| 慢性HBV携带者外周血T细胞亚群的不同年龄变化 |
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| 引用本文： | 乔燕伟,游晶,庄林,陈红英,俞岚,高惠芸,吴国宾,曲俊彦. 慢性HBV携带者外周血T细胞亚群的不同年龄变化[J]. 世界华人消化杂志, 2005, 13(1): 35-38 |
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| 作者姓名： | 乔燕伟 游晶 庄林 陈红英 俞岚 高惠芸 吴国宾 曲俊彦 |
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| 作者单位： | 昆明医学院第一附属医院传染病科,云南省,昆明市,650032;昆明市第三人民医院肝病科,云南省,昆明市,650032 |
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| 基金项目： | 云南省教育厅科研课题基金项目,No.028Y213 |
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| 摘 要： |
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| 关 键 词： | HBV T细胞亚群 免疫功能 |
| 收稿时间： | 2005-09-28 |
| 修稿时间： | 2004-10-18 |
Change in T cell subset of chronic HBV carriers with different ages |
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| Yan-Wei Qiao,Jing You,Lin Zhuang,Hong-Ying Chen,Lan Yu,Hui-Yun Gao,Guo-Bing Wu,Jun-Yah Qv. Change in T cell subset of chronic HBV carriers with different ages[J]. World Chinese Journal of Digestology, 2005, 13(1): 35-38 |
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| Authors: | Yan-Wei Qiao Jing You Lin Zhuang Hong-Ying Chen Lan Yu Hui-Yun Gao Guo-Bing Wu Jun-Yah Qv |
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| Affiliation: | Yan-Wei Qiao,Jing You,Hong-Ying Chen,Lan Yu,Hui-Yun Gao,Guo-Bing Wu,Jun-Yan Qv,Department of Infectious Diseases,First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China Lin Zhuang,Department of Hepatopathy,Third People's Hospital of Kunming,Kunming 650032,Yunnan Province,China |
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| Abstract: | AIM: To investigate the mechanism of the transition from immunological tolerance to immunological activation of chronic hepatitis B virus (HBV) carriers. METHODS: T cell subsets were examined in chronic HBV carriers (n = 104) and health controls (n = 40). The carriers were divided into different groups at age intervals of 5, 10 and 20 years. The T cell subsets and the positive rate of HBeAg were comparatively analyzed between different groups. RESULTS: In comparison with those in health controls, the levels of CD3, CD4, and CD4/CD8, in chronic HBV carriers were significantly lower (F = 5.976, P= 0.016, F= 46.244, P= 0.0001, and F= 254.357, P= 0.0001, for CD3, CD4, and CD4/CD8 respectively), but the level of CD8 was higher (F=103.848, P= 0.0001). The number of CD8, T cells was significantly decreased in chronic carriers over 30 years old (F= 6.726, P= 0.011). Before 30 years old, the CD4 level in HBeAg positive group was lower than that in HBeAg negative group. CONCLUSION: Human leukocyte antigen restriction and CD4 T cell nonresponsiveness as well as the HBeAg adjustment of immunological tolerance determine that the turning point of the illness state and cell immune function of chronic HBV carriers occurs at the age around 30 years old. |
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| Keywords: | HBV T cell subset Immune function |
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