| MSCT联合血清CA199、CEA检查对结直肠癌及转移的诊断价值 |
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| 引用本文： | 阳金豆, 李建浩, 周夏, 左智炜, 伍发, 黄怡, 蒋锐. MSCT联合血清CA199、CEA检查对结直肠癌及转移的诊断价值[J]. 分子影像学杂志, 2022, 45(6): 842-846. doi: 10.12122/j.issn.1674-4500.2022.06.09 |
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| 作者姓名： | 阳金豆 李建浩 周夏 左智炜 伍发 黄怡 蒋锐 |
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| 作者单位： | 中国人民解放军西部战区总医院放射诊断科，四川 成都 610083 |
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| 基金项目： | 四川省卫生健康委员会科研课题20PJ211 |
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| 摘 要： | 目的 探讨多层螺旋CT(MSCT)联合血清CA199、CEA检查对结直肠癌(CRC)及是否合并肝转移的诊断价值。方法 回顾性选取2019年1月~2021年12月在本院经病理确诊的110例CRC患者为CRC组，以及110例肠道良性病变患者为良性病变组，对比两组患者的MSCT资料以及血清CA199、CEA水平，并结合病理诊断结果分析MSCT联合血清CA199、CEA对CRC及是否合并肝转移的诊断价值。结果 两组患者的血清CA199、CEA水平差异具有统计学意义，CRC患者指标水平更高(P < 0.05);与病理诊断一致性检验，血清CA199、CEA水平和MSCT单独及联合诊断CRC的Kappa值分别为0.491、0.355、0.667、0.682，敏感度分别为84.54%、72.73%、91.82%、72.73%，特异性分别为64.55%、62.73%、74.55%、95.45%，准确率分别为74.55%、67.73%、83.18%、84.09%。是否合并肝转移CRC患者的血清CA199、CEA水平差异有统计学意义，合并肝转移患者指标水平更高(P < 0.05);与病理诊断一致性检验，血清CA199、CEA水平和MSCT单独及联合诊断CRC合并肝转移的Kappa值分别为0.408、0.353、0.445、0.726，敏感度分别为84.00%、72.00%、92.00%、72.00%，特异性分别为69.41%、71.76%、68.24%、96.47%，准确率分别为72.73%、71.82%、73.64%、90.91%。结论 MSCT及血清CA199、CEA对CRC诊断各有优点及不足，两者联合检测有助于CRC的肝转移诊断。
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| 关 键 词： | 多层螺旋CT 糖类抗原199 癌胚抗原 结直肠癌 诊断价值 |
| 收稿时间： | 2022-06-09 |
Diagnostic value of multi-slice spiral CT combined with serum CA199 and CEA for colorectal cancer and metastasis |
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| YANG Jindou, LI Jianhao, ZHOU Xia, ZUO Zhiwei, WU Fa, HUANG Yi, JIANG Rui. Diagnostic value of multi-slice spiral CT combined with serum CA199 and CEA for colorectal cancer and metastasis[J]. Journal of Molecular Imaging, 2022, 45(6): 842-846. doi: 10.12122/j.issn.1674-4500.2022.06.09 |
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| Authors: | YANG Jindou LI Jianhao ZHOU Xia ZUO Zhiwei WU Fa HUANG Yi JIANG Rui |
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| Affiliation: | Department of Radiology Diagnosis, Western Theater General Hospital, Chengdu 610083, China |
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| Abstract: | Objective To explore the diagnostic value of multi-slice spiral CT (MSCT) combined with serum CA199 and CEA for colorectal cancer (CRC) and liver metastases. Methods A total of 110 patients with CRC and 110 patients with benign intestinal lesions who were pathologically confirmed in the hospital from January 2019 to December 2021 were retrospectively selected as CRC group and benign lesion group, respectively. MSCT data and levels of serum CA199 and CEA in the two groups were compared and analyzed. Based on the results of pathological diagnosis, the diagnostic value of MSCT combined with serum CA199 and CEA in the diagnosis of CRC. The diagnostic value of for liver metastasis were analyzed. Results There were significant differences in serum CA199 and CEA levels in patients with colorectal cancer, and higher index levels in CRC patients (P < 0.05). The consistency test showed that kappa values, sensitivity, specificity and accuracy rates of serum CA199, CEA, MSCT and their combination in the diagnosis of CRC were 0.491, 0.355, 0.667, 0.682; 84.54%, 72.73%, 91.82%, 72.73%; 64.55%, 62.73%, 74.55%, 95.45% and 74.55%, 67.73%, 83.18%, 84.09%, respectively. Serum CA199 and CEA levels of CRC patients with or without liver metastasis were significantly different, and the levels of serum CA199 and CEA were higher in CRC patients with liver metastasis (P < 0.05). The results of kappa consistency test showed that kappa values, sensitivity, specificity and accuracy rates of serum CA199, CEA, MSCT and their combination in the diagnosis of liver metastases were 0.408, 0.353, 0.445, 0.726; 84.00%, 72.00%, 92.00%, 72.00%; 69.41%, 71.76%, 68.24%, 96.47% and 72.73%, 71.82%, 73.64%, 90.91%, respectively. Conclusion MSCT, serum CA199 and CEA have their own advantages and disadvantages in the diagnosis of CRC. The combined detection is conducive to the diagnosis of liver metastases in CRC. |
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| Keywords: | multi-slice spiral CT carbohydrate antigen 199 carcinoembryonic antigen colorectal cancer diagnostic value |
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