy;5. Department of Medical and Surgical Sciences, Unit of Infectious and Tropical Diseases, School of Medicine, University of “Magna Graecia”, Catanzaro, Italy |
| Abstract: | |
| Keywords: | computational analysis docking HCV phosphoprotein molecular dynamics simulations resistance‐associated substitutions |